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OPINION

HOW TO MAKE POWERFUL NEW OBESITY DRUGS AVAILABLE TO ALL

By the Editorial Board
|AddFollow
November 26, 2023 at 7:00 a.m. EST
(Washington Post staff illustration; photos by iStock)

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The medical sensation of the decade is a set of drugs that help people slim
down. With weekly injections, people can drop 15 percent to more than 22 percent
of their body weight on average, often 40, 50 pounds — or more. No safe medicine
or any other weight-loss strategy except surgery has been so effective. Given
that nearly 42 percent of Americans are obese, and thus vulnerable to diabetes,
heart disease, stroke and various kinds of cancer, Wegovy, Zepbound and other
so-called GLP-1 agonists come as a breakthrough. They offer a way to vastly
improve public health — not to mention quality of life among people who struggle
to lose weight.



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Surely, health insurers, including employers and Medicare, can find a way to pay
for these extraordinary drugs. If they don’t, only wealthy people will benefit —
while poorer Americans are more prone to obesity. And the opportunity to bring a
large share of the population back to good health will be largely lost.

Doing this without drastically inflating the price of U.S. health care and
straining public budgets will be hard. The monthly cost for the drugs is upward
of $1,000. (Zepbound is $1,060 and Wegovy $1,350.) If Medicare’s drug-coverage
program, Part D, were to cover Wegovy at the list price for all obese
beneficiaries, it would cost more than the entire Part D budget — and more than
the total amount of excess health-care spending on obese Americans of all ages
(estimated to be $260 billion in 2016), according to an analysis in the New
England Journal of Medicine.

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ALSO ON THE EDITORIAL BOARD’S AGENDA

arrow leftarrow right
 * Lawyers plead guilty in racketeering case in Fulton County, Ga.
 * The Biden administration announces more than $100 million to improve maternal
   health.
 * Wisconsin Republicans back off impeachment threat against justice.
 * Bahrain’s hunger strike ends, for now, after concessions to prisoners.
 * A Saudi court sentences a retired teacher to death based on tweets.

Attorneys for Donald Trump have pleaded guilty in the racketeering case led by
Fulton County, Ga., District Attorney Fani T. Willis. Even those lawyers related
to the deals focused on equipment-tampering in rural Coffee County are relevant
to the former president — they help to establish the “criminal enterprise” of
which prosecutors hope to prove Mr. Trump was the head. The news is a sign that
the courts might be the place where 2020 election lies finally crash upon the
rocks of reality. The Editorial Board wrote about the wide range of the
indictment in August.
The Department of Health and Human Services announced more than $103 million in
funding to address the maternal health crisis. The money will boost access to
mental health services, help states train more maternal health providers and
bolster nurse midwifery programs. These initiatives are an encouraging step
toward tackling major gaps in maternal health and well-being. In August, the
Editorial Board wrote about how the United States can address its maternal
mortality crisis.
Wisconsin state Assembly Speaker Robin Vos (R) announced Tuesday that
Republicans would allow the nonpartisan Legislative Reference Bureau to draw
legislative maps, a dramatic reversal after years of opposing such an approach
to redistricting. A new liberal majority on the state Supreme Court is expected
to throw out the current maps, which make Wisconsin the most gerrymandered state
in America. Mr. Vos has been threatening to impeach Justice Janet Protasiewicz,
whose election this spring flipped control of the court, in a bid to keep those
maps. This led to understandable outcry. Now it seems Mr. Vos is backing off his
impeachment threat and his efforts to keep the state gerrymandered. Read our
editorial on the Protasiewicz election here.
Prisoners are eating again in Bahrain after the government agreed to let them
spend more hours outside and expanded their access to visitors, a welcome
development ahead of the crown prince’s visit to Washington this week. Activists
say the monthlong hunger strike will resume on Sept. 30 if these promises aren’t
kept. Read our editorial calling for the compassionate release of Abdulhadi
al-Khawaja, a political prisoner since 2011 who participated in the strike.
A retired teacher in Saudi Arabia, Muhammad al-Ghamdi, has been sentenced to
death by the country’s Specialized Criminal Court solely based on his tweets,
retweets and YouTube activity, according to Human Rights Watch. The court’s
verdict, July 10, was based on two accounts on X, formerly Twitter, which had
only a handful of followers. The posts criticized the royal family. The sentence
is the latest example of dictatorships imposing harsh sentences on people who
use social media for free expression, highlighted in our February editorial.

1/6

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Part D pays for the drugs only to treat diabetes. The law bars the program from
covering weight-loss medications, but Congress could easily remove this obstacle
— put in place at a time when overweight status was stigmatized as a personal
failing, rather than reflective of deep-seated biological drives, and weight
loss was considered only a cosmetic benefit.

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The drugs stand to be alarmingly expensive for private insurers, too. If more
than a tiny fraction of the people they cover use the drugs, the cost will drive
up premiums for everyone. The injections are meant to be taken in perpetuity —
people who quit see much of the weight return — which could translate into an
enormous addition to America’s already world-beating health-care costs. Yet more
and more employers are covering them, as most Americans want them to do.

Limiting demand would be a daunting challenge because almost half the U.S.
population meets the Food and Drug Administration criteria for taking them: They
have either a body mass index of at least 30 (obesity) or a BMI of 27
(overweight) and at least one weight-related ailment (diabetes, high blood
pressure or high cholesterol, for example). Not everyone who qualifies will want
the drugs, of course, and many who start taking them will quit. A recent study
found that 68 percent of patients stop within a year of starting — presumably,
this is at least in part because of unpleasant gastrointestinal side effects.
But demand is already so high, the drugmakers are having trouble keeping up.

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This demand also keeps prices aloft. The medicines are priced at least 40
percent higher than what would be cost-effective, considering their benefits,
according to the Institute for Clinical and Economic Review, a research
organization. But the list prices aren’t immutable; they’re subject to
negotiation. Private insurers strike deals with drugmakers to pay significantly
less. And prices will fall as similar new drugs hit the market — and, in years
ahead, as generic versions of the drugs emerge. Note that Zepbound, which the
FDA approved for weight loss this month, is cheaper than Wegovy, approved in
2021, even though studies suggest Zepbound may work a bit better.

Insurers can lower their prices by buying the medicines in bulk, guaranteeing
drugmakers large markets. This strategy could also work for state Medicaid
programs, only a limited number of which now pay for the drugs.

For Medicare specifically, Congress needs to grant Part D the authority to not
only cover the medicines but also include them among the medicines for which the
program can negotiate prices.

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Even as prices fall, the federal government has a responsibility to support
broader studies of the drugs’ long-term safety. It must also keep up other
efforts to address obesity — including by discouraging ultra-processed food and
by encouraging greater physical activity (for example, by improving school
lunches, food package labeling, and public spaces and pathways for exercise).
The weight-loss drugs are not miracle cures. Many people cannot or do not want
to tolerate them, and even patients who shed many pounds often remain obese or
overweight. The medicines are one weapon in the obesity fight — but one that, if
broadly used, may be powerful enough to make a big difference.


THE POST’S VIEW | ABOUT THE EDITORIAL BOARD

Editorials represent the views of The Post as an institution, as determined
through discussion among members of the Editorial Board, based in the Opinions
section and separate from the newsroom.

Members of the Editorial Board: Opinion Editor David Shipley, Deputy Opinion
Editor Charles Lane and Deputy Opinion Editor Stephen Stromberg, as well as
writers Mary Duenwald, Christine Emba, Shadi Hamid, David E. Hoffman, James
Hohmann, Heather Long, Mili Mitra, Eduardo Porter, Keith B. Richburg and Molly
Roberts.


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