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COUNTERSTRIKE – Counteracting sarcopenia with proteins and exercise
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 * COUNTERSTRIKE


COUNTERSTRIKE – COUNTERACTING SARCOPENIA WITH PROTEINS AND EXERCISE

PROJECT IS COMPLETED
Project period: 2015 – 2019

The main aim of COUNTERSTRIKE is to develop a tool for rapidly assessing
age-related loss of skeletal muscle mass, termed sarcopenia, to find individual
treatments to promote the maintenance of a healthy level of skeletal muscle
mass.

The University of Copenhagen is running an ambitious intervention
study Counteracting Age-related Loss of Skeletal Muscle Mass (CALM) aimed at
providing evidence-based recommendations for alleviating sarcopenia through
protein supplementation and exercise.

The project is collecting a large number of blood and faecal samples to
determine the impact of increased protein intake and exercise on the gut
microbiota and the blood metabolome.

COUNTERSTRIKE aims to complement the CALM project with a full metabolomics
investigation of all samples in the CALM cohort with an emphasis on determining
the lipoprotein particle distribution and linking this to gut microbiota,
metabolomic potential and host physiological parameters focusing on skeletal
muscle mass.


GLOBAL SCREENING AND INDIVIDUAL COUNTERSTRIKE

The lipoprotein particle distribution predicts cardiovascular outcomes and is
associated with obesity and insulin resistance. Body weight decreases with age,
whereas a more atherogenic lipid profile is common, but little is known about
the lipoprotein particle distribution in elderly people or the effect of
exercise.

It is the ambition of this consortium, including national and international,
academic and industrial partners, to establish a rapid screening method to
determine the lipoprotein particle distribution based on nuclear magnetic
resonance (NMR) spectroscopy, apply it to the CALM cohort and link the results
to gut microbiota and host metabolism, making them available for future
research.

A new spectroscopy-based screening method will enable the global screening of
elderly people to determine each individual’s health status and allow for an
individual “counterstrike” against sarcopenia.




CENTRAL RESEARCH QUESTIONS / FOCUS AREAS

COUNTERSTRIKE will

• Develop a novel analytical methodology for LPD determination, sufficiently
rapid to allow for nation-wide screening efforts, which facilitate early
diagnostics of not only sarcopenia, but also metabolic syndrome and related
conditions, thus paving the way for development of personalised nutritional
recommendations

• Investigate the complexity of sarcopenia by studying LPD changes in a large
cohort of elderly as a function of increased exercise and protein intake and
linking LPD changes to overall metabolome, GM and host physiology

• Determine whether there is a causal link between an unhealthy LPD and
development of resistance towards muscle anabolic stimuli like exercise and
protein

• Develop the knowledge obtained through state-of-art analytical platforms and
advanced multivariate data-analysis into a format where it is readily
communicable to elderly as well as policy makers in Denmark.

COUNTERSTRIKE will train 2 PhDs and 3 post docs within metabolomics, physiology
and advanced data analysis and thus educate highly skilled scientists with flair
for interdisciplinary work for the benefit of Danish industry.


BACKGROUND


GLOBAL SCREENING AND INDIVIDUAL COUNTERSTRIKE

The prevention of age-related loss of skeletal muscle mass will have positive
effects on each elderly person’s quality of life and simultaneously diminish the
economic burden on society.

The lipoprotein particle distribution predicts cardiovascular outcomes and is
associated with obesity and insulin resistance. Body weight decreases with age,
whereas a more atherogenic lipid profile is common, but little is known about
the lipoprotein particle distribution in elderly people or the effect of
exercise.

Elderly lose up 2% of their skeletal muscle-mass per year, a condition termed
"sarcopenia". In the coming years human longevity will increase in Western
societies with huge socio-economic consequences. Thus, the ageing population
should be encouraged to remain self-supportive, not only to diminish the
economic burden for society, but also to retain their quality of life.
University of Copenhagen is currently starting an ambitious intervention study
“Counteracting Age-related Loss of Skeletal Muscle Mass (CALM)” aimed at
providing evidence-based recommendations for alleviating sarcopenia through
protein supplementation and exercise. The project includes collection of a large
number of blood and faecal samples to determine the impact of increased protein
intake and exercise on the gut microbiota (GM) and the blood metabolome.
COUNTERSTRIKE aims to complement the CALM project with a full metabolomic
investigation of all its 3000 samples with emphasis on determination of
lipoprotein particle distribution (LPD) and linking this to GM metabolomic
potential and host physiological parameters.



It is the ambition of this project that include national and international,
academic and industrial power centres, to establish a rapid screening method for
determination of LPD based on NMR spectroscopy, apply it to the CALM cohort and
relate the results to GM and host metabolism and ultimately making it available
for future research in for example personalized nutrition. The new screening
method will allow for global screening of elderly to determine individual health
status and facilitate a “COUNTERSTRIKE” against sarcopenia on the individual
level creating a new business area for the European food industry.

It is the ambition of this consortium, including national and international,
academic and industrial partners, to establish a rapid screening method to
determine the lipoprotein particle distribution based on nuclear magnetic
resonance (NMR) spectroscopy, apply it to the CALM cohort and link the results
to gut microbiota and host metabolism, making them available for future
research.

A new spectroscopy-based screening method will enable the global screening of
elderly people to determine each individual’s health status and allow for an
individual “counterstrike” against sarcopenia.


PARTICIPANTS

Associate Professor Dennis Sandris Nielsen

Department of Food ScienceUniversity of Copenhagen



Grant holder and Coordinator, Head of WP3.

--------------------------------------------------------------------------------

Professor Søren B. Engelsen

Department of Food ScienceUniversity of Copenhagen



Head of WP1.

--------------------------------------------------------------------------------

Associate Professor Lars Holm

Bispebjerg Hospital



Head of WP4.

--------------------------------------------------------------------------------

Post doc Mads Vendelbo Lind

Department of Nutrition, Exercise and SportsUniversity of Copenhagen



Runs WP2.

--------------------------------------------------------------------------------

Head of Department, Professor Arne Astrup

Department of Nutrition, Exercise and SportsUniversity of Copenhagen



Head of WP2.

--------------------------------------------------------------------------------

Associate Professor Astrid P. Jespersen

The Saxo InstituteUniversity of Copenhagen



Head of CALM, Head of WP6.

--------------------------------------------------------------------------------

Post doc Line Hillersdal

The Saxo InstituteUniversity of Copenhagen



--------------------------------------------------------------------------------

Professor Age Smilde

Biosystems Data AnalysisUniversity of Amsterdam



--------------------------------------------------------------------------------

Professor John van Duynhoven

Unilever and Wageningen University

ResearchGate profile

 

--------------------------------------------------------------------------------

Lead Scientist Doris Jacobs

Unilever 

--------------------------------------------------------------------------------

Director of Applied NMR Business Development Dr. Manfred Spraul & Dr. Hartmut
Schäfer

Bruker BioSpin GmbH 

--------------------------------------------------------------------------------

Research Scientist Simon M. M. Pedersen, PhD

Arla Strategic Research CentreArla Foods Amba

--------------------------------------------------------------------------------




PARTNERS

University of Copenhagen

 * Department of Food Science
 * Department of Nutrition Exercise and Sports
 * The Saxo Institute

--------------------------------------------------------------------------------



Bispebjerg Hospital

 * Institute of Sports Medicine

--------------------------------------------------------------------------------



University of Amsterdam

 * Biosystems Data Analysis

--------------------------------------------------------------------------------



Arla Foods Amba

--------------------------------------------------------------------------------



Bruker BioSpin GmbH

--------------------------------------------------------------------------------



Unilever R&D Vlaardingen

--------------------------------------------------------------------------------




FUNDED BY:



COUNTERSTRIKE has received DKK 15,633,418 from Innovation Fund Denmark

Additional funding from: Bruker BioSpin GmbH, Arla Foods Amba, Unilever R&D
Vlaardingen, and all university partners

Project: Counteracting Sarcopenia with proteins and exercise - screening the
CALM cohort for lipoprotein biomarkers - COUNTERSTRIKE
Period:  1 April 2015 - 31 August 2020




CONTACT

Dennis Sandris Nielsen
Associate Professor
Microbiology and Fermentation



BROCHURES ON SARCOPENIA AND CHOLESTEROL

Two brochures on sarcopenia and cholesterol, respectively, have been published
in connection with the COUNTERSTRIKE project.



Brochure on sarcopenia



Brochure on cholesterol

--------------------------------------------------------------------------------

Department of Food Science (FOOD)
University of Copenhagen
Rolighedsvej 26, DK-1958 Frederiksberg

Contact: Department of Food Science
food@food.ku.dk



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