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2. Aging Clinical and Experimental Research
3. Article
* Review Article
* Published: 07 February 2017
MEASUREMENT OF MUSCLE MASS IN SARCOPENIA: FROM IMAGING TO BIOCHEMICAL MARKERS
* Matteo Tosato1,
* Emanuele Marzetti1,
* Matteo Cesari2,3,
* Giulia Savera1,
* Ram R. Miller4,
* Roberto Bernabei1,
* Francesco Landi1 &
* …
* Riccardo Calvani1
Show authors
Aging Clinical and Experimental Research volume 29, pages 19–27 (2017)Cite this
article
* 8074 Accesses
* 189 Citations
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ABSTRACT
Sarcopenia encompasses the loss of muscle mass and strength/function during
aging. Several methods are available for the estimation of muscle or lean body
mass. Popular assessment tools include body imaging techniques (e.g., magnetic
resonance imaging, computed tomography, dual X-ray absorptiometry,
ultrasonography), bioelectric impedance analysis, anthropometric parameters
(e.g., calf circumference, mid-arm muscle circumference), and biochemical
markers (total or partial body potassium, serum and urinary creatinine,
deuterated creatine dilution method). The heterogeneity of the populations to be
evaluated as well as the setting in which sarcopenia is investigated impacts the
definition of “gold standard” assessment techniques. The aim of this article is
to critically review available methods for muscle mass estimation, highlighting
strengths and weaknesses of each of them as well as their proposed field of
application.
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ACKNOWLEDGEMENTS
The present work was funded by a Grant from the Innovative Medicines
Initiative—Joint Undertaking (IMI-JU 115621). The work was also partly supported
by the “Centro Studi Achille e Linda Lorenzon” (E.M., R.C.), Fondazione Roma
(NCDs Call for Proposals 2013; E.M., R.C.), and intramural research grants from
the Catholic University of the Sacred Heart (D3.2 2013 and D3.2 2015; E.M.,
F.L., M.T., R.C.).
AUTHOR INFORMATION
AUTHORS AND AFFILIATIONS
1. Department of Geriatrics, Neurosciences and Orthopedics, Catholic University
of the Sacred Heart School of Medicine, Rome, Italy
Matteo Tosato, Emanuele Marzetti, Giulia Savera, Roberto Bernabei, Francesco
Landi & Riccardo Calvani
2. Gérontopôle, Centre Hospitalier Universitaire de Toulouse, Toulouse, France
Matteo Cesari
3. Université de Toulouse III Paul Sabatier, Toulouse, France
Matteo Cesari
4. Novartis Institutes for Biomedical Research, Basel, Switzerland
Ram R. Miller
Authors
1. Matteo Tosato
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2. Emanuele Marzetti
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3. Matteo Cesari
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4. Giulia Savera
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5. Ram R. Miller
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6. Roberto Bernabei
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7. Francesco Landi
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8. Riccardo Calvani
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CORRESPONDING AUTHOR
Correspondence to Riccardo Calvani.
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The authors of the present work are partners of the SPRINTT Consortium, which is
partly funded by the European Federation of Pharmaceutical Industries and
Associations (EFPIA). E.M. served as a consultant for Huron Consulting Group,
Genactis and Novartis. M.C. served as a consultant for and/or received honoraria
for scientific presentations from Nestlé.
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Tosato, M., Marzetti, E., Cesari, M. et al. Measurement of muscle mass in
sarcopenia: from imaging to biochemical markers. Aging Clin Exp Res 29, 19–27
(2017). https://doi.org/10.1007/s40520-016-0717-0
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* Received: 12 January 2016
* Accepted: 10 October 2016
* Published: 07 February 2017
* Issue Date: February 2017
* DOI: https://doi.org/10.1007/s40520-016-0717-0
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KEYWORDS
* Muscle strength
* Physical function
* Body imaging
* Diagnosis
* Biomarkers
* Appendicular lean mass
* DXA
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