medcitynews.com Open in urlscan Pro
2606:4700:20::681a:250  Public Scan

Submitted URL: http://go.pardot.com/e/710433/-adhd-improves-brain-function-/cm9hf/461823222?h=5kb0NIw8TipV6HXnYOuwZsQ03h20RUohHH-bQD...
Effective URL: https://medcitynews.com/2022/03/new-study-shows-first-fda-cleared-video-game-treatment-for-pediatric-adhd-improves-brain...
Submission: On March 03 via api from US — Scanned from DE

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Health Tech


NEW STUDY SHOWS FIRST FDA-CLEARED VIDEO GAME TREATMENT FOR PEDIATRIC ADHD
IMPROVES BRAIN FUNCTION


IN THE U.S., ENDEAVORRX HAS BEEN CLEARED TO HELP IN IMPROVING ATTENTION FUNCTION
AS MEASURED BY COMPUTER-BASED TESTING IN CHILDREN AGES 8-12 YEARS WHO HAVE
PRIMARILY INATTENTIVE OR COMBINED-TYPE ADHD WHO STRUGGLE WITH MAINTAINING
ATTENTION.

By Emma Bardin

Post a comment / at 11:13 PM
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EndeavorRx is the first and only doctor-prescribed video game treatment for kids
with ADHD.

A study published in the medical journal PLOS ONE found that the EndeavorRx
video game treatment from Akili Interactive Labs improved brain function for
pediatric patients with ADHD, the company announced recently. Akili expects to
launch the treatment in the second half of this year.

University of California, San Francisco’s Courtney Gallen and Joaquin Anguera
led the single arm, unblinded study, which measured electroencephalography (EEG)
data in conjunction with both behavioral and clinical metrics of attention in
pediatric ADHD patients using EndeavorRx. As a result of the treatment, children
had increased brain activity related to the attention function.



“EndeavorRx was designed to target and activate attention networks in the brain
with the aim of driving clinically meaningful cognitive changes in patients.
What’s especially exciting about this data is that, for the first time, we can
see how the neural systems of a child with ADHD are impacted with EndeavorRx
treatment,” said Anil S. Jina, chief medical officer of Akili, in an email.

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DIVERSITY THROUGH ACCESSIBILITY: HOW IN-HOME CLINICAL TRIALS CAN ENROLL MORE
PATIENTS OF COLOR

Clinical trials have long struggled to enroll participants that reflect the
demographics of a patient population, but new models can change that

Eddie Peloke, CEO of Workpath

EndeavorRx is the first-and-only FDA-cleared digital therapeutic delivered
through a video game experience. In the U.S., EndeavorRx has been cleared to
help in improving attention function as measured by computer-based testing in
children ages 8-12 years. These kids have primarily inattentive or combined-type
ADHD, and have a demonstrated challenges with maintaining attention.

Akili is not simply targeting ADHD. The company has its eyes on other disease
areas, envisioning EndeavorRx as a potential platform technology, an avenue they
plan to pursue, according to Eddie Martucci, CEO of Akili.

“We are just beginning to scratch the surface of digital therapeutics’
potential. In the case of EndeavorRx, we are targeting specific areas of the
brain key to attention function,” said Martucci in an email. “The efficacy of
EndeavorRx has allowed its clearance as the first and only prescription video
game to treat medical conditions. Further, the safety profile of EndeavorRx is a
significant advantage in this patient population. For instance, there have been
no serious side effects associated with the use of EndeavorRx.”

The digital therapy requires a prescription and is designed to directly target
neural networks key to attention functions. It is intended to be part of a
child’s overall treatment plan, which can include cognitive behavioral therapy,
coaching, ADHD drugs, or other tools, depending on the patient’s needs,
according to Martucci.

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PARTNER PROGRAMS AT VIVE

Throughout our 4-day event in Miami, several ViVE strategic partners will be
taking the stage to share insights on how the healthcare landscape is changing
through the perspectives of cybersecurity, policy reform, voice & AI,
value-based care, continuity of care and more!

ViVE, powered by CHIME + HLTH

“EndeavorRx uses proprietary technology that uses sensory stimuli and
simultaneous motor challenges designed to target and activate the
fronto-parietal cortex which plays a key role in attention function,” Martucci
said. “It uses adaptive closed-loop algorithms to personalize the treatment
experience for each patient. This enables the treatment to continuously adapt to
challenge each patient at the individual level.”

The company is looking to shift the paradigm of medicine, envisioning a paradigm
where technology is itself the medicine. In the case of EndeavorRx, this happens
by directly targeting the neural networks essential to cognitive function.

“While digital therapeutics generally have the ability to deliver user-friendly
experiences for patients, we’ve taken that to the next level, developing
clinically-validated treatments that are designed to be indistinguishable from
high-end entertainment experiences,” Martucci added.

The clinical validation the study conducted by researchers at UCSF comes a few
weeks after the Boston-based company made a different announcement. In late
January, the company revealed its plans to go public via a special purpose
acquisition company (SPAC) in a deal that would bring in $412 million in gross
cash proceeds.

“Akili has created a unique disease-agnostic technology platform with an
advanced pipeline of product candidates across multiple indications where
proof-of-concept has already been achieved,” said Kishen Mehta, Portfolio
Manager of of the Averill strategy at Suvretta Capital Management and President
of SCS.

Social Capital Suvretta Holdings Corp is the SPAC entity with whom Akili intends
to merge and go public in the middle of this year.

Photo: Akili Interactive



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TOPICS

Akili Interactive Labs, Boston, digital therapeutics




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