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12 Billion Novel Molecules: CHEMriya - OTAVA's On-Demand Chemical Space
We are proud to announce the new Chemical Space CHEMriyaTM, created in
partnership with BioSolveIT.
The first release of the CHEMriya Space contains 12 billion accessible on-demand
molecules, based on thirty-thousand building blocks and 44 in-house
reactions. Several multi-component and ring-closure reactions provide a vast
chemical diversity with a broad range of molecular scaffolds.
Read more...
SARS-CoV-2 Main Protease Targeted Library
The COVID-19 pandemic caused by severe acute respiratory syndrome-coronavirus 2
(SARS-CoV-2) is a global health emergency. An attractive drug target for this
coronavirus is the main protease (3C-like proteinase, 3CLpro, Mpro) because of
its essential role in processing the polyproteins that are translated from the
viral RNA.
Read more...
Natural Product-Like Library
Natural Product-Like Library has been designed as a special screening library
containing synthetic compounds similar to natural products.
Read more...
Catechol O‑Methyl Transferase Targeted Library
Catechol O‑Methyl Transferase (COMT, HEL-S-98n) degrades catecholamines,
catecholestrogens and various drugs having a catechol structure. Mutation of
COMT is associated with obsessive-compulsive disorder in men, anxiety phenotypes
in women, schizophrenia and other. Developing of the COMT inhibitors is a
promising area of neuropsychiatric research. Also catechol‐O‐methyltransferase
inhibitors are used as adjuvants to the levodopa/AADC inhibitor therapy for
Parkinson's disease treatment.
Read more...
EZH2 Targeted Library
Enhancer of zeste homolog 2 (EZH2, ENX-1, ENX1, EZH1, EZH2b, KMT6, KMT6A, WVS,
WVS2, enhancer of zeste 2 polycomb repressive complex 2 subunit) is a
histone-lysine N-methyltransferase. This enzyme plays an important role in
histone methylation and, ultimately, transcriptional repression.
Mutation or over-expression of EZH2 has been linked to many forms of cancer,
including bladder, uterine, breast, prostate and renal cancers. EZH2 inhibits
genes responsible for suppressing of tumor development, and blocking of it
activity may slow tumor growth. Therefore, EZH2 is an attractive target for
anti-cancer therapy.
Read more...
Unsymmetrical Diaryliodonium Salts
Diaryliodonium salts are well-known to transfer an aryl group to carbon and
heteroatom nucleophiles, and in some cases a base is required [1]. However,
transition metal catalysts and supporting ligands are not needed. Moreover,
reactions conducted with diaryliodonium salts are operationally simple because
they are non-toxic and are not sensitive to air or moisture. Therefore
diaryliodonium salts offer an important alternative to metal-catalyzed arylation
reactions. Despite these attractive characteristics, a major obstacle to their
adoption in chemical synthesis and discovery chemistry has been commercial
availability.
Read more...
S1PR1 Targeted Libraries
Sphingosine-1-phosphate receptor 1 (S1PR1, S1P receptor 1, S1P1, endothelial
differentiation gene 1, EDG1) is a G-protein-coupled receptor which binds the
bioactive signaling molecule sphingosine 1-phosphate (S1P). S1PR1 has an
important role in regulating endothelial cell cytoskeletal structure, migration,
vascular maturation and capillary-like network formation. Also S1PR1 signaling
is important in the regulation of lymphocyte maturation, migration and
trafficking. Abnormal functioning of S1PR1 is associated with cancer and
multiple sclerosis. Agonists and antagonists of this receptor may have
therapeutic potential in the treatment of such diseases.
Read more...
RAR-related Orphan Receptor-γ Targeted Library
The Retinoic Acid Receptor-related Orphan Receptor-γ (RORγ, RORc, NR1F3, RORG,
RZR-GAMMA, RZRG, TOR or IMD42) plays an important role in metabolism, inimmunity
and circadian rhythm. Abnormal functioning of RORγ is associated with
inflammatory, immune and skin diseases including psoriasis. Antagonists and
inverse agonists of this receptor may have therapeutic potential in the
treatment of such diseases.
Read more...
MMP2 Targeted Library
The Matrix metalloproteinase-2 (MMP2, gelatinase A, 72 kDa type IV collagenase)
is involved in different functions such as reconstruction of the vasculature,
angiogenesis, tissue repair, inflammation, tumor invasion and atherosclerotic
plaque rupture. Mutations in the MMP2 gene are associated with Torg-Winchester
syndrome, arthritis syndrome, multicentric osteolysis and other pathologies.
Therefore, small molecule compounds targeting metalloproteinase-2 may be
potential treatment for a variety of diseases related to abnormality functioning
of MMP2.
Read more...
SARMs-Like Library
Selective androgen receptor modulators (SARMs) act on the androgen receptors
(ARs) in a tissue-selective manner and provide an opportunity to promote the
beneficial effects of androgens in target tissues with greatly reduced unwanted
side-effects. SARMs have been proposed as treatments of choice for various
diseases, including muscle-wasting, breast cancer, and osteoporosis.
Read more...
SARS-CoV-2 Targeted Libraries
The pandemic of coronavirus disease 2019 (COVID-19), which is caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a serious global
concern for public health with thousands of fatalities. Today, no specific drugs
are available to treat this disease. Thus, there remains an urgent need for the
development of specific antiviral therapeutics toward SARS-CoV-2.
Read more...
Viral RNA-dependent RNA Polymerases Targeted Library
RNA-dependent RNA polymerase (RdRP, RDR or RNA replicase) is an enzyme that
catalyzes the replication of RNA from an RNA template. RdRPs play a vital role
in the growth of RNA viruses and are important targets for antiviral drug
development.
Read more...
PDZ Domain Targeted Library
The PDZ domains play key roles in anchoring receptor proteins in the membrane to
cytoskeletal components, different intracellular signal transduction pathways
and many human diseases are associated with their dysregulation.
Read more...
GASC1 Targeted Library
Lysine-specific demethylase 4C (GASC1, KDM4C, JHDM3C, JMJD2C, TDRD14C,
bA146B14.1) is a histone demethylase that specifically demethylates 'Lys-9' and
'Lys-36' residues of histone H3, thereby plays a central role in histone
modification. Abnormal functioning of this epigenetic factor is associated with
different cancers, including breast cancer. Targeted inhibition of GASC1 in
cancer opens new avenues for therapeutic development.
Read more...
Cathepsin K Targeted Library
Cathepsin K (CTSK, CTS02, CTSO, CTSO1, CTSO2, PKND, PYCD) is a lysosomal
cysteine protease involved in bone remodeling and resorption. It has a major
role in osteoporosis and other bone-related pathologies, cancer, diabetes,
obesity and atherosclerosis. Cathepsin K inhibitors show great potential in the
treatment of such diseases.
Read more...
Quaternary Ammonium Salts
Our company is currently offering about 100 new quaternary ammonium salts that
could be of interest to your research. All quaternary ammonium salts are in
stock, and a full list of the salts in our catalog is available upon request.
Synthetic experience of Otava chemists allows to carry out custom syntheses of
even more complex structures of quaternary ammonium salts at a reasonable price.
Read more...
Renin Targeted Library
The Renin (REN, HNFJ2) is an aspartic protease (also known as an
angiotensinogenase). It participates in arterial vasoconstriction and the body's
renin–angiotensin–aldosterone system (RAAS) that mediates the volume of
extracellular fluid (blood plasma, lymph and interstitial fluid). Thus, it
regulates the body's mean arterial blood pressure. An over-active RAAS leads to
vasoconstriction and retention of sodium and water. These effects cause
hypertension. Therefore, renin inhibitors can be used for the treatment of
hypertension.
Read more...
Kallikrein 6 Targeted Library
Kallikrein 6 (KLK6, hK6, Bssp, Klk7, PRSS18, PRSS9, SP59, kallikrein related
peptidase 6) plays an important role in various physiological processes.
Disorders of KLK6 activity are observed at cancer and neurodegenerative
diseases, such as Alzheimer’s disease and multiple sclerosis. Therefore, small
molecule compounds modulating kallilrein 6 activity may have a significant
therapeutic potential.
Read more...
Peptidomimetic Libraries
The interaction of proteins are critical to nearly all biological processes,
including cellular signaling [1]. We offer special screening Peptidomimetic
Libraries: β-Turn Peptidomimetic Library containing synthetic compounds which
mimic beta-turns of proteins and a-Helix Peptidomimetic Library of compounds
mimic alpha-helixes of proteins. These libraries are intended for research and
drug discovery projects focused on protein-protein interactions.
Read more...
Agro-Targeted Libraries
To facilitate a process of finding new agrochemicals within the fields of weed,
pest and disease control, OTAVAchemicals design a set of focused libraries of
diverse compounds for agrochemical research and development.
Read more...
More Articles...
* Caspase 2 Targeted Library
* GABA Receptors Targeted Libraries
* SERMs-Like Library
* ß-Arrestin/ß2-Adaptin Interaction Targeted Library
* Transporter Targeted Libraries
* Nuclear ER Targeted Libraries
* ERR Gamma Targeted Library
* AD Polypharmacology Library
* SH2 Domain Targeted Library
* PRMTs Targeted Library
* ClpP Targeted Library
* RNA Targeted Library
* Phenotypic Screening Library
* hPreP Agonist Library
* PARP-1 Targeted Library
* 5-HT1B Receptor Targeted Library
* iPPI Focused Libraries
* SGLT2 Targeted Library
* DPP4 Targeted Library
* HMGCR Targeted Library
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