us.supersmart.com
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192.155.95.234
Public Scan
Submitted URL: http://r.info2.supersmart.com/mk/cl/f/sh/28xHLtxYQ50fkZwZbUf0nUTn2kDzG7Iruk/VkoSLXif51f-
Effective URL: https://us.supersmart.com/article.pl?id=0788&fromid=2405_BL2&utm_source=newsletter_en&utm_medium=mail&utm_campaign=2405_BL...
Submission: On May 09 via api from US — Scanned from FR
Effective URL: https://us.supersmart.com/article.pl?id=0788&fromid=2405_BL2&utm_source=newsletter_en&utm_medium=mail&utm_campaign=2405_BL...
Submission: On May 09 via api from US — Scanned from FR
Form analysis 7 forms found in the DOM
Name: search_form — GET /search.pl
<form method="get" name="search_form" id="search_form" action="/search.pl" class="project-form p-rel">
<input name="search" id="search" class="form-control abs-error 5s-error ui-autocomplete-input" type="text" placeholder="Search" maxlength="30" aria-label="What are you looking for ? (probiotics, diabetes, joints...)" autocomplete="off"><label
class="error-text mt-1"><span class="font--size-12" id="search_error"></span></label>
<span onclick="sendForm(0);" class="icon icon--search d-flex justify-content-center align-items-center">
<svg xmlns="http://www.w3.org/2000/svg" width="24" height="24" viewBox="0 0 24 24" fill="none">
<path d="M20.0002 20.0007L16.3765 16.377" stroke="#151517" stroke-width="1.5" stroke-linecap="round" stroke-linejoin="round"></path>
<path d="M4 11.25C4 15.2541 7.24594 18.5 11.25 18.5C15.2541 18.5 18.5 15.2541 18.5 11.25C18.5 7.24594 15.2541 4 11.25 4V4C7.24606 4.00029 4.00029 7.24606 4 11.25" stroke="#151517" stroke-width="1.5" stroke-linecap="round"
stroke-linejoin="round"></path>
</svg>
</span>
<span onclick="sendForm(1);" id="search_mobil" class="d-none">
<svg xmlns="http://www.w3.org/2000/svg" width="24" height="24" viewBox="0 0 24 24" fill="none">
<path d="M20.0002 20.0007L16.3765 16.377" stroke="#151517" stroke-width="1.5" stroke-linecap="round" stroke-linejoin="round"></path>
<path d="M4 11.25C4 15.2541 7.24594 18.5 11.25 18.5C15.2541 18.5 18.5 15.2541 18.5 11.25C18.5 7.24594 15.2541 4 11.25 4V4C7.24606 4.00029 4.00029 7.24606 4 11.25" stroke="#151517" stroke-width="1.5" stroke-linecap="round"
stroke-linejoin="round"></path>
</svg>
</span>
</form>Name: qteform — POST
<form method="post" name="qteform">
<div class="block--margin-tb-32 sur_btns" style="">
<div class="row">
<div onclick="switch_mode_achat(0);" class="col-6 block--padding-r-md-4">
<div id="div_achat_immediat" class="border-r block--padding-16 block--padding-md-12 block--height-100 border--primary block--height-100">
<p class="text-center text--primary font--size-18"> Buy now </p>
<p class="text-center text--black-600 font--size-14" style="margin-top:-5px;"> 60 tablets </p>
<div class="d-flex justify-content-center align-items-center block--margin-tb-12">
<p class="text-center text--black-700 block--padding-l-8 font--weight-700">$70.00</p>
</div>
<div class="d-flex justify-content-center align-items-center block--margin-tb-12 cart-item__counter border-r mx-auto">
<input type="hidden" name="mode_achat" value="achat">
<input type="hidden" name="abo_art" value="0788">
<input type="hidden" name="se_souvenir" value="0">
<span class="cart-item__decrement bg--hover-primary d-flex align-items-center justify-content-center"
onclick="var p=parseInt(document.qteform.qty.value);if(p!=1)document.qteform.qty.value=p-1;document.qteform2.qty.value=document.qteform.qty.value;">
<svg xmlns="http://www.w3.org/2000/svg" width="24" height="24" viewBox="0 0 24 24" fill="none">
<path d="M19 12H5" stroke="#151517" stroke-width="1.71429" stroke-linecap="round"></path>
</svg>
</span>
<span class="cart-item__amount d-flex align-items-center">
<input class="cart-item__input text--black-700" type="text" value="1" name="qty">
</span>
<span class="cart-item__increment bg--hover-primary d-flex align-items-center justify-content-center" onclick="document.qteform.qty.value=parseInt(document.qteform.qty.value)+1;document.qteform2.qty.value=document.qteform.qty.value;">
<svg xmlns="http://www.w3.org/2000/svg" width="24" height="24" viewBox="0 0 24 24" fill="none">
<path d="M12 6V18" stroke="#151517" stroke-width="1.71429" stroke-linecap="round"></path>
<path d="M18 12H6H18Z" fill="#151517"></path>
<path d="M18 12H6" stroke="#151517" stroke-width="1.71429" stroke-linecap="round"></path>
</svg>
</span>
</div>
</div>
</div>
<div onclick="switch_mode_achat(1);" class="col-6 block--padding-l-md-4">
<div id="div_abonnement" class="border-r block--padding-16 block--padding-md-12 block--height-100 border--black-300">
<p class="text-center text--primary font--size-18"> Auto-delivery </p>
<p class="text-center text--black-600 font--size-14" style="margin-top:-5px;"> 60 tablets </p>
<div class="d-flex justify-content-center align-items-center block--margin-tb-8">
<p class="text-center text--black-600 font--size-14 font--decoration-line-through">
<i>
$70.00
</i>
</p>
<p class="text-center text--black-700 block--padding-l-8 font--weight-700"> $64.40 </p>
</div>
<div>
<p class="justify-content-center d-flex align-items-center font--size-md-14">
<span style="white-space:nowrap"> I'd like </span>
<span class="text--primary block--margin-l-8 cursor--pointer border-b--primary-dashed">
<select name="abo_art_qt" id="abo_art_qt">
<option value="1" selected="">1 unit</option>
<option value="2">2 units</option>
<option value="3">3 units</option>
<option value="4">4 units</option>
<option value="5">5 units</option>
<option value="6">6 units</option>
<option value="7">7 units</option>
<option value="8">8 units</option>
<option value="9">9 units</option>
<option value="10">10 units</option>
</select>
</span>
<svg width="19" height="18" viewBox="0 0 19 18" fill="none" xmlns="http://www.w3.org/2000/svg">
<path d="M6.5 7.5L9.5 10.5L12.5 7.5" stroke="#151517" stroke-width="1.5" stroke-linecap="round" stroke-linejoin="round"></path>
</svg>
</p>
<p class="justify-content-center d-flex align-items-center font--size-md-14">
<span> every </span>
<span class="text--primary block--margin-l-8 cursor--pointer border-b--primary-dashed">
<select name="abo_art_freq" id="abo_art_freq">
<option value="1"> month</option>
<option value="2">2 months</option>
<option value="3">3 months</option>
<option value="4">4 months</option>
<option value="5">5 months</option>
<option value="6">6 months</option>
</select>
</span>
<svg width="19" height="18" viewBox="0 0 19 18" fill="none" xmlns="http://www.w3.org/2000/svg">
<path d="M6.5 7.5L9.5 10.5L12.5 7.5" stroke="#151517" stroke-width="1.5" stroke-linecap="round" stroke-linejoin="round"></path>
</svg>
</p>
</div>
</div>
</div>
</div>
</div>
</form>Name: qteform2 —
<form name="qteform2" class="cart-item__counter d-flex align-items-center border-r">
<span class="cart-item__decrement bg--hover-primary d-flex align-items-center justify-content-center"
onclick="var p=parseInt(document.qteform2.qty.value);if(p!=1)document.qteform2.qty.value=p-1;document.qteform.qty.value=document.qteform2.qty.value;prix_et_monnaie();">
<svg xmlns="http://www.w3.org/2000/svg" width="24" height="24" viewBox="0 0 24 24" fill="none">
<path d="M19 12H5" stroke="#151517" stroke-width="1.71429" stroke-linecap="round"></path>
</svg>
</span>
<span class="cart-item__amount d-flex align-items-center">
<input class="cart-item__input text--black-700" type="text" value="1" name="qty">
</span>
<span class="cart-item__increment bg--hover-primary d-flex align-items-center justify-content-center"
onclick="document.qteform2.qty.value=parseInt(document.qteform2.qty.value)+1;document.qteform.qty.value=document.qteform2.qty.value;prix_et_monnaie();">
<svg xmlns="http://www.w3.org/2000/svg" width="24" height="24" viewBox="0 0 24 24" fill="none">
<path d="M12 6V18" stroke="#151517" stroke-width="1.71429" stroke-linecap="round"></path>
<path d="M18 12H6H18Z" fill="#151517"></path>
<path d="M18 12H6" stroke="#151517" stroke-width="1.71429" stroke-linecap="round"></path>
</svg>
</span>
</form>POST /inscription.pl
<form action="/inscription.pl" method="POST" class="supersmart-form" id="sub_home" onsubmit="return check_nwsltr_form(this);">
<div class="p-rel newsletter-subscribe d-flex align-items-center">
<input type="hidden" name="op" value="newsletters">
<input type="hidden" name="civ" value="1">
<input type="hidden" name="nom" value="">
<input type="hidden" name="prenom" value="">
<input type="email" id="sub_email" name="email" aria-label="email, Newsletter" class="newsletter-subscribe__input-text" placeholder="Enter your email address here">
<input type="submit" aria-label="Register" class="newsletter-subscribe__submit p-abs font-roboto-bold" value="Send">
</div>
</form>Name: form — POST https://us.supersmart.com/login.pl
<form method="post" action="https://us.supersmart.com/login.pl" name="form" onsubmit="return check_login_form(form);">
<input type="hidden" name="from" value="a0788">
<div class="modal-content bg--white block--padding-24">
<span class="modal-close block--pointer p-abs" data-bs-dismiss="modal">
<svg xmlns="http://www.w3.org/2000/svg" width="16" height="16" viewBox="0 0 16 16" fill="none">
<path d="M14.6653 14.6673L1.33203 1.33398" stroke="#151517" stroke-width="1.71" stroke-linecap="round" stroke-linejoin="round"></path>
<path d="M1.33203 14.6673L14.6653 1.33398" stroke="#151517" stroke-width="1.71" stroke-linecap="round" stroke-linejoin="round"></path>
</svg>
</span>
<h3 class="heading-3 block--mb-32 text--primary" id="titre_modal_cb"> Login </h3>
<div class="row">
<div class="col-12 block--mb-16">
<input placeholder="Email" type="email" class="form-control" name="i_email" size="15" maxlength="50" value="" id="i_email"
onkeyup="if (this.value.search(/^[a-zA-Z0-9_.@-]*$/i) == -1) {if($(this).closest('.w3-modal').css('display')=='block'){jalert('Invalid character')};this.value=this.value.replace(/[^a-zA-Z0-9_.@-]/gi, '');}"
onchange="$('#mdp_email').val(this.value);$('#email').val(this.value);"><label class="error-text mt-1"><span class="font--size-12" id="i_email_error"></span></label>
</div>
<div class="col-12 block--mb-16 p-rel">
<input placeholder="Password" type="password" name="i_password" size="15" maxlength="20" id="i_password" class="form-control" value=""><label class="error-text mt-1"><span class="font--size-12" id="i_password_error"></span></label>
<span class="ss-reveal" target="i_password">
<svg xmlns="http://www.w3.org/2000/svg" width="24" height="24" viewBox="0 0 24 24">
<path fill="#9E9E9E"
d="M12.015 7c4.751 0 8.063 3.012 9.504 4.636-1.401 1.837-4.713 5.364-9.504 5.364-4.42 0-7.93-3.536-9.478-5.407 1.493-1.647 4.817-4.593 9.478-4.593zm0-2c-7.569 0-12.015 6.551-12.015 6.551s4.835 7.449 12.015 7.449c7.733 0 11.985-7.449 11.985-7.449s-4.291-6.551-11.985-6.551zm-.015 3c-2.209 0-4 1.792-4 4 0 2.209 1.791 4 4 4s4-1.791 4-4c0-2.208-1.791-4-4-4z">
</path>
</svg>
</span>
</div>
<div class="col-12 block--mb-16 text--tiny">
<a href="/en/mdp_oublie" class="" title="Forgotten your password?">Password Forgotten ?</a>
</div>
<div class="col-12 block--mb-16">
<input type="submit" value="Log in" class="w-100 btn btn--primary" style="border-radius:0.8rem">
</div>
<div class="col-12 block--mb-16 text--tiny"> New customer? <a href="#" data-bs-toggle="modal" data-bs-target="#modal_inscription" class="text--primary text--underline" title="Create account">Create account</a>
</div>
</div>
</div>
</form>Name: form_insc — POST /inscription.pl
<form method="post" action="/inscription.pl" name="form_insc" onsubmit="if(check_insc_form(form_insc) ){ jyesno('Confirm your registration ?','Yes','No','form_insc.submit()')}return false">
<input type="hidden" name="op" value="inscription">
<input type="hidden" name="pays" value="FR">
<input type="hidden" name="from" value="a0788">
<div class="modal-content bg--white block--padding-24">
<span class="modal-close block--pointer p-abs" data-bs-dismiss="modal">
<svg xmlns="http://www.w3.org/2000/svg" width="16" height="16" viewBox="0 0 16 16" fill="none">
<path d="M14.6653 14.6673L1.33203 1.33398" stroke="#151517" stroke-width="1.71" stroke-linecap="round" stroke-linejoin="round"></path>
<path d="M1.33203 14.6673L14.6653 1.33398" stroke="#151517" stroke-width="1.71" stroke-linecap="round" stroke-linejoin="round"></path>
</svg>
</span>
<h3 class="heading-3 block--mb-32 text--primary" id="titre_modal_cb"> Registration </h3>
<div class="row">
<div class="col-12 block--mb-16">
<input placeholder="Email" type="email" class="form-control" name="email" size="15" maxlength="50" value="" id="email"
onkeyup="if (this.value.search(/^[a-zA-Z0-9_.@-]*$/i) == -1) {if($(this).closest('.w3-modal').css('display')=='block'){jalert('Invalid character')};this.value=this.value.replace(/[^a-zA-Z0-9_.@-]/gi, '');}"
onchange="$('#mdp_email').val(this.value);$('#email').val(this.value);"><label class="error-text mt-1"><span class="font--size-12" id="email_error"></span></label>
</div>
<div class="col-12 block--mb-16">
<div class="form-select--general block--width-100 text--black-500">
<select class="form-select--search form-control" name="civ" id="civ" data-id="ss-x78l4kra" tabindex="-1" aria-hidden="true" style="display: none;">
<option value="" disabled="" selected="">Please enter your title</option>
<option value="1">Mr</option>
<option value="2">Mrs</option>
<option value="4">Mr and Mrs</option>
<option value="5">Dr</option>
<option value="8">Professor</option>
</select>
<div data-id="ss-x78l4kra" id="ss-x78l4kra" tabindex="0" class="ss-main form-select--search form-control" role="combobox" aria-haspopup="listbox" aria-controls="ss-x78l4kra" aria-expanded="false" aria-activedescendant="7m0m0apf">
<div class="ss-values">
<div class="ss-single">Please enter your title</div>
</div>
<div class="ss-deselect ss-hide"><svg viewBox="0 0 100 100">
<path d="M10,10 L90,90 M10,90 L90,10"></path>
</svg></div><svg class="ss-arrow" viewBox="0 0 100 100">
<path d="M10,30 L50,70 L90,30"></path>
</svg>
</div><label class="error-text mt-1"><span class="font--size-12" id="civ_error"></span></label>
</div>
</div>
<div class="col-12 block--mb-16">
<input placeholder="Last Name" type="text" class="form-control" name="nom" id="nom" size="50" maxlength="200" value=""
onkeyup="if (this.value.search(/^[A-ZÑ0-9&@. ''-]*$/i) == -1) {if($(this).closest('.w3-modal').css('display')=='block'){jalert('Invalid character')};this.value=this.value.replace(/[^A-ZÑ0-9&@. ''-]/gi, '');}"><label
class="error-text mt-1"><span class="font--size-12" id="nom_error"></span></label>
</div>
<div class="col-12 block--mb-16">
<input placeholder="First Name" type="text" class="form-control" name="prenom" id="prenom" size="50" maxlength="200" value=""
onkeyup="if (this.value.search(/^[0-9a-zàáâãäåæçèéêëìíîïðñòóôõöøœšÞùúûüýÿA-ZÀÁÂÃÄÅÆßÇČÈÉÊËĞÏÍÌÎÐÑÖÓÒÔŐÕØŒŠÞÜÚÙÛÝŸŽ&. ''-]*$/i) == -1) {if($(this).closest('.w3-modal').css('display')=='block'){jalert('Invalid character')};this.value=this.value.replace(/[^0-9a-zàáâãäåæçèéêëìíîïðñòóôõöøœšÞùúûüýÿA-ZÀÁÂÃÄÅÆßÇČÈÉÊËĞÏÍÌÎÐÑÖÓÒÔŐÕØŒŠÞÜÚÙÛÝŸŽ&. ''-]/gi, '');}"><label
class="error-text mt-1"><span class="font--size-12" id="prenom_error"></span></label>
</div>
<div class="col-12 block--mb-16 p-rel">
<input placeholder="Password" type="password" name="password" size="15" maxlength="20" id="password" class="form-control" value=""><label class="error-text mt-1"><span class="font--size-12" id="password_error"></span></label>
<span class="ss-reveal" target="password">
<svg xmlns="http://www.w3.org/2000/svg" width="24" height="24" viewBox="0 0 24 24">
<path fill="#9E9E9E"
d="M12.015 7c4.751 0 8.063 3.012 9.504 4.636-1.401 1.837-4.713 5.364-9.504 5.364-4.42 0-7.93-3.536-9.478-5.407 1.493-1.647 4.817-4.593 9.478-4.593zm0-2c-7.569 0-12.015 6.551-12.015 6.551s4.835 7.449 12.015 7.449c7.733 0 11.985-7.449 11.985-7.449s-4.291-6.551-11.985-6.551zm-.015 3c-2.209 0-4 1.792-4 4 0 2.209 1.791 4 4 4s4-1.791 4-4c0-2.208-1.791-4-4-4z">
</path>
</svg>
</span>
</div>
<div class="col-12 block--mb-16">
<input type="text" class="form-control" name="nee" id="nee" size="50" maxlength="50" value="" placeholder="Date of birth :" onfocus="(this.type='date')" onblur="if(!this.value){(this.type='text')}"><label class="error-text mt-1"><span
class="font--size-12" id="nee_error"></span></label>
</div>
<div class="col-12 block--mb-16">
<input type="text" class="form-control" name="code_option" id="code_option" size="50" maxlength="50" value="" placeholder="sponsor code / prescriber code"><label class="error-text mt-1"><span class="font--size-12"
id="code_option_error"></span></label>
</div>
<div class="col-12 block--mb-16">
<input type="submit" value="Confirm my registration" class="w-100 btn btn--primary" style="border-radius:0.8rem">
</div>
<div class="col-12 block--mb-16 text--tiny"> Existing customer? <a href="#" data-bs-toggle="modal" data-bs-target="#modal_connexion" class="text--primary text--underline" title="Log in">Log in</a>
</div>
</div>
</div>
</form>Name: n_form — POST /inscription.pl
<form method="post" action="/inscription.pl" name="n_form" onsubmit="return check_newsletter_form(n_form);">
<input type="hidden" name="from" value="a0788">
<div class="modal-content bg--white block--padding-24">
<span class="modal-close block--pointer p-abs" data-bs-dismiss="modal">
<svg xmlns="http://www.w3.org/2000/svg" width="16" height="16" viewBox="0 0 16 16" fill="none">
<path d="M14.6653 14.6673L1.33203 1.33398" stroke="#151517" stroke-width="1.71" stroke-linecap="round" stroke-linejoin="round"></path>
<path d="M1.33203 14.6673L14.6653 1.33398" stroke="#151517" stroke-width="1.71" stroke-linecap="round" stroke-linejoin="round"></path>
</svg>
</span>
<h3 class="heading-3 block--mb-16 text--primary"> Join the SuperSmart club </h3>
<div class="row">
<div class="col-12 block--mb-16">
<ul>
<li>Permanent <strong>5% Off on all your Orders!</strong></li>
<li>Free: our weekly science-based newsletter </li>
<li><strong>Special Offers</strong> for club members only</li>
</ul>
</div>
</div>
<div class="row">
<div class="col-12 block--mb-16">
<input type="hidden" name="op" value="newsletters">
<input type="hidden" name="civ" value="1">
<input type="hidden" name="nom" value="">
<input type="hidden" name="prenom" value="">
<input type="hidden" name="from" value="a0788">
<input placeholder="Email" type="email" class="form-control" name="email" size="15" maxlength="50" value="" id="n_email"
onkeyup="if (this.value.search(/^[a-zA-Z0-9_.@-]*$/i) == -1) {if($(this).closest('.w3-modal').css('display')=='block'){falert('Invalid character'),'n_email'};this.value=this.value.replace(/[^a-zA-Z0-9_.@-]/gi, '');}"><label
class="error-text mt-1"><span class="font--size-12" id="n_email_error"></span></label>
</div>
<div class="col-12 block--mb-16">
<input type="submit" value="I wish to register" class="w-100 btn btn--primary" style="border-radius:0.8rem">
</div>
<div class="col-12 block--mb-16 form-check">
<input type="checkbox" name="mailing_check" id="mailing_check">
<label class="label-md text--tiny" for="mailing_check"> I agree to receive promotional offers from SuperSmart. I can unsubscribe at any time. </label>
</div>
</div>
</div>
</form>Text Content
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* Fisetin
Certificate of AnalysisBest before : 12/30/2025
Longevity (Anti-aging)
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FISETIN
FISETIN SUPPLEMENT – 500 MG TABLETS THAT KILL SENESCENT CELLS
3 reviewsRead reviews
Our fisetin supplement is a most powerful and natural senolytic designed to
eliminate senescent cells and reactivate autophagy.
* Unparalleled fisetin supplement for deep-cleaning of the body.
* Encourages self-destruction of the senescent cells responsible for aging and
age-related health issues (muscle weakness, cognitive decline, cardiovascular
problems, chronic inflammation, and more).
* Helps cells eliminate toxic debris, which blocks cytoplasm for an instant
boost.
* Naturally extracted from the stem of Rhus succedanea and standardized to 98%
fisetin (maximum purity).
* Helps improve bone strength and neural communication (boosted memory and
cognitive processes).
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60 tablets
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* Description
* Composition
* Directions for use
* References
Our Fisetin supplement is one of the most powerful senolytic supplements on the
market. It is part of the large family of natural polyphenol antioxidants, which
include quercetin, kaempferol, and myricetin.
It is designed to eliminate senescent cells scattered throughout the body –
rogue cells that have stopped contributing to essential functions and induce
nearby healthy cells to join in the dysfunction. Important scientific studies
have shown that these senescent cells are directly linked to aging and decline.
Fisetin also helps activate autophagy. What is autophagy? It is the body’s
mechanism for eliminating toxic elements that accumulate in cells. It was
discovered by Professor Yoshinori Ohsumi, a finding for which he was awarded the
Nobel prize in medicine in October 2016.
Autophagy literally means "self-eat." That might sound scary, but it positively
affects the body, under the right conditions. Autophagy is actually a method of
self-preservation used by the body to remove bad cells while recycling parts for
cleaning and cellular repair. It is like your body hitting a reset button.
WHAT IS FISETIN?
Fisetin is a polyphenol found in fruits such as strawberries (160 mg/kg), apples
(27 mg/kg), and persimmon (10 mg/kg), as well as in some medicinal plants. The
benefits of fisetin include the inhibition of cell proliferation,
neuroprotection, bone protection, and suppression of inflammation.
But its two most extraordinary properties are its ability to destroy senescent
cells that pervade the body and aid in activating autophagy, which enables cells
to devour their own waste products. Several studies have shown it helps extend
longevity and reduce markers of senescence in humans.
Its hydrophobic nature means it easily penetrates cells via the cell membrane.
It then encourages the self-destruction of abnormal cells (such as senescent
cells) by activating various characteristic proteins.
One of its main advantages over other senolytics is its ability to reduce the
proportion of senescent immune cells (T lymphocytes and NK cells). Since immune
cells are themselves important for cleaning out senescent cells, this makes
fisetin even more effective. This study highlights its senolytic properties and
impact on longevity: Fisetin is a senotherapeutic that extends health and
lifespan.
It also helps cells get rid of their toxic debris by eating them. This is the
above-mentioned autophagy process. When this mechanism becomes disrupted – as a
result of mutations, for example, it can lead to chronic health conditions and
neurological problems.
People looking to slow the aging process, improve brain health, or boost the
strength of bones often turn to fisetin for support. This well-researched
supplement offers numerous benefits for the entire body.
THE LINK BETWEEN FISETIN AND AGING
Fisetin is a rare product that acts on three key processes associated with
aging: the increase in senescent cells, inactivation of the autophagy process,
and the decline in neural communication. People looking to combat the aging
process often turn to fisetin due to its well documented advantages.
HOW SENESCENT CELLS DAMAGE THE BODY AND HOW SENOTHERAPY WORKS
In 2014, there was a major scientific advance in the fight against aging:
researchers identified totally depleted cells in the tissues of individuals over
40 years old.
Spread throughout the body’s tissues, these so-called senescent cells are
defective, unable to fulfill their function. And, although they no longer work
properly, they are not eliminated from the body and thus accumulate
pathologically in the milieu, according to research.
Uncommon in young people, these senescent cells increase with age, particularly
in adipose tissue, skeletal muscle, blood vessels, the brain, the kidneys, and
skin.
Unfortunately, senescent cells do not simply stay-put; they also impede the
activity of neighboring healthy cells by continually releasing proinflammatory
substances (IL-1, IL-6, and IL-8), vesicles, and insoluble proteins
(fibronectin, collagen) in the extracellular milieu.
But these substances do not just signal to other cells the advanced state of
deterioration they are in; they affect the function of nearby healthy cells. And
numerous studies have shown that the number of senescent cells in the body is
directly linked to the aging process and the development of age-related health
problems.
Even a low level of senescent cells is enough to wreak havoc in healthy tissue
and trigger a number of age-related health problems: systemic inflammation,
arthritis, atherosclerosis, chronic conditions, sarcopenia, cataracts, vascular
hyporeactivity, and more.
That brings us to senotherapy, an early-stage research field looking into the
development of therapeutic agents and techniques that will target cellular
senescence. Fisetin supplements are one of the options that show great promise
in combating the negative effects of senescent cells.
USING SENOLYTICS TO DESTROY SENESCENT CELLS
Normally, when stimulated by the appropriate trigger, cells self-destruct to
avoid damaging the body. This is called apoptosis, or programmed cell death, but
in the case of senescent cells, this mechanism does not work. Instead, they are
left to parasitize the body and cause chaos all around them.
Fortunately, scientists have identified several compounds that are specifically
able to repair this defective mechanism, thus reinstating appropriate
self-destruction.
These extraordinary substances are called 'senolytics' and fisetin is the most
powerful one. It enables the selective destruction of senescent cells in order
to limit the severity of age-related diseases, increase resilience and
longevity, and delay the effects of aging. It essentially provides complete
clean-out benefits, allowing healthy cells to wrest back control and restore
full function to the body.
LEVERAGING AUTOPHAGY TO PREVENT HEALTHY CELLS FROM TURNING INTO SENESCENT CELLS
A young, healthy cell is able to digest part of its contents – proteins, cell
debris, and microorganisms – if those contents impair its ability to function.
This voluntary breakdown is called autophagy, and autophagy benefits include
both the cleansing and recycling of senescent cells.
"This process is very important because if the cell is unable to self-clean,
debris will accumulate," explains Isabelle Vergne, a scientist at the French
National Center for Scientific Research (CNRS) who studies autophagy. She adds
that, "if the process is unregulated," it could lead to a number of health
problems.
And according to Professor Ioannis Nezis of Warwick University in the UK,
researchers are trying to "understand why this process declines with age and to
find innovative ways of activating it in order to maintain our cells in a
healthy state for longer and to be able to live a better, longer life."
Professor Ohsumi, a recipient of the Nobel prize for medicine in 2016, succeeded
in identifying the genes necessary for this and showed that in certain
age-related conditions, it is necessary to stimulate or even reactivate the
autophagy process to help cells get rid of the protein aggregates that
accumulate in them.
Fisetin is one of the substances that can stimulate autophagy, and SuperSmart’s
formula is standardized to 98 percent purity, making it one of the best fisetin
supplements available.
ADDITIONAL FISETIN BENEFITS
Fisetin supplement benefits go on. Among anti-aging supplements, few can compete
with the number of benefits and qualities that studies show fisetin offers. Not
only does it appear to kill off senescent cells and combat aging naturally; it
can also be used to promote brain health and help preserve memory function. Here
are a few specific ways fisetin helps boost your overall health:
PROMOTES NEURON SURVIVAL AND OVERALL BRAIN HEALTH
The brain is the most complicated organ in the body, but it is also one of the
most difficult to maintain, especially as you get older. Studies show that brain
volume and weight decline by about 5% each decade after the age of 40, with the
largest decreases happening after age 70.
As brain health declines, it is possible to encounter several health issues,
including neurodegenerative diseases, strokes, and Parkinson’s disease. Neuron
survival is the key to promoting better brain health.
This study shows that fisetin supplements can act as substitutes for
neurotrophic factors. While some cells normally die within 24 hours, when
fisetin is introduced, those cells may survive longer and produce long neurites.
That same study indicates that fisetin enhances glutathione synthesis and
increases proteasome activity. In essence, Senolytic supplements are the
ultimate brain health supplements.
SUPPORTS MEMORY FUNCTIONALITY
Numerous studies have shown fisetin helps improve memory and concentration,
protect neurons, and promote their growth. Able to cross the blood-brain
barrier, fisetin encourages neural communication in the hippocampus, the area of
the brain associated with long-term memory.
STRENGTHENS BONES IN THOSE AGED 50 AND MORE
As the body gets older, bones begin to weaken naturally. Scientists are
investigating fisetin’s potential for combating osteoporosis, a problem that
affects more than 10 million Americans. This bone disorder significantly
increases the risk of fractures and impairs the quality of life of those
affected. And since conventional treatments often have adverse side-effects,
natural alternatives have been well researched.
Studies show fisetin may act on bone remodeling, the result of activity by
osteoblasts – bone-forming cells – and that of osteoclasts – bone-resorbing
cells. In osteoporosis, an imbalance between the activity of these two types of
cells gradually leads to an inadequate level of bone mineral density and changes
in the microarchitecture of the bones. But fisetin has the ability to
recalibrate bone remodeling by stimulating osteoblasts and blocking
differentiation caused by osteoclasts’ activities.
In addition to aging, bone loss may stem from poor nutrition, immobility,
certain medical procedures, and reduced lean body mass. Chronic inflammatory
conditions are often associated with bone loss as well.
These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.
Daily dose: 2 tablets
Number of doses per pack: 30
Amount per dose
Fisetin (from Rhus succedanea stem standardized to 98% fisetin
(7,3’,4’-flavon-3-ol) 500 mg Other ingredients: microcrystalline cellulose,
stearic acid, bamboo extract, calcium hydrogen phosphate dihydrate, HPMC,
glycerol.
HOW TO TAKE FISETIN?
There are several natural sources of fisetin. However, those sources, such as
strawberries, apples, persimmons, lotus root, onions, grapes, and kiwi contain
only small amounts of fisetin. However, taking a high-quality fisetin supplement
can help ensure you get enough.
Fisetin 500 mg can either be used once a year, as part of a three-month plan or
taken continuously, according to your needs. We recommend adults to take 2
Fisetin capsules per day, at mealtimes.
The serving size in one study was determined using the usual principle of
converting the serving size from animals to humans. Note that fisetin
constitutes a more powerful alternative to SuperSmart’s Senolytic Complex.
It should also be noted that curcumin inhibits the glucurono conjugation of
fisetin, and thus its bioavailability (by a factor of 30), according to some
studies.
DHA, however, acts in synergy with fisetin to reduce bone resorption.
Bioflavonoids, such as pycnogenol and quercetin are mutually reinforcing and it
is therefore equally appropriate to combine them.
Even at increased serving size, studies found very few fisetin supplement side
effects. But that does not mean that everyone should take this supplement. In
fact, there is not enough research to support pregnant or nursing mothers taking
them. Like any supplement, regardless of your current overall health, it is
important to do your own research on potential fisetin side effects before
committing to buying a fisetin supplement.
Lastly, note that fisetin should also not be taken alongside Vitamin K
antagonists, a widely prescribed class of anticoagulant drugs.
1. Syed, D. N., Adhami, V. M., Khan, N., Khan, M. I., & Mukhtar, H. (2016).
Exploring the molecular targets of dietary flavonoid fisetin in cancer.
Seminars in Cancer Biology, 40-41, 130–140.
doi:10.1016/j.semcancer.2016.04.003
2. Maher, P. (2006). A comparison of the neurotrophic activities of the
flavonoid fisetin and some of its derivatives. Free Radical Research,
40(10), 1105–1111. doi:10.1080/10715760600672509
3. Liu, S.-H., Lin, C.-H., Hung, S.-K., Chou, J.-H., Chi, C.-W., & Fu, S.-L.
(2010). Fisetin Inhibits Lipopolysaccharide-Induced Macrophage Activation
and Dendritic Cell Maturation. Journal of Agricultural and Food Chemistry,
58(20), 10831–10839. doi:10.1021/jf1017093
4. MJ Yousefzadeh, Zhu Y et al.Fisetin is a senotherapeutic that extends
health and lifespan.EBioMedicine.2018 Oct;36:18-28.
doi:10.1016/j.ebiom.2018.09.015. Epub 2018 Sep 29.
5. Wood J.G., Rogina B., Lavu S., Howitz K., Helfand S.L., Tatar M. Sirtuin
activators mimic caloric restriction and delay ageing in metazoans.Nature.
2004;430(7000):686-689.
6. Iannello A., Thompson T.W., Ardolino M., Lowe S.W., Raulet D.H.
p53-dependent chemokine production by senescent tumor cells supports
NKG2D-dependent tumor elimination by natural killer cells. J Exp Med.
2013;210(10):2057-2069
7. Swanson E.C., Manning B., Zhang H., Lawrence J.B.Higher-order unfolding of
satellite heterochromatin is a consistent and early event in cell
senescence.J Cell Biol. 2013;203(6):929-942.
8. Tchkonia T., Morbeck D.E., von Zglinicki T., van Deursen J., Lustgarten J.,
Scrable H. Fat tissue, aging, and cellular senescence.Aging Cell.
2010;9:667-684
9. Lee BY, Han JA, Im JS, Morrone A, Johung K, Goodwin EC, et
al.Senescence-associated beta-galactosidase is lysosomal
beta-galactosidase.Aging Cell.2006;5(2):187-95.Epub 2006/04/22.
10.1111/j.1474-9726.2006.00199.x
10. Toutfaire M, Bauwens E, Debacq-Chainiaux F. Biochem Pharmacol.The impact of
cellular senescence in skin ageing: A notion of mosaic and therapeutic
strategies.
11. L. Urbanelli, S. Buratta, K. Sagini, B. Tancini, C. Emiliani, Extracellular
vesicles as new players in cellular senescence, Int.J. Mol.Sci. 17 (9)
(2016).
12. M. Toutfaire et al., The impact of cellular senescence in skin ageing:A
notion of mosaic and therapeutic strategies, Biochem.Pharmacol. (2017),
http://dx.doi.org/10.1016/j.bcp.2017.04.011
13. Campisi J. Aging, cellular senescence, and cancer.Annual review of
physiology.2013;75:685-705.Epub 2012/11/13.
10.1146/annurev-physiol-030212-183653 .
14. Herbig U., Ferreira M., Condel L., Carey D., Sedivy J.M.Cellular senescence
in aging primates.Science. 2006;311(5765):1257.
15. Zhu Y, Armstrong JL, Tchkonia T, Kirkland JL.Cellular senescence and the
senescent secretory phenotype in age-related chronic diseases.Curr Opin
Clin Nutr Metab Care.2014;17:324-28. doi: 10.1097/MCO.0000000000000065.
16. Xu M, Palmer AK, Ding H, Weivoda MM, Pirtskhalava T, White TA, Sepe A,
Johnson KO, Stout MB, Giorgadze N, Jensen MD, LeBrasseur NK, Tchkonia T,
Kirkland JL.Targeting senescent cells enhances adipogenesis and metabolic
function in old age. eLife.2015;4:e12997. doi: 10.7554/eLife.12997.
17. Jeyapalan JC, Sedivy JM.Cellular senescence and organismal aging.Mech
Ageing Dev.2008;129(7-8):467-74.Epub 2008/05/27. 10.1016/j.mad.2008.04.001
18. Maher, P. (2017). Protective effects of fisetin and other berry flavonoids
in Parkinson’s disease. Food & Function, 8(9), 3033–3042.
doi:10.1039/c7fo00809k
19. He, W., Abe, K., & Akaishi, T. (2018). Oral administration of fisetin
promotes the induction of hippocampal long-term potentiation in vivo.
Journal of Pharmacological Sciences, 136(1), 42–45.
doi:10.1016/j.jphs.2017.12.008
20. Fu, C., Chen, M., Tseng, Y., Chen, M., Zhou, Z., Yang, J., … Huang, C.
(2019). Fisetin activates Hippo pathway and JNK/ERK/AP‐1 signaling to
inhibit proliferation and induce apoptosis of human osteosarcoma cells via
ZAK overexpression. Environmental Toxicology, 34(8), 902–911.
doi:10.1002/tox.22761
21. Léotoing, L., Davicco, M.-J., Lebecque, P., Wittrant, Y., & Coxam, V.
(2014). The flavonoid fisetin promotes osteoblasts differentiation through
Runx2 transcriptional activity. Molecular Nutrition & Food Research, 58(6),
1239–1248. doi:10.1002/mnfr.201300836
22. Zheng, W., Feng, Z., You, S., Zhang, H., Tao, Z., Wang, Q., … Wu, Y.
(2017). Fisetin inhibits IL-1β-induced inflammatory response in human
osteoarthritis chondrocytes through activating SIRT1 and attenuates the
progression of osteoarthritis in mice. International Immunopharmacology,
45, 135–147. doi:10.1016/j.intimp.2017.02.009
23. Anroop B. Nair & Shery Jacob, A simple practice guide for dose conversion
between animals and human, J Basic Clin Pharm. March 2016-May 2016 ; 7(2) :
27-31
24. Touil YS, Auzeil N, Boulinguez F, Saighi H, Regazzetti A, Scherman D,
Chabot GG.Fisetin disposition and metabolism in mice: identification of
geraldol as an active metabolite.Biochem Pharmacol.2011;82:1731-39. doi:
10.1016/j.bcp.2011.07.097
REVIEWS
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This product is rated 4.7 out of 5 stars
There are 3 reviews
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Excellent 3 Reviews
David Morales
september 16 2022
Too soon to tell but to know you have what could be the future of
mind,body,health and longevity it’s a very exciting journey to embark.
Couteau Christopher
january 2 2022
I got exactly what I expected and paid for in a timely fashion. Price point
could be lower. The 500mg dose is very convenient.
Nathan Levin
december 28 2020
possibly helps memory
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