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SMC Laboratories, Inc. is a global specialty CRO focusing on non-clinical
trials, with expertise in the area of inflammatory and fibrosis diseases. We
have been delivering non-clinical study services to more than 800 clients in 30
countries, such as global pharmaceuticals, biotech, and National Institutes
around the world. We have supported our partners with our strategic solutions
based on our knowledge and experience.


CHOOSE YOUR INTEREST ORGANS OR THERAPEUTIC TARGETS


ORGANS

Liver
Lungs
KIdneys
Brains
Large Intestine
Skin



THERAPEUTIC TARGETS

 * Inflammation
 * Fibrosis
 * Cancer


ORGANS

--------------------------------------------------------------------------------


LIVER


NASH-HCC


NASH-HCC MODEL (STAMTM MODEL)

Learn more about the many strengths of this model, including the STAM™ mice can
be used to calculate the NAFLD activity score (NAS), which is a main endpoint in
clinical trials.


＼SEE BELOW FOR THE DETAILS／

　Learn More　


CHOLESTATIC LIVER DISEASE


BDL-INDUCED LIVER FIBROSIS MODEL

The Bile duct ligation (BDL)-induced cholestatic liver disease model is a model
that reproduces the pathophysiological features of primary biliary cholangitis.
Download the slide deck to see time course data for histology, biochemistry and
gene expression analyses.


＼SEE BELOW FOR THE DETAILS／

　　Learn More　　


LIVER CIRRHOSIS


CCL4-INDUCED LIVER FIBROSIS MODEL

In this model, carbon tetrachloride (CCl4) is repeatedly administered to develop
a well-characterized model for cirrhosis. Download the pdf to see some
historical data obtained from analyses done on fibrosis in this model


＼SEE BELOW FOR THE DETAILS／

　Learn More　


ACUTE HEPATITIS


CCL4-INDUCED ACUTE LIVER FAILURE MODEL


THE ACUTE CARBON TETRACHLORIDE (CCL4) MODEL IS A GREAT WAY TO INVESTIGATE
DIFFERENT ASPECTS OF ACUTE LIVER INJURY, SUCH AS METABOLIC DISORDERS,
INFLAMMATION AND NECROSIS, AS WELL AS ASSESS A DRUG’S EFFICACY. IN THIS MODEL
THE METABOLISM OF CCL4 LEADS TO THE PRODUCTION OF HIGHLY REACTIVE RADICAL
SPECIES, WHICH CAUSE HEPATIC NECROSIS VIA LIPID PEROXIDATION AND CELL MEMBRANE
DAMAGE


＼SEE BELOW FOR THE DETAILS／

　Learn More　


ACUTE HEPATITIS


CONCANAVALIN A-INDUCED ACUTE LIVER FAILURE MODEL

Concanavalin A-induced acute liver failure imitates the pathophysiological
features of autoimmune hepatitis. This model causes abnormal T-cell activation,
leading to the development of fulminant hepatitis and tissue necrosis.


＼SEE BELOW FOR THE DETAILS／

　Learn More　


ACUTE HEPATITIS


D-GAL/LPS-INDUCED ACUTE LIVER FAILURE MODEL

The D-Gal/LPS model is just one of several acute liver failure models that we
offer     at SMC. In this model, liver injury is induced in a short period of
time by administrating both D-galactosamine (D-Gal) and lipopolysaccharide
(LPS). This model shows robust inflammation and apoptosis through immune cell
infiltration.


＼SEE BELOW FOR THE DETAILS／

　Learn More　


ACUTE HEPATITIS


ACUTE TAA-INDUCED ACUTE LIVER FAILURE MODEL

The Thioacetamide (TAA)-induced acute liver failure model is a classic liver
injury model. In this model, metabolites produced in the liver bind to lipids
and proteins, causing oxidative stress and central lobular necrosis.


＼SEE BELOW FOR THE DETAILS／

　Learn More　


CANCER


XENOGRAFT TUMOR MODEL

We have had experience working with many different cell lines, and can use our
many years of experience to recommend the best study design for you.


＼SEE BELOW FOR THE DETAILS／

　Learn More　


CANCER


ORTHOTOPIC XENOGRAFT TUMOR MODEL

Learn about how we are able consistently produce quality results in the
orthotopic xenograft model, despite the fact that it is often considered to be a
difficult model to implement and reproduce. 


＼SEE BELOW FOR THE DETAILS／

　Learn More　


CANCER


DEN/CCL4-INDUCED LIVER CANCER MODEL

In this model, the administration of carbon tetrachloride (CCl4) and
diethylnitrosamine (DEN) induces cirrhosis based hepatocellular carcinoma (HCC).
This is a great model for those looking to study fibrosis and its role in the
development of HCC, as well as test their compounds efficacy. 


＼SEE BELOW FOR THE DETAILS／

　Learn More　


LUNGS


IPF


BLM-INDUCED LUNG FIBROSIS MODEL

See how we used clinical data to choose IT administration for the BLM in this
model. Also learn more about our highly specialized sampling techniques as well
as our CT and tissue analysis methods that we have been honing for over 10
years. 


＼SEE BELOW FOR THE DETAILS／

　Learn More　


ARDS


LPS-INDUCED ACUTE LUNG INJURY MODEL

In this model the administration of LPS creates a pathology that mimics acute
respiratory distress syndrome (ARDS). Learn more about how we evaluate vascular
permeability, inflammation and cytokine levels in this model.


＼SEE BELOW FOR THE DETAILS／

　Learn More　


COPD


PPE-INDUCED EMPHYSEMA MODEL

This model mimics COPD as seen in human patients via the administration of
Porcine Pancreatic elastase (PPE). This model can aid anyone hoping to observe
lung inflammation and pulmonary emphysema.  


＼SEE BELOW FOR THE DETAILS／

　Learn More　



KIDNEYS


CKD


UUO-INDUCED RENAL FIBROSIS MODEL

See why this model is so popular for screening studies! Also learn more about
the evaluation of fibrosis via the FDA recommended Sirius Red Stain and our
positive control, the ALK5 inhibitor. 


＼SEE BELOW FOR THE DETAILS／

　Learn More　


CKD


ADRIAMYCIN-INDUCED NEPHROPATHY MODEL

See how this model can be used to evaluate glomerulosclerosis, a condition that
occurs in patients who suffer from focal segmental glomerulosclerosis, as well
some time course data related to proteinuria levels and many other analyses
conducted on collected tissue samples. 


＼SEE BELOW FOR THE DETAILS／

　Learn More　


CKD


ADENINE-INDUCED NEPHROPATHY MODEL

See how in this model, just like in humans, blood biomarkers like serum
creatinine can be used to evaluate eGFR. It has even been reported that this
model allows for the evaluation of complications such as hyperphosphatemia and
renal anemia as well.


＼SEE BELOW FOR THE DETAILS／

　Learn More　



BRAINS


ALZHEIMER’S DISEASE


ICV-STZ-INDUCED ALZHEIMER’S DISEASE MODEL

The icv-STZ model reproduces brain inflammation similar to what is seen in the
early stages of human Alzheimer's disease patients. Download our slide deck to
see some time course data related to microgliosis and astrogliosis that was
gathered in our lab. 


＼SEE BELOW FOR THE DETAILS／

　Learn More　



LARGE INTESTINE


IBD


DSS-INDUCED COLITIS MODEL

This model can be used to establish both acute and chronic colitis. Learn more
about the disease activity index and its sub score, as well as how fibrosis can
be evaluated in this model.


＼SEE BELOW FOR THE DETAILS／

　Learn More　



SKIN


SSC


BLM-INDUCED SKIN FIBROSIS MODEL

The animals in this model are administered Bleomycin (BLM) subcutaneously over
the course of the model which causes them to develop skin fibrosis similar to
what is seen in human systemic sclerosis patients. Download the PDF to see data
obtained from the model, as well as learn more about our reference control
imatinib. 


＼SEE BELOW FOR THE DETAILS／

　Learn More　


SSC-ILD


BLM-INDUCED SKIN/LUNG FIBROSIS MODEL

Learn more about the model that can be used to simultaneously evaluate
scleroderma and interstitial lung disease, the SSc-ILD model. The fact that skin
and lung samples can both be collected and evaluated from just one mouse has led
to an increase in this model’s popularity in recent years.   


＼SEE BELOW FOR THE DETAILS／

　Learn More　


THERAPEUTIC TARGETS

--------------------------------------------------------------------------------


INFLAMMATION


NASH-HCC


NASH-HCC MODEL (STAMTM MODEL)

Learn more about the many strengths of this model, including how samples from
the STAM™ mice can be used to calculate the NAFLD activity score, which is a
main endpoint in clinical trials.   


＼SEE BELOW FOR THE DETAILS／

　Learn More　


LIVER CIRRHOSIS


CCL4-INDUCED LIVER FIBROSIS MODEL

In this model, carbon tetrachloride (CCl4) is repeatedly administered to develop
a well-characterized model for cirrhosis. Download the pdf to see some
historical data obtained from analyses done on fibrosis in this model.


＼SEE BELOW FOR THE DETAILS／

　Learn More　


ACUTE HEPATITIS


ACUTE TAA-INDUCED ACUTE LIVER FAILURE MODEL

The Thioacetamide (TAA)-induced acute liver failure model is a classic liver
injury model. In this model, metabolites produced in the liver bind to lipids
and proteins, causing oxidative stress and central lobular necrosis.


＼SEE BELOW FOR THE DETAILS／

　Learn More　


ACUTE HEPATITIS


D-GAL/LPS-INDUCED ACUTE LIVER FAILURE MODEL

The D-Gal/LPS model is just one of several acute liver failure models that we
offer     at SMC. In this model, liver injury is induced in a short period of
time by administrating both D-galactosamine (D-Gal) and lipopolysaccharide
(LPS). This model shows robust inflammation and apoptosis through immune cell
infiltration.


＼SEE BELOW FOR THE DETAILS／

　Learn More　


ARDS


LPS-INDUCED ACUTE LUNG INJURY MODEL

In this model the administration of LPS creates a pathology that mimics acute
respiratory distress syndrome. Learn more about how we evaluate vascular
permeability, inflammation and cytokine levels in this model. 


＼SEE BELOW FOR THE DETAILS／

　Learn More　


CKD


ADENINE-INDUCED NEPHROPATHY MODEL

See how in this model, just like in humans, blood biomarkers like serum
creatinine can be used to evaluate eGFR. It has even been reported that this
model allows for the evaluation of complications such as hyperphosphatemia and
renal anemia as well.


＼SEE BELOW FOR THE DETAILS／

　Learn More　


FIBROSIS


NASH-HCC


NASH-HCC MODEL (STAMTM MODEL)

Learn more about the many strengths of this model, including how samples from
the STAM™ mice can be used to calculate the NAFLD activity score, which is a
main endpoint in clinical trials.


＼SEE BELOW FOR THE DETAILS／

　Learn More　


LIVER CIRRHOSIS


CCL4-INDUCED LIVER FIBROSIS MODEL

In this model, carbon tetrachloride (CCl4) is repeatedly administered to develop
a well-characterized model for cirrhosis. Download the pdf to see some
historical data obtained from analyses done on fibrosis in this model.


＼SEE BELOW FOR THE DETAILS／

　Learn More　


CHOLESTATIC LIVER DISEASE


BDL-INDUCED LIVER FIBROSIS MODEL

The Bile duct ligation (BDL)-induced cholestatic liver disease model is a model
that reproduces the pathophysiological features of primary biliary cholangitis.
Download the slide deck to see time course data for histology, biochemistry and
gene expression analyses.


＼SEE BELOW FOR THE DETAILS／

　　Learn More　　


CANCER


DEN/CCL4-INDUCED LIVER CANCER MODEL

In this model, the administration of carbon tetrachloride (CCl4) and
diethylnitrosamine (DEN) induces cirrhosis based hepatocellular carcinoma (HCC).
This is a great model for those looking to study fibrosis and its role in the
development of HCC, as well as test their compounds efficacy.


＼SEE BELOW FOR THE DETAILS／

　Learn More　


CKD


UUO-INDUCED RENAL FIBROSIS MODEL

See why this model is so popular for screening studies! Also learn more about
the evaluation of fibrosis via the FDA recommended Sirius Red Stain and our
positive control, the ALK5 inhibitor. 


＼SEE BELOW FOR THE DETAILS／

　Learn More　


CKD


ADENINE-INDUCED NEPHROPATHY MODEL

See how in this model, just like in humans, blood biomarkers like serum
creatinine can be used to evaluate eGFR. It has even been reported that this
model allows for the evaluation of complications such as hyperphosphatemia and
renal anemia as well.


＼SEE BELOW FOR THE DETAILS／

　Learn More　


CANCER


NASH-HCC


NASH-HCC MODEL (STAMTM MODEL)

Learn more about the many strengths of this model, including how samples from
the STAM™ mice can be used to calculate the NAFLD activity score, which is a
main endpoint in clinical trials.   


＼SEE BELOW FOR THE DETAILS／

　Learn More　


CANCER


DEN/CCL4-INDUCED LIVER CANCER MODEL

In this model, the administration of carbon tetrachloride (CCl4) and
diethylnitrosamine (DEN) induces cirrhosis based hepatocellular carcinoma (HCC).
This is a great model for those looking to study fibrosis and its role in the
development of HCC, as well as test their compounds efficacy. 


＼SEE BELOW FOR THE DETAILS／

　Learn More　


CANCER


ORTHOTOPIC XENOGRAFT TUMOR MODEL

Learn about how we consistently produce quality results in the orthotopic
xenograft model, despite the fact that it is often considered to be a difficult
model to implement and reproduce. 


＼SEE BELOW FOR THE DETAILS／

　Learn More　


SMC Laboratories Inc.

Technoport Kamata Center Bldg. 2-16-1 Minami-Kamata Ota-City Tokyo, 144-0035
Japan
TEL +81-3-6715-9101


LA Office（USA）
20250 Acacia St. STE 240 Newport Beach,CA 92660
TEL：+1-949-756-8500

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