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 * Overview
 * Poll
 * Pretest
 * Activity
   * Treating Anemia of CKD: A Closer Look at Established and Investigational
     Therapies
   * Educational Tools
 * Posttest
 * Evaluation
 * Claim Credit
 * Certificate


 1. Healio
 2. CME
 3. Primary Care

 * Overview
 * Poll
 * Pretest
 * Activity
   * Treating Anemia of CKD: A Closer Look at Established and Investigational
     Therapies
   * Educational Tools
 * Posttest
 * Evaluation
 * Claim Credit
 * Certificate


TREATING ANEMIA OF CKD: A CLOSER LOOK AT ESTABLISHED AND INVESTIGATIONAL
THERAPIES

This educational activity is supported by an educational grant from
GlaxoSmithKline.

0.50 CME
0.50 CME with ABIM MOC
30 MINS
$0 FEE
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OVERVIEW


PROVIDER STATEMENT

This continuing medical education activity is provided by

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SUPPORT STATEMENT

This educational activity is supported by an educational grant from
GlaxoSmithKline.

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ACTIVITY DESCRIPTION

Anemia is common among individuals with chronic kidney disease (CKD). It
underlies many of the symptoms affiliated with reduced kidney function and is
associated with increased mortality and hospitalizations. Anemia is common among
nondialysis CKD patients, and the prevalence increases as the glomerular
filtration rate (GFR) declines. Many patients with anemia of CKD are not
receiving treatment for this disease. If not effectively managed, anemia may
lead to cardiovascular disease, stroke, cognitive impairment,
cardiovascular-related complications, and death. Current guidelines state that
iron and erythropoiesis stimulating agents (ESAs) are the primary therapeutic
options for anemia of CKD. Moreover, investigational agents are currently being
analyzed in clinical trials, and these therapies could have a huge impact on the
future treatment of this condition. These include hypoxia-inducible factor
prolyl hydroxylase inhibitors (HIF PHIs), which are a novel class of oral ESAs
that have been examined for treatment of anemia of CKD. Unlike other ESAs that
replace endogenous erythropoietin, HIF PHIs stimulate transcription of the
erythropoietin gene in the kidneys and liver, leading to increased levels of
endogenous erythropoietin. This educational activity will review the
pathogenesis of anemia of CKD, best practices for accurate diagnosis of anemia
of CKD, and emerging therapies and their potential impact on the treatment
landscape for anemia of CKD.

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TARGET AUDIENCE

The intended audience for this activity is nephrologists, family medicine
physicians, internists, and other health care professionals involved in the
management of patients with anemia of chronic kidney disease.

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LEARNING OBJECTIVES

Upon successful completion of this activity, participants should be better able
to examine clinical evidence regarding current and emerging therapies for the
treatment of anemia of CKD.

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ACTIVITY CHAIR

George L. Bakris MD, FAHA, FASN
Professor of Medicine
Director, American Heart Association Comprehensive Hypertension Center
University of Chicago Medicine
Chicago, IL

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FACULTY

Phuong-Chi T. Pham, MD, FASN
Clinical Professor of Medicine
David Geffen School of Medicine at UCLA
Los Angeles, CA

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REVIEWER

Ronald A. Codario, MD, EMBA, FACP, FNLA, RPVI, CHCP

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ACCREDITATION

Vindico Medical Education is accredited by the Accreditation Council for
Continuing Medical Education to provide continuing medical education for
physicians.

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CREDIT DESIGNATION

Vindico Medical Education designates this enduring material for a maximum of
0.50 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit
commensurate with the extent of their participation in the activity.

Successful completion of this CME activity enables the participant to earn up to
0.50 Medical Knowledge MOC points in the American Board of Internal Medicine’s
(ABIM) Maintenance of Certification (MOC) program. It is the CME activity
provider’s responsibility to submit participant completion information to ACCME
for the purpose of granting ABIM MOC credit.

Participants who opt-in will earn MOC points equivalent to the amount of CME
credits claimed for the activity.

This enduring material is approved for 1 year from the date of original release,
April 30, 2022, to April 29, 2023.

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HOW TO PARTICIPATE IN THIS ACTIVITY AND OBTAIN CME CREDIT

To participate in this CME activity, you must read the objective, answer the
polling and pretest questions, view the content, and complete the posttest and
evaluation. Provide only one (1) correct answer for each question. A
satisfactory score is defined as answering 100% of the posttest questions
correctly. Upon receipt of the completed materials, if a satisfactory score on
the posttest is achieved, Vindico Medical Education will issue an AMA PRA
Category 1 Credit(s)™ certificate.

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DISCLOSURES

Vindico Medical Education adheres to the Accreditation Council for Continuing
Medical Education’s (ACCME) Standards for Integrity and Independence in
Accredited Continuing Education. Any individuals in a position to control the
content of a continuing education activity, including faculty, planners,
reviewers, or others, are required to disclose all relevant financial
relationships with ineligible entities (commercial interests). All relevant
conflicts of interest have been mitigated prior to the commencement of the
activity.

ACTIVITY CHAIR AND FACULTY REPORT THE FOLLOWING RELEVANT RELATIONSHIP(S)

George L. Bakris MD, FAHA, FASN
Advisor: Merck
Consultant: AstraZeneca, Bayer, DiaMedica Therapeutics

Phuong-Chi T. Pham, MD, FASN
No relevant financial relationships to disclose.

REVIEWER REPORTS THE FOLLOWING RELATIONSHIP(S)

Ronald A. Codario, MD, EMBA, FACP, FNLA, RPVI, CHCP
No relevant financial relationships to disclose.

VINDICO MEDICAL EDUCATION STAFF REPORT THE FOLLOWING RELATIONSHIP(S)

No relevant financial relationships to disclose.

Signed disclosures are on file at Vindico Medical Education, Office of Medical
Affairs and Compliance.

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UNLABELED AND INVESTIGATIONAL USAGE

The audience is advised that this continuing medical education activity may
contain references to unlabeled uses of US Food and Drug Administration
(FDA)–approved products or to products not approved by the FDA for use in the
United States. The faculty members have been made aware of their obligation to
disclose such usage. All activity participants will be informed if any
speakers/authors intend to discuss either non–FDA-approved or investigational
use of products/devices.

--------------------------------------------------------------------------------


COPYRIGHT STATEMENT

Created and published by Vindico Medical Education, 6900 Grove Road, Building
100, Thorofare, NJ 08086-9447. Telephone: 856-994-9400; Fax: 856-384-6680.
Printed in the USA. Copyright © 2022 Vindico Medical Education. All rights
reserved. No part of this publication may be reproduced without written
permission from the publisher. The material presented at or in any of Vindico
Medical Education continuing medical education activities does not necessarily
reflect the views and opinions of Vindico Medical Education. Neither Vindico
Medical Education nor the faculty endorse or recommend any techniques,
commercial products, or manufacturers. The faculty/authors may discuss the use
of materials and/or products that have not yet been approved by the US Food and
Drug Administration. All readers and continuing education participants should
verify all information before treating patients or utilizing any product.

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CME QUESTIONS?

Contact us at cme@vindicoCME.com

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