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Submitted URL: https://doi.org/10.1159/000046212
Effective URL: https://karger.com/ajn/article-abstract/21/1/1/24892/Renal-Effects-of-COX-2-Selective-Inhibitors?redirectedFrom=ful...
Submission: On January 01 via manual from US — Scanned from US
Effective URL: https://karger.com/ajn/article-abstract/21/1/1/24892/Renal-Effects-of-COX-2-Selective-Inhibitors?redirectedFrom=ful...
Submission: On January 01 via manual from US — Scanned from US
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Skip to Main Content Close * Who We Serve * Overview * Researchers * Authors * Reviewers * Healthcare Professionals * Patients & Supporters * Librarians * Health Sciences Industry * Medical Societies * Agents & Distributors * What We Offer * Overview * Journals * Collections * Subject Areas * Books & Book Series * E-Learning Courses * Healthcare Podcasts * Who We Are * Overview * What We Solve * Accessing Knowledge * Presenting Knowledge * Applying Knowledge * About Us * Publish with Us * Overview * Publish Your Paper * Calls for Papers * Publication Services * Partner Publications * Resources for You * Overview * News & Media Releases * Exhibitions & Webinars * Fast Facts Info Series * Experience Karger Blog * The Waiting Room Blog * Embarrassing Problems Blog * Nephrology Viewpoints Blog Search Dropdown Menu header search search input Search input auto suggest filter your search All ContentAll JournalsAmerican Journal of Nephrology Search Advanced Search User Tools Dropdown Register Login Toggle MenuMenu * Content * Articles * Issues * Online First * Early View * About * Details * Contact * Editorial Board * Guidelines * Subscription Rates * Rights & Permissions * Advertising * Submission Skip Nav Destination Close navigation menu Article navigation Volume 21, Issue 1 January – February 2001 Article Navigation Review Articles| March 12 2001 RENAL EFFECTS OF COX-2-SELECTIVE INHIBITORS Subject Area: Nephrology D. Craig Brater; D. Craig Brater aDepartment of Medicine, Indiana University School of Medicine, Indianapolis, Ind., and Search for other works by this author on: This Site PubMed Google Scholar Cynthia Harris; Cynthia Harris aDepartment of Medicine, Indiana University School of Medicine, Indianapolis, Ind., and Search for other works by this author on: This Site PubMed Google Scholar Jan S. Redfern; Jan S. Redfern bMerck & Co., Inc., Rahway, N.J., USA Search for other works by this author on: This Site PubMed Google Scholar Barry J. Gertz Barry J. Gertz bMerck & Co., Inc., Rahway, N.J., USA Search for other works by this author on: This Site PubMed Google Scholar Am J Nephrol (2001) 21 (1): 1–15. https://doi.org/10.1159/000046212 Article history Published Online: March 12 2001 Content Tools * Views Icon Views * Article contents * Share Icon Share * Facebook * Twitter * LinkedIn * Email * Tools Icon Tools * Get Permissions * Cite Icon Cite * Search Site Citation D. Craig Brater, Cynthia Harris, Jan S. Redfern, Barry J. Gertz; Renal Effects of COX-2-Selective Inhibitors. Am J Nephrol 1 February 2001; 21 (1): 1–15. https://doi.org/10.1159/000046212 Download citation file: * Ris (Zotero) * Reference Manager * EasyBib * Bookends * Mendeley * Papers * EndNote * RefWorks * BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsAmerican Journal of Nephrology Search Advanced Search ABSTRACT Although nonsteroidal anti-inflammatory drugs (NSAIDs) effectively treat a variety of inflammatory diseases, these agents may cause deleterious effects on kidney function, especially with respect to solute homeostasis and maintenance of renal perfusion and glomerular filtration. NSAIDs act by reducing prostaglandin biosynthesis through inhibition of cyclooxygenase (COX) which exists as two isoforms (COX-1 and COX-2). NSAID-induced gastrointestinal toxicity is generally believed to occur through blockade of COX-1 activity, whereas the anti-inflammatory effects of NSAIDs are thought to occur primarily through inhibition of the inducible isoform, COX-2. However, the situation in the kidney may be somewhat different. Recent studies have demonstrated that COX-2 is constitutively expressed in renal tissues of all species; this isoform may, therefore, be intimately involved in prostaglandin-dependent renal homeostatic processes. Drugs that selectively inhibit COX-2 might, therefore, be expected to produce effects on renal function similar to nonselective NSAIDs which inhibit both COX-1 and COX-2. This assertion is borne out by recent clinical studies showing that the COX-2 inhibitors rofecoxib and celecoxib procedure qualitative changes in urinary prostaglandin excretion, glomerular filtration rate, sodium retention, and their consequences similar to nonselective NSAIDs. It, therefore, seems unlikely that these COX-2 inhibitors (and perhaps their successors) will offer renal safety benefits over nonselective NSAID therapies, and, at this juncture, it is reasonable to assume that all NSAIDs, including COX-2-selective inhibitors, share a similar risk for adverse renal effects. Keywords: Rofecoxib, Celecoxib, COX-2 inhibitors, Nonsteroidal anti-inflammatory drugs, Nephrotoxicity, Glomerular filtration, Hypertension, Acute renal failure This content is only available via PDF. © 2001 S. Karger AG, Basel 2001 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). 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Association Between Serum Klotho and All-Cause Mortality in Chronic Kidney Disease: Evidence From a Prospective Cohort Study Serum phosphorus management with sucroferric oxyhydroxide as a first-line phosphate binder within the first year of hemodialysis Contents Vol. 54, 2023 RELATED ARTICLES WE RECOMMEND 1. Renal Effects of Nabumetone, a COX-2 Antagonist: Impairment of Function in Isolated Perfused Rat Kidneys Contrasts with Preserved Renal Function in vivo James Reichman et al., Nephron Experimental Nephrology, 2001 2. Different Actions of the Cyclooxygenase 2 Selective Inhibitor Flosulide in Rats with Passive Heymann Nephritis Gunhild Heise et al., Nephron, 1998 3. Influence of Creatinine versus Glomerular Filtration Rate on Non-Steroidal Anti-Inflammatory Drug Prescriptions in Chronic Kidney Disease Krupa Patel et al., American Journal of Nephrology, 2012 4. Chronic COX Inhibition Reduces Diabetes-Induced Hyperfiltration, Proteinuria, and Renal Pathological Markers in 36-Week B6-Ins2Akita Mice Rania Nasrallah et al., American Journal of Nephrology, 2009 1. Shared Decision-Making on Using a CDK4/6 Inhibitor Plus an Aromatase Inhibitor for HR+/HER2− Metastatic Breast Cancer: A Podcast Brought to you by Pfizer Medical Affairs 2. Cardiovascular Risk Associated With NSAIDs and COX-2 Inhibitors Laura A. Perry et al., US Pharmacist, 2014 3. Strategies to safely interfere with prostanoid activity while avoiding adverse renal effects: could COX‐2 and COX‐LOX dual inhibition be the answer? Giovanni Gambaro, Nephrology Dialysis Transplantation, 2002 4. NSAIDs: Balancing the Risks and Benefits Pamela Gorczyca et al., US Pharmacist, 2016 Powered by * Targeting settings * Do not sell my personal information * Google Analytics settings I consent to the use of Google Analytics and related cookies across the TrendMD network (widget, website, blog). 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