wbcil.com
Open in
urlscan Pro
162.240.44.100
Public Scan
Submitted URL: https://u25506113.ct.sendgrid.net/ls/click?upn=ifyw2W0wC3c3UTP7gfJHDl3mqm-2F4yjtVCQeoJOJ17CMtGqVVNKohpq5Lim4ODCBToC6PvpK2qOdZvf0CL...
Effective URL: https://wbcil.com/productexposition/sodium-butyrate/?utm_campaign=Emailer-[Type]-[DB]-[Date]&utm_source=Email
Submission: On June 30 via api from DE — Scanned from DE
Effective URL: https://wbcil.com/productexposition/sodium-butyrate/?utm_campaign=Emailer-[Type]-[DB]-[Date]&utm_source=Email
Submission: On June 30 via api from DE — Scanned from DE
Form analysis 4 forms found in the DOM
POST /productexposition/sodium-butyrate/?utm_campaign=Emailer-%5BType%5D-%5BDB%5D-%5BDate%5D&utm_source=Email#wpcf7-f1647-o1
<form action="/productexposition/sodium-butyrate/?utm_campaign=Emailer-%5BType%5D-%5BDB%5D-%5BDate%5D&utm_source=Email#wpcf7-f1647-o1" method="post" class="wpcf7-form init" novalidate="novalidate" data-status="init">
<div style="display: none;">
<input type="hidden" name="_wpcf7" value="1647">
<input type="hidden" name="_wpcf7_version" value="5.5.6.1">
<input type="hidden" name="_wpcf7_locale" value="en_US">
<input type="hidden" name="_wpcf7_unit_tag" value="wpcf7-f1647-o1">
<input type="hidden" name="_wpcf7_container_post" value="0">
<input type="hidden" name="_wpcf7_posted_data_hash" value="">
</div>
<div class="col-lg-12">
<div class="tm-form-field">
<p> <label>Full Name<span class="star">*</span></label></p>
<p> <span class="wpcf7-form-control-wrap your-name"><input type="text" name="your-name" value="" size="40" class="wpcf7-form-control wpcf7-text wpcf7-validates-as-required" aria-required="true" aria-invalid="false"></span></p>
</div>
</div>
<div class="col-lg-12">
<div class="tm-form-field">
<p> <label>Phone Number</label></p>
<p> <span class="wpcf7-form-control-wrap phone"><input type="tel" name="phone" value="" size="40" class="wpcf7-form-control wpcf7-text wpcf7-tel wpcf7-validates-as-required wpcf7-validates-as-tel" aria-required="true"
aria-invalid="false"></span></p>
</div>
</div>
<div class="col-lg-6">
<div class="tm-form-field">
<p> <label>Email Address<span class="star">*</span></label></p>
<p> <span class="wpcf7-form-control-wrap your-email"><input type="email" name="your-email" value="" size="40" class="wpcf7-form-control wpcf7-text wpcf7-email wpcf7-validates-as-required wpcf7-validates-as-email" aria-required="true"
aria-invalid="false"></span></p>
</div>
</div>
<div class="col-lg-6">
<div class="tm-form-field">
<p> <label>Country Name<span class="star">*</span></label></p>
<p> <span class="wpcf7-form-control-wrap country"><input type="text" name="country" value="" size="40" class="wpcf7-form-control wpcf7-text wpcf7-validates-as-required" aria-required="true" aria-invalid="false"></span></p>
</div>
</div>
<div class="col-lg-12">
<div id="cf7sr-62bd6b7f3bd65" class="cf7sr-g-recaptcha" data-sitekey="6LdinoMfAAAAABYMU4ktV82Dvv6wxhMqy0CI-DsG">
<div style="width: 304px; height: 78px;">
<div><iframe title="reCAPTCHA"
src="https://www.google.com/recaptcha/api2/anchor?ar=1&k=6LdinoMfAAAAABYMU4ktV82Dvv6wxhMqy0CI-DsG&co=aHR0cHM6Ly93YmNpbC5jb206NDQz&hl=de&v=4rwLQsl5N_ccppoTAwwwMrEN&size=normal&cb=jlxryolrblj9" width="304"
height="78" role="presentation" name="a-4cpbnaub2gck" frameborder="0" scrolling="no" sandbox="allow-forms allow-popups allow-same-origin allow-scripts allow-top-navigation allow-modals allow-popups-to-escape-sandbox"></iframe></div>
<textarea id="g-recaptcha-response" name="g-recaptcha-response" class="g-recaptcha-response" style="width: 250px; height: 40px; border: 1px solid rgb(193, 193, 193); margin: 10px 25px; padding: 0px; resize: none; display: none;"></textarea>
</div>
</div><span class="wpcf7-form-control-wrap cf7sr-recaptcha"><input type="hidden" name="cf7sr-recaptcha" value="" class="wpcf7-form-control"></span>
</div>
<div class="col-lg-12">
<button class="tm-btn1" ["submit"]=""><span>SEND MESSAGE</span></button>
<p></p>
<div class="empty-space col-lg-b30"></div>
</div>
<div class="wpcf7-response-output" aria-hidden="true"></div>
</form><form autocomplete="off" aria-label="Ajax search form">
<input aria-label="Search input" type="search" class="orig" name="phrase" placeholder="Search here.." value="" autocomplete="off">
<input aria-label="Autocomplete input, do not use this" type="text" class="autocomplete" name="phrase" value="" autocomplete="off">
<input type="submit" value="Start search" style="width:0; height: 0; visibility: hidden;">
</form>Name: options —
<form name="options" autocomplete="off">
<input type="hidden" name="filters_changed" style="display:none;" value="0">
<input type="hidden" name="filters_initial" style="display:none;" value="1">
<div class="asl_option_inner hiddend">
<input type="hidden" name="qtranslate_lang" id="qtranslate_lang1" value="0">
</div>
<fieldset class="asl_sett_scroll">
<legend style="display: none;">Generic selectors</legend>
<div class="asl_option">
<div class="asl_option_inner">
<input type="checkbox" value="exact" id="set_exactonly1" title="Exact matches only" name="asl_gen[]">
<label for="set_exactonly1">Exact matches only</label>
</div>
<div class="asl_option_label"> Exact matches only </div>
</div>
<div class="asl_option">
<div class="asl_option_inner">
<input type="checkbox" value="title" id="set_intitle1" title="Search in title" name="asl_gen[]" checked="checked">
<label for="set_intitle1">Search in title</label>
</div>
<div class="asl_option_label"> Search in title </div>
</div>
<div class="asl_option asl-o-last">
<div class="asl_option_inner">
<input type="checkbox" value="content" id="set_incontent1" title="Search in content" name="asl_gen[]" checked="checked">
<label for="set_incontent1">Search in content</label>
</div>
<div class="asl_option_label"> Search in content </div>
</div>
<div class="asl_option_inner hiddend">
<input type="checkbox" value="excerpt" id="set_inexcerpt1" title="Search in excerpt" name="asl_gen[]">
<label for="set_inexcerpt1">Search in excerpt</label>
</div>
</fieldset>
<fieldset class="asl_sett_scroll">
<legend style="display: none;">Post Type Selectors</legend>
<div class="asl_option">
<div class="asl_option_inner">
<input type="checkbox" value="page" id="1customset_11" title="page" name="customset[]" checked="checked">
<label for="1customset_11">page</label>
</div>
<div class="asl_option_label"> page </div>
</div>
<div class="asl_option">
<div class="asl_option_inner">
<input type="checkbox" value="accreditations" id="1customset_12" title="accreditations" name="customset[]">
<label for="1customset_12">accreditations</label>
</div>
<div class="asl_option_label"> accreditations </div>
</div>
<div class="asl_option">
<div class="asl_option_inner">
<input type="checkbox" value="events" id="1customset_13" title="events" name="customset[]">
<label for="1customset_13">events</label>
</div>
<div class="asl_option_label"> events </div>
</div>
<div class="asl_option">
<div class="asl_option_inner">
<input type="checkbox" value="career" id="1customset_14" title="career" name="customset[]">
<label for="1customset_14">career</label>
</div>
<div class="asl_option_label"> career </div>
</div>
<div class="asl_option">
<div class="asl_option_inner">
<input type="checkbox" value="product" id="1customset_15" title="product" name="customset[]">
<label for="1customset_15">product</label>
</div>
<div class="asl_option_label"> product </div>
</div>
<div class="asl_option asl-o-last">
<div class="asl_option_inner">
<input type="checkbox" value="certificates" id="1customset_16" title="certificates" name="customset[]">
<label for="1customset_16">certificates</label>
</div>
<div class="asl_option_label"> certificates </div>
</div>
</fieldset>
<fieldset>
<legend>Filter by Categories</legend>
<div class="categoryfilter asl_sett_scroll">
<div class="asl_option hiddend">
<div class="asl_option_inner">
<input type="checkbox" value="1" id="1categoryset_1" title="Uncategorized" name="categoryset[]" checked="checked">
<label for="1categoryset_1">Uncategorized</label>
</div>
<div class="asl_option_label"> Uncategorized </div>
</div>
</div>
</fieldset>
</form>POST
<form class="newsletter-form" method="post" id="contact-form">
<div role="form" class="wpcf7" id="wpcf7-f1038-o2" lang="en-US" dir="ltr">
<div class="screen-reader-response">
<p role="status" aria-live="polite" aria-atomic="true"></p>
<ul></ul>
</div>
<div style="display: none;">
<input type="hidden" name="_wpcf7" value="1038">
<input type="hidden" name="_wpcf7_version" value="5.5.6.1">
<input type="hidden" name="_wpcf7_locale" value="en_US">
<input type="hidden" name="_wpcf7_unit_tag" value="wpcf7-f1038-o2">
<input type="hidden" name="_wpcf7_container_post" value="0">
<input type="hidden" name="_wpcf7_posted_data_hash" value="">
</div>
<div class="col-xl-6 col-lg-6 col-sm-12">
<div class="subscribe_input">
<span class="wpcf7-form-control-wrap your-name"><input type="text" name="your-name" value="" size="40" class="wpcf7-form-control wpcf7-text wpcf7-validates-as-required" aria-required="true" aria-invalid="false" placeholder="Name"></span>
</div>
</div>
<div class="col-xl-6 col-lg-6 col-sm-12">
<div class="subscribe_input">
<span class="wpcf7-form-control-wrap your-email"><input type="email" name="your-email" value="" size="40" class="wpcf7-form-control wpcf7-text wpcf7-email wpcf7-validates-as-required wpcf7-validates-as-email" aria-required="true"
aria-invalid="false" placeholder="Email ID"></span>
<p></p>
</div>
</div>
<div class="col-xl-12 col-lg-12 col-sm-12">
<span class="wpcf7-form-control-wrap acceptance-819"><span class="wpcf7-form-control wpcf7-acceptance"><span class="wpcf7-list-item"><label><input type="checkbox" name="acceptance-819" value="1" aria-invalid="false"><span
class="wpcf7-list-item-label">"Yes, I consent to my data being stored according to the guidelines set out in the <a href="https://wbcil.com/privacy-policy/">Privacy Policy</a>."</span></label></span></span></span>
</div>
<div class="col-xl-12 col-lg-12 col-sm-12">
<div id="cf7sr-62bd6b7f41ef6" class="cf7sr-g-recaptcha" data-sitekey="6LdinoMfAAAAABYMU4ktV82Dvv6wxhMqy0CI-DsG">
<div style="width: 304px; height: 78px;">
<div><iframe title="reCAPTCHA"
src="https://www.google.com/recaptcha/api2/anchor?ar=1&k=6LdinoMfAAAAABYMU4ktV82Dvv6wxhMqy0CI-DsG&co=aHR0cHM6Ly93YmNpbC5jb206NDQz&hl=de&v=4rwLQsl5N_ccppoTAwwwMrEN&size=normal&cb=myayjaq7z60f" width="304"
height="78" role="presentation" name="a-qqvxsw8e149q" frameborder="0" scrolling="no" sandbox="allow-forms allow-popups allow-same-origin allow-scripts allow-top-navigation allow-modals allow-popups-to-escape-sandbox"></iframe></div>
<textarea id="g-recaptcha-response-1" name="g-recaptcha-response" class="g-recaptcha-response"
style="width: 250px; height: 40px; border: 1px solid rgb(193, 193, 193); margin: 10px 25px; padding: 0px; resize: none; display: none;"></textarea>
</div><iframe style="display: none;"></iframe>
</div><span class="wpcf7-form-control-wrap cf7sr-recaptcha"><input type="hidden" name="cf7sr-recaptcha" value="" class="wpcf7-form-control"></span>
</div>
<div class="col-xl-12 col-lg-12 col-sm-12">
<br><br>
<button class="mb-4 tm-btn1" ["submit"]=""><span>Subscribe Now</span></button>
<p></p>
<div class="empty-space col-lg-b30"></div>
</div>
<div class="wpcf7-response-output" aria-hidden="true"></div>
</div>
</form>Text Content
Brochure
Full Name*
Phone Number
Email Address*
Country Name*
SEND MESSAGE
Close
Contact
English
Arabic Dutch English French German Italian Portuguese Russian Spanish
Powered by Google Übersetzer
+91 (33) 4025 1555 / 1539
wbcil@wbcil.com
* Home
* About
* Products
* API / Fine Chemical / Neutraceutical
* Iron
* Calcium
* Zinc
* Magnesium
* Potassium
* Copper
* Other Products
* DC Grade / Premix
* Chelated Minerals
* Iron
* Magnesium
* Copper
* Zinc
* Manganese
* Calcium
* Cobalt
* Chromium
* Boron
* Selenium
* Animal Nutrition
* Certifications
* Exposition
* Gallery
* Career
Generic selectors
Exact matches only
Exact matches only
Search in title
Search in title
Search in content
Search in content
Search in excerpt
Post Type Selectors
page
page
accreditations
accreditations
events
events
career
career
product
product
certificates
certificates
Filter by Categories
Uncategorized
Uncategorized
Close
Products
prev
next
Home › Product Exposition
PRODUCT EXPOSITION
PHARMACEUTICAL USE OF SODIUM BUTYRATE
WBCIL October 7, 2021
Product: Sodium Butyrate
Pharmacopeia: USP
What is Sodium Butyrate?
Sodium Butyrate is sodium salt of short-chain fatty acid (SCFA). Fatty acids are
the building blocks of fats that our cells need to function. Butyrate is
produced when the bacteria living in our guts ferment otherwise indigestible
fibres from grains, onions, beans, bananas, and other foods rich in complex
carbs.
Butyrate is the preferred energy source for the cells in your colon wall. It is
essential for maintaining a healthy barrier between the colon and bloodstream
and it prevents inflammation in the gut. Butyrate production depends largely on
the pH of the large intestine. Bacteria that produce butyrate thrive in a more
acidic environment (lower pH).
How Does Sodium Butyrate Work?
Sodium Butyrate inhibits Histone Deacetylase (HDAC), an enzyme that packs up DNA
into tight, compact structures and prevents it from being expressed; in other
words, butyrate loosens up the DNA structure and increases gene expression.
Drugs that inhibit HDAC are currently used to manage bipolar disorder and
prevent epileptic seizures. Early research suggests that they may also be
effective antidepressants.
The relationship between butyrate and HDAC helps explain why our gut floras have
such a large influence on our mental health. Sure enough, people with major
depressive disorder have fewer butyrate-producing bacteria in their intestines.
Colon Cell Energy Source
Butyrate nourishes the colon wall, maintains a healthy lining and barrier
function of the colon, and prevents intestinal inflammation in the mitochondria
of colon cells; 70-90% of butyrate is oxidized into acetyl-CoA, which is then
used to generate large quantities of ATP, the primary form of cellular energy.
If we don’t have enough butyrate-producing bacteria in your gut, you may be more
likely to develop diarrhoea, inflammatory bowel disease (IBD), and even colon
cancer.
Indication
* Inflammatory Bowel Disease: Short-chain fatty acids, especially butyrate, can
reduce the symptoms of inflammatory bowel disease (IBD). In one study of 13
people with Crohn’s disease, a type of IBD, butyrate supplements improved 69%
of cases, with symptoms completely disappearing in 54% (seven participants).
There are a variety of approaches for using butyrate to manage IBD and
colitis. The treatment strategies range from a high-fibre diet to
butyrate-producing probiotics, coated butyrate tablets, and rectal enemas.
* Diarrhoea & Gut Inflammation: Butyrate can also prevent inflammation and
stomach ulcers caused by alcohol. Mice given butyrate before alcohol had less
inflammation and damage to the lining of their stomachs Sodium butyrate in
combination with other SCFAs and silicon dioxide was also shown to benefit
traveller’s diarrhoea, a condition common among those who travel to exotic
countries. According to a great many studies, butyrate is vital for healthy
gut flora, controlling inflammation, and maintaining a strong intestinal
barrier.
* Colon Cancer: Butyric acid is the preferred fuel for the colonic enterocyte.
It has also been associated with several potential anti-cancer properties. An
increase in the rate of colonic cell proliferation is believed to be a risk
factor for cancer. However, all cells in the colon are programmed with a time
to die by a controlled process called Apoptosis.
It is probably the balance between the levels of proliferation and apoptosis
that determine whether a cancer will or will not develop. Although butyrate
has been shown to stimulate cell proliferation of normal colonic cells, it
has been shown to stimulate apoptosis in cancer cells in vitro. It may also
affect other important stages in carcinogenesis such as the promotion of cell
differentiation and inhibition of Histone Deacetylase, which may promote DNA
repair.
Benefits of Sodium Butyrate
* 1. Butyrate is a major short-chain fatty acid produced during gut
flora-mediated fermentation of dietary fibres. Legumes (beans, peas, and
soybeans), fruits, nuts, cereals, and whole grains are good sources of
dietary fibres. Butyrate is also found in butter and cheese.
* 2. Animal and epidemiological studies suggest that high-fibre diet may lower
colorectal cancer risk. The beneficial effects of butyrate appear to be
mediated by its HDAC inhibitory activity, which promotes histone acetylation,
leading to expression of genes involved in cellular differentiation and
apoptosis in several cancer models.
* 3. In this context, it has been proposed that butyrate can act in primary and
secondary chemoprevention by its pleiotropic potential. Therefore, butyrate
is evaluated for the prevention of inflammation-mediated ulcerative colitis
and colorectal cancer by lifelong continuous exposure to dietary fibre.
* 4. Besides its HDAC inhibitory activity, butyrate was also reported to
trigger DNA DE methylation by a mechanism most likely dependent on changes in
chromatin structure that could also contribute to chemo preventive properties
of butyrate.
Surprisingly, there are only a very limited number of reports about the effect
of butyrate on miRNA. Hu and collaborators have shown that the overexpression of
the cyclic-dependent kinase inhibitor (CDKN) 1A gene, coding for p21, a negative
regulator of cell cycle induced by most HDAC inhibitors, is not only dependent
on its HDAC inhibitory potential to increase the transcription via promoter
acetylation, but also depends on the inhibition of several members of the
miR-106b family, which control p21 translation. These data suggest that the
preventive role of butyrate may rely on the modulation of several epigenetic
mechanisms.
RECENT POST
* EFFICACY OF FERROUS GLYCINE SULPHATE VS FERROUS BISGLYCINATE IN THE TREATMENT
OF ANEMIA DURING PREGNANCY
June 24, 2022
* DOES CALCIUM PROPIONATE PLAY A MAJOR ROLE TO BE THE BEST FOOD PRESERVATIVE?
June 15, 2022
* TOP 5 BENEFITS OF CONSUMING LIPOSOMAL IRON
June 13, 2022
* IRON POLYMALTOSE COMPLEX VS. FERROUS SULPHATE IN THE TREATMENT OF IRON
DEFICIENCY ANEMIA IN PREGNANT WOMEN: EFFICACY, TOLERABILITY, AND COST
June 10, 2022
* ROLE OF FERRIC ORTHOPHOSPHATE IN IRON FORTIFICATION OF FLOUR
June 9, 2022
* ROLE OF ZINC PROPIONATE IN ANIMAL FEED OR POULTRY DIETS
June 8, 2022
PRODUCTS
API / Fine Chemical / Neutraceutical
DC Grade / Premix
Chelated Minerals
Animal Nutrition
QUICK LINKS
About Us
Product Exposition
Gallery
Certifications
Career
Contact Us
Privacy Policy
CONTACT INFO
* 145/1, Jessore Road,
Lake Town, Kolkata – 700 089,
West Bengal, India.
* wbcil@wbcil.com
* +91 (33) 4025 1555 / 1539
SIGN UP FOR UPDATES
SUBSCRIBE NEWSLATTER
Close
"Yes, I consent to my data being stored according to the guidelines set out in
the Privacy Policy."
Subscribe Now
WBCIL GMP & ISO 9001 : 2008 CERTIFIED COMPANY
ORIGINALTEXT
Bessere Übersetzung vorschlagen
--------------------------------------------------------------------------------
×
We Value Your Privacy
Settings
NextRoll, Inc. ("NextRoll") and our advertising partners use cookies and similar
technologies on this site and use personal data (e.g., your IP address). If you
consent, the cookies, device identifiers, or other information can be stored or
accessed on your device for the purposes described below. You can click "Allow
All" or "Decline All" or click Settings above to customize your consent.
NextRoll and our advertising partners process personal data to: ● Store and/or
access information on a device; ● Create a personalized content profile; ●
Select personalised content; ● Personalized ads, ad measurement and audience
insights; ● Product development. For some of the purposes above, our advertising
partners: ● Use precise geolocation data. Some of our partners rely on their
legitimate business interests to process personal data. View our advertising
partners if you wish to provide or deny consent for specific partners, review
the purposes each partner believes they have a legitimate interest for, and
object to such processing.
If you select Decline All, you will still be able to view content on this site
and you will still receive advertising, but the advertising will not be tailored
for you. You may change your setting whenever you see the Manage consent
preferences on this site.
Decline All
Allow All
Manage consent preferences