qepler.com Open in urlscan Pro
2a02:4a8:ac24:110::10:119  Public Scan

Submitted URL: https://qepler.com/events/gti23.html
Effective URL: https://qepler.com/events/3rd-genotoxic-impurities-in-pharmaceuticals-summit-2023.html
Submission: On November 21 via api from US — Scanned from DE

Form analysis 11 forms found in the DOM

POST https://qepler.com/virtual-registration-form.html

<form class="form-inline justify-content-center" method="post" action="https://qepler.com/virtual-registration-form.html">
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  <input type="hidden" name="workemail" value="">
  <select name="delegatesCount" class="form-control form-control-sm product-quantity">
    <option value="1">1</option>
  </select>
  <button type="submit" name="VGO" class="btn btn-primary btn-sm">SELECT</button>
</form>

POST https://qepler.com/virtual-registration-form.html

<form class="form-inline justify-content-center" method="post" action="https://qepler.com/virtual-registration-form.html">
  <input type="hidden" name="eventID" value="969">
  <input type="hidden" name="package" value="Online GROUP 2-3">
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  <input type="hidden" name="eventURL" value="https://qepler.com/events/3rd-genotoxic-impurities-in-pharmaceuticals-summit-2023.html">
  <input type="hidden" name="workemail" value="">
  <select name="delegatesCount" class="form-control form-control-sm product-quantity">
    <option value="2">2</option>
    <option value="3">3</option>
  </select>
  <button type="submit" name="VGO" class="btn btn-primary btn-sm">SELECT</button>
</form>

POST https://qepler.com/virtual-registration-form.html

<form class="form-inline justify-content-center" method="post" action="https://qepler.com/virtual-registration-form.html">
  <input type="hidden" name="eventID" value="969">
  <input type="hidden" name="package" value="Online GROUP 4+">
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  <input type="hidden" name="eventURL" value="https://qepler.com/events/3rd-genotoxic-impurities-in-pharmaceuticals-summit-2023.html">
  <input type="hidden" name="workemail" value="">
  <select name="delegatesCount" class="form-control form-control-sm product-quantity">
    <option value="4">4</option>
    <option value="5">5</option>
    <option value="6">6</option>
    <option value="7">7</option>
    <option value="8">8</option>
    <option value="9">9</option>
    <option value="10">10</option>
  </select>
  <button type="submit" name="VGO" class="btn btn-primary btn-sm">SELECT</button>
</form>

POST https://qepler.com/virtual-registration-form.html

<form class="form-inline justify-content-center" method="post" action="https://qepler.com/virtual-registration-form.html">
  <input type="hidden" name="eventID" value="969">
  <input type="hidden" name="package" value="Online - NPO/Academic">
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  <input type="hidden" name="price" value="195">
  <input type="hidden" name="priceEB" value="95">
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  <input type="hidden" name="eventURL" value="https://qepler.com/events/3rd-genotoxic-impurities-in-pharmaceuticals-summit-2023.html">
  <input type="hidden" name="workemail" value="">
  <select name="delegatesCount" class="form-control form-control-sm product-quantity">
    <option value="1">1</option>
    <option value="2">2</option>
    <option value="3">3</option>
    <option value="4">4</option>
    <option value="5">5</option>
    <option value="6">6</option>
    <option value="7">7</option>
    <option value="8">8</option>
    <option value="9">9</option>
    <option value="10">10</option>
  </select>
  <button type="submit" name="VGO" class="btn btn-primary btn-sm">SELECT</button>
</form>

POST https://qepler.com/virtual-registration-form.html

<form class="form-inline justify-content-center" method="post" action="https://qepler.com/virtual-registration-form.html">
  <input type="hidden" name="eventID" value="969">
  <input type="hidden" name="package" value="Past Attendees">
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  <input type="hidden" name="eventURL" value="https://qepler.com/events/3rd-genotoxic-impurities-in-pharmaceuticals-summit-2023.html">
  <input type="hidden" name="workemail" value="">
  <select name="delegatesCount" class="form-control form-control-sm product-quantity">
    <option value="1">1</option>
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    <option value="3">3</option>
    <option value="4">4</option>
    <option value="5">5</option>
    <option value="6">6</option>
    <option value="7">7</option>
    <option value="8">8</option>
    <option value="9">9</option>
    <option value="10">10</option>
  </select>
  <button type="submit" name="VGO" class="btn btn-primary btn-sm">SELECT</button>
</form>

POST https://qepler.com/sponsorship-registration-form.html

<form class="form-inline justify-content-center" method="post" action="https://qepler.com/sponsorship-registration-form.html">
  <input type="hidden" name="eventID" value="969">
  <input type="hidden" name="package" value="ONLINE Promo Sponsorship">
  <input type="hidden" name="packageID" value="DP2D">
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  <input type="hidden" name="includedparticipants" value="1">
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  <input type="hidden" name="includedparticipantsprice" value="0">
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  <input type="hidden" name="discount" value="">
  <input type="hidden" name="eventURL" value="https://qepler.com/events/3rd-genotoxic-impurities-in-pharmaceuticals-summit-2023.html">
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  <select name="delegatesCount" class="form-control form-control-sm product-quantity">
    <option value="1">1</option>
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    <option value="3">3</option>
    <option value="4">4</option>
    <option value="5">5</option>
  </select>
  <button type="submit" name="SGO" class="btn btn-primary btn-sm">SELECT</button>
</form>

POST https://qepler.com/sponsorship-registration-form.html

<form class="form-inline justify-content-center" method="post" action="https://qepler.com/sponsorship-registration-form.html">
  <input type="hidden" name="eventID" value="969">
  <input type="hidden" name="package" value="ONLINE - Presenter Sponsorship">
  <input type="hidden" name="packageID" value="GP2">
  <input type="hidden" name="price" value="1,595">
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  <input type="hidden" name="includedparticipants" value="2">
  <input type="hidden" name="packageCount" value="1">
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  <input type="hidden" name="discount" value="">
  <input type="hidden" name="eventURL" value="https://qepler.com/events/3rd-genotoxic-impurities-in-pharmaceuticals-summit-2023.html">
  <input type="hidden" name="workemail" value="">
  <select name="delegatesCount" class="form-control form-control-sm product-quantity">
    <option value="2">2</option>
    <option value="3">3</option>
    <option value="4">4</option>
    <option value="5">5</option>
  </select>
  <button type="submit" name="SGO" class="btn btn-primary btn-sm">SELECT</button>
</form>

POST https://qepler.com/sponsorship-registration-form.html

<form class="form-inline justify-content-center" method="post" action="https://qepler.com/sponsorship-registration-form.html">
  <input type="hidden" name="eventID" value="969">
  <input type="hidden" name="package" value="ONLINE - Partner Sponsorship">
  <input type="hidden" name="packageID" value="GP4">
  <input type="hidden" name="price" value="2,595">
  <input type="hidden" name="additionalprice" value="145">
  <input type="hidden" name="includedparticipants" value="3">
  <input type="hidden" name="packageCount" value="1">
  <input type="hidden" name="includedparticipantsprice" value="0">
  <input type="hidden" name="priceEB" value="">
  <input type="hidden" name="discount" value="">
  <input type="hidden" name="eventURL" value="https://qepler.com/events/3rd-genotoxic-impurities-in-pharmaceuticals-summit-2023.html">
  <input type="hidden" name="workemail" value="">
  <select name="delegatesCount" class="form-control form-control-sm product-quantity">
    <option value="3">3</option>
    <option value="4">4</option>
    <option value="5">5</option>
  </select>
  <button type="submit" name="SGO" class="btn btn-primary btn-sm">SELECT</button>
</form>

POST

<form class="ajax_form" method="post">
  <div class="row label">
    <div class="form-group">
      <input type="hidden" name="ip" value="2a01:4a0:1338:92::6">
      <input type="hidden" name="eventName" value="3rd Annual Genotoxic Impurities in Pharmaceuticals Virtual Summit">
      <input type="hidden" name="link" value="https://qepler.com/events/3rd-genotoxic-impurities-in-pharmaceuticals-summit-2023.html">
      <input type="hidden" name="formDate" value="21.11.2022 - 20:25">
      <input type="hidden" name="workemail" value="">
    </div>
    <div class="col-lg-12">
      <div class="form-group">
        <label>Title: </label>
        <br>
        <label class="custom-control custom-radio">
          <input type="radio" class="custom-control-input" name="title[]" required="" value="Mr.">
          <span class="custom-control-indicator"></span>
          <span class="custom-control-description">Mr.</span>
        </label>
        <label class="custom-control custom-radio">
          <input type="radio" class="custom-control-input" name="title[]" required="" value="Ms.">
          <span class="custom-control-indicator"></span>
          <span class="custom-control-description">Ms.</span>
        </label>
        <label class="custom-control custom-radio">
          <input type="radio" class="custom-control-input" name="title[]" required="" value="Mrs.">
          <span class="custom-control-indicator"></span>
          <span class="custom-control-description">Mrs.</span>
        </label>
        <label class="custom-control custom-radio">
          <input type="radio" class="custom-control-input" name="title[]" required="" value="Dr.">
          <span class="custom-control-indicator"></span>
          <span class="custom-control-description">Dr.</span>
        </label>
      </div>
    </div>
    <div class="col-lg-4">
      <div class="form-group">
        <label for="firstName">First Name:</label>
        <input id="firstName" type="text" class="form-control" placeholder="First Name*" value="" required="" name="firstName">
      </div>
    </div>
    <div class="col-lg-4">
      <div class="form-group">
        <label for="lastName">Last Name:</label>
        <input id="lastName" type="text" class="form-control" placeholder="Last Name*" value="" required="" name="lastName">
      </div>
    </div>
    <div class="col-lg-4">
      <div class="form-group">
        <label for="jobTitle">Job Title:</label>
        <input id="jobTitle" type="text" class="form-control" placeholder="Job Title*" value="" required="" name="jobTitle">
      </div>
    </div>
    <div class="col-lg-7">
      <div class="form-group">
        <label for="companyName">Company Name:</label>
        <input id="companyName" type="text" class="form-control" placeholder="Company Name*" value="" required="" name="companyName">
      </div>
    </div>
    <div class="col-lg-5">
      <div class="form-group">
        <label for="contactEmail">Email:</label>
        <input id="contactEmail" type="text" class="form-control" placeholder="Corporate Email*" value="" required="" name="contactEmail">
      </div>
    </div>
    <div class="col-lg-12">
      <div class="form-group">
        <label for="hearFrom">Where did you hear about us?</label>
        <select class="form-control" required="" id="hearFrom" value="" name="hearFrom">
          <option value="" disabled="" selected="" hidden="">Please Choose*</option>
          <option value="Email">Email</option>
          <option value="Colleague's">Colleague's recommendation</option>
          <option value="Google">Google</option>
          <option value="LinkedIn">LinkedIn</option>
          <option value="Other">Other method</option>
        </select>
      </div>
    </div>
    <div class="col-lg-12">
      <div class="form-group">
        <label for="commentMessage">Comment Message</label>
        <textarea id="commentMessage" class="form-control" rows="6" value="" name="commentMessage"></textarea>
      </div>
      <div class="form-group">
        <label class="custom-control custom-checkbox">
          <input id="agree" type="checkbox" class="custom-control-input" value="" required="" name="agree">
          <span class="custom-control-indicator"></span>
          <span class="custom-control-description">Click here to indicate that you have read and agree to the terms presented in the <a href="terms-and-conditions.html" target="_blank">Terms and Conditions</a> agreement.</span>
        </label>
        <label class="custom-control custom-checkbox">
          <input id="agree" type="checkbox" class="custom-control-input" value="" required="" name="gdpr">
          <span class="custom-control-indicator"></span>
          <span class="custom-control-description">Click here to indicate that you have read and agree to the privacy policy in the <a href="privacy-policy.html" target="_blank">Privacy Policy</a> agreement.</span>
        </label>
      </div>
      <button type="submit" class="btn btn-primary center-block">Send Query</button>
    </div>
  </div>
  <input type="hidden" name="af_action" value="f46231b81d67a752156b4677047a4dd1">
</form>

POST

<form class="ajax_form" method="post">
  <div class="row label">
    <div class="form-group">
      <input type="hidden" name="ip" value="2a01:4a0:1338:92::6">
      <input type="hidden" name="eventName" value="3rd Annual Genotoxic Impurities in Pharmaceuticals Virtual Summit">
      <input type="hidden" name="link" value="https://qepler.com/events/3rd-genotoxic-impurities-in-pharmaceuticals-summit-2023.html">
      <input type="hidden" name="formDate" value="21.11.2022 - 20:25">
      <input type="hidden" name="workemail" value="">
    </div>
    <div class="col-lg-12">
      <div class="form-group">
        <label>Title: </label>
        <br>
        <label class="custom-control custom-radio">
          <input type="radio" class="custom-control-input" name="title[]" required="" value="Mr.">
          <span class="custom-control-indicator"></span>
          <span class="custom-control-description">Mr.</span>
        </label>
        <label class="custom-control custom-radio">
          <input type="radio" class="custom-control-input" name="title[]" required="" value="Ms.">
          <span class="custom-control-indicator"></span>
          <span class="custom-control-description">Ms.</span>
        </label>
        <label class="custom-control custom-radio">
          <input type="radio" class="custom-control-input" name="title[]" required="" value="Mrs.">
          <span class="custom-control-indicator"></span>
          <span class="custom-control-description">Mrs.</span>
        </label>
        <label class="custom-control custom-radio">
          <input type="radio" class="custom-control-input" name="title[]" required="" value="Dr.">
          <span class="custom-control-indicator"></span>
          <span class="custom-control-description">Dr.</span>
        </label>
      </div>
    </div>
    <div class="col-lg-4">
      <div class="form-group">
        <label for="firstName">First Name:</label>
        <input id="firstName" type="text" class="form-control" placeholder="First Name*" value="" required="" name="firstName">
      </div>
    </div>
    <div class="col-lg-4">
      <div class="form-group">
        <label for="lastName">Last Name:</label>
        <input id="lastName" type="text" class="form-control" placeholder="Last Name*" value="" required="" name="lastName">
      </div>
    </div>
    <div class="col-lg-4">
      <div class="form-group">
        <label for="jobTitle">Job Title:</label>
        <input id="jobTitle" type="text" class="form-control" placeholder="Job Title*" value="" required="" name="jobTitle">
      </div>
    </div>
    <div class="col-lg-4">
      <div class="form-group">
        <label for="companyName">Company Name:</label>
        <input id="companyName" type="text" class="form-control" placeholder="Company Name*" value="" required="" name="companyName">
      </div>
    </div>
    <div class="col-lg-5">
      <div class="form-group">
        <label for="contactEmail">Email:</label>
        <input id="contactEmail" type="text" class="form-control" placeholder="Corporate Email*" value="" required="" name="contactEmail">
      </div>
    </div>
    <div class="col-lg-3">
      <div class="form-group">
        <label for="contactPhone">Phone Number:</label>
        <input id="contactPhone" type="text" class="form-control" placeholder="+420 000 000 000" value="" required="" name="contactPhone">
      </div>
    </div>
    <div class="col-lg-12">
      <div class="form-group">
        <label for="contactAddress">Address:</label>
        <input id="contactAddress" type="text" class="form-control" placeholder="* 123, Main Street" value="" required="" name="contactAddress">
      </div>
    </div>
    <div class="col-lg-4">
      <div class="form-group">
        <label for="contactCountry">Country:</label>
        <input id="contactCountry" type="text" class="form-control" placeholder="Country*" value="" required="" name="contactCountry">
      </div>
    </div>
    <div class="col-lg-3">
      <div class="form-group">
        <label for="contactCity">City:</label>
        <input id="contactCity" type="text" class="form-control" placeholder="City*" value="" required="" name="contactCity">
      </div>
    </div>
    <div class="col-lg-2">
      <div class="form-group">
        <label for="contactPost">Postal Code:</label>
        <input id="contactPost" type="text" class="form-control" placeholder="100 00" value="" required="" name="contactPost">
      </div>
    </div>
    <div class="col-lg-3">
      <div class="form-group">
        <label for="euVat">EU VAT #</label>
        <input id="euVat" type="text" class="form-control" placeholder="CZ 00000000" value="" name="euVat">
      </div>
    </div>
    <div class="col-lg-6">
      <div class="form-group">
        <label for="paymentMethod">Payment Method:</label>
        <select class="form-control" name="paymentMethod" required="" id="paymentMethod" value="">
          <option value="" disabled="" selected="" hidden="">Select the payment method*</option>
          <option value="Bank Transfer">Bank Transfer</option>
          <option value="Credit Card">Credit Card</option>
          <option value="PayPal">PayPal</option>
        </select>
      </div>
    </div>
    <div class="col-lg-6">
      <div class="form-group">
        <label for="hearFrom">Where did you hear about us?</label>
        <select class="form-control" required="" id="hearFrom" value="" name="hearFrom">
          <option value="" disabled="" selected="" hidden="">Please Choose*</option>
          <option value="Email">Email</option>
          <option value="Colleague's">Colleague's recommendation</option>
          <option value="Google">Google</option>
          <option value="LinkedIn">LinkedIn</option>
          <option value="Other">Other method</option>
        </select>
      </div>
    </div>
    <div class="col-lg-12">
      <div class="form-group">
        <label for="commentMessage">Comment Message</label>
        <textarea id="commentMessage" class="form-control" rows="6" value="" name="commentMessage"></textarea>
      </div>
      <div class="form-group">
        <span class="custom-control-description label">* Presentation content and contact details are subjects to approval for distribution.</span>
      </div>
      <div class="form-group">
        <label class="custom-control custom-checkbox">
          <input id="agree" type="checkbox" class="custom-control-input" value="" required="" name="agree">
          <span class="custom-control-indicator"></span>
          <span class="custom-control-description">Click here to indicate that you have read and agree to the terms presented in the <a href="terms-and-conditions.html" target="_blank">Terms and Conditions</a> agreement.</span>
        </label>
        <label class="custom-control custom-checkbox">
          <input id="agree" type="checkbox" class="custom-control-input" value="" required="" name="gdpr">
          <span class="custom-control-indicator"></span>
          <span class="custom-control-description">Click here to indicate that you have read and agree to the privacy policy in the <a href="privacy-policy.html" target="_blank">Privacy Policy</a> agreement.</span>
        </label>
      </div>
      <button type="submit" class="btn btn-primary center-block">Send Query</button>
    </div>
  </div>
  <input type="hidden" name="af_action" value="46edf245c7dc69789485490183174a95">
</form>

POST

<form class="ajax_form" method="post">
  <div class="row">
    <div class="col-lg-12">
      <h5 class="heading">Your <span class="text-primary">Details:</span></h5>
    </div>
    <div class="row">
      <div class="form-group">
        <input type="hidden" name="ip" value="2a01:4a0:1338:92::6">
        <input type="hidden" name="eventName" value="3rd Annual Genotoxic Impurities in Pharmaceuticals Virtual Summit">
        <input type="hidden" name="link" value="https://qepler.com/events/3rd-genotoxic-impurities-in-pharmaceuticals-summit-2023.html">
        <input type="hidden" name="formDate" value="21.11.2022 - 20:25">
        <input type="hidden" name="workemail" value="">
      </div>
    </div>
    <div class="col-lg-4">
      <img id="blah" src="images/avatar.png" class="img-fluid" style="max-height: 240px; max-width: 240px;" alt="">
      <br><br>
    </div>
    <div class="col-lg-8">
      <div class="row">
        <div class="col-lg-12">
          <div class="form-group">
            <label>Title: </label>
            <br>
            <label class="custom-control custom-radio">
              <input type="radio" class="custom-control-input" name="title[]" required="" value="Mr.">
              <span class="custom-control-indicator"></span>
              <span class="custom-control-description">Mr.</span>
            </label>
            <label class="custom-control custom-radio">
              <input type="radio" class="custom-control-input" name="title[]" required="" value="Ms.">
              <span class="custom-control-indicator"></span>
              <span class="custom-control-description">Ms.</span>
            </label>
            <label class="custom-control custom-radio">
              <input type="radio" class="custom-control-input" name="title[]" required="" value="Mrs.">
              <span class="custom-control-indicator"></span>
              <span class="custom-control-description">Mrs.</span>
            </label>
            <label class="custom-control custom-radio">
              <input type="radio" class="custom-control-input" name="title[]" required="" value="Dr.">
              <span class="custom-control-indicator"></span>
              <span class="custom-control-description">Dr.</span>
            </label>
          </div>
        </div>
        <div class="col-lg-6">
          <div class="form-group">
            <label for="firstName">First Name:</label>
            <input id="firstName" type="text" class="form-control" placeholder="First Name*" value="" required="" name="firstName">
          </div>
        </div>
        <div class="col-lg-6">
          <div class="form-group">
            <label for="lastName">Last Name:</label>
            <input id="lastName" type="text" class="form-control" placeholder="Last Name*" value="" required="" name="lastName">
          </div>
        </div>
        <div class="col-lg-6">
          <div class="form-group">
            <label for="jobTitle">Job Title:</label>
            <input id="jobTitle" type="text" class="form-control" placeholder="Job Title*" value="" required="" name="jobTitle">
          </div>
        </div>
        <div class="col-lg-6">
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3RD ANNUAL GENOTOXIC IMPURITIES IN PHARMACEUTICALS VIRTUAL SUMMIT 2023

 * Qepler.com
 * Upcoming Events
 * 3rd Annual Genotoxic Impurities in Pharmaceuticals Virtual Summit

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Event Location:
Online Conference
Platform:
HOPIN
Date:
09 - 10 March 2023
Language:
English
REGISTER NOW

 * Brief of Event
 * You Will Meet
 * Agenda
 * Participate
 * Sponsorship
 * Become a Speaker
 * Newsletter Form

CONTACT PERSON: EVGENIA MAKAR

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CONTACT PERSON: DENIS POLIKARPOV

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CONFERENCE OVERVIEW

For the transformation of starting material into the product is needed API
synthesis, which involves multiple reaction steps, including reagents,
intermediates, catalysts, solvents and others. As a result, low levels of
by-products may appear in API as impurities. This impurity may have toxicity,
incl. carcinogenicity and genotoxicity, what may cause mutations, potentially
leading to cancer. Due to this fact and focusing on ensuring safety of public
health is critical to identify, monitor, analyse and control genotoxic
impurities and strive to their minimum level. This has led to the crucial need
in the development and improvement of analytical methods.

The Genotoxic Impurities in Pharmaceuticals Summit 2023 is focusing on
overcoming challenges and barriers, sharing knowledge, strategies, best
techniques and new methodologies in GTI predictions, analysis and control during
the drug development process, overview and practical implementation of GTI
guidelines and regulations (ICH M7 and ICH Q3D), risk assessment, exposure
limits calculation and predictions' empowerment through in silico.

THE FEATURED TALKS ON:

 * Exploring the scale of potential nitrosamine risk associated with existing
   approved APIs
 * Development of a drug product workflow for nitrosamine risk assessments?
 * Quantitative analysis of in vivo mutagenicity dose-response data for risk
   assessment and regulatory decision-making: a case study of alkylnitrosamines.
 * Setting Limits for Complex Nitrosamines (NDSRIs)
 * Incorporating Nitrosamine Risk Mitigation Activities Across a Diverse
   Development Portfolio
 * Analytical testing and control approaches for GTIs in drug substance
 * Case Studies of Nitrosamines in Pharmaceuticals
 * How Sanofi scientists streamlined their in silico hazard assessment of
   potential genotoxic impurities by collaborating with Discngine
 * Development of in silico systems for expert review under ICH M7 guideline:
   increasing efficiency through automated arguments.
 * Review of in silico predictions
 * Analytical Strategies for Enhancing Selectivity and Sensitivity of Genotoxic
   Impurities
 * Applications of computational methods in the assessment of extractables and
   leachables

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WHO YOU WILL MEET

BY SENIORITY LEVEL

 * C-Level, Presidents, Chairs, Members of the Board & VPs
 * Directors, & Heads
 * Leaders & Managers
 * Fellows, Principals & Scientists
 * Toxicologists & Chemists
 * Advisors, Coordinators, Auditors & Consultants
 * Other Professionals, Experts & Specialists

BY DIVISION

 * ADME
 * Analytical Chemistry
 * Analytical Development
 * Analytical R&D
 * Analytical Science
 * Analytical Science & Technology
 * Analytical Sciences
 * API
 * Biocompatibility
 * Chemical Toxicology
 * CMC
 * Compound Safety
 * Computational Toxicology
 * Data Sciences & Artificial Intelligence
 * Drug Development
 * Drug Safety
 * Drug Safety Research & Evaluation
 * Genetic Toxicology
 * Genetics & Mutagenesis
 * Genotoxicity
 * GMP
 * GTIs
 * Impurities
 * In Silico Toxicology
 * Metabolism
 * Mutagenicity
 * Pharmaceutical Sciences
 * Pharmacokinetics
 * Pharmacology
 * Pharmacovigilance
 * Process Chemistry
 * Process Development
 * QbD
 * Quality Assurance & Operations
 * Quality Control
 * Regulatory Affairs & Compliance
 * Research & Development
 * Risks Assessment
 * Small Molecules
 * Toxicology
 * Toxicology Discovery
 * Validation

BY COMPANY TYPE

 * Pharmaceuticals
 * Biotechnology
 * CRO
 * CMO
 * Technologies & software providers
 * Equipment providers
 * Regulatory agencies
 * NOP
 * Other

BY REGION

 * Central and Eastern Europe
 * North America
 * Middle East and Africa
 * Asia-Pacific
 * Other

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CONFERENCE PROGRAMME

Download in PDF Format

DAY ONE - THURSDAY 09, MARCH 2023

TENTATIVE SCHEDULE:

CENTRAL EUROPEAN TIME (CET, PRAGUE, UTC/GMT +1 HOUR)

10:00 Registration

11:20 Opening Address

11:30 To Be Announced

Dr. Andrew Teasdale,
Senior Principal Scientist / Head of Impurity Management & CMC Strategy,
AstraZeneca, UK

12:10 To Be Announced

Dr. Tino Otte,
Senior Scientific Consultant, Intertek (Schweiz) AG, Basel-Landschaft,
Switzerland

12:50 Exploring the scale of potential nitrosamine risk associated with existing
approved APIs

Dr. Michael Burns,
Principal Research Scientist, Lhasa Limited, United Kingdom

13:30 Coffee break

13:50 Development of a Drug Product workflow for Nitrosamine Risk Assessments

Mike Urquhart,
Scientific Director, GlaxoSmithKline, Stevenage, United Kingdom

14:30 Quantitative analysis of in vivo mutagenicity dose-response data for risk
assessment and regulatory decision-making: a case study of alkylnitrosamines

 * Nitrosamine impurities are detectable in some pharmaceutical products.
 * Risk assessment of nitrosamine impurities can be carried out using genetic
   toxicology data.
 * Benchmark dose metrics can be calculated from in vivo gene mutation data
   which are used to calculate permitted daily exposures (PDE).
 * A threshold mechanism’ must be defined before the PDE can be used.
 * Adjustment/uncertainty factors used in the PDE may differ when using genetic
   toxicity data compared to when using cancer bioassay data.

Dr. George Johnson,
Associate Professor in the Institute of Life Science, Swansea University, United
Kingdom

15:10 To Be Announced

Mark Harrison,
Principal Analyst, AstraZeneca, Sheffield, United Kingdom

15:50 Coffee break

16:10 Setting Limits for Complex Nitrosamines (NDSRIs)

 * Differences between ICH M7 and nitrosamine guidances
 * Setting AIs for NDSRIs using SAR/read-across
 * Case studies - De-risking of NDSRIs of drug classes (Ca channel blockers,
   β-blockers, ACE inhibitors)

Raphael Nudelman, Ph.D., ERT,
Senior Director Impurity Expert, Teva Pharmaceutical Industries Ltd., Israel

16:50 Incorporating Nitrosamine Risk Mitigation Activities Across a Diverse
Development Portfolio

Jared Fennell,
Senior Scientist, Eli Lilly and Company, Indiana, United States

17:30 Panel Discussion:

Olivier Dirat,
Senior Director, Pfizer, UK

Lance Smallshaw,
Regulatory Intelligence and External Advocacy (Quality Analytical and
Pharmacopoeia), UCB Biopharma sprl., BE

Dr. Alexander Amberg,
Head of In Silico Toxicology, Sanofi Aventis Deutschland GmbH, DE

Dr. M. Vijay Reddy,
Senior Principal Scientist in the department of Genetic Toxicology, Merck & Co.,
Inc., USA

18:10 Closing remarks and end of day one

DAY TWO - FRIDAY 10, MARCH 2023

TENTATIVE SCHEDULE:

CENTRAL EUROPEAN TIME (CET, PRAGUE, UTC/GMT +1 HOUR)

10:00 Opening Address

10:10 Analytical testing and control approaches for GTIs in drug substance

Tom van Wijk,
Principal Scientist, Analytical Science and Technology Team lead Pharmaceutical
analysis, Abbott Healthcare Products B.V., Weesp, The Netherlands

10:50 To Be Announced

Dr. Stephanie Simon, PhD,
Head, Genetic Toxicology, Merck Healthcare KGaA, DE

11:30 To Be Announced

Jason Creasey,
Managing Director, Maven E&L Ltd, Stevenage, United Kingdom

12:10 Case Studies of Nitrosamines in Pharmaceuticals

 * NDMA in Metformin DP
 * Analytical challenges
 * Some NDSRI(s)

Dr. Joerg Schlingemann,
Director, Principal Expert Quality Control Systems, Merck Healthcare KGaA, DE

12:50 Nitrocellulose blister material as a source of N-nitrosamine contamination
of pharmaceutical drug products

Rok Grahek,
Head of Department, Sandoz, Slovenia

13:30 Coffee break

13:50 Partnership Presentation AVAILABLE

14:30 How Sanofi scientists streamlined their in silico hazard assessment of
potential genotoxic impurities by collaborating with Discngine

Sébastien Conilleau, PhD,
Customer Success and Delivery Manager, Discngine, FR

15:10 Development of in silico systems for expert review under ICH M7 guideline:
increasing efficiency through automated arguments

Robert Foster,
Senior Scientist, Lhasa Limited, United Kingdom

15:50 Coffee break

16:10 Review of in silico predictions

Alyssa Musso,
Senior Scientist, Drug Safety Research and Development, Global Risk Assessment
Services Toxicologist, Pfizer, USA

16:50 Analytical Strategies for Enhancing Selectivity and Sensitivity of
Genotoxic Impurities

C. J. Venkatramani,
Senior Principle Scientist, Genentech, USA

17:30 To Be Announced

Leon F. Stankowski,
Senior Scientific Director, Genetic and In Vitro Toxicology, Charles River
Laboratories, Chicago, USA

18:10 Applications of computational methods in the assessment of extractables
and leachables

 * Use of in silico approaches supporting the assessment of Extractables and
   Leachables (E&L)
 * Prevalence of predicted mutagens and potent sensitizers in large
   representative databases of E&L
 * Use of in silico models to assess leachable reactivity with biomolecules
 * Biomolecule reactivity in silico workflow

Dr. Candice Johnson,
Senior Research Scientist, Instem, Ohio, United States

18:50 Closing remarks and end of summit

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MEET OUR SPEAKERS

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DR. GEORGE JOHNSON

Associate Professor in the Institute of Life Science
Swansea University

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DR. TINO OTTE

Senior Scientific Consultant
Intertek (Schweiz) AG

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DR. ALEXANDER AMBERG

Head of In Silico Toxicology
Sanofi Aventis Deutschland GmbH

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ROK GRAHEK

Head of Department
Sandoz

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DR. STEPHANIE SIMON

Head, Genetic Toxicology
Merck Healthcare KGaA

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DR. MICHAEL BURNS

Principal Research Scientist
Lhasa Limited

View Profile

ALYSSA MUSSO

Senior Scientist, Drug Safety Research and Development, Global Risk Assessment
Services Toxicologist
Pfizer

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SÉBASTIEN CONILLEAU

Customer Success and Delivery Manager
Discngine

View Profile

VIJAY REDDY

Senior Principal Scientist in the department of Genetic Toxicology
Merck & Co., Inc.

View Profile

DR. CANDICE JOHNSON

Senior Research Scientist
Instem

View Profile

TOM VAN WIJK

Principal Scientist, Analytical Science and Technology Team lead Pharmaceutical
analysis
Abbott Healthcare Products B.V.

View Profile

RAPHAEL NUDELMAN

Senior Director Impurity Expert
Teva Pharmaceutical Industries Ltd.

View Profile

JARED FENNELL

Senior Scientist
Eli Lilly and Company

View Profile

LEON F. STANKOWSKI

Senior Scientific Director, Genetic and In Vitro Toxicology
Charles River Laboratories

View Profile

DR. ANDREW TEASDALE

Senior Principal Scientist / Head of Impurity Management & CMC Strategy
AstraZeneca

View Profile

C. J. VENKATRAMANI

Senior Principle Scientist
Genentech

View Profile

OLIVIER DIRAT

Senior Director
Pfizer

View Profile

LANCE SMALLSHAW

Regulatory Intelligence and External Advocacy (Quality Analytical and
Pharmacopoeia)
UCB Biopharma sprl.

View Profile

MIKE URQUHART

Scientific Director
GlaxoSmithKline

View Profile

DR. JOERG SCHLINGEMANN

Director, Principal Expert Quality Control Systems
Merck Healthcare KGaA

View Profile

ROBERT FOSTER

Senior Scientist
Lhasa Limited

View Profile

JASON CREASEY

Managing Director
Maven E&L Ltd

View Profile

MARK HARRISON

Principal Analyst
AstraZeneca

View Profile

DR. GEORGE JOHNSON

Associate Professor in the Institute of Life Science
Swansea University

View Profile

DR. TINO OTTE

Senior Scientific Consultant
Intertek (Schweiz) AG

View Profile

DR. ALEXANDER AMBERG

Head of In Silico Toxicology
Sanofi Aventis Deutschland GmbH

View Profile

ROK GRAHEK

Head of Department
Sandoz

View Profile

DR. STEPHANIE SIMON

Head, Genetic Toxicology
Merck Healthcare KGaA

View Profile

DR. MICHAEL BURNS

Principal Research Scientist
Lhasa Limited

View Profile

ALYSSA MUSSO

Senior Scientist, Drug Safety Research and Development, Global Risk Assessment
Services Toxicologist
Pfizer

View Profile

SÉBASTIEN CONILLEAU

Customer Success and Delivery Manager
Discngine

View Profile

VIJAY REDDY

Senior Principal Scientist in the department of Genetic Toxicology
Merck & Co., Inc.

View Profile

DR. CANDICE JOHNSON

Senior Research Scientist
Instem

View Profile

TOM VAN WIJK

Principal Scientist, Analytical Science and Technology Team lead Pharmaceutical
analysis
Abbott Healthcare Products B.V.

View Profile

RAPHAEL NUDELMAN

Senior Director Impurity Expert
Teva Pharmaceutical Industries Ltd.

View Profile

JARED FENNELL

Senior Scientist
Eli Lilly and Company

View Profile

LEON F. STANKOWSKI

Senior Scientific Director, Genetic and In Vitro Toxicology
Charles River Laboratories

View Profile

DR. ANDREW TEASDALE

Senior Principal Scientist / Head of Impurity Management & CMC Strategy
AstraZeneca

View Profile

C. J. VENKATRAMANI

Senior Principle Scientist
Genentech

View Profile

OLIVIER DIRAT

Senior Director
Pfizer

View Profile

LANCE SMALLSHAW

Regulatory Intelligence and External Advocacy (Quality Analytical and
Pharmacopoeia)
UCB Biopharma sprl.

View Profile

MIKE URQUHART

Scientific Director
GlaxoSmithKline

View Profile

DR. JOERG SCHLINGEMANN

Director, Principal Expert Quality Control Systems
Merck Healthcare KGaA

View Profile

ROBERT FOSTER

Senior Scientist
Lhasa Limited

View Profile

JASON CREASEY

Managing Director
Maven E&L Ltd

View Profile

MARK HARRISON

Principal Analyst
AstraZeneca

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PREVIOUS EVENT

SNAPSHOT OF ATTENDEES

Abbott Healthcare Products B.V. - Alkaloid AD - Angelini - Astellas Pharma
Europe BV - AstraZeneca - Bayer AG - Bristol-Myers Squibb - Charles River
Laboratories - Cipla Limited - Elanco Animal Health - Elpen Pharmaceutical
Co.Inc. - Eurofarma labs - F. Hoffmann-La Roche Ltd - Fresenius Kabi Deutschland
GmbH - GlaxoSmithKline - Intertek (Schweiz) AG - Lhasa Limited - Merck & Co.,
Inc. - Nelson Labs Europe - S-IN Soluzioni Informatiche Srl - SCIEX - Smithers
Rapra Ltd. - Teva - Teva Pharmaceutical Industries Ltd. - ToxMinds BVBA - UCB
Biopharma sprl. - Others

Presentatons


GENOTOXIC IMPURITIES IN
PHARMACEUTICALS SUMMIT 2019

BERLIN, GERMANY

GTI strategies & new methodologies: analysis, in silico & regulations.
Challenges & opportunities.


11-12 APRIL 2019

RIU PLAZA BERLIN

2 DAYS
18 TOPICS
LIVE DISCUSSIONS
PRACTICAL CASE STUDIES
50 + PARTICIPANTS

Case Studies
Networking


ANDREW FEILDEN

SMITHERS RAPRA LTD.

chaired a panel discussion, with speakers from Nelson Labs Europe, Angelini,
Astellas, UCB Biopharma, Roche, AstraZeneca, Fresenius Kabi, Bristol-Myers
Squibb and Teva.

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