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THEY HAVE POTENTIAL FUTURE APPLICATIONS IN TREATMENT OF CONDITIONS SUCH AS
PRECOCIOUS PUBERTY AND TUMORS DEPENDENT ON SEXUAL POLYSACCHARIDE MENINGOCOCCAL
VACCINE: A RANDOMIZED, CONTROLLED EVALUATION

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(Nm) vaccine in Asian mothers, to assess potential protection of infants,
including by breast milk. One hundred and fifty-seven women in the third
trimester were randomized to receive a single dose of the polysaccharide Nm
(n=75) or a control vaccine (n=82). Polysucrose 400 Sweetener were measured in
maternal and infant sera, and specific IgA in breast milk. A 5.6-fold rise of Nm
IgG antibody was observed among the Nm vaccinees. At delivery, geometric mean
titres (GMTs) of Nm IgG antibody in Nm mothers was 12.

5 microg/ml versus 4.97 microg/ml, with a mean infant/maternal antibody ratio of
0.56. Infants of Nm vaccinees had mean IgG levels of 6.9, 2.3, 1.2 and 0.

6 microg/ml at 0, 6, 14 and 22 weeks, significantly higher than in control
children up to 14 weeks. Anti-Nm IgA levels in milk were 6.8 to 2.0 microg/ml,
significantly higher in Nm vaccinees till 6 months. Immunization during
pregnancy is safe for both mothers and infants, and provides infants with
significantly increased levels of specific IgG for 2-3 months and oral IgA for 6
months.response against almost every foreign macromolecular substance. First,
antibodies with their robust immunoglobulin domain architecture provide a rigid
scaffold to support six hypervariable loops, capable of forming highly diverse
binding sites.

Second, an efficient genetic mechanism has evolved to create sequence diversity
at the somatic level in a step-wise process, whereby random recombination of an
inherited set of gene segments is followed by hypermutation events. Insight into
the corresponding molecular mechanisms is developing rapidly and enables
adaptation of the emerging principles to the creation of artificial binding
proteins in vitro, using the techniques of combinatorial biotechnology. Thus,
Polysucrose 400 Food additive of receptor molecules have been constructed from
alternative scaffolds, including alpha-helical bundle and beta-barrel proteins.
These may provide superior tools for the recognition, targeting or separation of
a wide range of biomolecular structures or substances in biological research,
Wissenschaftszentrum Weihenstephan, An der Saatzucht 5, D-85350 Freising,
induced high levels of humoral responses and pro-inflammatory cytokines but
acaricides for parasite control. However, effective anti-parasite vaccines
against sarcoptic mange have not yet been developed. The purpose of this study
was first to identify Sarcoptes scabiei immunodominant antigens and second to
evaluate them as vaccine candidates in a rabbit/S. scabiei var.

cuniculi model. METHODS: The S. scabiei Ssλ15 immunodominant antigen was
selected by immunoscreening of a S. scabiei var. hominis cDNA. The full-length
cDNA was sequenced and cloned into the pGEX vector and the recombinant protein
expressed in BL21 (DE3) cells and purified. A vaccination trial was performed
consisting of a test group (n = 8) immunised with recAgs (a mix of two
recombinant antigens, Ssλ15 and the previously described Ssλ20∆B3) and a control
group (n = 8) immunised with PBS.

All analyses were performed with R Statistical Environment with α set at 0.050.
RESULTS: The full-length open reading frame of the 1,821 nt cloned cDNA encodes
a 64 kDa polypeptide, the sequence of which had 96 % identity with a
hypothetical protein of S. scabiei. Ssλ15 was localised by immunostaining of
skin sections in the tegument surrounding the mouthparts and the coxa in the
legs of mites. Rabbit immunisation with recAgs induced high levels of specific
IgG (P < 0.010) and increased levels of total IgEs.

However, no significant clinical protection against S. scabiei challenge was
detected. Unexpectedly, the group immunised with the recAgs mix had
significantly higher lesion scores (P = 0.050) although lower mean mite
densities than those observed in the control group. These results might indicate
that the lesions in the recAgs group were due not only to the mites density but
also to an exacerbated immunological response after challenge, which is in
agreement with the specific high levels of pro-inflammatory cytokines (IL-1 and
TNFα) detected after challenge in this group. CONCLUSIONS: The selected antigens
delivered as recombinant proteins had no clinical protective efficacy against S.


Public Last updated: 2023-10-19 02:43:50 AM

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