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PREVENTION OF POST-FOCAL THERMAL DAMAGE BY FORMATION OF BUBBLES AT THE FOCUS
DURING HIGH INTENSITY FOCUSED ULTRASOUND THERAPY.
Vesna Zderic
Department of Electrical and Computer Engineering, The George Washington
University, Washington, DC 20052, USA.
* Search articles by 'Vesna Zderic'
Zderic V1,
Jessica Foley
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Foley J,
Wenbo Luo
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Luo W,
Shahram Vaezy
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Vaezy S
AUTHOR INFORMATION
AFFILIATIONS
* 1 author
1. Department of Electrical and Computer Engineering, The George Washington
University, Washington, DC 20052, USA.
Medical Physics, 01 Oct 2008, 35(10):4292-4299
DOI: 10.1118/1.2975149 PMID: 18975674 PMCID: PMC2673593
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ABSTRACT
--------------------------------------------------------------------------------
Safety concerns exist for potential thermal damage at tissue-air or tissue-bone
interfaces located in the post-focal region during high intensity focused
ultrasound (HIFU) treatments. We tested the feasibility of reducing thermal
energy deposited at the post-focal tissue-air interfaces by producing bubbles
(due to acoustic cavitation and/or boiling) at the HIFU focus. HIFU (in-situ
intensities of 460-3500 W/cm2, frequencies of 3.2-5.5 MHz) was applied for 30 s
to produce lesions (in turkey breast in-vitro (n = 37), and rabbit liver (n = 4)
and thigh muscle in-vivo (n = 11)). Tissue temperature was measured at the
tissue-air interface using a thermal (infrared) camera. Ultrasound imaging was
used to detect bubbles at the HIFU focus, appearing as a hyperechoic region.
In-vitro results showed that when no bubbles were present at the focus (at lower
intensities of 460-850 W/cm2), the temperature at the interface increased
continuously, up to 7.3 +/- 4.0 degrees C above the baseline by the end of
treatment. When bubbles formed immediately after the start of HIFU treatment (at
the high intensity of 3360 W/cm2), the temperature increased briefly for 3.5 s
to 7.4 +/- 3.6 degrees C above the baseline temperature and then decreased to
4.0 +/- 1.4 degrees C above the baseline by the end of treatment. Similar
results were obtained in in-vivo experiments with the temperature increases
(above the baseline temperature) at the muscle-air and liver-air interfaces at
the end of the high intensity treatment lower by 7.1 degrees C and 6.0 degrees
C, respectively, as compared to the low intensity treatment. Thermal effects of
HIFU at post-focal tissue-air interfaces, such as in bowels, could result in
clinically significant increases in temperature. Bubble formation at the HIFU
focus may provide a method for shielding the post-focal region from potential
thermal damage.
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CITATIONS & IMPACT
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SIMILAR ARTICLES
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To arrive at the top five similar articles we use a word-weighted algorithm to
compare words from the Title and Abstract of each citation.
* AN IMAGE-GUIDED HIGH INTENSITY FOCUSED ULTRASOUND DEVICE FOR UTERINE FIBROIDS
TREATMENT.
Chan AH, Fujimoto VY, Moore DE, Martin RW, Vaezy S
Med Phys, 29(11):2611-2620, 01 Nov 2002
Cited by: 48 articles | PMID: 12462728
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* BIOLOGICAL AND PHYSICAL MECHANISMS OF HIFU-INDUCED HYPERECHO IN ULTRASOUND
IMAGES.
Rabkin BA, Zderic V, Crum LA, Vaezy S
Ultrasound Med Biol, 32(11):1721-1729, 01 Nov 2006
Cited by: 56 articles | PMID: 17112958
--------------------------------------------------------------------------------
* HYPERECHO IN ULTRASOUND IMAGES OF HIFU THERAPY: INVOLVEMENT OF CAVITATION.
Rabkin BA, Zderic V, Vaezy S
Ultrasound Med Biol, 31(7):947-956, 01 Jul 2005
Cited by: 88 articles | PMID: 15972200
--------------------------------------------------------------------------------
* [CAVITATION AND BOILING OF BUBBLES AT THE FOCAL REGION DURING HIGH INTENSITY
FOCUSED ULTRASOUND EXPOSURE].
Zhong M, Ai H, Li F
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi, 29(5):983-986, 01 Oct 2012
Cited by: 0 articles | PMID: 23198445
Review
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* ROLE OF ACOUSTIC CAVITATION IN THE DELIVERY AND MONITORING OF CANCER
TREATMENT BY HIGH-INTENSITY FOCUSED ULTRASOUND (HIFU).
Coussios CC, Farny CH, Haar GT, Roy RA
Int J Hyperthermia, 23(2):105-120, 01 Mar 2007
Cited by: 183 articles | PMID: 17578336
Review
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FUNDING
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Funders who supported this work.
NIBIB NIH HHS (1)
NATIONAL AERONAUTICS AND SPACE ADMINISTRATION (1)
NATIONAL INSTITUTES OF HEALTH (1)
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