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 * Important Safety Information
 * Full Prescribing Information & Medication Guide for Patients
    * Important Safety Information
    * Full Prescribing Information
    * Medication Guide

 * Healthcare Professionals Website
 * Full Prescribing Information & Medication Guide for Patients
    * Important Safety Information
    * Medication Guide
    * Full Prescribing Information
    * Healthcare Professionals Website
    * Pregnancy Registry

 * Pregnancy Registry

An oral medication for heavy periods due to uterine fibroids in premenopausal
women
Get a Savings Card
 * 



 * Home
 * About ORIAHNN
    * What Is ORIAHNN?
    * Proven Results With ORIAHNN
    * ORIAHNN Stories and Reviews
    * Understanding Side Effects

 * Get Started With ORIAHNN
    * Talking to Your Gynecologist
    * Taking ORIAHNN

 * ORIAHNN Savings
 * About Uterine Fibroids
    * What Are Uterine Fibroids?
    * Symptoms of Uterine Fibroids
    * Heavy Periods Quiz

 * Get a Savings Card





FOCUS MORE ON THE MOMENT, LESS ON YOUR PERIOD.


ORIAHNN IS AN ORAL TREATMENT PROVEN TO HELP LIGHTEN HEAVY PERIODS DUE TO UTERINE
FIBROIDS.



Learn How ORIAHNN Can Help
Save With Oriahnn Savings Card*


PROVEN HEAVY PERIOD REDUCTION

ORIAHNN is an FDA-approved oral medication clinically proven to help reduce
heavy menstrual bleeding due to uterine fibroids in premenopausal women.

See Proven Results


PAY AS LITTLE AS $5 A MONTH

The Oriahnn Savings Card can help eligible, commercially insured patients pay as
little as $5 per month* for ORIAHNN.

Get Savings Card

*For eligible, commercially insured patients. Terms and
Conditions apply. View them in full.




LEARN HOW ORIAHNN HAS HELPED OTHER WOMEN

"ORIAHNN worked for me. It can work for you, too"

– Julie

diagnosed with uterine fibroids in 2016

See Julie's Story


LEARN HOW ORIAHNN HAS HELPED OTHER WOMEN

"ORIAHNN worked for me. It can work for you, too"

– Julie

diagnosed with uterine fibroids in 2016

See Julie's Story

 


USE

ORIAHNN® (elagolix, estradiol, and norethindrone acetate capsules; elagolix
capsules) is a prescription medicine used to control heavy menstrual bleeding
related to uterine fibroids in women before menopause. It should not be taken
for more than 24 months. It is not known if ORIAHNN is safe and effective in
children under 18 years of age.


IMPORTANT SAFETY INFORMATION

What is the most important information I should know about ORIAHNN?

ORIAHNN may cause serious side effects, including:

 * Cardiovascular Conditions
   * ORIAHNN may increase your chances of heart attack, stroke, or blood clots,
     especially if you are over 35 years of age and smoke, have uncontrolled
     high blood pressure, high cholesterol, diabetes, or are obese. Stop taking
     ORIAHNN and call your healthcare provider right away or go to the nearest
     hospital emergency room right away if you have:
     * Leg pain or swelling that will not go away
     * Sudden shortness of breath
     * Double vision, bulging of the eyes, or sudden blindness (partial or
       complete)
     * Pain or pressure in your chest, arm, or jaw
     * Sudden, severe headache unlike your usual headaches
     * Weakness or numbness in an arm or leg, or trouble speaking

 * Bone Loss (Decreased Bone Mineral Density [BMD])
   * While taking ORIAHNN, your estrogen levels may be low. Low estrogen levels
     can lead to BMD loss.
   * If you have bone loss on ORIAHNN, your BMD may improve after you stop
     taking ORIAHNN, but complete recovery may not occur. It is unknown if these
     BMD changes could increase your risk for broken bones as you age. For this
     reason, you should not take ORIAHNN for more than 24 months.
   * Your healthcare provider may order an X-ray test called a DXA scan to check
     your bone mineral density when you start taking ORIAHNN and periodically
     after you start.
   * Your doctor may advise you to take vitamin D and calcium supplements as
     part of a healthy lifestyle.

 * Effects on Pregnancy
   * Do not take ORIAHNN if you are pregnant or trying to become pregnant, as it
     may increase the risk of early pregnancy loss.
   * If you think you may be pregnant, stop taking ORIAHNN right away and call
     your HCP.
   * ORIAHNN can decrease your menstrual bleeding or result in no menstrual
     bleeding at all, making it hard to know if you are pregnant. Watch for
     other pregnancy signs like breast tenderness, weight gain, and nausea.
   * ORIAHNN does not prevent pregnancy. You will need to use effective methods
     of birth control while taking ORIAHNN and for 28 days after you stop taking
     ORIAHNN. Examples of effective methods can include condoms or spermicide,
     which do not contain hormones.
   * Talk to your HCP about which birth control to use during treatment with
     ORIAHNN. Your HCP may change the birth control you are on before you start
     taking ORIAHNN.

Do not take ORIAHNN if you:

 * Have or have had:
   * A stroke or heart attack
   * A problem that makes your blood clot more than normal
   * Blood circulation disorder
   * Certain heart valve problems or heart rhythm abnormalities that can cause
     blood clots to form in the heart
   * Blood clots in your legs (deep vein thrombosis), lungs (pulmonary
     embolism), or eyes (retinal thrombosis)
   * High blood pressure not well controlled by medicine
   * Diabetes with kidney, eye, nerve, or blood vessel damage
   * Certain kinds of headaches with numbness, weakness, or changes in vision,
     or have migraine headaches with aura if you are over age 35
   * Breast cancer or any cancer that is sensitive to female hormones
   * Osteoporosis
   * Unexplained vaginal bleeding that has not been diagnosed
   * Liver problems including liver disease
 * Smoke and are over 35 years old
 * Are taking medicines known as strong OATP1B1 inhibitors that are known or
   expected to significantly increase the blood levels of elagolix. Ask your HCP
   if you are not sure if you are taking this type of medicine.
 * Have had a serious allergic reaction to elagolix, estradiol, norethindrone
   acetate, or any of the ingredients in ORIAHNN. Ask your HCP if you are not
   sure.
 * FD&C Yellow No.5 (tartrazine) is an ingredient in ORIAHNN, which may cause an
   allergic type reaction such as bronchial asthma in some patients who are also
   allergic to aspirin.

What should I discuss with my HCP before taking ORIAHNN?

Tell your HCP about all your medical conditions, including if you:

 * Have or have had:
   * Broken bones or other conditions that may cause bone problems
   * Depression, mood swings, or suicidal thoughts or behavior
   * Yellowing of the skin or eyes (jaundice) or jaundice caused by pregnancy
     (cholestasis of pregnancy)
 * Are scheduled for surgery. ORIAHNN may increase your risk of blood clots
   after surgery. Your doctor may advise you to stop taking ORIAHNN before you
   have surgery. If this happens, talk to your HCP about when to restart ORIAHNN
   after surgery.
 * Are pregnant or think you may be pregnant.
 * Are breastfeeding. It is not known if ORIAHNN can pass into your breastmilk.
   Talk to your HCP about the best way to feed your baby if you take ORIAHNN.

Tell your HCP about all the medicines you take, including prescription and
over-the-counter medicines, vitamins, and herbal supplements.

Women on thyroid or cortisol replacement therapy may need increased doses of the
hormone.

Keep a list of your medicines with you to show to your HCP and pharmacist when
you get a new medicine.

What should I avoid while taking ORIAHNN?

 * Avoid grapefruit and grapefruit juice during treatment with ORIAHNN since
   they may affect the level of ORIAHNN in your blood, which may increase side
   effects.

What are the possible side effects of ORIAHNN?

ORIAHNN can cause additional serious side effects, including:

 * Suicidal thoughts, suicidal behavior, and worsening of mood. ORIAHNN may
   cause suicidal thoughts or actions. Call your HCP or get emergency medical
   help right away if you have any of these symptoms, especially if they are
   new, worse, or bother you: thoughts about suicide or dying, attempts to
   commit suicide, new or worse depression or anxiety, or other unusual changes
   in behavior or mood. Pay attention to any changes, especially sudden changes,
   in your mood, behaviors, thoughts, or feelings.
 * Abnormal liver tests. Call your HCP right away if you have any of these signs
   and symptoms of liver problems: jaundice, dark amber-colored urine, feeling
   tired, nausea and vomiting, generalized swelling, right upper stomach area
   pain, or bruising easily.
 * High blood pressure. You should see your HCP to check your blood pressure
   regularly.
 * Gallbladder problems (cholestasis), especially if you had cholestasis of
   pregnancy.
 * Increases in blood sugar, cholesterol, and fat (triglyceride) levels.
 * Hair loss (alopecia). Hair loss and hair thinning can happen while taking
   ORIAHNN, and it can continue even after you stop taking ORIAHNN. It is not
   known if this hair loss or hair thinning is reversible. Talk to your HCP if
   this is a concern for you.
 * Changes in laboratory tests, including thyroid and other hormone,
   cholesterol, and blood clotting tests.

The most common side effects of ORIAHNN include: hot flashes, headache, fatigue,
and irregular periods.

These are not all of the possible side effects of ORIAHNN. Tell your HCP if you
have any side effect that bothers you or that does not go away. Call your HCP
for medical advice about side effects.

Take ORIAHNN exactly as your HCP tells you. The recommended oral dosage of
ORIAHNN is one yellow/white capsule in the morning and one blue/white capsule in
the evening, with or without food.

This is the most important information to know about ORIAHNN. For more
information, talk to your doctor or HCP.

You are encouraged to report negative side effects of prescription drugs to the
FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

If you are having difficulty paying for your medicine, AbbVie may be able to
help. Visit AbbVie.com/myAbbVieAssist to learn more.

US-ORIA-210459

Please see the Full Prescribing Information, including the Medication Guide.

 * Home
 * Site Map
 * Contact Us
 * Privacy Policy
 * Terms of Use
 * Advertising Choices
 * Cookies Settings

Legal Notices/Privacy Policy. © 2022 AbbVie. All rights reserved.

If you have any questions about AbbVie's Oriahnn.com website that have not been
answered, click here. This website and the information contained herein is
intended for use by US residents only, is provided for informational purposes
only, and is not intended to replace a discussion with a healthcare provider.
All decisions regarding patients must be made with a healthcare provider and
consider the unique characteristics of each patient.

US-ORIA-220095










LEAVING ABBVIE WEBSITE

By clicking this link, you will be leaving this site and connecting to a site
neither owned nor operated by AbbVie. AbbVie is not responsible for the contents
of any such website or any further links from such website. AbbVie is providing
these links as a convenience, and the inclusion of any link does not imply
endorsement of the linked website by AbbVie. You should also be aware that the
linked website may be governed by its own set of terms and conditions and
privacy policy, for which AbbVie has no responsibility.

DO YOU WISH TO LEAVE THIS SITE?

No
Yes

US-ORIA-210305


HEALTHCARE PROFESSIONAL WEBSITE

By clicking this link, you will be leaving this site and connecting to a site
neither owned nor operated by AbbVie. AbbVie is not responsible for the contents
of any such website or any further links from such website. AbbVie is providing
these links as a convenience, and the inclusion of any link does not imply
endorsement of the linked website by AbbVie. You should also be aware that the
linked website may be governed by its own set of terms and conditions and
privacy policy, for which AbbVie has no responsibility.

DO YOU WISH TO LEAVE THIS SITE?

No
Yes

US-GYNUF-190058


PREGNANCY REGISTRY INFORMATION

AbbVie serves as the sponsor of a study, which monitors the pregnancy outcomes
of women exposed to ORIAHNN® (elagolix, estradiol, and norethindrone acetate
capsules; elagolix capsules) while pregnant. To conduct this study, AbbVie
contracted with a third-party Contract Research Organization.

By clicking “Proceed” below, you will be redirected to a third-party website
maintained by the Contract Research Organization. Data collected on that website
may assist the Contract Research Organization in the conduct of the study.
AbbVie will not receive, or have access to, identifiable data shared through use
of that website.

If you become pregnant while taking ORIAHNN, you are encouraged to enroll in the
Pregnancy Registry. The purpose of the pregnancy registry is to collect
information about the health of you and your baby. Talk to your healthcare
provider or call 1-833-782-7241 or visit https://www.bloompregnancyregistry.com
to enroll.

DO NOT take ORIAHNN if you are pregnant or trying to become pregnant. It may
increase the risk of early pregnancy loss. If you think you are pregnant, stop
taking ORIAHNN right away and call your healthcare provider.

Close
Proceed


LEAVING ABBVIE WEBSITE

By clicking this link, you will be leaving this site and connecting to a site
neither owned nor operated by AbbVie. AbbVie is not responsible for the contents
of any such website or any further links from such website. AbbVie is providing
these links as a convenience, and the inclusion of any link does not imply
endorsement of the linked website by AbbVie. You should also be aware that the
linked website may be governed by its own set of terms and conditions and
privacy policy, for which AbbVie has no responsibility.

DO YOU WISH TO LEAVE THIS SITE?

No
Yes

US-ORIA-210305


YOU ARE ABOUT TO ENTER A SITE THAT IS FOR US HEALTHCARE PROFESSIONALS ONLY.

By selecting "Continue" below, you certify that you are a Healthcare
Professional. Products or treatments described on this site are available in the
US but may not be available in all other countries. I am a licensed Healthcare
Professional and wish to proceed to the Healthcare Professionals Only section of
this site.

Back
Continue

US-ORIA-210305





IMPORTANT SAFETY INFORMATION

ORIAHNN® (elagolix, estradiol, and norethindrone acetate capsules; elagolix
capsules) may increase your chances of heart attack, stroke, or blood clots,
especially if you are over 35 years of age and smoke, have uncontrolled high
blood pressure, high cholesterol, diabetes, and/or are obese. Stop taking
ORIAHNN and call a doctor right away…


USE

ORIAHNN® is a prescription medicine used to control heavy menstrual bleeding
related to uterine fibroids in women before menopause. It should not be taken
for more than 24 months…


IMPORTANT SAFETY INFORMATION

ORIAHNN® may increase your chances of heart attack, stroke, or blood clots,
especially if you are over 35 years of age and smoke, have uncontrolled high
blood pressure, high cholesterol, diabetes, and/or are obese. Stop taking
ORIAHNN and call a doctor right away…


IMPORTANT SAFETY INFORMATION

ORIAHNN® (elagolix, estradiol, and norethindrone acetate capsules; elagolix
capsules) may increase your chances of heart attack, stroke, or blood clots,
especially if you are over 35 years of age and smoke, have uncontrolled high
blood pressure, high cholesterol, diabetes, and/or are obese. Stop taking
ORIAHNN and call a doctor right away…


USE

ORIAHNN® is a prescription medicine used to control heavy menstrual bleeding
related to uterine fibroids in women before menopause. It should not be taken
for more than 24 months…


IMPORTANT SAFETY INFORMATION

ORIAHNN® (elagolix, estradiol, and norethindrone acetate capsules; elagolix
capsules) may increase your chances of heart attack, stroke, or blood clots,
especially if you are over 35 years of age and smoke, have uncontrolled high
blood pressure, high cholesterol, diabetes, and/or are obese. Stop taking
ORIAHNN and call a doctor right away…

 


USE

ORIAHNN® (elagolix, estradiol, and norethindrone acetate capsules; elagolix
capsules) is a prescription medicine used to control heavy menstrual bleeding
related to uterine fibroids in women before menopause. It should not be taken
for more than 24 months. It is not known if ORIAHNN is safe and effective in
children under 18 years of age.


IMPORTANT SAFETY INFORMATION

What is the most important information I should know about ORIAHNN?

ORIAHNN may cause serious side effects, including:

 * Cardiovascular Conditions
   * ORIAHNN may increase your chances of heart attack, stroke, or blood clots,
     especially if you are over 35 years of age and smoke, have uncontrolled
     high blood pressure, high cholesterol, diabetes, or are obese. Stop taking
     ORIAHNN and call your healthcare provider right away or go to the nearest
     hospital emergency room right away if you have:
     * Leg pain or swelling that will not go away
     * Sudden shortness of breath
     * Double vision, bulging of the eyes, or sudden blindness (partial or
       complete)
     * Pain or pressure in your chest, arm, or jaw
     * Sudden, severe headache unlike your usual headaches
     * Weakness or numbness in an arm or leg, or trouble speaking

 * Bone Loss (Decreased Bone Mineral Density [BMD])
   * While taking ORIAHNN, your estrogen levels may be low. Low estrogen levels
     can lead to BMD loss.
   * If you have bone loss on ORIAHNN, your BMD may improve after you stop
     taking ORIAHNN, but complete recovery may not occur. It is unknown if these
     BMD changes could increase your risk for broken bones as you age. For this
     reason, you should not take ORIAHNN for more than 24 months.
   * Your healthcare provider may order an X-ray test called a DXA scan to check
     your bone mineral density when you start taking ORIAHNN and periodically
     after you start.
   * Your doctor may advise you to take vitamin D and calcium supplements as
     part of a healthy lifestyle.

 * Effects on Pregnancy
   * Do not take ORIAHNN if you are pregnant or trying to become pregnant, as it
     may increase the risk of early pregnancy loss.
   * If you think you may be pregnant, stop taking ORIAHNN right away and call
     your HCP.
   * ORIAHNN can decrease your menstrual bleeding or result in no menstrual
     bleeding at all, making it hard to know if you are pregnant. Watch for
     other pregnancy signs like breast tenderness, weight gain, and nausea.
   * ORIAHNN does not prevent pregnancy. You will need to use effective methods
     of birth control while taking ORIAHNN and for 28 days after you stop taking
     ORIAHNN. Examples of effective methods can include condoms or spermicide,
     which do not contain hormones.
   * Talk to your HCP about which birth control to use during treatment with
     ORIAHNN. Your HCP may change the birth control you are on before you start
     taking ORIAHNN.

Do not take ORIAHNN if you:

 * Have or have had:
   * A stroke or heart attack
   * A problem that makes your blood clot more than normal
   * Blood circulation disorder
   * Certain heart valve problems or heart rhythm abnormalities that can cause
     blood clots to form in the heart
   * Blood clots in your legs (deep vein thrombosis), lungs (pulmonary
     embolism), or eyes (retinal thrombosis)
   * High blood pressure not well controlled by medicine
   * Diabetes with kidney, eye, nerve, or blood vessel damage
   * Certain kinds of headaches with numbness, weakness, or changes in vision,
     or have migraine headaches with aura if you are over age 35
   * Breast cancer or any cancer that is sensitive to female hormones
   * Osteoporosis
   * Unexplained vaginal bleeding that has not been diagnosed
   * Liver problems including liver disease
 * Smoke and are over 35 years old
 * Are taking medicines known as strong OATP1B1 inhibitors that are known or
   expected to significantly increase the blood levels of elagolix. Ask your HCP
   if you are not sure if you are taking this type of medicine.
 * Have had a serious allergic reaction to elagolix, estradiol, norethindrone
   acetate, or any of the ingredients in ORIAHNN. Ask your HCP if you are not
   sure.
 * FD&C Yellow No.5 (tartrazine) is an ingredient in ORIAHNN, which may cause an
   allergic type reaction such as bronchial asthma in some patients who are also
   allergic to aspirin.

What should I discuss with my HCP before taking ORIAHNN?

Tell your HCP about all your medical conditions, including if you:

 * Have or have had:
   * Broken bones or other conditions that may cause bone problems
   * Depression, mood swings, or suicidal thoughts or behavior
   * Yellowing of the skin or eyes (jaundice) or jaundice caused by pregnancy
     (cholestasis of pregnancy)
 * Are scheduled for surgery. ORIAHNN may increase your risk of blood clots
   after surgery. Your doctor may advise you to stop taking ORIAHNN before you
   have surgery. If this happens, talk to your HCP about when to restart ORIAHNN
   after surgery.
 * Are pregnant or think you may be pregnant.
 * Are breastfeeding. It is not known if ORIAHNN can pass into your breastmilk.
   Talk to your HCP about the best way to feed your baby if you take ORIAHNN.

Tell your HCP about all the medicines you take, including prescription and
over-the-counter medicines, vitamins, and herbal supplements.

Women on thyroid or cortisol replacement therapy may need increased doses of the
hormone.

Keep a list of your medicines with you to show to your HCP and pharmacist when
you get a new medicine.

What should I avoid while taking ORIAHNN?

 * Avoid grapefruit and grapefruit juice during treatment with ORIAHNN since
   they may affect the level of ORIAHNN in your blood, which may increase side
   effects.

What are the possible side effects of ORIAHNN?

ORIAHNN can cause additional serious side effects, including:

 * Suicidal thoughts, suicidal behavior, and worsening of mood. ORIAHNN may
   cause suicidal thoughts or actions. Call your HCP or get emergency medical
   help right away if you have any of these symptoms, especially if they are
   new, worse, or bother you: thoughts about suicide or dying, attempts to
   commit suicide, new or worse depression or anxiety, or other unusual changes
   in behavior or mood. Pay attention to any changes, especially sudden changes,
   in your mood, behaviors, thoughts, or feelings.
 * Abnormal liver tests. Call your HCP right away if you have any of these signs
   and symptoms of liver problems: jaundice, dark amber-colored urine, feeling
   tired, nausea and vomiting, generalized swelling, right upper stomach area
   pain, or bruising easily.
 * High blood pressure. You should see your HCP to check your blood pressure
   regularly.
 * Gallbladder problems (cholestasis), especially if you had cholestasis of
   pregnancy.
 * Increases in blood sugar, cholesterol, and fat (triglyceride) levels.
 * Hair loss (alopecia). Hair loss and hair thinning can happen while taking
   ORIAHNN, and it can continue even after you stop taking ORIAHNN. It is not
   known if this hair loss or hair thinning is reversible. Talk to your HCP if
   this is a concern for you.
 * Changes in laboratory tests, including thyroid and other hormone,
   cholesterol, and blood clotting tests.

The most common side effects of ORIAHNN include: hot flashes, headache, fatigue,
and irregular periods.

These are not all of the possible side effects of ORIAHNN. Tell your HCP if you
have any side effect that bothers you or that does not go away. Call your HCP
for medical advice about side effects.

Take ORIAHNN exactly as your HCP tells you. The recommended oral dosage of
ORIAHNN is one yellow/white capsule in the morning and one blue/white capsule in
the evening, with or without food.

This is the most important information to know about ORIAHNN. For more
information, talk to your doctor or HCP.

You are encouraged to report negative side effects of prescription drugs to the
FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

If you are having difficulty paying for your medicine, AbbVie may be able to
help. Visit AbbVie.com/myAbbVieAssist to learn more.

US-ORIA-210459




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