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* Prescribing Information
* Important Safety Information
* For Healthcare Professionals

*
* About Advanced Prostate Cancer
* About LUPRON DEPOT
* What Is LUPRON DEPOT?
* How LUPRON DEPOT Is Given
* Study Results With LUPRON DEPOT
* Common Side Effects
* Managing Side Effects

* Getting Started
* What to Expect
* Coverage

* Your Experience
* Talking With Your Healthcare Team
* Taking Care of Yourself
* Real Patient Stories

* Support & Resources
* Support PLUS Specialist
* Community Support
* Glossary

* FAQs
*

LUPRON DEPOT® (leuprolide acetate for depot suspension) 7.5 mg for 1-month, 22.5
mg for 3-month, 30 mg for 4-month, and 45 mg for 6-month administration are
prescribed for the treatment of advanced prostate cancer. LUPRON DEPOT is a
prescription medication that must be administered in your doctor’s office.

DESIGNED WITH YOUR EXPERIENCE IN MIND.

See study results with LUPRON DEPOT
SEE REAL PATIENT STORIES BELOW

LET US HELP YOU FIND THE INFORMATION YOU NEED

--------------------------------------------------------------------------------

SELECT WHICH BEST APPLIES TO YOU:

I've Just been diagnosed with advanced prostate cancer
I'm just getting started on LUPRON DEPOT
I'm currently taking LUPRON DEPOT
I'm a caregiver for someone taking LUPRON DEPOT

ABOUT ADVANCED PROSTATE CANCER

Learn more about advanced prostate cancer, one of the most frequently diagnosed
cancers in American men.

LEARN MORE

ABOUT LUPRON DEPOT

LUPRON DEPOT is a hormonal therapy for patients with advanced prostate cancer
that lowers testosterone levels.

LEARN MORE

SUPPORT & RESOURCES

Discover various types of support resources and tips for finding the right
community for you.

EXPLORE

ABOUT LUPRON DEPOT

LUPRON DEPOT is a hormonal therapy for patients with advanced prostate cancer
that lowers testosterone levels.

LEARN MORE

WHAT TO EXPECT WITH LUPRON DEPOT

Being informed is a positive first step in your LUPRON DEPOT treatment
experience.

LEARN MORE

TREATMENT EXPERIENCE

Check out these tips for getting informed, communicating with your physicians,
and getting the most out of your LUPRON DEPOT treatment.

EXPLORE

ABOUT LUPRON DEPOT

LUPRON DEPOT is a hormonal therapy for patients with advanced prostate cancer
that lowers testosterone levels.

LEARN MORE

TREATMENT EXPERIENCE

Check out these tips for getting informed, communicating with your physicians,
and getting the most out of your LUPRON DEPOT treatment.

EXPLORE

SUPPORT & RESOURCES

Discover various types of support resources and tips for finding the right
community for you.

EXPLORE

FREQUENTLY ASKED QUESTIONS

Find questions and answers to some of your most common questions about LUPRON
DEPOT and treatment.

ABOUT LUPRON DEPOT

LUPRON DEPOT is a hormonal therapy for patients with advanced prostate cancer
that lowers testosterone levels.

LEARN MORE

ABOUT ADVANCED PROSTATE CANCER

Learn more about advanced prostate cancer, one of the most frequently diagnosed
cancers in American men.

LEARN MORE
I’ve just been diagnosed with advanced prostate cancer

ABOUT ADVANCED PROSTATE CANCER

Learn more about advanced prostate cancer, one of the most frequently diagnosed
cancers in American men.

LEARN MORE

ABOUT LUPRON DEPOT

LUPRON DEPOT is a hormonal therapy for patients with advanced prostate cancer
that lowers testosterone levels.

LEARN MORE

SUPPORT & RESOURCES

Discover various types of support resources and tips for finding the right
community for you.

EXPLORE
I’m just getting started on LUPRON DEPOT

ABOUT LUPRON DEPOT

LUPRON DEPOT is a hormonal therapy for patients with advanced prostate cancer
that lowers testosterone levels.

LEARN MORE

WHAT TO EXPECT WITH LUPRON DEPOT

Being informed is a positive first step in your LUPRON DEPOT treatment
experience.

LEARN MORE

TREATMENT EXPERIENCE

Check out these tips for getting informed, communicating with your physicians,
and getting the most out of your LUPRON DEPOT treatment.

EXPLORE
I’m currently taking LUPRON DEPOT

ABOUT LUPRON DEPOT

LUPRON DEPOT is a hormonal therapy for patients with advanced prostate cancer
that lowers testosterone levels.

LEARN MORE

TREATMENT EXPERIENCE

Check out these tips for getting informed, communicating with your physicians,
and getting the most out of your LUPRON DEPOT treatment.

EXPLORE

SUPPORT & RESOURCES

Discover various types of support resources and tips for finding the right
community for you.

EXPLORE
I’m a caregiver for someone taking LUPRON DEPOT

FREQUENTLY ASKED QUESTIONS

Find questions and answers to some of your most common questions about LUPRON
DEPOT and treatment.

ABOUT LUPRON DEPOT

LUPRON DEPOT is a hormonal therapy for patients with advanced prostate cancer
that lowers testosterone levels.

LEARN MORE

ABOUT ADVANCED PROSTATE CANCER

Learn more about advanced prostate cancer, one of the most frequently diagnosed
cancers in American men.

LEARN MORE
What is a PSA test, and what does an elevated PSA level mean?

* A PSA test measures the level of prostate-specific antigen in your
bloodstream
* PSA testing is an important part of detecting and managing prostate cancer

A DOCTOR MAY PRESCRIBE HORMONE THERAPY FOR ADVANCED PROSTATE CANCER:

Tertiary Button
I’ve just been diagnosed with advanced prostate cancer

MEET LARRY AND DON

--------------------------------------------------------------------------------

AS MEN DIAGNOSED WITH ADVANCED PROSTATE CANCERADVANCED PROSTATE CANCER A TUMOR
THAT HAS SPREAD OUTSIDE OF THE PROSTATE TO OTHER AREAS OF YOUR BODY IS
CONSIDERED TO BE ADVANCED PROSTATE CANCER. YOUR DOCTOR WILL PERFORM TESTS IN
ORDER TO CONFIRM THAT YOU HAVE ADVANCED PROSTATE CANCER. MEN WITH ADVANCED
PROSTATE CANCER MAY HAVE NO SYMPTOMS., LARRY AND DON ARE GOING THROUGH MANY OF
THE SAME THINGS THAT OTHER DIAGNOSED MEN ARE GOING THROUGH. NOW, THEY'RE SHARING
THEIR EXPERIENCES WITH YOU.

LARRY’S JOURNEY WITH ADVANCED PROSTATE CANCER

Patient Testimonial Video-Larry LC 04.2022
Patient Video - Larry

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PATIENT TESTIMONIAL VIDEO-LARRY LC 04.2022

Patient Video - Larry

Transcript

Larry opens up about the anxiety he felt after his diagnosis, his positive
relationship with his care team, and how his passion for cooking has helped him
through it all.

Transcript

“Hello. My name is Larry. I've been a professional chef for 40 years. One of my
greatest passions is my home garden. I cook almost everything that comes out of
there. I feel cooking brings me so much joy. It takes my mind off of what’s
happening in life.

Two years ago, I was diagnosed with advanced prostate cancer. My wife was with
me when we went to the urologist, and when he came in – and really just sat down
and said, "Hey, I have some bad news. You have stage 4 prostate cancer." After
that you don't hear anything else. I didn't really know what he said after that,
I was in such shock.

And at that point is when your body kind of shuts down, your mind shuts down,
and you start anxiety and worrying. You hear the cancer word…

Both my children were in college and Thanksgiving was coming. We were going to
see them at Thanksgiving, so we decided to kind of get more information, process
our self, and go through, get all the scans and see what's going on, get
everything finalized before we would tell the children.

Right after diagnosis, to me, was the hardest part. You know what you have, but
you're not quite sure of what the future is.

So, you start getting anxiety, you start thinking about things. You start
thinking about, “am I going to see grandchildren, am I going to see my daughter
get married, am I going to see my son get married?” Those are things that you
start to get really upset about.

Your emotions are running wild. So, I really think that first three month-period
is a hard time because you don't understand the disease, you don't understand
the treatment. I was lucky enough that my urologist has an advanced prostate
cancer center and there's a nurse navigator there who took the time and actually
met with my wife and I.

She met us after hours at the office and she prepared a binder for us, and she
went through the binder with my wife and I and explained this is the ADT
treatment and this is what you're going to be on.

I've been taking Lupron Depot for my advanced prostate cancer since shortly
after my diagnosis.

The doctor talked to me about the side effects of the injection. He laid out the
possible things that could happen and what were the most common. I started with
the six-month dose. We wanted to test the PSA and the testosterone more often.
So, I now get a three-month dose and I also get my testing of my testosterone at
that time.

Being a chef, I started looking at healthy recipes. I focus in on creating a
meal that tastes great.

I make something, people sit down, they eat it, we share it, they love it, and
it makes them feel good. That makes me feel good.”

DON’S JOURNEY WITH ADVANCED PROSTATE CANCER

Patient Testimonial Video Don LC 04.2022
Patient Video - Don

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* captions off, selected

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PATIENT TESTIMONIAL VIDEO DON LC 04.2022

Patient Video - Don

Transcript

Don reveals the shock of his diagnosis, his role as a mentor in the prostate
cancer community, and how his new-found interest in painting helps him cope with
stress.

Transcript

“My name is Don. I have two adult children and one grandchild. I’m married, been
married for 35 years. I’m an army veteran of 25 years, and also a Department of
the Army Civilian for 10 years.

What makes me really happy is spending time with my family. I also like to do a
little golfing and some bowling with my family. When I’m doing those things, I
basically forget about cancer and enjoy life.

This is my Thriver Fish. I needed to find a way to have some calmness and
insight in my life, so I wanted to get in to painting, and painting is something
that brightens me up, and I even got one of my pieces that I had painted in a
virtual show. It gets you through to thinking about something else other than
all the stuff in life that you’re going through.

My history with prostate cancer begins with my father. He succumbed to prostate
cancer in 2018. That was one month before I was diagnosed with prostate cancer.
My uncles on my mother’s side, have had prostate cancer, so really prostate
cancer is on both sides of my family.

In September 2017, I actually passed out at work, and so I was transported to
the local hospital, where they ran many tests, but they couldn’t find out
anything. When I went to the urologist, he noticed that the PSA was high. He
told me that I had advanced prostate cancer.

I think I was in a state of shock, because I called my wife, I just blurted it
out.

It really helps to have a care team that looks at you as a whole person and
cares about you and knows your situation. Knowing that, it eased my anxiety. It
kind of lifted me up and gave me a reason to want to move forward.

The discussion with my care team surrounded of which LUPRON DEPOT that I would
take. Would I take the three-month LUPRON DEPOT or would I take the six-month
LUPRON DEPOT? And so, after all the information that my care team gave me, it
was decided that I would take the six-month LUPRON DEPOT, and as my treatment
got further along, we’ll reassess whether or not to stay at six months or go to
a different length of period.

After I started Lupron Depot as my ADT, I’ve been able to keep my PSA and
testosterone levels within the goal levels my doctors want.

I’m a mentor to honor my father, because he didn’t have a mentor. He had no one
to tell him about prostate cancer. I thought that that would honor him, if I
shared with other men the things that he didn’t have the opportunity for someone
to share with him.”

Individual results may vary.

READ THEIR FULL STORIES

ABOUT LUPRON DEPOT

--------------------------------------------------------------------------------

LUPRON DEPOT is a hormonal therapy for patients with advanced prostate cancer
that lowers testosterone levels. Learn more about what LUPRON DEPOT is and how
it works.

WHAT IS LUPRON DEPOT?

GETTING STARTED ON LUPRON DEPOT

--------------------------------------------------------------------------------

Being informed is a positive first step in your LUPRON DEPOT treatment
experience. Find out more about what to expect while taking LUPRON DEPOT for
treatment.

WHAT TO EXPECT

SUPPORT PLUS SPECIALISTS*

--------------------------------------------------------------------------------

Get personalized support throughout your treatment journey with a dedicated
LUPRON DEPOT specialist.

*Support PLUS Specialists are provided by AbbVie and do not work under the
direction of a healthcare professional (HCP) or give medical advice. They are
trained to direct patients to speak with their HCP for treatment-related advice,
including further referrals.

EXPLORE

USE

--------------------------------------------------------------------------------

* LUPRON DEPOT® (leuprolide acetate for depot suspension) 7.5 mg for 1-month,
22.5 mg for 3-month, 30 mg for 4-month, and 45 mg for 6-month administration
are prescribed for the treatment of advanced prostate cancer.
* LUPRON DEPOT is a prescription medication that must be administered in your
doctor’s office.

IMPORTANT SAFETY INFORMATION

--------------------------------------------------------------------------------

* LUPRON DEPOT is not for people who have had any type of allergic reaction to
LUPRON DEPOT or similar drugs.
* LUPRON DEPOT causes an increase in testosterone during the first few weeks of
therapy.
* Some men may experience temporary new or worsening symptoms of prostate
cancer, including urinary symptoms and/or bone pain.
* If your cancer has spread to the urinary tract, urinary blockage may occur.
If your cancer has spread to the spine, this may lead to paralysis, which
may be life threatening.
* You may require close medical attention during the first few weeks of
therapy. Notify your doctor if you develop any new or worsened symptoms
after beginning LUPRON DEPOT treatment.
* High blood sugar, increased risk of diabetes, high lipids (such as
cholesterol and triglycerides), and/or the accumulation of liver fat without
drinking alcohol can occur in men using LUPRON DEPOT. Your doctor will
monitor for these changes.
* Increased risk of heart attack, sudden death, and stroke can occur in men
using LUPRON DEPOT. Discuss this increased risk with your doctor before
starting treatment and report any new symptoms during treatment.
* LUPRON DEPOT can affect the electrical activity of your heart. Your doctor
must determine if the benefits of using LUPRON DEPOT outweigh the risks,
especially if you have congenital long QT syndrome, abnormal blood tests for
electrolytes, congestive heart failure, or if you take medications to
regulate your heartbeat.
* Convulsions have been observed in patients taking leuprolide acetate,
including patients who have a history of seizures, epilepsy, or brain
disorders (related to blood vessels, nerves, or tumors), and in those taking
medications associated with convulsions. Convulsions have also been reported
in patients without any of these conditions.
* Regular blood tests are needed to check your testosterone and
prostate-specific antigen (PSA) levels.
* LUPRON DEPOT may cause fetal harm if administered to a pregnant woman.
* LUPRON DEPOT may cause impotence.
* The most common side effects of LUPRON DEPOT include hot flashes/sweats;
injection site reaction/pain; general pain; swelling; testicular shrinkage;
difficulty urinating; fatigue/weakness; headache; and joint,
gastrointestinal, and respiratory problems.

For more information, talk with your healthcare provider.

You are encouraged to report negative side effects of prescription drugs to the
FDA. Visit www.fda.gov/medwatch or call
1-800-FDA-1088.

If you are having difficulty paying for your medicine, AbbVie may be able to
help. Visit AbbVie.com/PatientAccessSupport to learn more.

US-LUPR-230465

Please click here for Full Prescribing information.

* About Advanced Prostate Cancer

ABOUT LUPRON DEPOT

* What Is LUPRON DEPOT?
* How LUPRON DEPOT Is Given
* Study Results With LUPRON DEPOT
* Common Side Effects
* Managing Side Effects

GETTING STARTED

* What to Expect
* Coverage

YOUR EXPERIENCE

* Talking With Your Healthcare Team
* Taking Care of Yourself
* Real Patient Stories

SUPPORT & RESOURCES

* Support PLUS Specialist
* Community Support
* Glossary

* FAQs

US-LUPR-210420

YOU ARE NOW LEAVING LUPRONPROSTATECANCER.COM

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IMPORTANT SAFETY INFORMATION

LUPRON DEPOT is not for people who have had any type of allergic reaction to
LUPRON DEPOT or similar drugs. LUPRON DEPOT causes an increase in testosterone
during the first few weeks of therapy.Some men may experience temporary new or
worsening symptoms of prostate cancer, including urinary symptoms and/or bone
pain.

IMPORTANT SAFETY INFORMATION

USE

--------------------------------------------------------------------------------

IMPORTANT SAFETY INFORMATION

USE

--------------------------------------------------------------------------------

IMPORTANT SAFETY INFORMATION

USE

--------------------------------------------------------------------------------

IMPORTANT SAFETY INFORMATION

--------------------------------------------------------------------------------

For more information, talk with your healthcare provider.

You are encouraged to report negative side effects of prescription drugs to the
FDA. Visit www.fda.gov/medwatch or call
1-800-FDA-1088.

If you are having difficulty paying for your medicine, AbbVie may be able to
help. Visit AbbVie.com/PatientAccessSupport to learn more.

US-LUPR-230465

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