us.supersmart.com
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192.155.95.234
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Submitted URL: http://r.info3.supersmart.com/mk/cl/f/sh/28xHLtxYQ51BfaTdwV9SMc4tA4EH3pdY7W/9jEUmANlUExR
Effective URL: https://us.supersmart.com/article.pl?id=0681&fromid=2406_ST1&utm_source=newsletter_en&utm_medium=mail&utm_campaign=2406_ST...
Submission: On June 11 via api from US — Scanned from FR
Effective URL: https://us.supersmart.com/article.pl?id=0681&fromid=2406_ST1&utm_source=newsletter_en&utm_medium=mail&utm_campaign=2406_ST...
Submission: On June 11 via api from US — Scanned from FR
Form analysis 7 forms found in the DOM
Name: search_form — GET /search.pl
<form method="get" name="search_form" id="search_form" action="/search.pl" class="project-form p-rel">
<input name="search" id="search" class="form-control abs-error 5s-error ui-autocomplete-input" type="text" placeholder="Search" maxlength="30" aria-label="What are you looking for ? (probiotics, diabetes, joints...)" autocomplete="off"><label
class="error-text mt-1"><span class="font--size-12" id="search_error"></span></label>
<span onclick="sendForm(0);" class="icon icon--search d-flex justify-content-center align-items-center">
<svg xmlns="http://www.w3.org/2000/svg" width="24" height="24" viewBox="0 0 24 24" fill="none">
<path d="M20.0002 20.0007L16.3765 16.377" stroke="#151517" stroke-width="1.5" stroke-linecap="round" stroke-linejoin="round"></path>
<path d="M4 11.25C4 15.2541 7.24594 18.5 11.25 18.5C15.2541 18.5 18.5 15.2541 18.5 11.25C18.5 7.24594 15.2541 4 11.25 4V4C7.24606 4.00029 4.00029 7.24606 4 11.25" stroke="#151517" stroke-width="1.5" stroke-linecap="round"
stroke-linejoin="round"></path>
</svg>
</span>
<span onclick="sendForm(1);" id="search_mobil" class="d-none">
<svg xmlns="http://www.w3.org/2000/svg" width="24" height="24" viewBox="0 0 24 24" fill="none">
<path d="M20.0002 20.0007L16.3765 16.377" stroke="#151517" stroke-width="1.5" stroke-linecap="round" stroke-linejoin="round"></path>
<path d="M4 11.25C4 15.2541 7.24594 18.5 11.25 18.5C15.2541 18.5 18.5 15.2541 18.5 11.25C18.5 7.24594 15.2541 4 11.25 4V4C7.24606 4.00029 4.00029 7.24606 4 11.25" stroke="#151517" stroke-width="1.5" stroke-linecap="round"
stroke-linejoin="round"></path>
</svg>
</span>
</form>Name: qteform — POST
<form method="post" name="qteform">
<div class="block--margin-tb-32 sur_btns" style="">
<div class="row">
<div onclick="switch_mode_achat(0);" class="col-6 block--padding-r-md-4">
<div id="div_achat_immediat" class="border-r block--padding-16 block--padding-md-12 block--height-100 border--primary block--height-100">
<p class="text-center text--primary font--size-18"> Buy now </p>
<p class="text-center text--black-600 font--size-14" style="margin-top:-5px;"> 90 Veg. Caps. </p>
<div class="d-flex justify-content-center align-items-center block--margin-tb-12">
<p class="text-center text--black-700 block--padding-l-8 font--weight-700">$35.00</p>
</div>
<div class="d-flex justify-content-center align-items-center block--margin-tb-12 cart-item__counter border-r mx-auto">
<input type="hidden" name="mode_achat" value="achat">
<input type="hidden" name="abo_art" value="0681">
<input type="hidden" name="se_souvenir" value="0">
<span class="cart-item__decrement bg--hover-primary d-flex align-items-center justify-content-center"
onclick="var p=parseInt(document.qteform.qty.value);if(p!=1)document.qteform.qty.value=p-1;document.qteform2.qty.value=document.qteform.qty.value;">
<svg xmlns="http://www.w3.org/2000/svg" width="24" height="24" viewBox="0 0 24 24" fill="none">
<path d="M19 12H5" stroke="#151517" stroke-width="1.71429" stroke-linecap="round"></path>
</svg>
</span>
<span class="cart-item__amount d-flex align-items-center">
<input class="cart-item__input text--black-700" type="text" value="1" name="qty">
</span>
<span class="cart-item__increment bg--hover-primary d-flex align-items-center justify-content-center" onclick="document.qteform.qty.value=parseInt(document.qteform.qty.value)+1;document.qteform2.qty.value=document.qteform.qty.value;">
<svg xmlns="http://www.w3.org/2000/svg" width="24" height="24" viewBox="0 0 24 24" fill="none">
<path d="M12 6V18" stroke="#151517" stroke-width="1.71429" stroke-linecap="round"></path>
<path d="M18 12H6H18Z" fill="#151517"></path>
<path d="M18 12H6" stroke="#151517" stroke-width="1.71429" stroke-linecap="round"></path>
</svg>
</span>
</div>
</div>
</div>
<div onclick="switch_mode_achat(1);" class="col-6 block--padding-l-md-4">
<div id="div_abonnement" class="border-r block--padding-16 block--padding-md-12 block--height-100 border--black-300">
<p class="text-center text--primary font--size-18"> Auto-delivery </p>
<p class="text-center text--black-600 font--size-14" style="margin-top:-5px;"> 90 Veg. Caps. </p>
<div class="d-flex justify-content-center align-items-center block--margin-tb-8">
<p class="text-center text--black-600 font--size-14 font--decoration-line-through">
<i>
$35.00
</i>
</p>
<p class="text-center text--black-700 block--padding-l-8 font--weight-700"> $32.20 </p>
</div>
<div>
<p class="justify-content-center d-flex align-items-center font--size-md-14">
<span style="white-space:nowrap"> I'd like </span>
<span class="text--primary block--margin-l-8 cursor--pointer border-b--primary-dashed">
<select name="abo_art_qt" id="abo_art_qt">
<option value="1" selected="">1 unit</option>
<option value="2">2 units</option>
<option value="3">3 units</option>
<option value="4">4 units</option>
<option value="5">5 units</option>
<option value="6">6 units</option>
<option value="7">7 units</option>
<option value="8">8 units</option>
<option value="9">9 units</option>
<option value="10">10 units</option>
</select>
</span>
<svg width="19" height="18" viewBox="0 0 19 18" fill="none" xmlns="http://www.w3.org/2000/svg">
<path d="M6.5 7.5L9.5 10.5L12.5 7.5" stroke="#151517" stroke-width="1.5" stroke-linecap="round" stroke-linejoin="round"></path>
</svg>
</p>
<p class="justify-content-center d-flex align-items-center font--size-md-14">
<span> every </span>
<span class="text--primary block--margin-l-8 cursor--pointer border-b--primary-dashed">
<select name="abo_art_freq" id="abo_art_freq">
<option value="1"> month</option>
<option value="2">2 months</option>
<option value="3">3 months</option>
<option value="4">4 months</option>
<option value="5">5 months</option>
<option value="6">6 months</option>
</select>
</span>
<svg width="19" height="18" viewBox="0 0 19 18" fill="none" xmlns="http://www.w3.org/2000/svg">
<path d="M6.5 7.5L9.5 10.5L12.5 7.5" stroke="#151517" stroke-width="1.5" stroke-linecap="round" stroke-linejoin="round"></path>
</svg>
</p>
</div>
</div>
</div>
</div>
</div>
</form>Name: qteform2 —
<form name="qteform2" class="cart-item__counter d-flex align-items-center border-r">
<span class="cart-item__decrement bg--hover-primary d-flex align-items-center justify-content-center"
onclick="var p=parseInt(document.qteform2.qty.value);if(p!=1)document.qteform2.qty.value=p-1;document.qteform.qty.value=document.qteform2.qty.value;prix_et_monnaie();">
<svg xmlns="http://www.w3.org/2000/svg" width="24" height="24" viewBox="0 0 24 24" fill="none">
<path d="M19 12H5" stroke="#151517" stroke-width="1.71429" stroke-linecap="round"></path>
</svg>
</span>
<span class="cart-item__amount d-flex align-items-center">
<input class="cart-item__input text--black-700" type="text" value="1" name="qty">
</span>
<span class="cart-item__increment bg--hover-primary d-flex align-items-center justify-content-center"
onclick="document.qteform2.qty.value=parseInt(document.qteform2.qty.value)+1;document.qteform.qty.value=document.qteform2.qty.value;prix_et_monnaie();">
<svg xmlns="http://www.w3.org/2000/svg" width="24" height="24" viewBox="0 0 24 24" fill="none">
<path d="M12 6V18" stroke="#151517" stroke-width="1.71429" stroke-linecap="round"></path>
<path d="M18 12H6H18Z" fill="#151517"></path>
<path d="M18 12H6" stroke="#151517" stroke-width="1.71429" stroke-linecap="round"></path>
</svg>
</span>
</form>POST /inscription.pl
<form action="/inscription.pl" method="POST" class="supersmart-form" id="sub_home" onsubmit="return check_nwsltr_form(this);">
<div class="p-rel newsletter-subscribe d-flex align-items-center">
<input type="hidden" name="op" value="newsletters">
<input type="hidden" name="civ" value="1">
<input type="hidden" name="nom" value="">
<input type="hidden" name="prenom" value="">
<input type="email" id="sub_email" name="email" aria-label="email, Newsletter" class="newsletter-subscribe__input-text" placeholder="Enter your email address here">
<input type="submit" aria-label="Register" class="newsletter-subscribe__submit p-abs font-roboto-bold" value="Send">
</div>
</form>Name: form — POST https://us.supersmart.com/login.pl
<form method="post" action="https://us.supersmart.com/login.pl" name="form" onsubmit="return check_login_form(form);">
<input type="hidden" name="from" value="a0681">
<div class="modal-content bg--white block--padding-24">
<span class="modal-close block--pointer p-abs" data-bs-dismiss="modal">
<svg xmlns="http://www.w3.org/2000/svg" width="16" height="16" viewBox="0 0 16 16" fill="none">
<path d="M14.6653 14.6673L1.33203 1.33398" stroke="#151517" stroke-width="1.71" stroke-linecap="round" stroke-linejoin="round"></path>
<path d="M1.33203 14.6673L14.6653 1.33398" stroke="#151517" stroke-width="1.71" stroke-linecap="round" stroke-linejoin="round"></path>
</svg>
</span>
<h3 class="heading-3 block--mb-32 text--primary" id="titre_modal_cb"> Login </h3>
<div class="row">
<div class="col-12 block--mb-16">
<input placeholder="Email" type="email" class="form-control" name="i_email" size="15" maxlength="50" value="" id="i_email"
onkeyup="if (this.value.search(/^[a-zA-Z0-9_.@-]*$/i) == -1) {if($(this).closest('.w3-modal').css('display')=='block'){jalert('Invalid character')};this.value=this.value.replace(/[^a-zA-Z0-9_.@-]/gi, '');}"
onchange="$('#mdp_email').val(this.value);$('#email').val(this.value);"><label class="error-text mt-1"><span class="font--size-12" id="i_email_error"></span></label>
</div>
<div class="col-12 block--mb-16 p-rel">
<input placeholder="Password" type="password" name="i_password" size="15" maxlength="20" id="i_password" class="form-control" value=""><label class="error-text mt-1"><span class="font--size-12" id="i_password_error"></span></label>
<span class="ss-reveal" target="i_password">
<svg xmlns="http://www.w3.org/2000/svg" width="24" height="24" viewBox="0 0 24 24">
<path fill="#9E9E9E"
d="M12.015 7c4.751 0 8.063 3.012 9.504 4.636-1.401 1.837-4.713 5.364-9.504 5.364-4.42 0-7.93-3.536-9.478-5.407 1.493-1.647 4.817-4.593 9.478-4.593zm0-2c-7.569 0-12.015 6.551-12.015 6.551s4.835 7.449 12.015 7.449c7.733 0 11.985-7.449 11.985-7.449s-4.291-6.551-11.985-6.551zm-.015 3c-2.209 0-4 1.792-4 4 0 2.209 1.791 4 4 4s4-1.791 4-4c0-2.208-1.791-4-4-4z">
</path>
</svg>
</span>
</div>
<div class="col-12 block--mb-16 text--tiny">
<a href="/en/mdp_oublie" class="" title="Forgotten your password?">Password Forgotten ?</a>
</div>
<div class="col-12 block--mb-16">
<input type="submit" value="Log in" class="w-100 btn btn--primary" style="border-radius:0.8rem">
</div>
<div class="col-12 block--mb-16 text--tiny"> New customer? <a href="#" data-bs-toggle="modal" data-bs-target="#modal_inscription" class="text--primary text--underline" title="Create account">Create account</a>
</div>
</div>
</div>
</form>Name: form_insc — POST /inscription.pl
<form method="post" action="/inscription.pl" name="form_insc" onsubmit="if(check_insc_form(form_insc) ){ jyesno('Confirm your registration ?','Yes','No','form_insc.submit()')}return false">
<input type="hidden" name="op" value="inscription">
<input type="hidden" name="pays" value="FR">
<input type="hidden" name="from" value="a0681">
<div class="modal-content bg--white block--padding-24">
<span class="modal-close block--pointer p-abs" data-bs-dismiss="modal">
<svg xmlns="http://www.w3.org/2000/svg" width="16" height="16" viewBox="0 0 16 16" fill="none">
<path d="M14.6653 14.6673L1.33203 1.33398" stroke="#151517" stroke-width="1.71" stroke-linecap="round" stroke-linejoin="round"></path>
<path d="M1.33203 14.6673L14.6653 1.33398" stroke="#151517" stroke-width="1.71" stroke-linecap="round" stroke-linejoin="round"></path>
</svg>
</span>
<h3 class="heading-3 block--mb-32 text--primary" id="titre_modal_cb"> Registration </h3>
<div class="row">
<div class="col-12 block--mb-16">
<input placeholder="Email" type="email" class="form-control" name="email" size="15" maxlength="50" value="" id="email"
onkeyup="if (this.value.search(/^[a-zA-Z0-9_.@-]*$/i) == -1) {if($(this).closest('.w3-modal').css('display')=='block'){jalert('Invalid character')};this.value=this.value.replace(/[^a-zA-Z0-9_.@-]/gi, '');}"
onchange="$('#mdp_email').val(this.value);$('#email').val(this.value);"><label class="error-text mt-1"><span class="font--size-12" id="email_error"></span></label>
</div>
<div class="col-12 block--mb-16">
<div class="form-select--general block--width-100 text--black-500">
<select class="form-select--search form-control" name="civ" id="civ" data-id="ss-7c8j3sus" tabindex="-1" aria-hidden="true" style="display: none;">
<option value="" disabled="" selected="">Please enter your title</option>
<option value="1">Mr</option>
<option value="2">Mrs</option>
<option value="4">Mr and Mrs</option>
<option value="5">Dr</option>
<option value="8">Professor</option>
</select>
<div data-id="ss-7c8j3sus" id="ss-7c8j3sus" tabindex="0" class="ss-main form-select--search form-control" role="combobox" aria-haspopup="listbox" aria-controls="ss-7c8j3sus" aria-expanded="false" aria-activedescendant="bdiruo99">
<div class="ss-values">
<div class="ss-single">Please enter your title</div>
</div>
<div class="ss-deselect ss-hide"><svg viewBox="0 0 100 100">
<path d="M10,10 L90,90 M10,90 L90,10"></path>
</svg></div><svg class="ss-arrow" viewBox="0 0 100 100">
<path d="M10,30 L50,70 L90,30"></path>
</svg>
</div><label class="error-text mt-1"><span class="font--size-12" id="civ_error"></span></label>
</div>
</div>
<div class="col-12 block--mb-16">
<input placeholder="Last Name" type="text" class="form-control" name="nom" id="nom" size="50" maxlength="200" value=""
onkeyup="if (this.value.search(/^[A-ZÑ0-9&@. ''-]*$/i) == -1) {if($(this).closest('.w3-modal').css('display')=='block'){jalert('Invalid character')};this.value=this.value.replace(/[^A-ZÑ0-9&@. ''-]/gi, '');}"><label
class="error-text mt-1"><span class="font--size-12" id="nom_error"></span></label>
</div>
<div class="col-12 block--mb-16">
<input placeholder="First Name" type="text" class="form-control" name="prenom" id="prenom" size="50" maxlength="200" value=""
onkeyup="if (this.value.search(/^[0-9a-zàáâãäåæçèéêëìíîïðñòóôõöøœšÞùúûüýÿA-ZÀÁÂÃÄÅÆßÇČÈÉÊËĞÏÍÌÎÐÑÖÓÒÔŐÕØŒŠÞÜÚÙÛÝŸŽ&. ''-]*$/i) == -1) {if($(this).closest('.w3-modal').css('display')=='block'){jalert('Invalid character')};this.value=this.value.replace(/[^0-9a-zàáâãäåæçèéêëìíîïðñòóôõöøœšÞùúûüýÿA-ZÀÁÂÃÄÅÆßÇČÈÉÊËĞÏÍÌÎÐÑÖÓÒÔŐÕØŒŠÞÜÚÙÛÝŸŽ&. ''-]/gi, '');}"><label
class="error-text mt-1"><span class="font--size-12" id="prenom_error"></span></label>
</div>
<div class="col-12 block--mb-16 p-rel">
<input placeholder="Password" type="password" name="password" size="15" maxlength="20" id="password" class="form-control" value=""><label class="error-text mt-1"><span class="font--size-12" id="password_error"></span></label>
<span class="ss-reveal" target="password">
<svg xmlns="http://www.w3.org/2000/svg" width="24" height="24" viewBox="0 0 24 24">
<path fill="#9E9E9E"
d="M12.015 7c4.751 0 8.063 3.012 9.504 4.636-1.401 1.837-4.713 5.364-9.504 5.364-4.42 0-7.93-3.536-9.478-5.407 1.493-1.647 4.817-4.593 9.478-4.593zm0-2c-7.569 0-12.015 6.551-12.015 6.551s4.835 7.449 12.015 7.449c7.733 0 11.985-7.449 11.985-7.449s-4.291-6.551-11.985-6.551zm-.015 3c-2.209 0-4 1.792-4 4 0 2.209 1.791 4 4 4s4-1.791 4-4c0-2.208-1.791-4-4-4z">
</path>
</svg>
</span>
</div>
<div class="col-12 block--mb-16">
<input type="text" class="form-control" name="nee" id="nee" size="50" maxlength="50" value="" placeholder="Date of birth :" onfocus="(this.type='date')" onblur="if(!this.value){(this.type='text')}"><label class="error-text mt-1"><span
class="font--size-12" id="nee_error"></span></label>
</div>
<div class="col-12 block--mb-16">
<input type="text" class="form-control" name="code_option" id="code_option" size="50" maxlength="50" value="" placeholder="sponsor code / prescriber code"><label class="error-text mt-1"><span class="font--size-12"
id="code_option_error"></span></label>
</div>
<div class="col-12 block--mb-16">
<input type="submit" value="Confirm my registration" class="w-100 btn btn--primary" style="border-radius:0.8rem">
</div>
<div class="col-12 block--mb-16 text--tiny"> Existing customer? <a href="#" data-bs-toggle="modal" data-bs-target="#modal_connexion" class="text--primary text--underline" title="Log in">Log in</a>
</div>
</div>
</div>
</form>Name: n_form — POST /inscription.pl
<form method="post" action="/inscription.pl" name="n_form" onsubmit="return check_newsletter_form(n_form);">
<input type="hidden" name="from" value="a0681">
<div class="modal-content bg--white block--padding-24">
<span class="modal-close block--pointer p-abs" data-bs-dismiss="modal">
<svg xmlns="http://www.w3.org/2000/svg" width="16" height="16" viewBox="0 0 16 16" fill="none">
<path d="M14.6653 14.6673L1.33203 1.33398" stroke="#151517" stroke-width="1.71" stroke-linecap="round" stroke-linejoin="round"></path>
<path d="M1.33203 14.6673L14.6653 1.33398" stroke="#151517" stroke-width="1.71" stroke-linecap="round" stroke-linejoin="round"></path>
</svg>
</span>
<h3 class="heading-3 block--mb-16 text--primary"> Join the SuperSmart club </h3>
<div class="row">
<div class="col-12 block--mb-16">
<ul>
<li>Permanent <strong>5% Off on all your Orders!</strong></li>
<li>Free: our weekly science-based newsletter </li>
<li><strong>Special Offers</strong> for club members only</li>
</ul>
</div>
</div>
<div class="row">
<div class="col-12 block--mb-16">
<input type="hidden" name="op" value="newsletters">
<input type="hidden" name="civ" value="1">
<input type="hidden" name="nom" value="">
<input type="hidden" name="prenom" value="">
<input type="hidden" name="from" value="a0681">
<input placeholder="Email" type="email" class="form-control" name="email" size="15" maxlength="50" value="" id="n_email"
onkeyup="if (this.value.search(/^[a-zA-Z0-9_.@-]*$/i) == -1) {if($(this).closest('.w3-modal').css('display')=='block'){falert('Invalid character'),'n_email'};this.value=this.value.replace(/[^a-zA-Z0-9_.@-]/gi, '');}"><label
class="error-text mt-1"><span class="font--size-12" id="n_email_error"></span></label>
</div>
<div class="col-12 block--mb-16">
<input type="submit" value="I wish to register" class="w-100 btn btn--primary" style="border-radius:0.8rem">
</div>
<div class="col-12 block--mb-16 form-check">
<input type="checkbox" name="mailing_check" id="mailing_check">
<label class="label-md text--tiny" for="mailing_check"> I agree to receive promotional offers from SuperSmart. I can unsubscribe at any time. </label>
</div>
</div>
</div>
</form>Text Content
0
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WSMUS
38096001
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Certificate of AnalysisBest before : 06/30/2026
Longevity (Anti-aging)
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AMPK BOOSTER
AMPK SUPPLEMENT DESIGNED TO COMBAT AGING
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AMPK Booster supplement that combats aging and metabolic decline.
* Plays a fundamental role in energy homeostasis and supports longevity.
* Designed to replicate the effects of calorie restriction, particularly the
development of excess fat.
* Helps adults recapture a certain youthfulness without causing side effects.
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90 Veg. Caps.
$35.00
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No controversial excipients
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* Description
* Composition
* Directions for use
* References
Our AMPK supplement is an innovative formulation that combines the most
effective activators – or reactivators – of cellular AMP-activated protein
kinase, also known as AMPK, and promotes health and longevity.
WHAT ARE THE BENEFITS OF AMPK SUPPLEMENTS?
Inside each of our cells is a key metabolism enzyme called AMPK (adenosine
monophosphate-activated protein kinase), which plays a fundamental role in
energy homeostasis and supports longevity, essentially.
AMPK is expressed in a number of body parts – the liver, the brain, and muscles
– where it functions like a metabolic master switch, regulating several
intracellular systems.
AMPK benefits, more specifically, are as follows:
* Can help delay aging, as shown in animal studies.
* Lowers blood sugar levels by increasing cellular glucose uptake. More
specifically, research shows it promotes glucose production coming from the
liver and also uptake to the muscles.
* Studies show an AMPK booster may inhibit the synthesis of surplus fats.
* Reduces triglyceride levels in the blood. Studies indicate it also inhibits
fatty acid production.
* Combats liver degeneration and increases fat oxidation, according to
research.
* May spur an increase in the number of new, healthy mitochondria. Studies
suggest that autophagy occurs more frequently, allowing quick removal of the
misfolded and damaged proteins or mitochondria to make room for healthier
cellular components.
* Studies further suggest AMPK may inhibit protein production during low energy
times in order to conserve energy for later. And this helps cells become less
wasteful and more efficient.
As studies show, boosting the activity of AMPK can have several positive effects
on the body. Our AMPK supplement is designed to activate or reactivate AMPK via
the action of barberry, jiaogulan, and Rhus succedanea. Together, these
constitute a natural, effective formulation for supporting overall health.
You may also be interested in two other natural extracts available to buy at
SuperSmart for improving your general state of health and combating the aging
process: Astragalus Extract and Reishi Extract.
OUR AMPK ACTIVATOR'S INGREDIENTS
Restoring AMPK enzyme activity may not only help you recapture a certain
youthfulness; it may also help you combat the development of excess fat. When
you boost AMPK, cells are thrown into survival mode and stop storing new fat.
Instead, they burn stored fat – similar to what a calorie restriction does.
As far as how to boost AMPK, our AMPK Booster supplement combines three plant
extracts able to reactivate this cellular enzyme. Those three ingredients are as
follows:
GYNOSTEMMA PENTAPHYLLUM
What is gynostemma pentaphyllum?
Gynostemma pentaphyllum (or jiaogulan), standardized in gypenosides, has also
demonstrated AMPK-activating capacity. Used in traditional Asian medicine, this
plant is sometimes called the "immortality herb," both because it increases
longevity and has a number of other properties conferring antioxidant, adaptogen
and anti-atherosclerotic effects.
Gynostemma pentaphyllum has been heavily researched:
* Scientists observed that in activating AMPK, administration of this herb led
to an increase in fat-burning and an uptick in cellular glucose uptake.
* In a pre-clinical trial, obese mice given gynostemma pentaphyllum showed
impressive reductions in signs of excessive weight gain.
* Obese rats supplemented for just four days showed reductions in
triglycerides, total cholesterol, LDL-cholesterol and post-prandial blood
sugar, compared with a control group.
Combined, these results show how the activation of AMPK produces huge benefits
in reducing circulating sugar and fats. And human studies have found similar
results: gynostemma pentaphyllum boosts AMPK activity, which may lead to certain
long-term health benefits.
FISETIN
Our natural AMPK activator also contains fisetin, a flavonoid extracted from
Rhus succedanea that sends a switch-on signal (like epitalon) to longevity
transporter genes in a way similar to calorie restriction but without the need
to make dietary changes.
BERBERINE
Berberine (Berberis vulgaris), an isoquinoline alkaloid, scientifically
demonstrated to be one of the best AMPK-activators, which acts on a number of
parameters.
Further confirmation of berberine's AMPK-activating efficacy comes from recent
studies that showed it promoted the multimerization of adiponectin in adipocytes
into high molecular weight (HMW) multimers. These have greater metabolic
activity and are closely associated with pancreatic hormone sensitivity of
cells.
Even though berberine inhibits adiponectin expression, its activation of AMPK
promotes multimerization of adiponectin and thus helps combat the development of
excess fat.
More specifically, berberine:
* Helps balance energy metabolism and control dietary intake.
li>Improves cell sensitivity to the pancreatic hormone by increasing
production of the transporter GLUT4.
* Stimulates fatty acid metabolism in the mitochondria.
WHY IS BOOSTING AMPK IMPORTANT?
As we get older, activation of cellular AMPK declines. This can spur the
development of surplus fat, as AMPK determines body fat composition. In order to
combat the aging process, it is therefore essential to restore AMPK production,
and there are various ways of doing this, such as physical exercise and calorie
restriction, in addition to supporting those efforts with the right dietary
supplements.
Most Western societies today are facing a significant problem with
over-consumption. Eating too many calories impairs vital functions, such as
healthy uptake of glucose and fat from the blood and leads to the accumulation
of cellular waste and changes to longevity genes.
Oftentimes, this results in the development of surplus fat. Few people are able
to successfully maintain long-term calorie restriction, and so the research by
scientists of AMPK activation supplements is extremely helpful. When activated,
this cellular enzyme mimics calorie restriction and may even lead to a decrease
in body fat. Pre-clinical research has shown that boosting AMPK activity is
associated with:
* A reduction in lipogenesis (storage of fat, particularly abdominal fat);
* Stimulation of fatty acid oxidation;
* An increase in sensitivity to the hormone that regulates blood sugar levels;
* A change in secretion of the blood sugar regulating hormone by pancreatic
beta cells;
* Improved glucose absorption by cells;
* Enhanced activation of the SIRT1 enzyme and of the P53 tumor-suppressor gene.
As more research is performed, we expect to learn more benefits of AMPK booster
supplements.
WHAT ARE THE SIDE EFFECTS OF AMPK BOOSTER?
You want the strongest AMPK activator to achieve maximum benefits, but it is
also important to understand any possible side effects of jiaogulan AMPK
products. While our AMPK supplement is considered safe for most healthy adults,
it's still important to do your own research.
Talk to your healthcare provider before you start taking an AMPK activator
berberine gynostemma la-3 supplement. Your physician will want to know what
products are in the AMPK activator supplement and will determine how it may
interact with other supplements, prescriptions or health issues you have.
If you notice any strange symptoms after you start taking a gynostemma
pentaphyllum AMPK supplement, you should stop using it immediately and talk to
your healthcare provider.
Additionally, there has been minimal research related to pregnant or
breastfeeding women taking AMPK boosters. For this reason, we advise against
taking them unless otherwise directed by your doctor.
These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.
Daily dose: 3 capsules
Number of doses per pack: 30 Amount per dose Extract of Gynostemma pentaphyllum
standardized to 98% gypenosides 550 mg Extract of Berberis vulgaris standardized
to 97% berberine 600 mg Extract of Rhus succedanea stem standardized to 98%
fisetin 70 mg Other ingredients: acacia gum, white rice flour.
HOW TO TAKE OUR AMPK SUPPLEMENT?
Regardless of whether or not you are already taking an AMPK booster or it is
your first time, it is vital to follow the directions on the package. At
SuperSmart, we recommend adults to take 2 capsules every day with lunch and 1
other capsule with dinner. That dosage means that you will use capsules each
day, giving you a month's supply of our supplement.
We do not put anything artificial in this supplement and believe in complete
transparency when it comes to the ingredients that we use.
Additionally, you should store this supplement out of direct sunlight to ensure
potency. Keep it in a dry, dark location for the best results. Once this
supplement reaches its "best by" date, it is time to dispose of it and purchase
a new bottle. And, as always, keep all supplements out of the reach of children
and pets.
* Stancu AL. AMPK activation can delay aging. Discoveries (Craiova).
2015;3(4):e53. Published 2015 Dec 31. doi:10.15190/d.2015.45
* Huynh MK, Kinyua AW, Yang DJ, Kim KW. Hypothalamic AMPK as a Regulator of
Energy Homeostasis. Neural Plast. 2016;2016:2754078. doi:10.1155/2016/2754078
* Richter EA, Ruderman NB. AMPK and the biochemistry of exercise: implications
for human health and disease. Biochem J. 2009;418(2):261-275.
doi:10.1042/BJ20082055
* Jeon SM. Regulation and function of AMPK in physiology and diseases. Exp Mol
Med. 2016;48(7):e245. Published 2016 Jul 15. doi:10.1038/emm.2016.81
* Foretz M, Even PC, Viollet B. AMPK Activation Reduces Hepatic Lipid Content
by Increasing Fat Oxidation In Vivo. Int J Mol Sci. 2018;19(9):2826.
Published 2018 Sep 19. doi:10.3390/ijms19092826
* Burkewitz K, Zhang Y, Mair WB. AMPK at the nexus of energetics and aging.
Cell Metab. 2014;20(1):10-25. doi:10.1016/j.cmet.2014.03.002
* Jeon SM. Regulation and function of AMPK in physiology and diseases. Exp Mol
Med. 2016;48(7):e245. Published 2016 Jul 15. doi:10.1038/emm.2016.81
* Park SH, Huh TL, Kim SY, et al. Antiobesity effect of Gynostemma pentaphyllum
extract (actiponin): a randomized, double-blind, placebo-controlled trial
[published correction appears in Obesity (Silver Spring). 2015
Dec;23(12):2520] [published correction appears in Obesity (Silver Spring).
2020 Sep;28(9):1770-1773]. Obesity (Silver Spring). 2014;22(1):63-71.
doi:10.1002/oby.20539
* Lee HS, Lim SM, Jung JI, et al. Gynostemma Pentaphyllum Extract Ameliorates
High-Fat Diet-Induced Obesity in C57BL/6N Mice by Upregulating SIRT1.
Nutrients. 2019;11(10):2475. Published 2019 Oct 15. doi:10.3390/nu11102475
* Megalli S, Davies NM, Roufogalis BD. Anti-hyperlipidemic and hypoglycemic
effects of Gynostemma pentaphyllum in the Zucker fatty rat. J Pharm Pharm
Sci. 2006;9(3):281-291.
* Gao D, Zhao M, Qi X, et al. Hypoglycemic effect of Gynostemma pentaphyllum
saponins by enhancing the Nrf2 signaling pathway in STZ-inducing diabetic
rats. Arch Pharm Res. 2016;39(2):221-230. doi:10.1007/s12272-014-0441-2
* Nguyen PH, Gauhar R, Hwang SL, et al. New dammarane-type glucosides as
potential activators of AMP-activated protein kinase (AMPK) from Gynostemma
pentaphyllum. Bioorg Med Chem. 2011;19(21):6254-6260.
doi:10.1016/j.bmc.2011.09.013
* Jang J, Jung Y, Seo SJ, et al. Berberine activates AMPK to suppress
proteolytic processing, nuclear translocation and target DNA binding of
SREBP-1c in 3T3-L1 adipocytes. Mol Med Rep. 2017;15(6):4139-4147.
doi:10.3892/mmr.2017.6513
* Zhu X, Bian H, Gao X. The Potential Mechanisms of Berberine in the Treatment
of Nonalcoholic Fatty Liver Disease. Molecules. 2016;21(10):1336. Published
2016 Oct 14. doi:10.3390/molecules21101336
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