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Home > Does CBD Oil Really Help Treat Arthritis Pain?
Jennifer Freeman, MD

Doctor of Medicine (M.D.) in 2008 from UT Health San Antonio, Surgeon at TRACC
Dallas

Oct 4, 2019 10 min read


DOES CBD OIL REALLY HELP TREAT ARTHRITIS PAIN?

 

Jump to the 1 that Works

Best CBD – Editor’s Pick 🏆

Approximately 54 million adults and 300,000 children in the U.S. have been
diagnosed with arthritis or some other type of rheumatic disease causing joint
pain according to the Arthritis Foundation (AF).

If you consider all of the individuals who have arthritis but have not yet been
diagnosed, the AF suggests that the true count is likely closer to 91.2 million
in total. To make matters even worse, that number is expected to grow by 49
percent by the year 2040.

The most precarious and debilitating symptoms suffered by arthritis patients
include pain, stiffness, and decreased movement within the joints, all of which
can be severe and worsen over time. In addition, there are other symptoms that
are just as troublesome, such as anxiety and depression. Not only that, but it
can become especially trying when you have to contend with other medical
problems that tend to coexist with arthritis, like heart disease, diabetes, and
obesity.

Some medications and treatment programs can potentially help ease these negative
effects, but many people are searching for a more natural pain relief option.
This is where CBD oil comes into play.




WHAT IS CBD OIL?

CBD is short for cannabidiol, which MedlinePlus explains is one of more than 80
chemical cannabinoids found in the marijuana plant Cannabis sativa. Thus,
cannabis oil, or CBD oil as it is more commonly known, is an oil that is
developed using this particular compound.

Although CBD oil is just now becoming fairly mainstream, largely because of the
debates surrounding medical marijuana, cannabis actually has a long history of
providing relief in many different countries around the world.


CBD’S LONG HISTORY

In June 2015, National Geographic ran a story about how Siberian burial mounds
as far back as 3000 B.C. were found to contain charred cannabis seeds. Cannabis
has also been used in Chinese medicine for thousands and thousands of years.

The article went on to explain how American use of cannabis goes back to our
country’s founding fathers as well. In fact, George Washington himself grew hemp
at his plantation estate and the location of his burial, Mount Vernon.

Because of its somewhat tumultuous history marijuana has had with the law
(regarding whether it is illegal or not), research on the positive properties of
hemp plants’ derivatives such as cannabidiol oil has been extremely limited.

This has caused many people to question its use for modern day ailments,
primarily because they don’t know a lot about how it works.


HOW CANNABIS OIL WORKS

According to Medical News Today, the body’s endocannabinoid system has two
cannabinoid receptors: CB1 and CB2.

A majority of CB1 receptors are located in the brain and are associated with
cognitive actions related to coordination, mood, thinking, memory, and
appetite. The CB2 receptors, on the other hand, can be found in the immune
system. This makes them more responsible for the body’s response to pain and
inflammation.

Tetrahydrocannabinol, or THC, attaches to the CB1 receptors, which explains why
smoking or otherwise ingesting marijuana affects users on a cognitive level.

However, CBD impacts the CB2 receptors. And it does so indirectly, not by
attaching to the CB2 receptor, but by enticing the body to make more of its own
cannabinoids. This creates a positive effect on the body’s pain and inflammation
responses.


BENEFITS OF CBD OIL

Many studies have been conducted on CBD and found that this compound offers
individuals diagnosed with arthritis several potential benefits.


CBD OIL EASES ARTHRITIS PAIN

One of the primary CBD oil benefits for arthritis sufferers is its positive
effect on pain, and research confirms it.

A study published in the journal Pain in December 2017 analyzed whether CBD
could prevent osteoarthritis pain and joint neuropathy. Based on their findings,
researchers affirmed that it did both because it decreased joint inflammation
and served as a protectant to the nerves.


CBD OIL RELIEVES OTHER CHRONIC PAIN CONDITIONS

CBD oil has been found to relieve other chronic pains as well. For instance,
research published in Therapeutics and Clinical Risk Management indicates that
cannabinoids have been helpful with easing pain for individuals diagnosed with
conditions such as multiple sclerosis and cancer.

Other studies have reported positive effects for individuals taking CBD to ease
their fibromyalgia pain, many of whom only experienced mild side effects from
this chemical compound, such as dry mouth, drowsiness, and dizziness.


CBD OIL AND ANXIETY

CBD oil has also been linked to a variety of mental health benefits, such as a
reduction in anxiety. Research suggests that it is so effective in this regard
that it has “considerable potential as a treatment for multiple anxiety
disorders.” One study published in The Permanente Journal even found that CBD
oil can help reduce anxiety in young children.


CBD OIL FOR DEPRESSION

Several studies have also linked CBD to a reduction of symptoms associated with
depression. This is extremely important because as the Arthritis Foundation says
that the depression rates of those diagnosed with certain types of arthritis
“can be between two- and ten-times greater than the rates of the general
population.”


IS CBD OIL LEGAL?

Although CBD oil has a number of potential benefits, one of the top questions
that individuals diagnosed with rheumatoid arthritis have is whether or not it
is legal. Answering this question requires some understanding of certain
components of the marijuana plant.

The compound in the cannabis plant that is most well-known is THC. This is the
chemical responsible for marijuana’s notorious high. However, unlike THC, CBD
does not have psychoactive properties. This means that it does not create the
same effect that one normally gets when smoking, inhaling, or otherwise
ingesting marijuana. Furthermore, the U.S. Drug Enforcement Administration (DEA)
says that it is the THC that makes marijuana illegal in a number of different
states.

As a result, the answer to “Is CBD oil legal?” isn’t quite so clear.

Originally, marijuana use and sales became illegal under the Marijuana Tax Act
of 1937, with this illegality continuing under the Controlled Substances Act.
Yet, since then, several states have taken the steps to legalize this drug, even
if just for use as medical cannabis.

For instance, some states allow the consumption of marijuana and its extracts
only for medical reasons, which makes a medical marijuana card necessary for its
use. Some states have approved this drug and its components for recreational use
as well.

To make matters more complex, on December 14, 2016, the DEA issued a Final
Rule that created a new code number (7350) designed to cover “any material,
compound, mixture, or preparation” surrounding the marijuana plant.

Upon clarification of this new code, the DEA indicated that CBD extracts that
contains even small amounts of other cannabinoids would still fall under the old
code, making them illegal under federal rule. However, CBD extracts that contain
no other cannabinoids would fall under the new code, where they could
potentially be legal to use.

Plus, some CBD oils are derived from hemp, the fiber of the cannabis plant.
Though the 2014 Farm Bill declared certain hemp cultivation practices legal,
muddying the legal waters even more, the president signed the new Farm Bill into
law in December 2018, effectively legalizing hemp under federal law.

What does all of this mean in real-life terms?

In short, to determine whether a CBD oil or any other CBD product is legal or
illegal depends on a multitude of factors. Your geographical location, local
laws, and whether there are any other cannabinoids in the extract must all be
taken into consideration before arriving at a final answer.


IS CBD OIL SAFE?

The second most common question people have when it comes to CBD oil for pain
management or its anti-inflammatory properties is whether or not it is safe to
use for arthritis symptoms.

Patients are always concerned with additional potential and side effects (as
they should be). According to some top health experts and agencies, the answer
is yes. It is safe to use.

For instance, Medscape shares that while cannabinoid medicine is still in its
early stages, “unlike marijuana and THC, the risks associated with CBD are
extremely low, with not a single case report of CBD overdose in the
literature. The National Institute on Drug Abuse agrees and states that “CBD
appears to be a safe drug with no addictive effects.”

In the future, it is likely that the Food and Drug Administration (FDA) will
also begin to regulate CBD products, providing an additional safety net, as this
agency indicates that “increasing public interest” in this substance increases
the importance of establishing regulatory procedures.


POTENTIAL RISKS OF CBD OIL

Many health experts have deemed CBD safe to use, but like with any substance,
there does appear to be a few potential risks when it comes to using this
extract.


MEDICATION/DRUG INTERACTIONS

MedlinePlus indicates that CBD can sometimes interact with certain prescription
medications, primarily those that are “changed and broken down by the liver.”

These include, but are not limited to common medications such as:

 * ondansetron (Zofran)
 * clozapine (Clozaril, FazaClo)
 * progesterone (Endometrin, Prometrium)
 * testosterone
 * disulfiram (Antabuse)
 * ketamine (Ketalar)
 * phenobarbital (Luminal)
 * omeprazole (Prilosec)
 * lansoprazole (Prevacid)
 * diazepam (Valium)
 * carisoprodol (Soma)
 * ibuprofen (Motrin)
 * celecoxib (Celebrex)
 * amitriptyline (Elavil)
 * warfarin (Coumadin)
 * codeine
 * paroxetine (Paxil)
 * tramadol (Ultram)
 * venlafaxine (Effexor)
 * alprazolam (Xanax)
 * fexofenadine (Allegra)
 * benzodiazepines
 * morphine

MedlinePlus further states that there are other “drugs” that can potentially
interact with CBD as well, including caffeine and nicotine. However, research
has not necessarily supported these claims.

For instance, a 2015 study published in the journal Pharmacology Biochemistry
and Behavior found that, in the right dose, caffeine can actually potentially
help prevent CBD effects on memory.

Another piece of research, this one published in the Addictive Behaviors
journal, found that CBD “significantly reduced” (as much as 40 percent) the
number of cigarettes smoked by individuals who wanted to quit.


CBD AND DROWSINESS

Another potential risk of CBD is that it can cause drowsiness. Therefore, if
you’re taking supplements or medications to help you sleep, CBD could enhance
these effects even more. It’s important to keep this in mind if you’re
performing activities that require maximum alertness, such as driving or
operating heavy machinery.


CBD DOSING CONSIDERATIONS

If you’d like to use CBD oil to help ease your arthritis pain, you may be
wondering how much to administer or apply. However, when talking about proper
CBD dosing, it’s important to first understand bioavailability.


CBD BIOAVAILABILITY

Bioavailability is defined as the “amount of a substance that becomes available
(reaches the target organ or system circulation) to an organism’s body for
bioactivity when introduced through ingestion, inhalation, injection, or skin
contact.” In short, it is how much of the substance your body can effectively
use based on the type and route taken.

In the case of CBD oil specifically, Medscape shares that while intranasal
administration of CBD has a bioavailability of 34 to 46 percent and CBD
vaporization has 40 percent bioavailability, “oral CBD is thought to be as low
as 6 percent, owing to significant first pass-metabolism.”


FIRST-PASS METABOLISM AND CBD

An article published in the journal Nurse Prescribing explains that first-pass
metabolism occurs in the gut or the liver and is when some of the drug is
destroyed before it is able to be circulated around the body. Thus, based on the
research above, taking CBD oil in pill form may mean that your body only
receives as little as 6 percent of the CBD.

Another option is to take CBD oil topically, either alone or as part of a lotion
or cream. Research published in the European Journal of Pain studied the
effectiveness of this approach and found that “topical CBD application has
therapeutic potential for relief of arthritis pain-related behaviours and
inflammation without evident side-effects.”


PROPER CBD DOSING

Because CBD is so new, Medscape recommends that users “start low, go slow.” This
enables you to see how well your body responds without giving it more than the
necessary amount.

Plus, there are no government regulations regarding the manufacture and sale of
CBD, so you never know if you’re getting the amount actually listed on the
label. This makes erring on the side of caution even more important.


CBD OIL OPTIONS

Consumer Health Digest (CHD) researched products on the web and, according to
this guide, the three most important terms to know before purchasing your CBD
oil are CBD volume, hemp oil volume, and CBD concentration. The second and third
are the most critical, according to CHD, because they indicate the oil’s
potency.

It’s also important to realize that there are different product options with
regard to CBD oils. They are:

 * CBD oil, which is the “more potent version and delivery system of CBD”
 * CBD oil topical solutions, enabling the user to use it on a more targeted
   area
 * CBD oil tinctures, which are alcohol-based cannabis extracts that can be
   ingested orally, and the most popular CBD oil choice
 * CBD dietary supplements, or capsules containing CBD oil in in a powdered form

The one you choose will depend largely on the location and severity of your
pain. If you want to target a specific area, an oil or oil topical may be the
best. However, if the pain is all over, then a tincture or dietary supplement
may provide the most relief.

Also, if you’re new to using CBD oil, we recommend you start with 10 milligrams
per day to establish a safe, effective amount for you. Most of our RA colleagues
end up getting relief when they take 20mg of full spectrum lab grade CBD
tincture under the tongue twice per day. It’s important to hold it there for at
least 60 seconds. Others with more severe pain go as high as 80mg twice or more
per day to get full relief.




WHERE TO BUY LAB GRADE CBD OIL AND TOPICAL CBD CREAM?

There has been an explosion of new CBD products hitting the market in the past
year. We’re seeing reports of many of them having far less CBD than they report
or even including no CBD at all. Worse some have even failed testing for
pesticides and dangerous bacteria. The FDA seems to be ramping up enforcement to
tackle this problem. We tested dozens of products amongst our staff, and through
our network of RA readers and found Spruce CBD to be the most effective.

--------------------------------------------------------------------------------




EDITOR’S CHOICE FOR MOST EFFECTIVE:


SPRUCE CBD

Spruce Natural Labs is a 100% US grown, tested, and bottled company dedicated to
producing the highest quality, lab grade CBD products aimed at getting the
maximum effect. Spruce only sells full spectrum CBD oil tinctures in a 750mg and
extra strength 2,400mg for people with the worst pain needs. No gummies, no
capsules, and no CBD isolate which the founders tell us “has a low rate of
success for most people”. It is important to note that Spruce products do
contain the legal limit of no more than 0.3% THC which means you do run a risk
of possibly testing positive if you take a marijuana drug test. You should
probably avoid it if you will be drug tested.

Our best results came from taking both the CBD oil under the tongue while at the
same time applying the CBD cream (or more potent salve) directly to the joints
in pain.

💵RASN Members can use coupon code RASN to get 15% off your order 💵

TakeSpruce.com

 

*** As always, discuss with your healthcare provider before starting any new
medications or supplements to ensure that there are no interactions with your
current medication and treatment regimens.

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