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CENTRAL NERVOUS SYSTEM AGENTS IN MEDICINAL CHEMISTRY


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PEER REVIEW REQUEST - ACCEPTANCE CONFIRMATION


BMS-CNSAMC-2023-65

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Article Title:
Safeguarding Neuronal Integrity: Unveiling Possible role of NFκB in the
Neuroprotective Efficacy of Andrographolide contrary to Aluminium chloride
induce Neurotoxicity and associated spatial memory impairments in Rats
Abstract:
Objective: The current study was structured to evaluate the neuroprotective
properties of andrographolide in the context of aluminum chloride
(AlCl3)-induced neurotoxicity, along with its concurrent impact on spatial
memory impairment in wistar rats. The present investigation elucidated the
biochemical and neurobehavioral outcomes of andrographolide treatment in rats,
emphasising on the areas of the brain associated with memory i.e. the cortex and
the hippocampus. Materials and Methods: Prolonged dosing of AlCl3 (7 mg/kg),
intraperitoneally, for 10 days, exhibited a substantial enhancement in the
values of oxidative stress markers, associated with reduction in the
concentrations of antioxidant enzymes within the brain. The selection of
andrographolide doses (1, 2 and 3 mg/kg) was grounded in precedent safety and
toxicity investigations, with subsequent oral administration. The evaluation of
behavioral parameters, specifically spatial memory, was conducted through the
utilization of Radial Eight Arm Maze (RAM) test. On the concluding day of the
experiment, the assessment encompassed biochemical parameter analysis and
histological scrutiny of the brain tissue. Results: The oral dosing of
andrographolide at 1, 2 and 3 mg/kg, in conjunction with AlCl3, effectively
mitigated the behavioral deficits induced by aluminum exposure. Notably, a
significant suppression of NFκB was uncovered in the rats treated with
andrographolide. Furthermore, histopathological examinations of the rat brain's
cortex and hippocampus provided corroborative evidence, demonstrating that
andrographolide substantially alleviated the toxic impact of AlCl3, thereby
maintaining the typical histoarchitectural arrangement of these regions. These
findings collectively suggest that andrographolide holds the potential to
counteract memory impairment instigated by aluminum toxicity, accomplished
through the modulation of NFκB activity and the amelioration of the adverse
consequences of AlCl3 exposure.

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