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TopicBiotechnologyGenetics & GenomicsPathologyReproductive HealthMedical Devices
& ImagingPediatrics



PATHOLOGY NEWS


EARLY DEPRESSION DIAGNOSIS LINKED TO HIGHER RATE OF DEMENTIA


JAMA STUDY LINKS DEPRESSION DIAGNOSIS IN EARLY AND MIDDLE LIFE TO HIGHER RATES
OF DEMENTIA, WITH A STRONGER LINK IN MEN.

Source: Getty Images

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By Veronica Salib



July 25, 2023 - A recent study published in JAMA Neurology on July 24, 2023,
linked depression diagnoses to dementia diagnoses later in life. Researchers’
analysis revealed that early- and middle-life depression diagnoses correlated
with a higher risk of dementia later in life.

The study focused on a cohort of Danish patients, collecting data from April
2022 to March 2023. Researchers evaluated data from participants between 1977
and 2018 using the Danish National Patient Registry (DNPR) and the Danish
Psychiatric Central Research Register (DPCRR).

The study used data from 246,499 individuals with depression and 1,190,302
without depression. The majority of patients with depression were diagnosed
before the age of 60.

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According to the study, across all patients, those with depression were 2.41
times more likely to be diagnosed with dementia later in life than those without
depression.

A depression diagnosis early in life, between 18 and 44, was associated with the
highest risk of dementia later in life, with a 3.08 times greater probability
compared to those who did not have a depression diagnosis. Meanwhile, a
depression diagnosis in middle life —ages 45 to 59 — was linked to a 2.95 times
greater probability of dementia. The final age bracket, which had a depression
diagnosis starting at age 60 or older, had a 2.31 times greater risk of dementia
than their counterparts without depression.

While the dementia rate was higher for anyone with a depression diagnosis,
regardless of age, the risk was significantly higher for those diagnosed with
depression earlier in life.

Beyond analyzing risk by age, the researchers also evaluated the impact of
gender, finding that men with depression were at a higher risk for dementia than
women with depression, with a hazard ratio of 2.95 and 2.31, respectively.

“Results suggest that the risk of dementia was more than doubled for both men
and women with diagnosed depression. The persistent association between dementia
and depression diagnosed in early and middle life suggests that depression may
increase dementia risk,” concluded researchers in the study.

Although the insights from this study provide potential hypotheses on the link
between mental health and dementia, additional clinical research on a broader
patient population is necessary for definitive conclusions.



 * Tagged
 * American Medical Association
 * Dementia
 * Depression
 * Mental Healthcare
 * Neuroscience

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