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You are here：HOME>Products>Preparation Excipient>8-(2-Sodium
hydroxybenzamido)ocrylate (SNAC)
Contact Us：


8-(2-SODIUM HYDROXYBENZAMIDO)OCRYLATE (SNAC)

Pharmaceutical Grade.
   
 * CAS Number 203787-91-1
   
 * Package：100g, 1Kg, 5Kg
   
 * Function: Oral absorption enhancer with potential in delivering oral forms of
   heparin and insulin.
 * Application: Used in pharmaceutical formulations.
 * Tags: Featured products


 * Summary
 * Properties
 * Product Detail

Sodium 8-(2-hydroxybenzamido)octanoate (SNAC) is utilized as an oral absorption
enhancer, gaining attention for its potential in delivering oral forms of
heparin and insulin. Salcaprozate sodium enhances passive transcellular
penetration of small intestinal epithelial cells by augmenting lipophilicity
through non-covalent macromolecular complexation.


Key Information

Molecular Weight: 301.32
Molecular Formula: C15H20NNaO4
Purity: 98.0%~102.0% on an anhydrous basis
Chiasma, an Israeli company, established a TPE technology absorption promotion
platform based on sodium octanoate's characteristics. This technology was
successfully employed in preparing oral octreotide. The formulation comprises
medium-chain fatty acids, sodium octanoate, and other excipients, combined with
octreotide in an oily suspension. It is then encapsulated in a pH-dependent
polymer enteric coating. In June 2020, the U.S. FDA approved the somatostatin
analog octreotide enteric-coated capsules (Mycapssa) for the long-term
maintenance treatment of acromegaly patients. Sodium octanoate influences the
fluidity of the gastrointestinal tract membrane, enhancing cell permeability and
increasing protein release within cells.

Preparation of Stock Solution

Solvent: DMSO
Concentration: 50 mg/ml (165.94 mM; Requires ultrasonication)
Note: Solubility may vary in different solvents; choose an appropriate solvent
to avoid compromising product effectiveness. Refrain from repeated freezing and
thawing, as it can impact the product's efficacy.





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