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MARIJUANA MOMENT
MILITARY VETERANS WHO RECEIVED PSYCHEDELIC IBOGAINE TREATMENT SAW ‘DRAMATIC’ AND
‘LIFE-CHANGING’ IMPROVEMENTS IN PTSD AND DEPRESSION, STANFORD STUDY FINDS
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‘Dramatic’ And ‘Life-Changing’ Improvements In PTSD And Depression,
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SCIENCE & HEALTH
MILITARY VETERANS WHO RECEIVED PSYCHEDELIC IBOGAINE TREATMENT SAW ‘DRAMATIC’ AND
‘LIFE-CHANGING’ IMPROVEMENTS IN PTSD AND DEPRESSION, STANFORD STUDY FINDS
Published
3 hours ago
on
January 11, 2024
By
Kyle Jaeger
Military combat veterans with traumatic brain injuries (TBI) saw “dramatic” and
“life-changing” improvements in their symptoms and cognitive functioning
immediately after receiving treatment with the psychedelic ibogaine, new
research shows.
Stanford University researchers behind the study, which was published in the
journal Nature Medicine last week, followed 30 veterans who were functionally
disabled from symptoms of TBI such as post-traumatic stress, depression and
anxiety and who had a history of repeated blast or combat exposures.
The team, which collaboration with the foundation VETS, Inc., assessed the
veterans before and after they visited a clinic in Mexico to receive ibogaine
treatment, and they identified profound changes in the participants’ mental
health, with minimal side effects.
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Prior to the treatment, the veterans each met the criteria for clinically
significant levels of disability. Twenty-three had diagnosable PTSD, 14 had
anxiety disorder, 15 had alcohol use disorder and 19 had been suicidal at some
point in their lifetimes.
After receiving ibogaine, in addition to magnesium to protect against potential
heart-related complications, there was an immediate “remarkable reduction” in
symptoms, “with large effect sizes” that sustained over time.
> Ibogaine “resulted in significant improvements in functioning both immediately
> and 1 month after treatment and in PTSD, depression and anxiety at 1 month
> after treatment. There were no unexpected or serious adverse events.”
After a month, the veterans’ average disability rating plummeted from 30.2 to
5.1, no longer qualifying as being disabled. They also saw an average reduction
of 88 percent in symptoms of PTSD, 87 percent in depression and 81 percent in
anxiety. Further, cognitive assessments shows improvements in “concentration,
information processing, memory and impulsivity.”
“No other drug has ever been able to alleviate the functional and
neuropsychiatric symptoms of traumatic brain injury,” Nolan Williams, an
associate professor of psychiatry and behavioral sciences at Stanford, said in a
press release. “The results are dramatic, and we intend to study this compound
further.”
The reason that the veterans had to visit Mexico is because ibogaine is
classified as a Schedule I controlled substance in the U.S., though interest in
exploring the psychedelic’s therapeutic potential has greatly expanded in recent
years.
> Ibogaine “could be a powerful therapeutic for the transdiagnostic psychiatric
> symptoms that can emerge after TBI and repeated exposure to blasts and combat,
> including suicidality.”
“These men were incredibly intelligent, high-performing individuals who
experienced life-altering functional disability from TBI during their time in
combat,” Williams said. “They were all willing to try most anything that they
thought might help them get their lives back.”
The Stanford team is planning to build on the initial findings, including
possibly incorporating brain scans to better understand how the psychedelic
affects cognition.
“In addition to treating TBI, I think this may emerge as a broader neuro-rehab
drug,” Williams said. “I think it targets a whole host of different brain areas
and can help us better understand how to treat other forms of PTSD, anxiety and
depression that aren’t necessarily linked to TBI.”
> “This is possibly the first study to report evidence for a single treatment
> with a drug that can improve chronic disability related to repeated TBI from
> combat/blast exposures.”
In response to the increased demand for research, the Drug Enforcement
Administration (DEA) has proposed a dramatic escalation in the production quota
for ibogaine and other psychedelic compounds in 2024.
In another major milestone, the U.S. Department of Veterans Affairs (VA)
recently issued a request for applications to conduct in-depth research on the
use of the psychedelics psilocybin and MDMA to treat PTSD and depression.
A recent survey of veterans and active military respondents showed that two
thirds (64 percent) supported allowing VA doctors to legally recommend
psychedelics.
In November of last year, lawmakers in a U.S. House subcommittee met for
a first-ever congressional hearing on psychedelics, with the panel focusing on
how substances like psilocybin and MDMA can aid therapy for military veterans’
facing mental health challenges.
Meanwhile, a psychedelics-focused drug development company has formally asked
the Food and Drug Administration (FDA) to review an application to approve MDMA
as a prescription medication for the treatment of PTSD after identifying
compelling results from a Phase 3 clinical trial.
> Illinois Marijuana Retailers Sold $2 Billion Worth Of Legal Products In 2023,
> Including A New Monthly Record In December
Photo courtesy of Flickr/Scamperdale.
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Kyle Jaeger
Kyle Jaeger is Marijuana Moment's Sacramento-based managing editor. His work has
also appeared in High Times, VICE and attn.
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