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PUSH THE BOUNDS OF SCIENCE MAKE LIFE-CHANGING MEDICINES

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REGENERON NEWS: SEP 16TH

Intellia and Regeneron Announce Initial Data from the Cardiomyopathy Arm of
Ongoing Phase 1 Study of NTLA-2001, an Investigational CRISPR Therapy for the
Treatment of Transthyretin (ATTR) Amyloidosis

REGENERON NEWS: SEP 15TH

Positive Dupixent® (dupilumab) Phase 3 Data in Children Aged 6 Months to 5 Years
with Moderate-to-severe Atopic Dermatitis Published in The Lancet

REGENERON NEWS: SEP 15TH

Regeneron and Alnylam Report Promising Data from Ongoing Phase 1 Study of
ALN-HSD in NASH Patients and Healthy Volunteers

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At Regeneron, we've been committed to making a difference in patients' lives for
over 30 years.

We've done this by following the science.

One of the things that's made Regeneron really unique is its willingness to
invest in cutting edge technologies.

We're one of the few companies in the world that go all the way from
foundational discovery, to research, from research to development, to
manufacturing and commercialization.

We do that all at our campuses in New York, New Jersey, Ireland, and the UK.

It's really cool because we go from the really big thought, the really big idea,
all the way to seeing the impact on a person.

One of the things that distinguishes Regeneron is that we are a founder-led
organization.

Both Len and George are scientists, and they've really set the tone of focusing
on science from the very beginning.

And it spreads the through the organization in terms of our mission, our vision,
our activities, our behaviors.

We're one of the unique places where we've put such a big emphasis on human
genetics and deep biology.

Our genetics research is focused on looking at differences in our genes and
connecting that to diseases.

We have a capability of combining human gene sequence data with electronic
medical records.

We have a rich genomic database, and we apply that across our organization,
looking for new for new insights and to advance our research programs.

We've invested in a set of core technologies we call the VelociSuite
Technologies.

These include things like VelociGene, VelocImmune, and together this suite of
technologies gives us an engine for drug discovery.

We can use that engine again, and again, and again to produce new drugs.

Our VelociGene technologies give us an unprecedented ability to precisely
manipulate the mouse genome and work very rapidly.

Likewise, the VelocImmune technology gives us an unprecedented speed in
producing new drugs candidates.

So at a high level in drug development, there are really three key questions
that we need to answer.

One is does it work? Is it safe? And the third is can we produce it?

Before we can even start to explore whether it works, part of the role in
pre-clinical development is to establish whether it's safe and also develop a
manufacturing process by which we can produce it.

So, I see ourselves as a link between the discovery world and the manufacturing
facility where they will produce the drugs that we can test in clinical trials
and ultimately also do commercial production.

Once we've completed pre-clinical research to confirm safety, we work internally
with our medical experts to develop our trial designs.

We take those designs and work with healthcare providers across the globe to
help us implement clinical trials.

After decades of research at a lab bench and years of clinical trial work, we
take tremendous pride in being able to determine whether we've made a difference
in patient lives.

After completion of our clinical trials and data analysis, we then take that
data to regulatory authorities across the globe, so that they can give us our
stamp of approval.

With this approval, we work with our manufacturing group to switch into high
gear.

All of our drugs, whether they're for a clinical trial or a commercial market,
are made across our manufacturing footprint, in both Rensselaer, New York and
Raheen, Ireland.

Our quality standard is very simple. We want to make something that at the end
of the day, we would put in ourselves, our children, our siblings, our parents,
our grandparents and we have a just tremendous responsibility to get things that
are safe and efficacious to those people.

The commercial organization at Regeneron is responsible and accountable for the
really important step of making sure that our medicines get to patients who need
them.

We want to lead the industry in competitive commercialization and that activity
is powered by our science.

It's really a dream to work at Regeneron where number one is patients and using
science to help them.

I love the commitment to science.

I love that we have foundationally a deeply ethical company.

At Regeneron, we study genetics.

We build cutting edge technologies.

We develop biologic medicines.

We conduct thorough research.

We follow the science.

We bring innovative medicines to patients.

Because the potential.

To use science.

To improve human health is endless.

And we're driven.

By what we've yet to discover.


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Join us for a series decades in the making.

We explore millions of genetic codes, advance drug discovery through technology,
identify powerful genes and triumph against the most challenging diseases.

Follow Regeneron's quest for Spectacular Science.

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