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Submission: On September 21 via api from US — Scanned from DE
Submission Tags: falconsandbox
Submission: On September 21 via api from US — Scanned from DE
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COVIDRESEARCHTRIALS * Home * Vaccine * References * API * Figures * Previous * Reports ANALYSIS OF COVID-19 CLINICAL TRIALS: A DATA-DRIVEN, ONTOLOGY-BASED, AND NATURAL LANGUAGE PROCESSING APPROACH DEVELOPED BY SHRAY ALAG, THE HARKER SCHOOL, SAN JOSE, CA SARS-CoV-2 Vaccines Coronavirus Report VACCINES RELATED ANALYSIS A special analysis was done considering only COVID-19 vaccine related clinical trials. The analysis makes it easier to look at correlations and clinical trials associated with various vaccines. Moderna vaccine related clinical trials Moderna Vaccines Moderna Vaccines SARS-COV-2 vaccine related clinical trials SARS-CoV-2 Vaccines SARS-COV-2 Vaccines REFERENCES Alag S (September, 2020). Analysis of COVID-19 clinical trials: A data-driven, ontology-based, and natural language processing approach PLOS ONE 15(9): e0239694. https://doi.org/10.1371/journal.pone.0239694 pmid:32997699 PLOS ONE PubMed/NCBI Google Scholar PLOS ONE Alag S (May, 2020). Unique insights from ClinicalTrials.gov by mining protein mutations and RSids in addition to applying the Human Phenotype Ontology PLOS ONE 15(5): e0233438. https://doi.org/10.1371/journal.pone.0233438 pmid:32459809 PLOS ONE PubMed/NCBI Google Scholar PLOS ONE SNPMinerTrials.com: Unique insights from ClinicalTrials.gov by mining protein mutations and RSids in addition to applying the Human Phenotype Ontology http://snpminertrials.com/ SNPMinerTrials SNPMinerTrials 362,558 Total number of clincal trials. 4,344 COVID-19 related clinical trials 15,803 HPO nodes used in analysis 559 Number of unique MeSH terms associated with COVID-19 clinical trials REPORTS Data processed on January 01, 2020. An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report. Drug Reports MeSH Reports HPO Reports INTERVENTIONS 4,151 reports on interventions/drugs Report MESH 569 reports on MeSH terms Report HPO 252 reports on HPO terms Report GOOGLE COLAB Python example via Google Colab Notebook Notebook API JAVA APIs to access the data. Each Java class is a stand-alone program and does not require any other package beyond the Java core classes: Users can simply download a Java IDE, install Java, and run the class on that IDE. Access the documentation ( JavaDocs ) for each of the six APIs mentioned below. RELEVANT CLINICAL TRIALS AND DESCRIPTIONS VACCINES TO CLINICAL TRIALS DRUGS TO CLINICAL TRIALS HPO TO CLINICAL TRIALS MESH TO CLINICAL TRIALS CLINICAL TRIALS AND OUTCOMES FIGURES AND TABLES Key insights. Please refer to Alag September, 2020 for details. * All * Figure * Table * Pipeline PIPELINE Steps required to generate the results. FIGURE 1 COVID-19 clinical trial trends: Longitudinal trends from COVID-19 related clinical trials. The data is plotted across five time points. FIGURE 2 Intervention/Drug information. The graph shows the relative frequency of the different intervention/drugs that are referenced in COVID-19 related clinical trials (August 2020). FIGURE 3 Intervention Categories. The majority of the interventions used in clinical trials are drugs, other, behavioral, biological, and diagnostic tests FIGURE 4 Outcomes. FIGURE 5 Phase information FIGURE 6 Recruitment status FIGURE 7 MeSH information details the most prevalent MeSH terms across COVID-19 related clinical trials. FIGURE 8 HPO information portrays the most widely noted HPO terms. TABLE 1. Related drugs, MeSH, and HPO terms using co-occurrences with D018352: Coronavirus infection. TABLE 2. Related drugs, MeSH, and HPO terms using co-occurrences with drug: Hydroxychloroquine. DATA FROM JANUARY 01, 2021 Note: For this analysis the list of clinical trials was matched to those COVID-19 and vaccine related clinical Trials that are available at ClinicalTrials.gov. A special section associated with vaccine related clinical trial was also added to the website. * Total number of clincal trials: 362,558 * COVID-19 related clinical trials: 4,344 * HPO: nodes: 15,803, Parent-child hierarchy: 19,678, Phenotype to gene: 944,915, Unique genes: 4,503 JAVA SDK The JAVA APIs for information about drugs, vaccines, HPO, outcomes, and MeSH terms relevant to COVID-19 clinical trials. * Relevant Clinical Trials and Descriptions * Vaccines to Clinical Trials * Drugs to Clinical Trials * HPO to Clinical Trials * MeSH to Clinical Trials * Clinical Trials and Outcomes GOOGLE COLAB NOTEBOOK * Google Colab Notebook with Python Example REPORTS * Reports for Interventions/Drugs * Reports for MeSH terms * Reports for HPO terms Details of COVID 19 related reports across ClinicalTrials.gov: Item Number 1 Number of unique Interventions/Drugs 4,151 2 Number of unique MeSH terms 569 3 Number of unique HPO terms 252 DATA FROM DECEMBER 24, 2020 Note: For this analysis the list of clinical trials was matched to those COVID-19 and vaccine related clinical Trials that are available at ClinicalTrials.gov. A special section associated with vaccine related clinical trial was also added to the website. * Total number of clincal trials: 361,624 * COVID-19 related clinical trials: 4,087 * HPO: nodes: 15,803, Parent-child hierarchy: 19,678, Phenotype to gene: 944,915, Unique genes: 4,503 JAVA SDK The JAVA APIs for information about drugs, vaccines, HPO, outcomes, and MeSH terms relevant to COVID-19 clinical trials. * Relevant Clinical Trials and Descriptions * Vaccines to Clinical Trials * Drugs to Clinical Trials * HPO to Clinical Trials * MeSH to Clinical Trials * Clinical Trials and Outcomes GOOGLE COLAB NOTEBOOK * Google Colab Notebook with Python Example REPORTS * Reports for Interventions/Drugs * Reports for MeSH terms * Reports for HPO terms Details of COVID 19 related reports across ClinicalTrials.gov: Item Number 1 Number of unique Interventions/Drugs 4,087 2 Number of unique MeSH terms 559 3 Number of unique HPO terms 247 DATA FROM DECEMBER 13, 2020 Details of data processed * Total number of clincal trials: 360,497 * COVID-19 related clinical trials: 5,105 * HPO: nodes: 15,803, Parent-child hierarchy: 19,678, Phenotype to gene: 944,915, Unique genes: 4,503 JAVA SDK The JAVA APIs for information about drugs, vaccines, HPO, outcomes, and MeSH terms relevant to COVID-19 clinical trials. * Relevant Clinical Trials and Descriptions * Vaccines to Clinical Trials * Drugs to Clinical Trials * HPO to Clinical Trials * MeSH to Clinical Trials * Clinical Trials and Outcomes GOOGLE COLAB NOTEBOOK * Google Colab Notebook with Python Example REPORTS * Reports for Interventions/Drugs * Reports for MeSH terms * Reports for HPO terms Details of COVID 19 related reports across ClinicalTrials.gov: Item Number 1 Number of unique Interventions/Drugs 5,309 2 Number of unique MeSH terms 779 3 Number of unique HPO terms 337 DATA FROM NOVEMBER 07, 2020 Details of data processed * Total number of clincal trials: 357,017 * COVID-19 related clinical trials: 4,620 * HPO: nodes: 15,656, Parent-child hierarchy: 19,523, Phenotype to gene: 919,672, Unique genes: 4,484 JAVA SDK The JAVA APIs for information about drugs, vaccines, HPO, outcomes, and MeSH terms relevant to COVID-19 clinical trials. * Relevant Clinical Trials and Descriptions * Vaccines to Clinical Trials * Drugs to Clinical Trials * HPO to Clinical Trials * MeSH to Clinical Trials * Clinical Trials and Outcomes GOOGLE COLAB NOTEBOOK * Google Colab Notebook with Python Example REPORTS * Reports for Interventions/Drugs * Reports for MeSH terms * Reports for HPO terms Details of COVID 19 related reports across ClinicalTrials.gov: Item Number 1 Number of unique Interventions/Drugs 4,818 2 Number of unique MeSH terms 706 3 Number of unique HPO terms 306 DATA FROM SEPTEMBER 26, 2020 Details of data processed * Total number of clincal trials: 352,841 * COVID-19 related clinical trials: 4,038 * HPO: nodes: 15,530, Parent-child hierarchy: 19,395, Phenotype to gene: 850,606, Unique genes: 4,366 JAVA SDK The JAVA APIs for information about drugs, vaccines, HPO, outcomes, and MeSH terms relevant to COVID-19 clinical trials. * Relevant Clinical Trials and Descriptions * Vaccines to Clinical Trials * Drugs to Clinical Trials * HPO to Clinical Trials * MeSH to Clinical Trials * Clinical Trials and Outcomes GOOGLE COLAB NOTEBOOK * Google Colab Notebook with Python Example REPORTS * Reports for Interventions/Drugs * Reports for MeSH terms * Reports for HPO terms Details of COVID 19 related reports across ClinicalTrials.gov: Item Number 1 Number of unique Interventions/Drugs 4,180 2 Number of unique MeSH terms 691 3 Number of unique HPO terms 263 DATA FROM AUGUST 16, 2020 Details of data processed * Total number of clincal trials: 348,891 * COVID-19 related clinical trials: 3,467 * HPO: nodes: 15,530, Parent-child hierarchy: 19,395, Phenotype to gene: 850,606, Unique genes: 4,366 JAVA SDK The JAVA APIs for information about drugs, vaccines, HPO, outcomes, and MeSH terms relevant to COVID-19 clinical trials. * Relevant Clinical Trials and Descriptions * Vaccines to Clinical Trials * Drugs to Clinical Trials * HPO to Clinical Trials * MeSH to Clinical Trials * Clinical Trials and Outcomes GOOGLE COLAB NOTEBOOK * Google Colab Notebook with Python Example REPORTS * Reports for Interventions/Drugs * Reports for MeSH terms * Reports for HPO terms Details of COVID 19 related reports across ClinicalTrials.gov: Item Number 1 Number of unique Interventions/Drugs 3,523 2 Number of unique MeSH terms 622 3 Number of unique HPO terms 254 DATA FROM JULY 18, 2020 Details of data processed * Total number of clincal trials: 345,959 * COVID-19 related clinical trials: 3,030 * HPO: nodes: 15,530, Parent-child hierarchy: 19,395, Phenotype to gene: 850,606, Unique genes: 4,366 REPORTS * Reports for Interventions/Drugs * Reports for MeSH terms * Reports for HPO terms Details of COVID 19 related reports across ClinicalTrials.gov: Item Number 1 Number of unique Interventions/Drugs 3,055 2 Number of unique MeSH terms 572 3 Number of unique HPO terms 229 DATA FROM JUNE 06, 2020 Details of data processed * Total number of clincal trials: 341,642 * COVID-19 related clinical trials: 1,680 * HPO: nodes: 15,229, Parent-child hierarchy: 18,949, Phenotype to gene: 839,551, Unique genes: 4,315 REPORTS * Reports for Interventions/Drugs * Reports for MeSH terms * Reports for HPO terms Details of COVID 19 related reports across ClinicalTrials.gov: Item Number 1 Number of unique Interventions/Drugs 1,688 2 Number of unique MeSH terms 323 3 Number of unique HPO terms 123 DATA FROM MAY 23, 2020 Details of data processed * Total number of clincal trials: 340,614 * COVID-19 related clinical trials: 1,437 * HPO: nodes: 15,229, Parent-child hierarchy: 18,949, Phenotype to gene: 839,551, Unique genes: 4,315 REPORTS * Reports for Interventions/Drugs * Reports for MeSH terms * Reports for HPO terms Details of COVID 19 related reports across ClinicalTrials.gov: Item Number 1 Number of unique Interventions/Drugs 1,424 2 Number of unique MeSH terms 293 3 Number of unique HPO terms 122 DATA FROM MAY 02, 2020 Details of data processed * Total number of clincal trials: 332,418 * Covid-19 related clinical trials: 1,019 * HPO: nodes: 14,961, Parent-child hierarchy: 18,547, Phenotype to gene: 820,297, Unique genes: 4,312 REPORTS * Reports for Interventions/Drugs * Reports for MeSH terms * Reports for HPO terms Details of COVID 19 related reports across ClinicalTrials.gov: Item Number 1 Number of unique Interventions/Drugs 1044 2 Number of unique MeSH terms 229 3 Number of unique HPO terms 28 Home References * Home * Vaccine * References * API * Figures * Previous * Reports