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 * info@SeqMatic.com


 * Mon - Fri 9AM - 7PM PST

 * 1.510.870.0965




 * Home
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EPIGENOME SEQUENCING

Home > Services > Epigenome Sequencing
 * Home
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 * Services
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 * Epigenome Sequencing


EPIGENOME SEQUENCING

HIGH-THROUGHPUT GENE EXPRESSION & REGULATION



The SeqMatic Laboratory employs Illumina NovaSeq platforms for high-throughput
epigenomic profiling to investigate the various aspects of chromatin
architecture. SeqMatic specializes in a variety of sequencing techniques to
analyze epigenetic modifications and the impact on gene regulation. Available
epigenomic analysis methods include DNA methylation (bisulfite sequencing),
Single-cell ATAC-Seq and Bulk ATAC-Seq for chromatin accessibility, ChIP-Seq for
examining transcription factor binding. We also offer Multiomics for integrated
ATAC-Seq and gene expression analyses. Our comprehensive services support
research studies across diverse genome, transcriptome and epigenome applications
for many organisms.


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Learn about SeqMatic’s service solutions for epigenome profiling:

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Bulk ATAC-Seq

SeqMatic offers Bulk ATAC-Seq services for efficient detection of chromatin
accessibility and its impact on gene regulation, cell fate determination, and
disease processes. The Assay for Transposase-Accessible Chromatin with
high-throughput sequencing utilizes a hyperactive Tn5 transposase method, which
allows for bulk processing. The Tn5 transposase is used to insert sequencing
adapters into open chromatin regions. By capturing temporal changes in chromatin
accessibility, ATAC-Seq provides valuable insights into the underlying molecular
mechanisms that drive biological processes and disease progression.

When analyzing changes over time in ATAC-seq data, a primary focus is on
identifying the open chromatin regions (OCRs) that undergo changes throughout
the process. In this context, the input for analysis consists of the
differential OCRs between each pair of time points. Unlike pseudotime analysis
in single cells, bulk ATAC-seq data is generated at predetermined time points.
This eliminates the need to infer the temporal order between samples.

> Learn about SeqMatic’s Bulk ATAC-Seq services




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Methylation (Methyl-Seq)

DNA methylation is an important mechanism in the field of epigenetics. This
process involves the addition of a methyl group to a molecule, leading to
changes that can influence the expression of certain genes and impact biological
functions. Gene expression research studies engage SeqMatic methylation services
for genome-wide analysis as well as targeted approaches.

SeqMatic’s high-throughput targeted bisulfite sequencing (Methyl-Seq) solutions
enable the evaluation of site-specific DNA methylation changes and the
identification of 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)
within genomes.

The SeqMatic comprehensive methylation analyses provide valuable insights into
methylation patterns at a single nucleotide level for a number of applications
including the study of disease states such as cancer, monitoring embryonic
development, and advancing research in the field of agricultural plants.

Learn more about SeqMatic’s Methylation services (Methyl-Seq)

EM-seq and sodium bisulfite conversion methods



Figure Source: New England BioLabs Inc. Technical Note “NEBNext® Enzymatic
Methyl-seq (EM-seq™)”


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Single Cell ATAC-Seq

The simplicity and scalability provided by the assay for transposase-accessible
chromatin using sequencing (ATAC-Seq) drives the popularity and adoption of this
technique for the detection and assessment of genome-wide chromatin
accessibility of cell types and how their normal state may be altered by
triggers.

> Learn more about SeqMatic’s ATAC-Seq services




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Chromatin Immunoprecipitation (ChIP-Seq)
ChIP-Seq is a powerful method that combines chromatin immunoprecipitation with
Next-Generation Sequencing (NGS) to conduct comprehensive surveys of gene
regulation on a genome-wide scale. The Seqmatic laboratory offers ChIP-Seq as a
valuable tool to investigate protein interactions with DNA and the binding sites
of transcription factors. This technique is particularly useful in research
projects focused on understanding the progression of cancer and other diseases.
By generating millions of counts across multiple samples, ChIP-Seq yields
important data and insights into gene regulation. One of the key advantages of
the ChIP-Seq method is its compatibility with various types of input DNA
samples. It enables the identification of DNA targets bound by transcription
factors and histone modifications throughout an organism’s entire genome.
Moreover, when combined with RNA sequencing and methylation analysis, ChIP-Seq
unveils intricate gene regulation networks. This approach provides a
comprehensive understanding of how transcription factors interact with DNA and
the impact on gene expression.

Workflow Image Source: Wikipedia free licensed image

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10x Genomics Chromium Multiome

10x Genomics Chromium Single Cell Multiome ATAC + Gene Expression – The SeqMatic
facility offers the ability to simultaneously profile gene expression and open
chromatin within the same cell, thereby enabling a more comprehensive
characterization of cell types and states through dual readouts. This integrated
method proves especially valuable in discerning disease subtypes and predicting
biomarkers. The multidimensional aspect of the multi-omics solution supports
numerous research projects with focus on cancer and other diseases, including
the investigation of genetic and phenotypic alterations, as well as resistance
mechanisms to target therapies.

> Learn about SeqMatic’s Single Cell ATAC-Seq Services

> Learn about SeqMatic’s Single Cell Gene Expression Services






ABOUT US

We are a certified service provider of Next Generation Sequencing and omics
research solutions.

Learn more about our science-first approach!



TECHNOLOGY

Browse a broad spectrum of sequencing solutions - SeqMatic provides a tailored
approach to your research needs, including sequencing platform optimization,
custom workflows, tailored-multiplexing and consistent runs led by high-value
Quality Controls.

Explore Solutions



GET A QUOTE

Start a conversation; we can help with your research right-away!

Your Project Details



Service Features
Service Highlights
Service Features
 * 10x Genomics Certified Service Provider – Single Cell ATAC-Seq and Multiome
   offerings have been validated and approved by 10x Genomics
 * Methyl-Seq – validated NEB protocols and kits for Enzymatic Methyl-seq
   (EM-Seq™)
 * Scalability from pilot to production – One partner for any scale project –
   equipped to support any size project – no sample minimum or maximum!
 * Expert pooling validated by MiSeq Nano – to ensure equal sample distribution
 * Proprietary TailorMix PhiX control – For reducing cross-talk during data
   processing and analysis
 * All DNA projects are performed in a CLIA environment – To ensure consistent
   quality

Epigenetic Discovery - Expression and Regulation

Service Highlights

SeqMatic Onsite-Seq™ Premium Mobile Service OperationsSeqMatic Fetch-Seq™
Premium Courier Service Operations

We can come to your laboratory! We provide “Onsite-Seq” service for all Single
Cell RNA sequencing needs.

Expert handling and transportation of your samples. Your domestic advantage
available to the S.F. Bay Area.

 * Expert Consultation – Our scientists can help you select the most
   scientifically viable and cost-effective choice of Single-Cell or Bulk
   ATAC-Seq and/or Methyl-Seq
 * Comprehensive Services – Complete DNA workflow, including extraction from
   virtually any sample type, library generation, sequencing, and data analysis
   services
 * Prepare Libraries From Difficult Samples – Low input DNA (as low as 1ng),
   blood, blood cards, saliva, stool, cell-free DNA and FFPE
 * Stringent Quality Controls – All sample preparation and library construction
   steps are validated by multiple assays (Qubit, TapeStation, qPCR and test
   sequencing)
 * Fast Turnaround Time – Standard and Express Services available
 * Technical Support – QC reports prepared for review by the customer to decide
   which samples qualify for library preparation, or alternative library
   preparation/sample re-submission
 * Flexibility – Choice for sample processing: manually or automated using a
   wide-range of processing technologies
 * Wide-Range of Sample Types – human, animal, fish, from virtually any source



DISCLAIMER: Supporting images (charts, figures, tables) and descriptions on this
page are adapted from information originally compiled and presented by the
various sources which are cited and linked within each individual topic module.

Bioinformatic Analysis
Histopathology



THE SEQMATIC DIFFERENCE


EXPERT NGS

The SeqMatic approach starts with proven genomic workflows and proprietary
controls that have been refined and optimized over the past decade to deliver
considerably more data than Illumina specifications.


EXPERT NGS

The SeqMatic approach starts with proven genomic workflows and proprietary
controls that have been refined and optimized over the past decade to deliver
considerably more data than Illumina specifications.

View More


CONSCIENTIOUS ATTENTION TO DETAIL

We learn about the goals of our customer’s scientific research and the type of
sequencing data that would be most beneficial to their project.


CONSCIENTIOUS ATTENTION TO DETAIL

We learn about the goals of our customer’s scientific research and the type of
sequencing data that would be most beneficial to their project.

View More


TAILOR-MADE SERVICES WITH FAST TAT

Then we modify our workflow to target those specific reads. Couple that effort
with world class turnaround time.


TAILOR-MADE SERVICES WITH FAST TAT

Then we modify our workflow to target those specific reads. Couple that effort
with world class turnaround time.

View More


OPTIMAL SOLUTIONS TO RESEARCH NEEDS

This application of best science, higher quality data, more read depth per lane,
and fast delivery makes SeqMatic an exceptional partner and value per research
dollar spent.


OPTIMAL SOLUTIONS TO RESEARCH NEEDS

This application of best science, higher quality data, more read depth per lane,
and fast delivery makes SeqMatic an exceptional partner and value per research
dollar spent.

View More


GET YOUR RESULTS

Optimal solutions are custom-made according to research needs

PRE-SUBMISSION

Planning & Consultation - Assurance of de-identified sample submission and
handling

SAMPLE SUBMISSION

Nucleic Acid Extraction - We accept a wide range of sample types

LIBRARY PREPARATION

Library Generation - Amplified cDNA is used for sequence libraries' construction

SEQUENCING

Different platforms for different data outputs

DATA ANALYSIS

Custom BioInformatics

Get a Quote

World-Class Omics Services




Email: info@seqmatic.com

Address: 44846 Osgood Rd.
                 Fremont, CA 94539

Phone : 1.510.870.0965


SERVICES

 * DNA Sequencing
 * RNA Sequencing
 * Single-Cell RNA Sequencing
 * Histopathology
 * Pre-Clinical & Clinical Services
 * Spatial Transcriptomics
 * Bioinformatics
 * Epigenome Sequencing
 * Universal Sequencing Services
 * Sequencing Platforms


COMPANY

 * About Us
 * Careers
 * Location
 * Customers
 * Publications
 * Products
 * Technology
 * Privacy Policy

Multi-Site Project Coordination




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