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Podcast Reports
Home News and Trends AI program finds multiple influenza drug targets
AI PROGRAM FINDS MULTIPLE INFLUENZA DRUG TARGETS
By Jim Cornall
2 minutesmins
June 29, 2023
2 minutesmins
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Photo/Shutterstock
Poolbeg Pharma, a clinical-stage biopharma company focusing on infectious and
other prevalent diseases, has announced a breakthrough in its world-first
influenza Artificial Intelligence (AI) Programme working with the company
CytoReason.
Poolbeg’s disease progression data from influenza human challenge trials
combined with CytoReason’s broad repositories of curated disease data were
analyzed using CytoReason’s AI-led platform. The analysis has led to the
discovery of multiple novel drug targets for the treatment of influenza.
Identification of drug targets from this data-set has previously been successful
as p38 MAP Kinase, inhibited by POLB 001, was identified as a driver of severe
influenza but this required manual analysis that took several years. However,
through the utilization of CytoReason’s AI technology, Poolbeg has now
identified multiple novel drug targets in 15 months. Also, CytoReason’s analysis
independently confirmed the significance of the p38 MAP kinase pathway in
influenza, providing further validation for Poolbeg’s POLB 001 program.
SECOND AI PROGRAM
The company is exploring the most effective way to further develop the novel
drug targets to generate value. This marks Poolbeg’s second successful AI
program, following the identification of potential new drug candidates for
respiratory syncytial virus (RSV) announced in December 2022.
Jeremy Skillington, chief executive officer of Poolbeg Pharma, said: “Our
collaboration with CytoReason has put Poolbeg at the forefront of AI drug
discovery. CytoReason’s deep interrogation of the uniquely rich data derived
from human challenge trials has deepened our knowledge of influenza, resulting
in the identification of multiple novel influenza drug targets. There is a
significant unmet need for new and better treatments for vulnerable patients
with influenza and this is a major milestone in the delivery of new therapies
that can improve patient outcomes and global health.”
David Harel, chief executive officer of CytoReason, said: “Once again, we’re
pleased to see that leveraging CytoReason’s computational disease models to
extract insights from Poolbeg’s unique human challenge data can optimize the
target discovery process. More importantly, these impressive results would not
be possible without the commitment, transparency, and reciprocity of both
teams.”
In December, Poolbeg Pharma announced it had successfully identified potential
new drug candidates from its respiratory syncytial virus (RSV) AI program with
OneThree Biotech, Inc.
ADVERTISEMENT
Explore other topics: Artificial intelligenceinfluenzaPoolbeg Pharma
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