journals.physiology.org Open in urlscan Pro
104.18.17.3  Public Scan

Form analysis
4 forms found in the DOM

Name: defaultQuickSearch — GET /action/doSearch

<form action="/action/doSearch" name="defaultQuickSearch" method="get">
  <fieldset>
    <legend class="sr-only">Quick Search anywhere</legend>
    <div class="input-group option-0 "><label for="AllField464c6581-0950-4dba-885b-92b54f5ea4f10" class="sr-only">Search all content</label>
      <div class="autoComplete_wrapper" role="combobox" aria-owns="autoComplete_list_1" aria-haspopup="true" aria-expanded="false"><input type="search" autocomplete="off" id="AllField464c6581-0950-4dba-885b-92b54f5ea4f10" name="AllField"
          placeholder="Search all content" data-auto-complete-max-words="7" data-auto-complete-max-chars="32" data-contributors-conf="3" data-topics-conf="3" data-publication-titles-conf="3" data-history-items-conf="3" value="" class="auto-complete"
          aria-controls="autoComplete_list_1" aria-autocomplete="both"></div>
    </div>
    <ul id="autoComplete_list_1" role="listbox" hidden="" class="autoComplete rlist"></ul><button type="submit" title="Search" class="btn quick-search__button icon-search"><span class="sr-only">Search</span><span>Advanced Search</span></button>
  </fieldset>
</form>

Name: thisJournalQuickSearch — GET /action/doSearch

<form action="/action/doSearch" name="thisJournalQuickSearch" method="get">
  <fieldset>
    <legend class="sr-only">Quick Search in Journals</legend>
    <div class="input-group option-1 option-journal"><label for="AllField464c6581-0950-4dba-885b-92b54f5ea4f11" class="sr-only">Search all content</label>
      <div class="autoComplete_wrapper" role="combobox" aria-owns="autoComplete_list_2" aria-haspopup="true" aria-expanded="false"><input type="search" autocomplete="off" id="AllField464c6581-0950-4dba-885b-92b54f5ea4f11" name="AllField"
          placeholder="Search all content" data-auto-complete-max-words="7" data-auto-complete-max-chars="32" data-contributors-conf="3" data-topics-conf="3" data-publication-titles-conf="3" data-history-items-conf="3" value="" class="auto-complete"
          aria-controls="autoComplete_list_2" aria-autocomplete="both"></div><input type="hidden" name="SeriesKey" value="jappl">
    </div>
    <ul id="autoComplete_list_2" role="listbox" hidden="" class="autoComplete rlist"></ul><button type="submit" title="Search" class="btn quick-search__button icon-search"><span class="sr-only">Search</span><span>Advanced Search</span></button>
  </fieldset>
</form>

Name: defaultQuickSearch — GET /action/doSearch

<form action="/action/doSearch" name="defaultQuickSearch" method="get">
  <fieldset>
    <legend class="sr-only">Quick Search anywhere</legend>
    <div class="input-group"><label for="AllField5f3d7597-990d-4067-af44-714106a41c46" class="sr-only">Search this journal</label><input type="search" id="AllField5f3d7597-990d-4067-af44-714106a41c46" name="AllField" placeholder="Search this journal"
        data-auto-complete-max-words="7" data-auto-complete-max-chars="32" data-contributors-conf="3" data-topics-conf="3" data-publication-titles-conf="3" data-history-items-conf="3" value="" class="autocomplete"><button type="submit" title="Search"
        class="btn quick-search__button icon-search"><span class="sr-only">Search this journal</span></button></div>
  </fieldset>
</form>

Name: defaultQuickSearch — GET /action/doSearch

<form action="/action/doSearch" name="defaultQuickSearch" method="get">
  <fieldset>
    <legend class="sr-only">Quick Search anywhere</legend>
    <div class="input-group"><label for="AllField5f3d7597-990d-4067-af44-714106a41c46" class="sr-only">Search this journal</label><input type="search" id="AllField5f3d7597-990d-4067-af44-714106a41c46" name="AllField" placeholder="Search this journal"
        data-auto-complete-max-words="7" data-auto-complete-max-chars="32" data-contributors-conf="3" data-topics-conf="3" data-publication-titles-conf="3" data-history-items-conf="3" value="" class="autocomplete"><button type="submit" title="Search"
        class="btn quick-search__button icon-search"><span class="sr-only">Search this journal</span></button></div>
  </fieldset>
</form>

Text Content

LOGIN TO YOUR ACCOUNT

Institutional Login
Sign In / Register


PHYSIOLOGY.ORG
Skip main navigation
Close Drawer MenuOpen Drawer Menu
Home
 * Journals
   * AJP-Cell
   * AJP-Endo
   * AJP-GI
   * AJP-Heart
   * AJP-Lung
   * AJP-Regu
   * AJP-Renal
   * AJP (1898-1976)
   * Function
   * J Appl Physiol
   * J Neurophysiol
   * Physiol Genomics
   * Adv Physiol Educ
   * Physiology
   * Physiol Rev
   * PHYSIOL REP
   * COMPR PHYSIOL
   * APSselect


 * All journals
    * All journals
    * This Journal
   
   Quick Search anywhere
   Search all content
   
   SearchAdvanced Search
   Quick Search in Journals
   Search all content
   
   SearchAdvanced Search
   Advanced Search
 * 0
 * Sign in

Journal of Applied PhysiologyVol. 20, No. 3
 * Journal home
 * Issues
   Archive of all online content
   July 1948August 2023
    * 1940s
    * 1950s
    * 1960s
    * 1970s
    * 1980s
    * 1990s
    * 2000s
    * 2010s
    * 2020s
   
    * 1948
    * 1949
   
   
    * 1950
    * 1951
    * 1952
    * 1953
    * 1954
    * 1955
    * 1956
    * 1957
    * 1958
    * 1959
   
   
    * 1960
    * 1961
    * 1962
    * 1963
    * 1964
    * 1965
    * 1966
    * 1967
    * 1968
    * 1969
   
   
    * 1970
    * 1971
    * 1972
    * 1973
    * 1974
    * 1975
    * 1976
    * 1977
    * 1978
    * 1979
   
   
    * 1980
    * 1981
    * 1982
    * 1983
    * 1984
    * 1985
    * 1986
    * 1987
    * 1988
    * 1989
   
   
    * 1990
    * 1991
    * 1992
    * 1993
    * 1994
    * 1995
    * 1996
    * 1997
    * 1998
    * 1999
   
   
    * 2000
    * 2001
    * 2002
    * 2003
    * 2004
    * 2005
    * 2006
    * 2007
    * 2008
    * 2009
   
   
    * 2010
    * 2011
    * 2012
    * 2013
    * 2014
    * 2015
    * 2016
    * 2017
    * 2018
    * 2019
   
   
    * 2020
    * 2021
    * 2022
    * 2023
   
    * Articles in Press
    * 
      Volume 135, Issue 2
      August 2023
      
      Pages 239-435
    * 
      Volume 135, Issue 1
      July 2023
      
      Pages 1-237
    * 
      Volume 134, Issue 6
      June 2023
      
      Pages 1321-1549
    * 
      Volume 134, Issue 5
      May 2023
      
      Pages 1063-1320
    * 
      Volume 134, Issue 4
      April 2023
      
      Pages 787-1062
    * 
      Volume 134, Issue 3
      March 2023
      
      Pages 491-785
    * 
      Volume 134, Issue 2
      February 2023
      
      Pages 217-489
    * 
      Volume 134, Issue 1
      January 2023
      
      Pages 1-215

 * Collections
 * Information
   * For Authors
   * For Reviewers
   * For Librarians
   * For Advertisers
   * For Media/Public
   * For APS Members
 * About
     
   * About jappl
     
   * Article Types
     
     
     
   * Editor's Message
     
   * Editor's Bio
   * Editorial Board

SubmitSubscribe
Quick Search anywhere
Search this journalSearch this journal
Journal Menu
Quick Search anywhere
Search this journalSearch this journal
 * Home
 * Issues
 * Collections
 * Information
 * About

SubmitSubscribe
SPECIAL COMMUNICATIONS


DEMONSTRATION OF BILE STASIS IN THE MOUSE BY A DIRECT AND AN INDIRECT METHOD

 * Gabriel L. Plaa
   , and
 * Bernard A. Becker

Gabriel L. Plaa

Department of Pharmacology, College of Medicine, State University of Iowa, Iowa
City, Iowa

Search for more papers by this author

, and
Bernard A. Becker

Department of Pharmacology, College of Medicine, State University of Iowa, Iowa
City, Iowa

Search for more papers by this author

Published Online:01 May 1965https://doi.org/10.1152/jappl.1965.20.3.534
 * 

More
 * Figures
 * References
 * Related
 * Information

 * 

 * PDF (1022 KB)
   * Download PDF
 * Tools
    * Export citation
    * Add to favorites
    * Get permissions
    * Track citations

 * Share
   
   Share on
    * Facebook
    * Twitter
    * LinkedIn
    * WeChat
      


ABSTRACT

Cannulation of the common bile duct of the mouse has been effected. Bile flow
rates and bile pigment concentrations have been determined in these
preparations. These values are lower than comparable values in bile
duct-cannulated rats. An indirect test for detection of bile flow in the mouse,
using injected fluorescein as an indicator, has been devised. Using all-or-none
criteria, results obtained using the indirect technique correlate well with
those obtained by the direct (cannulation) method. The use of the indirect test
in conjunction with liver function tests, e.g., Bromsulphalein (BSP) retention,
is recommended as a means of elucidating causes of liver dysfunction. By this
means, a difference has been demonstrated between two hepatotoxic agents which
effect BSP retention in the mouse: carbon tetrachloride and
alpha-naphthylisothiocyanate (ANIT). The latter agent interferes with BSP
excretion as shown by the indirect bile flow test; carbon tetrachloride does not
cause blockage of bile flow.

bile flow; alpha-naphthylisothiocyanate; CCl4; cannulation of bile duct in mice;
fluorescein; measure of bile flow in mice; sulfobromophthalein; bile pigment
concentration in mice

Submitted on September 10, 1964




WE RECOMMEND

 1. Bile secretory function of intrahepatic biliary epithelium in the rat
    G. Alpini et al., American Journal of Physiology - Gastrointestinal and
    Liver Physiology, 1989
 2. Bile Volume and Excretion of Pigment and Bromsulfalein in Dogs Receiving
    Carbon Tetrachloride
    B. Delserone et al., American Journal of Physiology -- Legacy Content, 1951
 3. Pathophysiological basis of liver disease in cystic fibrosis employing a
    DeltaF508 mouse model.
    Folke Freudenberg et al., American Journal of Physiology - Gastrointestinal
    and Liver Physiology, 2008
 4. Pathophysiological basis of liver disease in cystic fibrosis employing a
    ΔF508 mouse model
    Folke Freudenberg et al., American Journal of Physiology - Gastrointestinal
    and Liver Physiology, 2008
 5. Bile salt absorption in the irradiated rat
    Maurice F. Sullivan, American Journal of Physiology -- Legacy Content, 1965

 1. Study on Antioxidant Effect and Preparation Technology of Chewable Tablets
    of Betacyanins Spray-Dried Powder
    LIU Qilong et al., Xinjiang Agricultural Sciences, 2021
 2. Astrocytic Gap Junctions Contribute to Aberrant Neuronal Synchronization in
    a Mouse Model of MeCP2 Duplication Syndrome
    Shengnan Xia et al., Neuroscience Bulletin, 2022
 3. Prestin-Mediated Frequency Selectivity Does not Cover Ultrahigh Frequencies
    in Mice
    Jie Li et al., Neuroscience Bulletin, 2022
 4. Interaction Effects of Early-maturing Upland Cotton Varieties and
    Meteorological Factors on Cotton Fiber Quality
    MA Xiaomei et al., Xinjiang Agricultural Sciences, 2021
 5. Liver macrophages show an immunotolerance phenotype in nonalcoholic fatty
    liver combined with Porphyromonas gingivalis-lipopolysaccharide infection
    Guo Lijia et al., West China Journal of Stomatology, 2023

Powered by
 * Privacy policy
 * Do not sell my personal information
 * Google Analytics settings


I consent to the use of Google Analytics and related cookies across the TrendMD
network (widget, website, blog). Learn more
Yes No

Previous
Back to Top
Next
Download PDF
 * Figures
 * References
 * Related
 * Information

See PDF
 * Cited By
    * Mechanosensor transient receptor potential vanilloid member 4 (TRPV4)
      regulates mouse cholangiocyte secretion and bile formation
       * Qin Li
         ,
       * Charles Kresge
         ,
       * Kristy Boggs
         ,
       * Julie Scott
         , and
       * Andrew Feranchak
      
      27 January 2020 | American Journal of Physiology-Gastrointestinal and
      Liver Physiology, Vol. 318, No. 2
    * The effect of α-naphthylisothiocyanate on bile secretion prior to and
      during the onset of cholestasis in the rat
      
      Toxicology Letters, Vol. 10, No. 4
    * Microsomal drug metabolism during α-naphthylisothiocyanate-induced
      cholestasis
      
      Toxicology and Applied Pharmacology, Vol. 35, No. 3
    * The effect of acute and sub-acute treatment with
      diethylenetriaminepentaacetic acid on the hepatic function of mice
      
      Toxicology, Vol. 2, No. 1
    * Effects of phenobarbital and SKF 525A pretreatment, sex, liver injury, and
      vehicle on Δ9-tetrahydrocannabinol toxicity
      
      Toxicology and Applied Pharmacology, Vol. 27, No. 1
    * Comparative toxicity and distribution of endrin and dieldrin after
      intravenous administration in mice
      
      Toxicology and Applied Pharmacology, Vol. 23, No. 3
    * Functional effects of α-naphthylisothiocyanate in various species
      
      Toxicology and Applied Pharmacology, Vol. 19, No. 1
    * Studies on bilirubin production and excretion in mice and rats treated
      with phenobarbital, chlorpromazine, norethandrolone, acetohexamide or
      enovid
      
      Toxicology and Applied Pharmacology, Vol. 15, No. 2
    * Effect of norethandrolone, acetohexamide, and enovid on
      α-naphthylisothiocyanate-induced hyperbilirubinemia and cholestasis
      
      Biochemical Pharmacology, Vol. 15, No. 3
    * Hepatotoxicity of α-naphthylisothiocyanate congeners with particular
      emphasis on phenylisothiocyanate
      
      Toxicology and Applied Pharmacology, Vol. 7, No. 6
    * Quantitative and temporal delineation of various parameters of liver
      dysfunction due to α-naphthylisothiocyanate
      
      Toxicology and Applied Pharmacology, Vol. 7, No. 5


 * MORE FROM THIS ISSUE >

Volume 20Issue 3May 1965Pages 534-537


--------------------------------------------------------------------------------

Copyright & Permissions

Copyright © 1965 the American Physiological Society

 * https://doi.org/10.1152/jappl.1965.20.3.534
 * PubMed5837569

History
Published online 1 May 1965
Published in print 1 May 1965

--------------------------------------------------------------------------------


METRICS

Downloaded 9 times

18
CITATIONS
18 Total citations
0 Recent citations
n/a Field Citation Ratio
0.27 Relative Citation Ratio

publications
19
supporting
0
mentioning
4
contrasting
0
Smart Citations
19
0
4
0
Citing PublicationsSupportingMentioningContrasting
View Citations

See how this article has been cited at scite.ai

scite shows how a scientific paper has been cited by providing the context of
the citation, a classification describing whether it supports, mentions, or
contrasts the cited claim, and a label indicating in which section the citation
was made.


Close Figure Viewer
Browse All FiguresReturn to FigureChange zoom levelZoom inZoom out

Previous FigureNext Figure

Caption

back

Sign up for alertsSign Up
 * Twitter
 * Facebook
 * LinkedIn
 * YouTube

 * Contact Us
 * About Us

AMERICAN PHYSIOLOGICAL SOCIETY JOURNALS

 * American Journal of Physiology-Cell Physiology
 * American Journal of Physiology-Endocrinology and Metabolism
 * American Journal of Physiology-Gastrointestinal and Liver Physiology
 * American Journal of Physiology-Heart and Circulatory Physiology
 * American Journal of Physiology-Lung Cellular and Molecular Physiology
 * American Journal of Physiology-Regulatory, Integrative and Comparative
   Physiology
 * American Journal of Physiology-Renal Physiology
 * American Journal of Physiology (1898-1976)
 * Physiological Genomics
 * Journal of Applied Physiology
 * Journal of Neurophysiology
 * Advances in Physiology Education
 * Physiological Reviews
 * Physiology
 * Physiological Reports
 * Comprehensive Physiology
 * Function

INFORMATION FOR

 * Authors
 * Reviewers
 * Librarians
 * Advertisers
 * APS Members
 * Media/Public

   PROGRAMS

 * APSselect
 * Legacy Collection
 * APS Books Program

APS

 * Visit the APS website
 * Become an APS member
 * I Spy Physiology Blog

STAY CONNECTED

 * Submit
 * Subscribe
 * About Us
 * Contact Us
 * Your Account

NEWS

 * APS Press Releases
 * Publication News

 * Privacy Policy
 * Disclaimer
 * Terms & Conditions

Copyright © 2023 the American Physiological Society
✓
Thanks for sharing!
AddToAny
More…

Close crossmark popup