www.mdedge.com Open in urlscan Pro
104.18.86.85  Public Scan

Form analysis
2 forms found in the DOM

GET /cardiology/search

<form accept-charset="UTF-8" id="" method="get" action="/cardiology/search"><label for="search-text-label"></label><input type="text" placeholder="Search" value="" name="keywords" id="nav-search"><button onclick="wmdTrack('hd-srch-btn', this)"
    type="submit"><i class="fa fa-search"></i></button></form>

GET /cardiology/search

<form accept-charset="UTF-8" id="" method="get" action="/cardiology/search">
  <label for="search-text-label"></label>
  <input type="text" placeholder="Search MDedge" value="" name="keywords" id="nav-search">
  <button type="submit"><i class="fa fa-search"></i></button>
</form>

Text Content

Skip to main content

Cardiology
FULL MENU Close Menu

 * 
 * REGISTER or LOGIN

Cardiology
 * CME
 * Diseases and Conditions
   * Acute Coronary Syndromes
   * Arryhthmias
   * CAD & Atherosclerosis
   * Diabetes
   * Heart Failure
   * Lipid Disorders
   * Peripheral Vascular Disorders
   * Stroke
   * Hypertension
   * Thrombosis
 * Subspecialties
   * Imaging
   * Interventional Cardiology & Surgery
   * Pediatrics
   * Preventive Care
 * Multimedia
   * 
   * 
   * Podcasts
   * Videos
 * Coronavirus Updates

AHA 2022 Conference Coverage


From the Journals


VITAMIN D DEFICIENCY LINKED TO DEATH, NEW STUDY FINDS

Publish date: October 26, 2022
By Miriam E. Tucker





FROM ANNALS OF INTERNAL MEDICINE

Vitamin D deficiency increases mortality risk and raising levels even slightly
could decrease the risk, researchers examining data from the UK Biobank have
found.

They used a Mendelian randomization approach, which uses genetic variants as
“proxy indicators” for external factors that affect vitamin D levels, such as
sun exposure or dietary intake. It allows for analysis of the relationship
between deficiency and outcomes including mortality, which can’t be done in
randomized clinical trials for ethical reasons.

Using this method, nutritionist Joshua P. Sutherland, PhD, of the Australian
Centre for Precision Health, Adelaide, and colleagues found an association
between genetically predicted vitamin D levels [25-(OH)D] and mortality from
several major causes, with evidence of causality among people with measured
concentrations below, but not above, 50 nmol/L. The findings were published
online in Annals of Internal Medicine.



“Unlike other types of observational studies, we have overcome some of the
methodological obstacles. What is special about this new study is we were able
to look at people with very low vitamin D concentrations and what would happen
if their concentrations were a little bit higher. Most randomized controlled
trials don’t show much of an effect. That’s because most people have sufficient
concentrations. Ethically you can’t do a trial of people with very low levels
without treating them,” senior author Elina Hyppönen, PhD, told this news
organization.



The data support the 50 nmol/L cut-off endorsed by the United States National
Academy of Medicine and align with previous data suggesting the benefit of
vitamin D supplementation is largely seen in people with deficiency.

“Everybody with vitamin D levels less than 50 nmol/L is recommended to increase
their levels. Our results suggest there’s no need to go very high. The positive
message is that if we are able to raise levels to just the current U.S.
recommendations, that’s fine. There’s no need to use large supplement doses,”
Dr. Hyppönen explained.

Thus, she advised, “Supplementation will clearly help, especially during
wintertime or if a person isn’t getting enough vitamin D from the sun or in
places where food isn’t fortified with vitamin D.”

But the data don’t support the approach of using large intermittent doses, she
added.

“Sometimes doctors want to fix the deficiency quickly with a large ‘bolus’ dose,
then continue with a maintenance dose. Increasing evidence suggests that’s not
beneficial and might disturb the body’s metabolism so that it can’t get the
amount it needs. It’s safe overall but might not work the way we want it to
work.”

Rather, Dr. Hyppönen said, “My sense is that daily modest vitamin D dose
supplementation when it’s needed is the best way forward.”


GENETIC APPROACH REVEALS CAUSAL RELATIONSHIP

The investigators analyzed data from 307,601 individuals in the UK Biobank, a
prospective cohort of people recruited from England, Scotland, and Wales during
March 2006 and July 2010. Most were of White European ancestry and were aged
37-73 years at baseline.

Genetically predicted vitamin D levels were estimated using 35 confirmed
25-(OH)D variants. Participants were followed for outcomes up to June 2020.

The average baseline measured 25-(OH)D concentration was 45.2 nmol/L, and 11.7%
(n = 36,009) of participants had levels between 10.0 and 24.9 nmol/L. Higher
levels were seen in people living in southern areas and nonsmokers as well as
those with a higher level of physical activity, less socioeconomic deprivation,
and lower body mass index.

During follow-up, 6.1% of participants died (n = 18,700). After adjustment for
variables, odds ratios for all causes of mortality were highest among people
with 25-(OH)D levels below 25 nmol/L and appeared to plateau between 50 and 75
nmol/L, with no further reduction in mortality at values of 75-125 nmol/L.


To continue reading this article …

Log In

or

Register for Free

Join the top medical resource for physicians today. Free membership!


PAGES

 * 1
 * 2
 * 
 * last »




NEXT ARTICLE:

Goodbye ‘diabetes insipidus’, hello ‘AVP-D’ and ‘AVP-R’
 * Preventive Care
 * Mixed Topics
 * Lipid Disorders




THIS PUBLICATION

 * Advertise
 * Contact Us
 * Corporate Management
 * Editorial Staff

 * Facebook
 * Twitter


SPECIALTY FOCUS

 * Arrhythmias & EP
 * Business of Medicine
 * Interventional Cardiology & Surgery
 * Lipid Disorders


TOP SECTIONS

 * Conference Coverage
 * Latest News


HIGHLIGHTED FROM THIS SITE AND NETWORK

 * Contact ClinicalEdge
 * Contact MD-IQ
 * MedJob Network

Privacy Policy

Terms of Use

Editorial Policy

Cookie Policy

Manage Preferences

Ad Policy

Medscape Customer Support

Frequently Asked Questions

 

Advertise with MDedge

See more with MDedge! See our Other Publications

MDedge: Keeping You Informed. Saving You Time.



Copyright  © 2022 Frontline Medical Communications Inc., Newark, NJ, USA. All
rights reserved. Unauthorized use prohibited. The information provided is for
educational purposes only. Use of this Web site is subject to the medical
disclaimer.

Close
REGISTER or LOGIN

 * MDedge Home
 * Diseases and Conditions
   * Acute Coronary Syndromes
   * Arrhythmias
   * CAD & Atherosclerosis
   * COVID-19 Updates
   * Diabetes
   * Heart Failure
   * Lipid Disorders
   * Long COVID
   * Peripheral Vascular Disorders
   * Hypertension
   * Stroke
   * Thrombosis
 * Subspecialties
   * Imaging
   * Interventional Cardiology & Surgery
   * Pediatrics
   * Preventive Care
 * Business of Medicine
   * Medicolegal Issues
 * Diversity in Medicine


EXPLORE

 * News
   
   
   EXPLORE
   
   * Conference Coverage
   * From the Journals
   * Guidelines
   * Medicine’s Lighter Side
   * News From the FDA/CDC
   * News by Conference
 * Perspectives
   
   
   EXPLORE
   
   * Commentaries
   * Heart Of The Matter
 * CME
 * Conference ReCAP
 * Supplements
 * Quizzes and Polls
   
   
   EXPLORE
   
   * MD-IQ
   * Reader Poll
 * Multimedia
   
   
   EXPLORE
   
   * Audio
     
     
     EXPLORE
     
     * MDedge Podcasts
   * Videos
 * Roundtables
 * Sponsored Content
   
   
   EXPLORE
   
   * Acquisition Insights: Expert-led discussions on buy-and-bill
 * Subscribe to Cardiology News

 * MDedge Home
 * Careers
 * Medical Directors / Pharmacy Directors
 * Nurse Practitioners / Physician Assistants
 * Residents
 * VA / DoD / PHS


MORE

 * MDedge.com



Would you like to receive breaking news alerts on your web browser or mobile
phone?
Notifications can be turned off at any time.
DismissYes!


YOUR PRIVACY AND MANAGE COOKIES

We process your data to deliver content or advertisements and measure the
delivery of such content or advertisements to extract insights about our
website. We share this information with our partners on the basis of consent and
legitimate interest. You may exercise your right to consent or object to a
legitimate interest, based on a specific purpose below or at a partner level in
the link under each purpose. These choices will be signaled to our vendors
participating in the Transparency and Consent Framework.
More Information
Allow All


MANAGE CONSENT PREFERENCES

STRICTLY NECESSARY COOKIES

Always Active

These cookies are necessary for the website to function and cannot be switched
off in our systems. They are usually only set in response to actions made by you
which amount to a request for services, such as setting your privacy
preferences, logging in or filling in forms. You can set your browser to block
or alert you about these cookies, but some parts of the site will not then work.
These cookies do not store any personally identifiable information.

PERFORMANCE COOKIES

Performance Cookies

These cookies allow us to count visits and traffic sources so we can measure and
improve the performance of our site. They help us to know which pages are the
most and least popular and see how visitors move around the site. All
information these cookies collect is aggregated and therefore anonymous. If you
do not allow these cookies we will not know when you have visited our site, and
will not be able to monitor its performance.

TARGETING COOKIES

Targeting Cookies

These cookies may be set through our site by our advertising partners. They may
be used by those companies to build a profile of your interests and show you
relevant adverts on other sites. They do not store directly personal
information, but are based on uniquely identifying your browser and internet
device. If you do not allow these cookies, you will experience less targeted
advertising.

FUNCTIONAL COOKIES

Functional Cookies

These cookies enable the website to provide enhanced functionality and
personalisation. They may be set by us or by third party providers whose
services we have added to our pages. If you do not allow these cookies then some
or all of these services may not function properly.

STORE AND/OR ACCESS INFORMATION ON A DEVICE

Store and/or access information on a device

Cookies, device identifiers, or other information can be stored or accessed on
your device for the purposes presented to you.

List of IAB Vendors‎ | View Full Legal Text Opens in a new Tab

PERSONALISED ADS AND CONTENT, AD AND CONTENT MEASUREMENT, AUDIENCE INSIGHTS AND
PRODUCT DEVELOPMENT

Personalised ads and content, ad and content measurement, audience insights and
product development

 * SELECT BASIC ADS
   
   Switch Label
   
   Ads can be shown to you based on the content you’re viewing, the app you’re
   using, your approximate location, or your device type.
   
   Object to Legitimate Interests Remove Objection

 * CREATE A PERSONALISED ADS PROFILE
   
   Switch Label
   
   A profile can be built about you and your interests to show you personalised
   ads that are relevant to you.
   
   Object to Legitimate Interests Remove Objection

 * SELECT PERSONALISED ADS
   
   Switch Label
   
   Personalised ads can be shown to you based on a profile about you.
   
   Object to Legitimate Interests Remove Objection

 * CREATE A PERSONALISED CONTENT PROFILE
   
   Switch Label
   
   A profile can be built about you and your interests to show you personalised
   content that is relevant to you.
   
   Object to Legitimate Interests Remove Objection

 * SELECT PERSONALISED CONTENT
   
   Switch Label
   
   Personalised content can be shown to you based on a profile about you.
   
   Object to Legitimate Interests Remove Objection

 * MEASURE AD PERFORMANCE
   
   Switch Label
   
   The performance and effectiveness of ads that you see or interact with can be
   measured.
   
   Object to Legitimate Interests Remove Objection

 * MEASURE CONTENT PERFORMANCE
   
   Switch Label
   
   The performance and effectiveness of content that you see or interact with
   can be measured.
   
   Object to Legitimate Interests Remove Objection

 * APPLY MARKET RESEARCH TO GENERATE AUDIENCE INSIGHTS
   
   Switch Label
   
   Market research can be used to learn more about the audiences who visit
   sites/apps and view ads.
   
   Object to Legitimate Interests Remove Objection

 * DEVELOP AND IMPROVE PRODUCTS
   
   Switch Label
   
   Your data can be used to improve existing systems and software, and to
   develop new products
   
   Object to Legitimate Interests Remove Objection

List of IAB Vendors‎ | View Full Legal Text Opens in a new Tab

USE PRECISE GEOLOCATION DATA

Use precise geolocation data

Your precise geolocation data can be used in support of one or more purposes.
This means your location can be accurate to within several meters.

List of IAB Vendors‎ | View Full Legal Text Opens in a new Tab

ACTIVELY SCAN DEVICE CHARACTERISTICS FOR IDENTIFICATION

Actively scan device characteristics for identification

Your device can be identified based on a scan of your device's unique
combination of characteristics.

List of IAB Vendors‎ | View Full Legal Text Opens in a new Tab

ENSURE SECURITY, PREVENT FRAUD, AND DEBUG

Always Active

Your data can be used to monitor for and prevent fraudulent activity, and ensure
systems and processes work properly and securely.

List of IAB Vendors‎ | View Full Legal Text Opens in a new Tab

TECHNICALLY DELIVER ADS OR CONTENT

Always Active

Your device can receive and send information that allows you to see and interact
with ads and content.

List of IAB Vendors‎ | View Full Legal Text Opens in a new Tab

MATCH AND COMBINE OFFLINE DATA SOURCES

Always Active

Data from offline data sources can be combined with your online activity in
support of one or more purposes

List of IAB Vendors‎ | View Full Legal Text Opens in a new Tab

LINK DIFFERENT DEVICES

Always Active

Different devices can be determined as belonging to you or your household in
support of one or more of purposes.

List of IAB Vendors‎ | View Full Legal Text Opens in a new Tab

RECEIVE AND USE AUTOMATICALLY-SENT DEVICE CHARACTERISTICS FOR IDENTIFICATION

Always Active

Your device might be distinguished from other devices based on information it
automatically sends, such as IP address or browser type.

List of IAB Vendors‎ | View Full Legal Text Opens in a new Tab
Back Button


PERFORMANCE COOKIES



Vendor Search Search Icon
Filter Icon

Clear
checkbox label label
Apply Cancel
Consent Leg.Interest
checkbox label label
checkbox label label
checkbox label label

Confirm My Choices



YOUR CHOICE ON COOKIES

We and our partners store and/or access information on a device, such as unique
IDs in cookies to process personal data. You may accept or manage your choices
by clicking below, including your right to object where legitimate interest is
used, or at any time in the privacy policy page. These choices will be signaled
to our partners and will not affect browsing data.See our Cookie Notice.


WE AND OUR PARTNERS PROCESS DATA TO:

Use precise geolocation data. Actively scan device characteristics for
identification. Store and/or access information on a device. Personalised ads
and content, ad and content measurement, audience insights and product
development. List of Partners

I Accept Manage Settings