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Apply Online Application Due: December 1, 2023



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The Science

The People

The City

TPCB is a leading PhD graduate program in chemical biology, offered jointly by
three premier institutions in New York City. We provide an unparalleled
combination of world-class faculty, state-of-the-art facilities, and
collaborative research opportunities to the next generation of scientific
leaders working at the interface of chemistry, biology, and medicine.

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NEWS

TPCB is now accepting applications for admission to the entering class of 2024!
Please note that the deadline for receipt of all application materials,
including letters of recommendation, is December 1, 2023. Selected students will
be invited to attend our Open House event on January 21–23, 2024. [Start your
application today!]


TPCB is now accepting applications for admission to the entering class of 2024!
Please note that the deadline for receipt of all application materials,
including letters of recommendation, is December 1, 2023. Selected students will
be invited to attend our Open House event on January 21–23, 2024. [Start your
application today!]

TPCB welcomed the 2023 class of undergraduate summer interns in the Chemical
Biology Summer Program (ChBSP)! These students pursued forefront chemical
biology research in TPCB labs, working alongside our students and faculty, as
well as participating in career development training. [more]

Our Diversity is Our Strength. TPCB has a long-standing commitment to promoting
diversity and inclusion at all levels in science. Our outstanding students come
from many different backgrounds and the program has zero tolerance for racism or
discrimination in any form. We have taken numerous recent efforts to promote
these principles. [more].

Congratulations to Gianna Stella, who has been recognized for her exceptional
contributions to the community with the inaugural TPCB Student Service Award!
Gianna has been a leader in science outreach and mentorship, and a strong
advocate for student interests in the graduate schools. [more]

The 19th Annual Tri-Institutional Chemical Biology Symposium, sponsored by TPCB,
was held on September 6, 2023. Keynote lectures were given by Profs. Danica
Fujimori, Viviana Risca, Brian Shoichet, and Jorge Torres. Attendees also
enjoyed student talks and a large poster session. Stay tuned for a recap!

A team of TPCB researchers has discovered that linker histone H1 may play a role
in protecting the genome from damage during replication. The work published in
Nature Structural & Molecular Biology was led by Rachel Leicher, Wola Osunsade,
and Gabriella Chua in the labs of Prof. Yael David and Prof. Shixin Liu. [more]

TPCB recently welcomed four new faculty to the program, Prof. Arvin Dar at MSK,
Prof. Tobias Meyer at Weill Cornell, and Prof. Jiankun Lyu and Prof. Michael
Rout at Rockefeller. Their labs bringing exciting new research opportunities in
drug discovery and the molecular mechanisms underlying key cellular processes.
[more]

TPCB student J. Peter Lee and colleagues in the labs of TPCB faculty members
Prof. David Scheinberg and Prof. Derek Tan have developed a novel class of CAR-T
cells that home to tumors where they activate small-molecule anticancer drugs in
situ. These “SEAKER” cells were reported in a recent paper in Nature Chemical
Biology. [more]

Alumni Profile: TPCB alumni Dr. Renato Bauer and Dr. Jacqueline Wurst discuss
the flexibility of the graduate program, the unique opportunities in the
Tri-Institutional research environment, and how their training in chemistry
prepared them for their current careers in the pharmaceutical industry at Eli
Lilly. [more]

Student Profile: TPCB student Chaya Stern describes her non-traditional path to
graduate school, where she is now working in Prof. John Chodera’s computational
chemistry lab at Sloan Kettering as an NSF Graduate Research Fellow. She also
discusses the support she has received from TPCB as a parent. [more]

Alumni Profile: TPCB alumna Prof. Niroshika Keppetipola discusses her training
experience with mentor Prof. Stewart Shuman and how it prepared her for an
independent academic career. Now a faculty member at Cal State Fullerton, her
lab studies post-translational regulation of RNA binding proteins in alternative
splicing. [more]

Faculty Profile: TPCB faculty member Prof. Yael David is a new faculty member at
Sloan Kettering. She describe her lab’s approach using protein engineering to
study epigenetic regulation and its correlation with disease states. She also
discusses her approach to mentoring and her experiences as a woman in science.
[more]

Alumni Profile: TPCB alumna Dr. Amy Grunbeck Perea developed photoactivatable
probes to study G protein-coupled receptors with Prof. Tom Sakmar. After
graduating with 9 papers on her CV, she did a postdoc fellowship at Genzyme,
then joined Abcam, a biotech company in Cambridge, developing new tools for
protein analysis. [more]

Faculty Profile: TPCB faculty member Prof. Jue Chen is an HHMI Investigator who
studies the structure and function of molecular pumps called ABC transporters
that are involved in many important biological processes. She discusses the
recent cryo-EM ‘resolution revolution’ and her personalized approach to
mentoring her students. [more]

RECENT PUBLICATIONS

Vandana, J. J.; Manrique, C.; Lacko, L. A.; Chen, S. Human
pluripotent-stem-cell-derived organoids for drug discovery and evaluation. Cell
Stem Cell 2023, 30, 571–591. DOI: 10.1016/j.stem.2023.04.011 PMID: 37146581


Vandana, J. J.; Manrique, C.; Lacko, L. A.; Chen, S. Human
pluripotent-stem-cell-derived organoids for drug discovery and evaluation. Cell
Stem Cell 2023, 30, 571–591. DOI: 10.1016/j.stem.2023.04.011 PMID: 37146581

Dahl, L.; Kotliar, I. B.; Bendes, A.; Dodig-Crnković, T.; Fromm, S.; Elofsson,
A.; Uhlén, M.; Sakmar, T. P.; Schwenk, J. M. Multiplexed selectivity screening
of anti-GPCR antibodies. Sci Adv 2023, 9, eadf9297. DOI: 10.1126/sciadv.adf9297
PMID: 37134173

Holm, M.; Natchiar, S. K.; Rundlet, E. J.; Myasnikov, A. G.; Watson, Z. L.;
Altman, R. B.; Wang, H. Y.; Taunton, J.; Blanchard, S. C. mRNA decoding in human
is kinetically and structurally distinct from bacteria. Nature 2023, 617,
200–207. DOI: 10.1038/s41586-023-05908-w PMID: 37020024

Mattheisen, J. M.; Limberakis, C.; Ruggeri, R. B.; Dowling, M. S.; Am Ende, C.
W.; Ceraudo, E.; Huber, T.; McClendon, C. L.; Sakmar, T. P. Bioorthogonal
Tethering Enhances Drug Fragment Affinity for G Protein-Coupled Receptors in
Live Cells. J Am Chem Soc 2023, 145, 11173–11184. DOI: 10.1021/jacs.3c00972
PMID: 37116188

Knörlein, A.; Xiao, Y.; David, Y. Leveraging histone glycation for cancer
diagnostics and therapeutics. Trends Cancer 2023, 9, 410–420.
DOI: 10.1016/j.trecan.2023.01.005 PMID: 36804508

Ray, D. M.; Flood, J. R.; David, Y. Harnessing Split-Inteins as a Tool for the
Selective Modification of Surface Receptors in Live Cells. Chembiochem 2023, 24,
e202200487. DOI: 10.1002/cbic.202200487 PMID: 36178424

Hou, Q.; Jaffrey, S. R. Synthetic biology tools to promote the folding and
function of RNA aptamers in mammalian cells. RNA Biol 2023, 20, 198–206.
DOI: 10.1080/15476286.2023.2206248 PMID: 37129556

Kim, M.; Chen, C.; Yaari, Z.; Frederiksen, R.; Randall, E.; Wollowitz, J.; Cupo,
C.; Wu, X.; Shah, J.; Worroll, D.; Lagenbacher, R. E.; Goerzen, D.; Li, Y. M.;
An, H.; Wang, Y.; Heller, D. A. Nanosensor-based monitoring of
autophagy-associated lysosomal acidification in vivo. Nat Chem Biol 2023, in
press. DOI: 10.1038/s41589-023-01364-9 PMID: 37322156

Yang, S.; Hiotis, G.; Wang, Y.; Chen, J.; Wang, J. H.; Kim, M.; Reinherz, E. L.;
Walz, T. Dynamic HIV-1 spike motion creates vulnerability for its membrane-bound
tripod to antibody attack. Nat Commun 2022, 13, 6393.
DOI: 10.1038/s41467-022-34008-y PMID: 36302771

Jordan, V. N.; Ordureau, A.; An, H. Identifying E3 Ligase Substrates With
Quantitative Degradation Proteomics. Chembiochem 2023, 24, e202300108.
DOI: 10.1002/cbic.202300108 PMID: 37166757

Juette, M. F.; Carelli, J. D.; Rundlet, E. J.; Brown, A.; Shao, S.; Ferguson,
A.; Wasserman, M. R.; Holm, M.; Taunton, J.; Blanchard, S. C. Didemnin B and
ternatin-4 differentially inhibit conformational changes in eEF1A required for
aminoacyl-tRNA accommodation into mammalian ribosomes. Elife 2022, 11, e81608.
DOI: 10.7554/eLife.81608 PMID: 36264623

Mei, L.; Reynolds, M. J.; Garbett, D.; Gong, R.; Meyer, T.; Alushin, G. M.
Structural mechanism for bidirectional actin cross-linking by T-plastin. Proc
Natl Acad Sci U S A 2022, 119, e2205370119. DOI: 10.1073/pnas.2205370119
PMID: 36067297

Berman, A. Y.; Wieczorek, M.; Aher, A.; Olinares, P. D. B.; Chait, B. T.;
Kapoor, T. M. A nucleotide binding-independent role for γ-tubulin in microtubule
capping and cell division. J Cell Biol 2023, 222, e202204102.
DOI: 10.1083/jcb.202204102 PMID: 36695784

Harper, N. J.; Burnside, C.; Klinge, S. Principles of mitoribosomal small
subunit assembly in eukaryotes. Nature 2023, 614, 175–181.
DOI: 10.1038/s41586-022-05621-0 PMID: 36482135

Leicher, R.; Osunsade, A.; Chua, G. N. L.; Faulkner, S. C.; Latham, A. P.;
Watters, J. W.; Nguyen, T.; Beckwitt, E. C.; Christodoulou-Rubalcava, S.; Young,
P. G.; Zhang, B.; David, Y.; Liu, S. Single-stranded nucleic acid binding and
coacervation by linker histone H1. Nat Struct Mol Biol 2022, 29, 463–471.
DOI: 10.1038/s41594-022-00760-4 PMID: 35484234

Lee, H. G.; Lemmon, A. A.; Lima, C. D. SUMO enhances unfolding of
SUMO-polyubiquitin-modified substrates by the Ufd1/Npl4/Cdc48 complex. Proc Natl
Acad Sci U S A 2023, 120, e2213703120. DOI: 10.1073/pnas.2213703120
PMID: 36574706

Orth-He, E. L.; Huang, H. C.; Rao, S. D.; Wang, Q.; Chen, Q.; O'Mara, C. M.;
Chui, A. J.; Saoi, M.; Griswold, A. R.; Bhattacharjee, A.; Ball, D. P.; Cross,
J. R.; Bachovchin, D. A. Protein folding stress potentiates NLRP1 and CARD8
inflammasome activation. Cell Rep 2023, 42, 111965.
DOI: 10.1016/j.celrep.2022.111965 PMID: 36649711



Apply online Application Due: December 1, 2023

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