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Submitted URL: https://doi.org/10.1101/2021.07.21.21260223
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Submission: On February 25 via manual from US — Scanned from DE
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Submission: On February 25 via manual from US — Scanned from DE
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<a href="/content/10.1101/2021.07.21.21260223v2" class="active" data-icon-position="" data-hide-link-title="0">Early multidrug treatment of SARS-CoV-2 (COVID-19) and decreased case fatality rates in Honduras</a>
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Skip to main content * Home * About * Submit * News & Notes * ALERTS / RSS Search for this keyword Advanced Search Comment on this paper EARLY MULTIDRUG TREATMENT OF SARS-COV-2 (COVID-19) AND DECREASED CASE FATALITY RATES IN HONDURAS View ORCID ProfileSidney Ontai, Li Zeng, Miguel Sierra Hoffman, Fernando Valerio Pascua, View ORCID ProfileVincent VanBuren, View ORCID ProfilePeter A McCullough doi: https://doi.org/10.1101/2021.07.21.21260223 This article is a preprint and has not been peer-reviewed [what does this mean?]. It reports new medical research that has yet to be evaluated and so should not be used to guide clinical practice. Sidney Ontai 1Texas A&M University Health Science Center, Department of Primary Care and Population Health * Find this author on Google Scholar * Find this author on PubMed * Search for this author on this site * ORCID record for Sidney Ontai * For correspondence: ontai@ontai.com Li Zeng 2Texas A&M University School of Engineering, Department of Industrial and Systems Engineering * Find this author on Google Scholar * Find this author on PubMed * Search for this author on this site Miguel Sierra Hoffman 1Texas A&M University Health Science Center, Department of Primary Care and Population Health * Find this author on Google Scholar * Find this author on PubMed * Search for this author on this site Fernando Valerio Pascua 4Department of Critical Care, Hospital CEMESA, Cortés, Honduras * Find this author on Google Scholar * Find this author on PubMed * Search for this author on this site Vincent VanBuren 5Texas A&M University Health Science Center, Department of Medical Education * Find this author on Google Scholar * Find this author on PubMed * Search for this author on this site * ORCID record for Vincent VanBuren Peter A McCullough 6Baylor Dallas Campus, Department of Internal Medicine, Dallas TX * Find this author on Google Scholar * Find this author on PubMed * Search for this author on this site * ORCID record for Peter A McCullough * Abstract * Full Text * Info/History * Metrics * Data/Code * Preview PDF ABSTRACT INTRODUCTION Within 2 months of first detection of SARS-CoV-2 in Honduras, its government promoted nationwide implementation of multi-drug COVID-19 inpatient and outpatient treatment protocols. This was associated with a case fatality rate decrease from 9.33% to 2.97%. No decrease was seen in Mexico, a similar Latin American country that did not introduce multi-drug treatment protocols at that time. OBJECTIVE The primary objective of the study was to use statistical process control to assess the likelihood that the decrease in case fatality rate in Honduras was due to chance, using Mexico as a control country. METHODS Fourteen day running average COVID-19 case fatality rates in Honduras and Mexico were used to create Shewhart control charts during the first 6 months of the epidemic. The date of implementation in Honduras of the inpatient and outpatient multi-drug COVID-19 protocols were plotted on control charts, with a Mexican COVID-19 case fatality control chart for comparison. RESULTS The case fatality rate for COVID-19 in Honduras dropped below the lower control limit 9 days after implementation of an inpatient and outpatient multi-drug therapeutic protocol, from an average 9.33% case fatality rate to 5.01%. The Honduran COVID-19 case fatality rate again dropped below the lower control limit to 2.97%, 17 days after launching a substantial government program to make the protocol medications accessible to underserved areas. Shewhart control chart plots of case fatality rates in Honduras suggest a plausible temporal association between the implementation dates of both the initial protocol implementation on May 3, 2020, and the outreach effort on June 10, 2020, and statistically significant control chart anomalies. No control chart anomalies were seen during that time in Mexico. CONCLUSION Decreases in COVID-19 case fatality rates in Honduras were associated with both the initial publication a multi-drug COVID-19 therapeutic protocol and a subsequent outreach program. COMPETING INTEREST STATEMENT The authors have declared no competing interest. CLINICAL TRIAL Not a clinical trial. FUNDING STATEMENT Neither the authors nor their institutions at any time received payment or services from a third party for any aspect of the submitted work (including but not limited to grants, data monitoring board, study design, manuscript preparation, statistical analysis, etc.). AUTHOR DECLARATIONS I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: The Texas A&M University IRB determined that this research publication does not involve human subjects and is exempt. All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable. Yes FOOTNOTES * This work was unfunded. It did not received support from the National Institutes of Health (NIH); Wellcome Trust; Howard Hughes Medical Institute (HHMI); or any other organizations. * Changed photo file format of Figure from JPG to TIFF. DATA AVAILABILITY All COVID-19 case fatality data were obtained from the publicly available World Health Organization Coronavirus Disease (COVID-19) Dashboard. https://covid19.who.int/table Paper in collection COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv Copyright The copyright holder for this preprint is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license. Tweets referencing this article: 174 followers phillip parker @Drphilparker LinkedIn blocked this original post. I'm re-posting with minor modification. Let's see. FLCCC reports on a BMJ preprint article describing a population-wide, early-treatment intervention in Honduras (FLCCC article title "Honduras’…https://t.co/shAi9ErSwj 21 Feb 2022 ReplyRetweetFavourite 913 followers Alexa Scientista Data @Scientista_Data https://t.co/jkEDdVrfd4 https://t.co/fcCTYvi0gW https://t.co/rby8VWzs5k https://t.co/ZqxtUXLp49 https://t.co/l1euWreOHV https://t.co/2QQban0pVf https://t.co/GbTa6Mvtu4 https://t.co/Y2qkuaSfRE https://t.co/Bt0JOT5S8X https://t.co/kCHIeX2Xir 11/ 20 Feb 2022 ReplyRetweetFavourite 814 followers mark klugmann @mkcentral Early multidrug treatment of SARS-CoV-2 (COVID-19) and decreased case fatality rates in Honduras https://t.co/vBplcze88g 20 Feb 2022 ReplyRetweetFavourite 8 followers Nikodem @Jerzykd1Nikodem RT @MariuszJagora: Wczesne leczenie wielolekowe SARS-CoV-2 (COVID-19) i obniżony wskaźnik śmiertelności przypadków w Hondurasie. Tam chyba… 18 Feb 2022 ReplyRetweetFavourite 741 followers tt @tuja_tajos RT @MariuszJagora: Wczesne leczenie wielolekowe SARS-CoV-2 (COVID-19) i obniżony wskaźnik śmiertelności przypadków w Hondurasie. Tam chyba… 17 Feb 2022 ReplyRetweetFavourite 83 followers Grażyna @Grayna14980488 RT @MariuszJagora: Wczesne leczenie wielolekowe SARS-CoV-2 (COVID-19) i obniżony wskaźnik śmiertelności przypadków w Hondurasie. Tam chyba… 17 Feb 2022 ReplyRetweetFavourite 2,172 followers Mariusz Jagóra @MariuszJagora Wczesne leczenie wielolekowe SARS-CoV-2 (COVID-19) i obniżony wskaźnik śmiertelności przypadków w Hondurasie. Tam chyba nie znają badań lek. Fiałka... https://t.co/PQ4GhokyzV 17 Feb 2022 ReplyRetweetFavourite 19 followers Linda West @LWcellos @MaryJaneBryksa @RepThomasMassie @CDCgov I found over 50 in ten minutes. I guess your fingers and research ability is lacking. https://t.co/3gUrN8Y5M2 https://t.co/2nPGgFcTr4 https://t.co/zUHu5jxnjr https://t.co/c4Dn8iwzSC https://t.co/S1ViVqZUuO 15 Jan 2022 ReplyRetweetFavourite 659 followers 🇳🇱SoldiersOfOdin_nl🇳🇱 5000+ foto op TWfotos.tk @NederlandEO RT @ReneDercksen: Wetenschap, Honduras groot succes met early treatment https://t.co/NZNoqgpGrL 03 Jan 2022 ReplyRetweetFavourite 114 followers #unacceptable Koos Korswagen @kooskorswagen RT @ReneDercksen: Wetenschap, Honduras groot succes met early treatment https://t.co/NZNoqgpGrL 03 Jan 2022 ReplyRetweetFavourite 2,928 followers Henk @Spaardam11 Het heeft niets met wetenschap van doen, het zijn politieke besluiten. 03 Jan 2022 ReplyRetweetFavourite 5,029 followers René Dercks🚫n @ReneDercksen Wetenschap, Honduras groot succes met early treatment https://t.co/NZNoqgpGrL 03 Jan 2022 ReplyRetweetFavourite 33 followers Mark Triplett @triplett_mark @ATree02645601 @TrumpJew2 Honduras used… wait for it… bleach mouth rinses to treat Covid https://t.co/cLspRxSqIK 25 Dec 2021 ReplyRetweetFavourite 335 followers Christiaan de Jong @ChristiaandeJo4 @Doc_Box Waarom denk je dat het niet werkt? En waarom denk je dat toen het in Japan toegelaten werd zo snel een daling in besmettingen intrad? Is daar een andere reden voor? En waarom zoveel succes in Honduras? https://t.co/YpZTW6hJrj 18 Dec 2021 ReplyRetweetFavourite 171 followers Clark L. Coleman @ClarkLColeman @Antidiocy @Mrtraveler02 @Anelwynd @i_am_hydraa @BadCOVID19Takes You have no clue what you are talking about. How about a trial in which the ivermectin group is an entire country, compared to a nearby country that didn't use it? Big enough trial? https://t 14 Oct 2021 ReplyRetweetFavourite 3,127 followers Constanza G. ☀️⚡️ @constanzag77 @tavotoya @LaryssaAleman @Mon08Ra @maeldeju @MINSAPma https://t.co/iGSSQwo7qA 06 Oct 2021 ReplyRetweetFavourite 225 followers just the facts @llrmiller @law_sandie @BBCRosAtkins @Spicy4Democracy @briony_sowden Also watch Dallas Buyers Club to understand how the FDA operates. Plenty of docs will prescribe and advocate for vaccines. In Tx lots of Honduran immigrants know what Honduras prescribed pre vacci 15 Sep 2021 ReplyRetweetFavourite 225 followers just the facts @llrmiller @BBCRosAtkins @briony_sowden FDA bullies doctors that prescribe off-label. A practice that is allowed in the US. FDA and (and you) fueling this false dichotomy between early treatment and vaccines. Did the same in AIDS crisis. See Dallas Buyers Club. 15 Sep 2021 ReplyRetweetFavourite 225 followers just the facts @llrmiller @EricTopol This looks like another Dallas Buyers Club saga. FDA bullies doctors who develop multi drug treatments that seem to work, and so FDA squanders their reputation and blames the citizens they are supposed to serve. https://t.co/ncwzXMvUdp https:/ 15 Sep 2021 ReplyRetweetFavourite 111 followers hmm @dogzrcoolnstuff @AngryCardio Where is the evidence of harm caused by treatment? In Absence of harm, we must respect the evidence that does exist that shows it’s effectiveness against a “pandemic“. lack of in vivo study does not predicate in effectiveness. https://t.co 09 Sep 2021 ReplyRetweetFavourite 190 followers Ronnieb831 @Ronnieb831 @covidgoesawayw1 @diddykongman @jondutoit @StormRiderOroro @joerogan Hmmm: https://t.co/rhE08exyHF 03 Sep 2021 ReplyRetweetFavourite 18 followers David Turner @tanuvein @rick_blame @itsjustkris48 @MSNBC No, please listen to scientist instead of whoever is informing you. https://t.co/PsKR7Ailom https://t.co/YSXGWCgv81 https://t.co/RbUzuEDcqq https://t.co/to2oa2GggB 02 Sep 2021 ReplyRetweetFavourite 347 followers Hisayo @DQE0522738 RT @TigerGyroscope: ホンジュラス政府は、COVID-19に対して早期多剤併用療法を全国的に推進。その結果，死亡率が9.33％から2.97％に低下した。 外来治療は「マイス（MAIZ）」、院内治療は「カトラッチョ（Catracho）」と独自のプロトコールを行… 31 Aug 2021 ReplyRetweetFavourite 8 followers Cromedome @JasonCromer27 @tedlieu @US_FDA https://t.co/HK0Ee3Rm6y 21 Aug 2021 ReplyRetweetFavourite 171 followers Clark L. Coleman @ClarkLColeman @KANUTATOR @Covid19Crusher An ivermectin-based early treatment in Honduras compared VERY favorably to no-early-treatment Mexico. Will public health agencies respond logically? No. https://t.co/7ciwflTE3K 20 Aug 2021 ReplyRetweetFavourite 1,365 followers 🇯🇵Kay✝ @May_J278094 RT @TigerGyroscope: ホンジュラス政府は、COVID-19に対して早期多剤併用療法を全国的に推進。その結果，死亡率が9.33％から2.97％に低下した。 外来治療は「マイス（MAIZ）」、院内治療は「カトラッチョ（Catracho）」と独自のプロトコールを行… 16 Aug 2021 ReplyRetweetFavourite 3,127 followers Constanza G. ☀️⚡️ @constanzag77 @sabribacal @tvnnoticias https://t.co/iGSSQwo7qA 14 Aug 2021 ReplyRetweetFavourite 83 followers Alexander Ruz @alex_ruz1 @PolarBearby Los estudios de las vacunas que han demostrado prevenir hospitalizaciones o muertes solo son observacionales Por qué no analizar estudios similares para la ivermectina? Honduras: https://t.co/kOGIajZJg5 Ciudad de México: https://t.co/aEAM73 11 Aug 2021 ReplyRetweetFavourite 277 followers michaelsquest6 @jorgensenmc1 “The initial 7-day course of outpatient therapy was prepackaged as “MAIZ” (Spanish for “corn,” Honduras’ staple food), an acronym for mouthwash of sodium hypochlorite and hydrogen peroxide, azithromycin, ivermectin, and zinc.” https://t.co/RuaDBZvoDz 08 Aug 2021 ReplyRetweetFavourite 344 followers SciScore Reports @SciscoreReports The preprint “Early multidrug treatment of SARS-CoV-2 (COVID-19)…” (https://t.co/1IKAu2vjWt) has been reviewed by automated tools, find results here: https://t.co/vr3saMcG3I. We detected 0 resources and no limitations statement. 04 Aug 2021 ReplyRetweetFavourite 1,210 followers ラヴェルパヴァーヌ🎌🇯🇵 @bach753 RT @TigerGyroscope: ホンジュラス政府は、COVID-19に対して早期多剤併用療法を全国的に推進。その結果，死亡率が9.33％から2.97％に低下した。 外来治療は「マイス（MAIZ）」、院内治療は「カトラッチョ（Catracho）」と独自のプロトコールを行… 03 Aug 2021 ReplyRetweetFavourite 1,314 followers mitsuko @mitsuko_49 RT @TigerGyroscope: ホンジュラス政府は、COVID-19に対して早期多剤併用療法を全国的に推進。その結果，死亡率が9.33％から2.97％に低下した。 外来治療は「マイス（MAIZ）」、院内治療は「カトラッチョ（Catracho）」と独自のプロトコールを行… 03 Aug 2021 ReplyRetweetFavourite 330 followers サトシ株（恒大ショック警戒中 @seagrate_kabu RT @TigerGyroscope: ホンジュラス政府は、COVID-19に対して早期多剤併用療法を全国的に推進。その結果，死亡率が9.33％から2.97％に低下した。 外来治療は「マイス（MAIZ）」、院内治療は「カトラッチョ（Catracho）」と独自のプロトコールを行… 03 Aug 2021 ReplyRetweetFavourite 221 followers go @one_big_world RT @Alzhacker: https://t.co/Qs2YhJSPzA ホンジュラスでSARS-CoV-2が初めて検出されてから2カ月以内に、ホンジュラス政府は多剤併用のCOVID-19による入院・外来治療プロトコルの全国展開を推進した。その結果，致死率は9.33％から2… 02 Aug 2021 ReplyRetweetFavourite 1,081 followers Evelyn @Evelyn31721 RT @GeorgeFareed2: Within 2 months of first detection of SARS-CoV-2 in Honduras, its government promoted nationwide implementation of multi… 30 Jul 2021 ReplyRetweetFavourite 4,196 followers ✠Aragua✠🇧🇷🇵🇱🇭🇺🇮🇪🇩🇰🇷🇸🇸🇪🇳🇴🇨🇭🇨🇦✠ @araguaci RT @Ellengyn: Queda da taxa de letalidade após instituição de tratamento imediato em Honduras. Tratamento imediato é assim: pra quem presc… 29 Jul 2021 ReplyRetweetFavourite 64 followers Shirl @xShirleyx_ RT @GeorgeFareed2: Within 2 months of first detection of SARS-CoV-2 in Honduras, its government promoted nationwide implementation of multi… 29 Jul 2021 ReplyRetweetFavourite 329 followers Mark Reeder @franklin_reeder RT @GeorgeFareed2: Within 2 months of first detection of SARS-CoV-2 in Honduras, its government promoted nationwide implementation of multi… 29 Jul 2021 ReplyRetweetFavourite 2,538 followers Rosarinos con voz @Rosarinosconvoz RT @AOlavarria: Estudio (ecológico) de los posibles efectos del #TratamientoTemprano en Honduras. Concluye que la caída en la mortalidad… 28 Jul 2021 ReplyRetweetFavourite 1,491 followers The Desert Review @DesertReview RT @GeorgeFareed2: Within 2 months of first detection of SARS-CoV-2 in Honduras, its government promoted nationwide implementation of multi… 28 Jul 2021 ReplyRetweetFavourite 2,421 followers Cristina @sokris RT @Ellengyn: Queda da taxa de letalidade após instituição de tratamento imediato em Honduras. Tratamento imediato é assim: pra quem presc… 28 Jul 2021 ReplyRetweetFavourite 2,965 followers Marcelo Caminha @CaminhaMarc RT @Ellengyn: Queda da taxa de letalidade após instituição de tratamento imediato em Honduras. Tratamento imediato é assim: pra quem presc… 28 Jul 2021 ReplyRetweetFavourite 4,626 followers Zeca 22 @JoseReldah RT @Ellengyn: Queda da taxa de letalidade após instituição de tratamento imediato em Honduras. Tratamento imediato é assim: pra quem presc… 28 Jul 2021 ReplyRetweetFavourite 230 followers Yamile M Barquet @ymbarquet RT @GeorgeFareed2: Within 2 months of first detection of SARS-CoV-2 in Honduras, its government promoted nationwide implementation of multi… 28 Jul 2021 ReplyRetweetFavourite 53 followers Caverman @BCaverman @EdValozza @WGreat @pastordc3110 @quimicobenitez Que tal el país de Honduras? https://t.co/xjnZmtlT38 28 Jul 2021 ReplyRetweetFavourite 4,816 followers Minga 🦺🦺🦺+🦺 @revoltes RT @DrEmbrace: Early multidrug treatment of SARS-CoV-2 (COVID-19) and decreased case fatality rates in Honduras | medRxiv (preprint) CONCL… 28 Jul 2021 ReplyRetweetFavourite 904 followers 🇧🇷 Alinne Lis 🇧🇷 @alinnelisreal RT @Ellengyn: Queda da taxa de letalidade após instituição de tratamento imediato em Honduras. Tratamento imediato é assim: pra quem presc… 28 Jul 2021 ReplyRetweetFavourite 449 followers Adriana Bicalho Ribeiro @AdrianaBicalho3 RT @Ellengyn: Queda da taxa de letalidade após instituição de tratamento imediato em Honduras. Tratamento imediato é assim: pra quem presc… 28 Jul 2021 ReplyRetweetFavourite 654 followers João Carneiro🐸 @jcscarneiro RT @Ellengyn: Queda da taxa de letalidade após instituição de tratamento imediato em Honduras. Tratamento imediato é assim: pra quem presc… 28 Jul 2021 ReplyRetweetFavourite 58 followers LWH 🇺🇸🇫🇷 @LWH73724948 RT @GeorgeFareed2: Within 2 months of first detection of SARS-CoV-2 in Honduras, its government promoted nationwide implementation of multi… 28 Jul 2021 ReplyRetweetFavourite 780 followers 渚まどか🐬 @Bisuke23 RT @TigerGyroscope: ホンジュラス政府は、COVID-19に対して早期多剤併用療法を全国的に推進。その結果，死亡率が9.33％から2.97％に低下した。 外来治療は「マイス（MAIZ）」、院内治療は「カトラッチョ（Catracho）」と独自のプロトコールを行… 28 Jul 2021 ReplyRetweetFavourite 580 followers マルえむ🌏政府が可決したい『緊急事態条項』で私達の生活は必ず『悪い方へ』変わる🌏 @EhJv8S7mDmlOXJK RT @TigerGyroscope: ホンジュラス政府は、COVID-19に対して早期多剤併用療法を全国的に推進。その結果，死亡率が9.33％から2.97％に低下した。 外来治療は「マイス（MAIZ）」、院内治療は「カトラッチョ（Catracho）」と独自のプロトコールを行… 28 Jul 2021 ReplyRetweetFavourite 107 followers Robson Zanoli🇧🇷🇺🇸 @razanoli RT @Ellengyn: Queda da taxa de letalidade após instituição de tratamento imediato em Honduras. Tratamento imediato é assim: pra quem presc… 28 Jul 2021 ReplyRetweetFavourite 143 followers emiko @emiko_marine RT @TigerGyroscope: ホンジュラス政府は、COVID-19に対して早期多剤併用療法を全国的に推進。その結果，死亡率が9.33％から2.97％に低下した。 外来治療は「マイス（MAIZ）」、院内治療は「カトラッチョ（Catracho）」と独自のプロトコールを行… 28 Jul 2021 ReplyRetweetFavourite 74 followers Kelly @Kelly96616707 RT @Ellengyn: Queda da taxa de letalidade após instituição de tratamento imediato em Honduras. Tratamento imediato é assim: pra quem presc… 28 Jul 2021 ReplyRetweetFavourite 1,616 followers Eileen Clark @EileenC96245740 RT @GeorgeFareed2: Within 2 months of first detection of SARS-CoV-2 in Honduras, its government promoted nationwide implementation of multi… 28 Jul 2021 ReplyRetweetFavourite 486 followers Dom @Psidinim RT @GabinJean3: Honduras: un protocole de traitement précoce incluant l'ivermectine a été associé à une baisse de la létalité COVID. Le no… 28 Jul 2021 ReplyRetweetFavourite 213 followers Mary Elizabeth @MaryEli61439678 RT @Ellengyn: Queda da taxa de letalidade após instituição de tratamento imediato em Honduras. Tratamento imediato é assim: pra quem presc… 28 Jul 2021 ReplyRetweetFavourite 2,847 followers Leao Patriota 2000 @ThomersonSanta1 RT @Ellengyn: Queda da taxa de letalidade após instituição de tratamento imediato em Honduras. Tratamento imediato é assim: pra quem presc… 28 Jul 2021 ReplyRetweetFavourite 52 followers いろいろ @inunosewa2 RT @TigerGyroscope: ホンジュラス政府は、COVID-19に対して早期多剤併用療法を全国的に推進。その結果，死亡率が9.33％から2.97％に低下した。 外来治療は「マイス（MAIZ）」、院内治療は「カトラッチョ（Catracho）」と独自のプロトコールを行… 27 Jul 2021 ReplyRetweetFavourite 307 followers Dr Elliott Grosvenor @grosvenor_dr RT @DrEmbrace: Early multidrug treatment of SARS-CoV-2 (COVID-19) and decreased case fatality rates in Honduras | medRxiv (preprint) CONCL… 27 Jul 2021 ReplyRetweetFavourite 134 followers Sem Sofisticação🇧🇷 @SemSofisticacao RT @Ellengyn: Queda da taxa de letalidade após instituição de tratamento imediato em Honduras. Tratamento imediato é assim: pra quem presc… 27 Jul 2021 ReplyRetweetFavourite 1,219 followers 🇧🇷Breno Guerra🇧🇷 @Brenoguerraaju RT @Ellengyn: Queda da taxa de letalidade após instituição de tratamento imediato em Honduras. 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Tratamento imediato é assim: pra quem presc… 27 Jul 2021 ReplyRetweetFavourite 119 followers ichiro @ichiro0318kb RT @Alzhacker: https://t.co/Qs2YhJSPzA ホンジュラスでSARS-CoV-2が初めて検出されてから2カ月以内に、ホンジュラス政府は多剤併用のCOVID-19による入院・外来治療プロトコルの全国展開を推進した。その結果，致死率は9.33％から2… 27 Jul 2021 ReplyRetweetFavourite 13,980 followers Jorge Wam 🇧🇷 @jorge_wam RT @Ellengyn: Queda da taxa de letalidade após instituição de tratamento imediato em Honduras. Tratamento imediato é assim: pra quem presc… 27 Jul 2021 ReplyRetweetFavourite 226 followers Wendy Arrington @wendy_arrington RT @GeorgeFareed2: Within 2 months of first detection of SARS-CoV-2 in Honduras, its government promoted nationwide implementation of multi… 27 Jul 2021 ReplyRetweetFavourite 178 followers CYNTHIA LOBATO @CYNTHIALOBATO_ RT @Ellengyn: Queda da taxa de letalidade após instituição de tratamento imediato em Honduras. Tratamento imediato é assim: pra quem presc… 27 Jul 2021 ReplyRetweetFavourite 14 followers Telma Regina @Fadadinhaazul RT @Ellengyn: Queda da taxa de letalidade após instituição de tratamento imediato em Honduras. Tratamento imediato é assim: pra quem presc… 27 Jul 2021 ReplyRetweetFavourite 5,196 followers Jorge Luiz Carvalho🇧🇷🇧🇷 22 🇧🇷🇧🇷 @netunocarvalho RT @Ellengyn: Queda da taxa de letalidade após instituição de tratamento imediato em Honduras. Tratamento imediato é assim: pra quem presc… 27 Jul 2021 ReplyRetweetFavourite 6 followers Bauer_1577 @Glb883 RT @Ellengyn: Queda da taxa de letalidade após instituição de tratamento imediato em Honduras. Tratamento imediato é assim: pra quem presc… 27 Jul 2021 ReplyRetweetFavourite 976 followers Fernando Vaz 🇧🇷 @Fernand53371822 RT @Ellengyn: Queda da taxa de letalidade após instituição de tratamento imediato em Honduras. Tratamento imediato é assim: pra quem presc… 27 Jul 2021 ReplyRetweetFavourite 2,633 followers LEONLIMA @leonlima RT @Ellengyn: Queda da taxa de letalidade após instituição de tratamento imediato em Honduras. Tratamento imediato é assim: pra quem presc… 27 Jul 2021 ReplyRetweetFavourite 763 followers Kamilla 🇧🇷 🥊 🚀 @KamillaES RT @Ellengyn: Queda da taxa de letalidade após instituição de tratamento imediato em Honduras. Tratamento imediato é assim: pra quem presc… 27 Jul 2021 ReplyRetweetFavourite 196 followers Lord Of Darkness @GabrielF2810 RT @Ellengyn: Queda da taxa de letalidade após instituição de tratamento imediato em Honduras. Tratamento imediato é assim: pra quem presc… 27 Jul 2021 ReplyRetweetFavourite 5,086 followers Lou Novak 💚💛💚💛 @Lou_novak RT @Ellengyn: Queda da taxa de letalidade após instituição de tratamento imediato em Honduras. Tratamento imediato é assim: pra quem presc… 27 Jul 2021 ReplyRetweetFavourite 324 followers 🇧🇷Flávio Sgroi🖖🏻 @flsgroi RT @Ellengyn: Queda da taxa de letalidade após instituição de tratamento imediato em Honduras. Tratamento imediato é assim: pra quem presc… 27 Jul 2021 ReplyRetweetFavourite 287 followers coco-nuts @coconut18347519 RT @Alzhacker: https://t.co/Qs2YhJSPzA ホンジュラスでSARS-CoV-2が初めて検出されてから2カ月以内に、ホンジュラス政府は多剤併用のCOVID-19による入院・外来治療プロトコルの全国展開を推進した。その結果，致死率は9.33％から2… 27 Jul 2021 ReplyRetweetFavourite 128 followers Elaine Noonan @ElaineNoonan16 RT @DrEmbrace: Early multidrug treatment of SARS-CoV-2 (COVID-19) and decreased case fatality rates in Honduras | medRxiv (preprint) CONCL… 27 Jul 2021 ReplyRetweetFavourite 46 followers ROBERTO ARIAS HIRATA @arias_hirata RT @AOlavarria: Estudio (ecológico) de los posibles efectos del #TratamientoTemprano en Honduras. Concluye que la caída en la mortalidad… 27 Jul 2021 ReplyRetweetFavourite 927 followers Lorraine Lanning 🙂 🇺🇸🍖🍗🥓🧀🐕🌲🏕🦅🦉 @Common_SenseCO RT @GeorgeFareed2: Within 2 months of first detection of SARS-CoV-2 in Honduras, its government promoted nationwide implementation of multi… 27 Jul 2021 ReplyRetweetFavourite 711 followers 女性差別に反対するHMTサヨンチュ🐥 @husigisearch RT @Alzhacker: https://t.co/Qs2YhJSPzA ホンジュラスでSARS-CoV-2が初めて検出されてから2カ月以内に、ホンジュラス政府は多剤併用のCOVID-19による入院・外来治療プロトコルの全国展開を推進した。その結果，致死率は9.33％から2… 27 Jul 2021 ReplyRetweetFavourite 2,667 followers マイ君 @maikun27 RT @Alzhacker: https://t.co/Qs2YhJSPzA ホンジュラスでSARS-CoV-2が初めて検出されてから2カ月以内に、ホンジュラス政府は多剤併用のCOVID-19による入院・外来治療プロトコルの全国展開を推進した。その結果，致死率は9.33％から2… 27 Jul 2021 ReplyRetweetFavourite 170 followers Derrabi @Derrabi RT @GabinJean3: Honduras: un protocole de traitement précoce incluant l'ivermectine a été associé à une baisse de la létalité COVID. Le no… 27 Jul 2021 ReplyRetweetFavourite 250 followers Justin Ward @JustinW05482353 RT @GeorgeFareed2: Within 2 months of first detection of SARS-CoV-2 in Honduras, its government promoted nationwide implementation of multi… 27 Jul 2021 ReplyRetweetFavourite 1,166 followers Sabrina_Metayer @SabrinaMetayer1 RT @GabinJean3: Honduras: un protocole de traitement précoce incluant l'ivermectine a été associé à une baisse de la létalité COVID. Le no… 27 Jul 2021 ReplyRetweetFavourite 3,041 followers えめ @Y623PhG61O6Z5qY RT @TigerGyroscope: ホンジュラス政府は、COVID-19に対して早期多剤併用療法を全国的に推進。その結果，死亡率が9.33％から2.97％に低下した。 外来治療は「マイス（MAIZ）」、院内治療は「カトラッチョ（Catracho）」と独自のプロトコールを行… 27 Jul 2021 ReplyRetweetFavourite 215 followers Taro Run @lightfulocean RT @Alzhacker: https://t.co/Qs2YhJSPzA ホンジュラスでSARS-CoV-2が初めて検出されてから2カ月以内に、ホンジュラス政府は多剤併用のCOVID-19による入院・外来治療プロトコルの全国展開を推進した。その結果，致死率は9.33％から2… 27 Jul 2021 ReplyRetweetFavourite 651 followers Richard White @Richard93752856 RT @GeorgeFareed2: Within 2 months of first detection of SARS-CoV-2 in Honduras, its government promoted nationwide implementation of multi… 27 Jul 2021 ReplyRetweetFavourite 165 followers MADELINE @KkXqz RT @TigerGyroscope: ホンジュラス政府は、COVID-19に対して早期多剤併用療法を全国的に推進。その結果，死亡率が9.33％から2.97％に低下した。 外来治療は「マイス（MAIZ）」、院内治療は「カトラッチョ（Catracho）」と独自のプロトコールを行… 27 Jul 2021 ReplyRetweetFavourite 217 followers phsycho pâtes @PomaC10 RT @GabinJean3: Honduras: un protocole de traitement précoce incluant l'ivermectine a été associé à une baisse de la létalité COVID. Le no… 27 Jul 2021 ReplyRetweetFavourite 435 followers Mollyb @Mollyb36968024 RT @GeorgeFareed2: Within 2 months of first detection of SARS-CoV-2 in Honduras, its government promoted nationwide implementation of multi… 27 Jul 2021 ReplyRetweetFavourite 770 followers Wert Yuio, Social Distancing @SirBears RT @TigerGyroscope: ホンジュラス政府は、COVID-19に対して早期多剤併用療法を全国的に推進。その結果，死亡率が9.33％から2.97％に低下した。 外来治療は「マイス（MAIZ）」、院内治療は「カトラッチョ（Catracho）」と独自のプロトコールを行… 27 Jul 2021 ReplyRetweetFavourite 2,263 followers 🐙明石のタマ🍤🇨🇭🐈🎸💉🚃鉄旅食情報人🥩🦵 @hcd01040 RT @TigerGyroscope: ホンジュラス政府は、COVID-19に対して早期多剤併用療法を全国的に推進。その結果，死亡率が9.33％から2.97％に低下した。 外来治療は「マイス（MAIZ）」、院内治療は「カトラッチョ（Catracho）」と独自のプロトコールを行… 27 Jul 2021 ReplyRetweetFavourite 86 followers Chris Dark @cd1m RT @GeorgeFareed2: Within 2 months of first detection of SARS-CoV-2 in Honduras, its government promoted nationwide implementation of multi… 27 Jul 2021 ReplyRetweetFavourite 570 followers Meredith @Meredit98242684 RT @DrEmbrace: Early multidrug treatment of SARS-CoV-2 (COVID-19) and decreased case fatality rates in Honduras | medRxiv (preprint) CONCL… 27 Jul 2021 ReplyRetweetFavourite 18,150 followers Tabatha @araran100 RT @TigerGyroscope: ホンジュラス政府は、COVID-19に対して早期多剤併用療法を全国的に推進。その結果，死亡率が9.33％から2.97％に低下した。 外来治療は「マイス（MAIZ）」、院内治療は「カトラッチョ（Catracho）」と独自のプロトコールを行… 27 Jul 2021 ReplyRetweetFavourite Back to top PreviousNext Posted August 01, 2021. Download PDF Author Declarations Data/Code XML Revision Summary Email Share Early multidrug treatment of SARS-CoV-2 (COVID-19) and decreased case fatality rates in Honduras Sidney Ontai, Li Zeng, Miguel Sierra Hoffman, Fernando Valerio Pascua, Vincent VanBuren, Peter A McCullough medRxiv 2021.07.21.21260223; doi: https://doi.org/10.1101/2021.07.21.21260223 This article is a preprint and has not been peer-reviewed [what does this mean?]. It reports new medical research that has yet to be evaluated and so should not be used to guide clinical practice. 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Citation Toolsclose Early multidrug treatment of SARS-CoV-2 (COVID-19) and decreased case fatality rates in Honduras Sidney Ontai, Li Zeng, Miguel Sierra Hoffman, Fernando Valerio Pascua, Vincent VanBuren, Peter A McCullough medRxiv 2021.07.21.21260223; doi: https://doi.org/10.1101/2021.07.21.21260223 This article is a preprint and has not been peer-reviewed [what does this mean?]. It reports new medical research that has yet to be evaluated and so should not be used to guide clinical practice. CITATION MANAGER FORMATS * BibTeX * Bookends * EasyBib * EndNote (tagged) * EndNote 8 (xml) * Medlars * Mendeley * Papers * RefWorks Tagged * Ref Manager * RIS * Zotero We use cookies on this site to enhance your user experience. By clicking any link on this page you are giving your consent for us to set cookies. Continue Find out more