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 * Contact
 * Our Mission
 * Regions of Interest
 * Ukraine
 * IVD
 * COVID-19

 * Contact
 * Our Mission
 * Regions of Interest
 * Ukraine
 * IVD
 * COVID-19




SUPPORTING ACCESS TO 
CLINICAL DIAGNOSTICS.

Contact Details Our Mission

Thalloo promotes the availability of in-vitro diagnostic (IVD) equipment in
countries with high incidences of cancers and other conditions, focusing on
Eastern Europe and the Baltic States. 

Its mission is to innovate and enhance laboratory and point-of-care services to
improve patient outcomes in both public and private healthcare sectors.
Leveraging a robust network of clinical and medical expertise, industry
specialists, and regulated professionals, Thalloo ensures the integrity and
excellence of their international operations. 

Through extensive manufacturer relationships and industry expertise, Thalloo
supports access to cutting-edge diagnostics and testing solutions, maintaining
high standards of probity and professionalism to meet the evolving needs of the
global healthcare community.


OUR MISSION

THALLOO PROMOTES THE AVAILABILITY OF IVD (IN-VITRO CLINICAL DIAGNOSTIC)
EQUIPMENT IN COUNTRIES WHICH HAVE EXCEPTIONAL NEEDS THROUGH A HIGH INCIDENCE OF
CANCERS AND OTHER CONDITIONS.

Thalloo's mission is to innovate and promote cutting-edge technologies that
enhance the capabilities of laboratories and point-of-care services, ultimately
improving patient outcomes in both public and private healthcare sectors. 

We leverage a robust network of clinical and medical expertise, industry sector
specialists, and regulated professionals to ensure the integrity and excellence
of our international sales and financial operations. Our commitment to
maintaining high standards of probity and professionalism drives us to deliver
superior solutions that meet the evolving needs of the global healthcare
community.



HOW WE ACHIEVE OUR MISSION:

By focusing on these three key areas, Thalloo effectively drives innovation and
excellence in the global healthcare sector, fulfilling our mission to enhance
patient outcomes through advanced medical technologies.

INVESTOR

We actively invest in new and emerging companies that align with our mission of
delivering advancing healthcare technologies. By providing loans and venture
capital, we support their growth and the development of innovative solutions
that have the potential to make a significant impact on patient care and
healthcare delivery.

PARTNER

Thalloo forms strategic joint operations with entrepreneurs and local healthcare
providers in our target countries. These partnerships allow us to extend our
reach and deliver localised healthcare solutions that meet the specific needs of
each community. Through these collaborations, we ensure that our advanced
technologies and services are accessible to a broader audience.

SPONSOR

We are committed to supporting clinics and hospitals by introducing new
technologies and donating essential training and equipment. This sponsorship
enables healthcare providers to adopt and utilise cutting-edge diagnostic and
treatment tools, ultimately improving the quality of care they can offer to
their patients.


REGIONS OF INTEREST

We focus on working within Eastern Europe and the Baltic States. Our interest in
supporting this region developed from the significant impact that the Chernoybl
disaster of 1986 had on health in the region. 

Our interest has since expanded to improving healthcare in the region by
developing access to a wide range of diagnostics technologies that focus from
cancer related testing through to other testing requirements, including most
recently COVID-19. 

Our attention remains on providing support to the healthcare requirements of
Ukraine during the challenges and pressures that its healthcare system finds
itself in under difficult circumstances.

Thalloo affirms its commitment to compliance with international sanctions and
cross-border trade regulations. We have no operations, partnerships, or business
engagements in Russia. Thalloo does not collaborate with manufacturers based in
Russia, and our end-user partnerships do not serve customers within the Russian
market. This stance reflects our support for Ukraine and adherence to global
regulatory standards.


> We are working with partners in over 20 countries to bring access to clinical
> diagnostics solutions into public and private healthcare laboratories;
> including from Belgium, China, Finland, France, Germany, Greece, Hungary,
> Ireland, Italy, Latvia, Lithuania, Poland, Slovenia, South Korea, Spain,
> Switzerland, Taiwan, Turkey, United Arab Emirates, United Kingdom and the
> United States.

A LEGACY OF CHERNOBYL

Countries affected by the Chernobyl nuclear disaster in 1986 continue to face
exceptional healthcare needs due to the high incidence of cancers and other
conditions resulting from the radioactive fallout. The disaster released large
amounts of radioactive isotopes, leading to significant health consequences,
particularly among those exposed at a young age.

Thyroid cancer is the most significant health impact observed, with about 4,000
cases primarily among those exposed as children or adolescents. These regions
continue to see higher rates of leukemia and other cancers.

The healthcare systems in these areas must also address congenital malformations
and other long-term health effects potentially linked to radiation exposure. 

The long-term health monitoring of these populations is crucial as these risks
persist decades after the initial exposure. Consequently, clinical and medical
diagnostics technologies play a critical role in monitoring and diagnosing the
health implications for the population of the region over the  long-term.

THE IMPACT OF CLINICAL DIAGNOSTICS IN THE REGION.

Implementing advanced clinical diagnostics, up-to-date equipment, and
sophisticated diagnostic testing can significantly benefit healthcare systems in
countries affected by the Chernobyl disaster. 

These regions continue to grapple with high incidences of thyroid cancer and
other health conditions due to radiation exposure. Enhanced diagnostic tools,
such as high-throughput sequencing and advanced imaging technologies, allow for
early detection and precise characterization of cancers, leading to better
treatment outcomes and personalized care. 

For instance, next-generation sequencing has been used to study genetic
mutations in thyroid cancers caused by radiation from Chernobyl, helping to
understand the specific genomic alterations involved and guiding targeted
therapies. Additionally, comprehensive diagnostic equipment ensures accurate
monitoring and management of radiation-induced conditions, thereby improving
patient prognosis and quality of life . 

These advancements not only aid in clinical management but also enhance
epidemiological surveillance, providing critical data for ongoing public health
efforts and research into the long-term effects of radiation exposure .

SUPPORT OF UKRAINE

At Thalloo, we remain steadfast in our commitment to supply essential medical
diagnostics and healthcare equipment to hospitals and laboratories across
Eastern Europe, including Ukraine. We believe it is our duty to support patients
and healthcare providers who rely on our products for critical medical services.
Despite the significant challenges posed by international sanctions, we continue
to operate with integrity and dedication to ensure that healthcare delivery is
not compromised during these difficult times.

> Thalloo can confirm that it is not involved in Russia as a region of interest
> – to be clear, Thalloo has no partners in Russia, does not work with
> manufacturers based in Russia; and our end user-facing partnerships do not
> have customers based in Russia. 

ADDRESSING THE IMPACT OF SANCTIONS

Companies working in Eastern Europe and the Baltic States face significant
challenges while operating under international restrictions and sanctions
imposed due to the Ukraine-Russia conflict. The sanctions, aimed at limiting
Russia's economic capabilities, have resulted in complex regulatory environments
that businesses must navigate. These include restrictions on exports and imports
of a wide range of goods, especially those with dual-use capabilities and
advanced technologies.

Operating under international sanctions requires stringent compliance with a
complex array of regulations. The UK and EU have implemented extensive export
controls and restrictions on goods that could potentially be used in military
applications, including certain medical technologies.

Sanctions have disrupted traditional supply chains, with the additional
administration of ensuring compliance with sanctions contributing to delays.
Ensuring that medical supplies reach their destinations on time requires
meticulous planning and coordination .


COMPLIANCE

Compliance with sanctions involves continuous monitoring and adaptation to
evolving regulations. This includes maintaining up-to-date knowledge of
sanctioned entities and goods, which can be resource-intensive. The introduction
of new clauses prohibiting the re-exportation of certain goods adds another
layer of complexity to operating in this region.

Thalloo has regular dialogue with its partners to ensure that they have robust
processes in place to work within International regulations and the related
restrictions. This includes monitoring updates to UK, EU and US lists; working
closely with local customs agents to ensure any cross-border trade is within
guidelines; and where required, working with Government agencies to clarify or
seek approval where required. 

Access to in-market partners that provide local installation, and regular
servicing of equipment provides opportunities to ensure that equipment remains
for its intended use. 


IVD
IN-VITRO DIAGNOSTICS 

In-vitro diagnostics (IVD) are critical tools in modern healthcare, enabling the
diagnosis and monitoring of diseases by analyzing samples such as blood, urine,
or tissue outside the human body. IVDs play a pivotal role in detecting a wide
array of health conditions, including cancers, infectious diseases, and genetic
disorders.

IVD has made a major contribution to the diagnosis and management of treatments
for cancers. 

Our interest started two decades ago in countries with the World’s highest
incidence of gastric, breast and infantile cancers after the nuclear disaster at
Chernobyl – Eastern Europe and the Baltic States. 

IVD has developed for treatment of a much wider range of conditions and our
interest is being extended throughout Europe and into Asia.

Recent technological advancements have significantly enhanced the accuracy,
speed, and accessibility of these diagnostic tools, making them indispensable in
both clinical and point-of-care settings.  




RECENT DEVELOPMENTS IN IVD TECHNOLOGY

The field of IVD has seen remarkable advancements in recent years. The
integration of molecular diagnostics, such as Polymerase Chain Reaction (PCR)
and Next-Generation Sequencing (NGS), has revolutionized disease detection and
monitoring. These technologies allow for the precise identification of
pathogens, genetic mutations, and biomarkers, facilitating early diagnosis and
personalized treatment plans. 

For example, the development of CRISPR-based diagnostics has shown promise in
providing rapid and highly specific detection of genetic material from
pathogens, including viruses like SARS-CoV-2 . Additionally, the use of digital
PCR (dPCR) has improved the quantification of low-abundance targets, making it a
powerful tool for cancer detection and monitoring .  

THALLOO & IVD

> Thalloo's mission to innovate and promote cutting-edge IVD technologies aligns
> with the evolving needs of the global healthcare community. By leveraging a
> robust network of clinical and medical expertise, industry specialists, and
> regulated professionals, Thalloo ensures the integrity and excellence of its
> international operations. 
> 
> The advancements in IVD technology not only improve diagnostic accuracy and
> speed but also contribute significantly to patient outcomes in both public and
> private healthcare sectors. Through strategic investments, partnerships, and
> sponsorships, Thalloo continues to drive innovation and excellence in
> healthcare diagnostics.

APPLICATIONS OF IVD IN DIAGNOSING HEALTH CONDITIONS

IVD technologies are utilized across various medical disciplines, each
application enhancing patient care through early and accurate diagnosis. 

 1. Cancer Diagnosis and Management
    Liquid Biopsies: Non-invasive tests that detect cancer-related genetic
    mutations and biomarkers from a blood sample. Liquid biopsies enable the
    early detection of cancers and monitoring of treatment efficacy .
    Immunoassays: Used to detect specific proteins associated with different
    types of cancers. These tests help in the early detection and staging of
    cancers such as prostate and ovarian cancer .
 2. Infectious Diseases PCR and RT-PCR: Widely used for the detection of
    infectious agents, including viruses and bacteria. These tests were crucial
    during the COVID-19 pandemic for the rapid detection of SARS-CoV-2 .
    Antigen and Antibody Tests: Employed for the diagnosis of infections like
    HIV, hepatitis, and influenza. These tests provide quick results, aiding in
    timely treatment decisions.
 3. Genetic Disorders Next-Generation Sequencing (NGS): Enables comprehensive
    genomic analysis to identify genetic disorders. NGS is instrumental in
    diagnosing conditions like cystic fibrosis and muscular dystrophy, allowing
    for personalized treatment approaches .
    Chromosomal Microarray Analysis: Used to detect chromosomal abnormalities
    that cause genetic disorders. CMA is valuable in prenatal testing and in
    diagnosing developmental delays and congenital anomalies in children .

COVID-19

The COVID-19 pandemic (novel coronavirus SARS-CoV-2) emerged in late 2019 and
rapidly spread worldwide, leading to significant global health, economic, and
social impacts. 

The pandemic resulted in millions of infections and deaths, overwhelming
healthcare systems, and prompting unprecedented public health measures.

It has also accelerated the development and deployment of diagnostic
technologies and treatments, highlighting the importance of global cooperation
in addressing public health crises.

> Thalloo worked with healthcare services in 3 countries to help deliver
> technologies to assist in their response to COVID-19,  working with
> established and new partners to ensure timely delivery of equipment, tests and
> PPE.

THE IMPACT OF ADVANCED MEDICAL DIAGNOSTICS TECHNOLOGIES DURING COVID-19.

The COVID-19 pandemic created unprecedented challenges for healthcare systems
across the EU and Ukraine. Advanced medical diagnostics technologies played a
crucial role in addressing these challenges, particularly in the realm of
medical testing. The rapid development and deployment of these technologies
significantly enhanced the capacity to detect and manage COVID-19 cases,
providing a critical backbone for the public health response. 

Utilization of Existing Techniques Existing diagnostic techniques, such as
RT-PCR (reverse transcription-polymerase chain reaction), became the gold
standard for COVID-19 testing. Laboratories across Europe scaled up their
operations to meet the surge in demand. The robustness and accuracy of RT-PCR
tests made them indispensable for identifying active infections, helping to
control the spread of the virus through timely isolation and treatment of
patients.

The pandemic also spurred innovation in diagnostic technologies. Rapid antigen
tests, which provide results in minutes, became widely used for mass screening
in various settings, including airports, schools, and workplaces. These tests
complemented RT-PCR by offering quicker, though slightly less sensitive,
results. 

Additionally, advancements in molecular diagnostics, such as CRISPR-based tests
and next-generation sequencing, allowed for more detailed understanding of the
virus and its variants, aiding in effective public health interventions.

Emerging manufacturers from Asia, particularly China and South Korea, played a
pivotal role in meeting the global demand for diagnostic tests. Companies
rapidly scaled up production and exported millions of test kits to Europe. Their
expertise in high-throughput testing and cost-effective production was crucial
in bridging the supply gaps, ensuring that European healthcare systems had the
necessary tools to combat the pandemic effectively.


The influx of advanced diagnostics from both European and Asian manufacturers
ensured that healthcare providers could swiftly identify and isolate COVID-19
cases, thereby reducing transmission rates. The collaboration between
international and local manufacturers also highlighted the importance of global
trade and cooperation in addressing public health emergencies. This synergy not
only improved testing capacity but also accelerated the development of new
diagnostic tools, fostering innovation within the industry.

Ukraine's response to the COVID-19 pandemic was marked by a robust public health
initiative and significant international support. These efforts helped Ukraine
manage the pandemic's impact effectively and improve healthcare delivery during
the crisis. Lithuania demonstrated exemplary management of the COVID-19 pandemic
through effective containment measures, economic stimulus plans. Additionally,
Lithuania actively participated in regional cooperation, providing humanitarian
aid to other EU countries and its eastern neighbours.


> Thalloo leveraged its extensive manufacturer relationships and industry
> expertise, combined with its network of clinical and medical professionals, to
> provide critical advice on COVID-19 testing solutions. 
> 
> By collaborating with existing manufacturer partners and establishing new
> relationships with manufacturers across Asia, Thalloo developed robust
> supply-chain solutions that ensured the timely delivery of essential
> equipment, tests, and personal protective equipment (PPE). 
> 
> As a result, Thalloo successfully assisted healthcare services in three
> countries, delivering innovative technologies to support their COVID-19
> response efforts.

CONTACT

If you have interest in our mission then please contact us at:
mission@thalloo.co.im.

3rd Floor, Quay House, South Quay, Douglas, 
IM1 5AR, Isle of Man

Company No. 011852V

ISLE OF MAN

Thalloo operates from the Isle of Man as a respected international base in the
British Isles and a close neighbour to the United Kingdom and its support
services. Consequently it shares a reputation for probity of arrangements in
business. It also has a presence in many of those countries of its featured
interest and operates in association with key international manufacturers.

Web Page References

The following references have been used for some of the content shown on the
site.

 * –
   A Recent Update on Advanced Molecular Diagnostic Techniques for COVID-19
   Pandemic: An Overview
   (https://www.frontiersin.org/articles/10.3389/fmed.2021.640810/full),
   Published 2021
 * –
   Advances and Challenges in SARS-CoV-2 Detection: A Review of Molecular and
   Serological Technologies (https://www.mdpi.com/2075-4418/11/2/182), Published
   February 2021
 * –
   Building on Success: Ukraine’s New Fight Against COVID-19
   (https://www.worldbank.org/en/news/feature/2021/04/02/building-on-success-ukraine-s-new-fight-against-covid-19),
   Published April 2, 2021
 * –
   COVID-19 and the IVD industry: New market forces at play in pharmaceuticals
   and medical technology
   (https://www.mckinsey.com/industries/pharmaceuticals-and-medical-products/our-insights/covid-19-and-the-ivd-industry-new-market-forces-at-play-in-pharmaceuticals-and-medical-technology),
   Published 2020
 * –
   COVID-19 Impact on Diagnostic Innovations: Emerging Trends and Implications
   (https://www.mdpi.com/2075-4418/11/2/519), Published February 2021
 * –
   EU response to COVID-19
   (https://european-union.europa.eu/news/eu-response-covid-19_en), Published
   2020
 * –
   Improving access to health care in Lithuania during the pandemic
   (https://www.who.int/europe/news/item/09-12-2021-improving-access-to-health-care-in-lithuania-during-the-pandemic),
   Published December 9, 2021
 * –
   Lithuania’s pandemic: The power of regional cooperation
   (https://ecfr.eu/article/commentary_lithuanias_pandemic_the_power_of_regional_cooperation/),
   Published March 16, 2021
 * –
   OECD Economic Surveys: Lithuania 2022
   (https://www.oecd-ilibrary.org/economics/oecd-economic-surveys-lithuania-2022_c8c1b047-en),
   Published 2022
 * –
   Public health and social measures to mitigate the health and economic impact
   of the COVID-19 pandemic in Turkey, Egypt, Ukraine, Kazakhstan, and Poland
   during 2020–2021: situational analysis
   (https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-021-11071-5),
   Published 2021

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