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Effective URL: https://www.mdpi.com/
Submission: On June 03 via api from US — Scanned from DE
Effective URL: https://www.mdpi.com/
Submission: On June 03 via api from US — Scanned from DE
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<div id="js-action-disabled-modal-submit" class="small-12 columns" style="margin-top: 10px; display: none;"> You can make submissions to other journals <a href="https://susy.mdpi.com/user/manuscripts/upload">here</a>. </div>
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<select id="journal" tabindex="-1" name="journal" class="chosen-select" style="display: none;">
<option value="">All Journals</option>
<option value="acoustics"> Acoustics </option>
<option value="amh"> Acta Microbiologica Hellenica (AMH) </option>
<option value="actuators"> Actuators </option>
<option value="admsci"> Administrative Sciences </option>
<option value="adolescents"> Adolescents </option>
<option value="arm"> Advances in Respiratory Medicine (ARM) </option>
<option value="aerobiology"> Aerobiology </option>
<option value="aerospace"> Aerospace </option>
<option value="agriculture"> Agriculture </option>
<option value="agriengineering"> AgriEngineering </option>
<option value="agrochemicals"> Agrochemicals </option>
<option value="agronomy"> Agronomy </option>
<option value="ai"> AI </option>
<option value="air"> Air </option>
<option value="algorithms"> Algorithms </option>
<option value="allergies"> Allergies </option>
<option value="alloys"> Alloys </option>
<option value="analytica"> Analytica </option>
<option value="analytics"> Analytics </option>
<option value="anatomia"> Anatomia </option>
<option value="anesthres"> Anesthesia Research </option>
<option value="animals"> Animals </option>
<option value="antibiotics"> Antibiotics </option>
<option value="antibodies"> Antibodies </option>
<option value="antioxidants"> Antioxidants </option>
<option value="applbiosci"> Applied Biosciences </option>
<option value="applmech"> Applied Mechanics </option>
<option value="applmicrobiol"> Applied Microbiology </option>
<option value="applnano"> Applied Nano </option>
<option value="applsci"> Applied Sciences </option>
<option value="asi"> Applied System Innovation (ASI) </option>
<option value="appliedchem"> AppliedChem </option>
<option value="appliedmath"> AppliedMath </option>
<option value="aquacj"> Aquaculture Journal </option>
<option value="architecture"> Architecture </option>
<option value="arthropoda"> Arthropoda </option>
<option value="arts"> Arts </option>
<option value="astronomy"> Astronomy </option>
<option value="atmosphere"> Atmosphere </option>
<option value="atoms"> Atoms </option>
<option value="audiolres"> Audiology Research </option>
<option value="automation"> Automation </option>
<option value="axioms"> Axioms </option>
<option value="bacteria"> Bacteria </option>
<option value="batteries"> Batteries </option>
<option value="behavsci"> Behavioral Sciences </option>
<option value="beverages"> Beverages </option>
<option value="BDCC"> Big Data and Cognitive Computing (BDCC) </option>
<option value="biochem"> BioChem </option>
<option value="bioengineering"> Bioengineering </option>
<option value="biologics"> Biologics </option>
<option value="biology"> Biology </option>
<option value="blsf"> Biology and Life Sciences Forum </option>
<option value="biomass"> Biomass </option>
<option value="biomechanics"> Biomechanics </option>
<option value="biomed"> BioMed </option>
<option value="biomedicines"> Biomedicines </option>
<option value="biomedinformatics"> BioMedInformatics </option>
<option value="biomimetics"> Biomimetics </option>
<option value="biomolecules"> Biomolecules </option>
<option value="biophysica"> Biophysica </option>
<option value="biosensors"> Biosensors </option>
<option value="biotech"> BioTech </option>
<option value="birds"> Birds </option>
<option value="blockchains"> Blockchains </option>
<option value="brainsci"> Brain Sciences </option>
<option value="buildings"> Buildings </option>
<option value="businesses"> Businesses </option>
<option value="carbon"> C </option>
<option value="cancers"> Cancers </option>
<option value="cardiogenetics"> Cardiogenetics </option>
<option value="catalysts"> Catalysts </option>
<option value="cells"> Cells </option>
<option value="ceramics"> Ceramics </option>
<option value="challenges"> Challenges </option>
<option value="ChemEngineering"> ChemEngineering </option>
<option value="chemistry"> Chemistry </option>
<option value="chemproc"> Chemistry Proceedings </option>
<option value="chemosensors"> Chemosensors </option>
<option value="children"> Children </option>
<option value="chips"> Chips </option>
<option value="civileng"> CivilEng </option>
<option value="cleantechnol"> Clean Technologies (Clean Technol.) </option>
<option value="climate"> Climate </option>
<option value="ctn"> Clinical and Translational Neuroscience (CTN) </option>
<option value="clinpract"> Clinics and Practice </option>
<option value="clockssleep"> Clocks & Sleep </option>
<option value="coasts"> Coasts </option>
<option value="coatings"> Coatings </option>
<option value="colloids"> Colloids and Interfaces </option>
<option value="colorants"> Colorants </option>
<option value="commodities"> Commodities </option>
<option value="complications"> Complications </option>
<option value="compounds"> Compounds </option>
<option value="computation"> Computation </option>
<option value="csmf"> Computer Sciences & Mathematics Forum </option>
<option value="computers"> Computers </option>
<option value="condensedmatter"> Condensed Matter </option>
<option value="conservation"> Conservation </option>
<option value="constrmater"> Construction Materials </option>
<option value="cmd"> Corrosion and Materials Degradation (CMD) </option>
<option value="cosmetics"> Cosmetics </option>
<option value="covid"> COVID </option>
<option value="crops"> Crops </option>
<option value="cryptography"> Cryptography </option>
<option value="crystals"> Crystals </option>
<option value="cimb"> Current Issues in Molecular Biology (CIMB) </option>
<option value="curroncol"> Current Oncology </option>
<option value="dairy"> Dairy </option>
<option value="data"> Data </option>
<option value="dentistry"> Dentistry Journal </option>
<option value="dermato"> Dermato </option>
<option value="dermatopathology"> Dermatopathology </option>
<option value="designs"> Designs </option>
<option value="diabetology"> Diabetology </option>
<option value="diagnostics"> Diagnostics </option>
<option value="dietetics"> Dietetics </option>
<option value="digital"> Digital </option>
<option value="disabilities"> Disabilities </option>
<option value="diseases"> Diseases </option>
<option value="diversity"> Diversity </option>
<option value="dna"> DNA </option>
<option value="drones"> Drones </option>
<option value="ddc"> Drugs and Drug Candidates (DDC) </option>
<option value="dynamics"> Dynamics </option>
<option value="earth"> Earth </option>
<option value="ecologies"> Ecologies </option>
<option value="econometrics"> Econometrics </option>
<option value="economies"> Economies </option>
<option value="education"> Education Sciences </option>
<option value="electricity"> Electricity </option>
<option value="electrochem"> Electrochem </option>
<option value="electronicmat"> Electronic Materials </option>
<option value="electronics"> Electronics </option>
<option value="ecm"> Emergency Care and Medicine </option>
<option value="encyclopedia"> Encyclopedia </option>
<option value="endocrines"> Endocrines </option>
<option value="energies"> Energies </option>
<option value="eng"> Eng </option>
<option value="engproc"> Engineering Proceedings </option>
<option value="entropy"> Entropy </option>
<option value="environsciproc"> Environmental Sciences Proceedings </option>
<option value="environments"> Environments </option>
<option value="epidemiologia"> Epidemiologia </option>
<option value="epigenomes"> Epigenomes </option>
<option value="ebj"> European Burn Journal (EBJ) </option>
<option value="ejihpe"> European Journal of Investigation in Health, Psychology and Education (EJIHPE) </option>
<option value="fermentation"> Fermentation </option>
<option value="fibers"> Fibers </option>
<option value="fintech"> FinTech </option>
<option value="fire"> Fire </option>
<option value="fishes"> Fishes </option>
<option value="fluids"> Fluids </option>
<option value="foods"> Foods </option>
<option value="forecasting"> Forecasting </option>
<option value="forensicsci"> Forensic Sciences </option>
<option value="forests"> Forests </option>
<option value="fossstud"> Fossil Studies </option>
<option value="foundations"> Foundations </option>
<option value="fractalfract"> Fractal and Fractional (Fractal Fract) </option>
<option value="fuels"> Fuels </option>
<option value="future"> Future </option>
<option value="futureinternet"> Future Internet </option>
<option value="futurepharmacol"> Future Pharmacology </option>
<option value="futuretransp"> Future Transportation </option>
<option value="galaxies"> Galaxies </option>
<option value="games"> Games </option>
<option value="gases"> Gases </option>
<option value="gastroent"> Gastroenterology Insights </option>
<option value="gastrointestdisord"> Gastrointestinal Disorders </option>
<option value="gastronomy"> Gastronomy </option>
<option value="gels"> Gels </option>
<option value="genealogy"> Genealogy </option>
<option value="genes"> Genes </option>
<option value="geographies"> Geographies </option>
<option value="geohazards"> GeoHazards </option>
<option value="geomatics"> Geomatics </option>
<option value="geometry"> Geometry </option>
<option value="geosciences"> Geosciences </option>
<option value="geotechnics"> Geotechnics </option>
<option value="geriatrics"> Geriatrics </option>
<option value="glacies"> Glacies </option>
<option value="gucdd"> Gout, Urate, and Crystal Deposition Disease (GUCDD) </option>
<option value="grasses"> Grasses </option>
<option value="hardware"> Hardware </option>
<option value="healthcare"> Healthcare </option>
<option value="hearts"> Hearts </option>
<option value="hemato"> Hemato </option>
<option value="hematolrep"> Hematology Reports </option>
<option value="heritage"> Heritage </option>
<option value="histories"> Histories </option>
<option value="horticulturae"> Horticulturae </option>
<option value="hospitals"> Hospitals </option>
<option value="humanities"> Humanities </option>
<option value="humans"> Humans </option>
<option value="hydrobiology"> Hydrobiology </option>
<option value="hydrogen"> Hydrogen </option>
<option value="hydrology"> Hydrology </option>
<option value="hygiene"> Hygiene </option>
<option value="immuno"> Immuno </option>
<option value="idr"> Infectious Disease Reports </option>
<option value="informatics"> Informatics </option>
<option value="information"> Information </option>
<option value="infrastructures"> Infrastructures </option>
<option value="inorganics"> Inorganics </option>
<option value="insects"> Insects </option>
<option value="instruments"> Instruments </option>
<option value="ijerph"> International Journal of Environmental Research and Public Health (IJERPH) </option>
<option value="ijfs"> International Journal of Financial Studies (IJFS) </option>
<option value="ijms"> International Journal of Molecular Sciences (IJMS) </option>
<option value="IJNS"> International Journal of Neonatal Screening (IJNS) </option>
<option value="ijpb"> International Journal of Plant Biology (IJPB) </option>
<option value="ijt"> International Journal of Topology </option>
<option value="ijtm"> International Journal of Translational Medicine (IJTM) </option>
<option value="ijtpp"> International Journal of Turbomachinery, Propulsion and Power (IJTPP) </option>
<option value="ime"> International Medical Education (IME) </option>
<option value="inventions"> Inventions </option>
<option value="IoT"> IoT </option>
<option value="ijgi"> ISPRS International Journal of Geo-Information (IJGI) </option>
<option value="J"> J </option>
<option value="jal"> Journal of Ageing and Longevity (JAL) </option>
<option value="jcdd"> Journal of Cardiovascular Development and Disease (JCDD) </option>
<option value="jcto"> Journal of Clinical & Translational Ophthalmology (JCTO) </option>
<option value="jcm"> Journal of Clinical Medicine (JCM) </option>
<option value="jcs"> Journal of Composites Science (J. Compos. Sci.) </option>
<option value="jcp"> Journal of Cybersecurity and Privacy (JCP) </option>
<option value="jdb"> Journal of Developmental Biology (JDB) </option>
<option value="jeta"> Journal of Experimental and Theoretical Analyses (JETA) </option>
<option value="jfb"> Journal of Functional Biomaterials (JFB) </option>
<option value="jfmk"> Journal of Functional Morphology and Kinesiology (JFMK) </option>
<option value="jof"> Journal of Fungi (JoF) </option>
<option value="jimaging"> Journal of Imaging (J. Imaging) </option>
<option value="jintelligence"> Journal of Intelligence (J. Intell.) </option>
<option value="jlpea"> Journal of Low Power Electronics and Applications (JLPEA) </option>
<option value="jmmp"> Journal of Manufacturing and Materials Processing (JMMP) </option>
<option value="jmse"> Journal of Marine Science and Engineering (JMSE) </option>
<option value="jmahp"> Journal of Market Access & Health Policy (JMAHP) </option>
<option value="jmp"> Journal of Molecular Pathology (JMP) </option>
<option value="jnt"> Journal of Nanotheranostics (JNT) </option>
<option value="jne"> Journal of Nuclear Engineering (JNE) </option>
<option value="ohbm"> Journal of Otorhinolaryngology, Hearing and Balance Medicine (JOHBM) </option>
<option value="jpm"> Journal of Personalized Medicine (JPM) </option>
<option value="jpbi"> Journal of Pharmaceutical and BioTech Industry (JPBI) </option>
<option value="jor"> Journal of Respiration (JoR) </option>
<option value="jrfm"> Journal of Risk and Financial Management (JRFM) </option>
<option value="jsan"> Journal of Sensor and Actuator Networks (JSAN) </option>
<option value="jtaer"> Journal of Theoretical and Applied Electronic Commerce Research (JTAER) </option>
<option value="jvd"> Journal of Vascular Diseases (JVD) </option>
<option value="jox"> Journal of Xenobiotics (JoX) </option>
<option value="jzbg"> Journal of Zoological and Botanical Gardens (JZBG) </option>
<option value="journalmedia"> Journalism and Media </option>
<option value="kidneydial"> Kidney and Dialysis </option>
<option value="kinasesphosphatases"> Kinases and Phosphatases </option>
<option value="knowledge"> Knowledge </option>
<option value="laboratories"> Laboratories </option>
<option value="land"> Land </option>
<option value="languages"> Languages </option>
<option value="laws"> Laws </option>
<option value="life"> Life </option>
<option value="limnolrev"> Limnological Review </option>
<option value="lipidology"> Lipidology </option>
<option value="liquids"> Liquids </option>
<option value="literature"> Literature </option>
<option value="livers"> Livers </option>
<option value="logics"> Logics </option>
<option value="logistics"> Logistics </option>
<option value="lubricants"> Lubricants </option>
<option value="lymphatics"> Lymphatics </option>
<option value="make"> Machine Learning and Knowledge Extraction (MAKE) </option>
<option value="machines"> Machines </option>
<option value="macromol"> Macromol </option>
<option value="magnetism"> Magnetism </option>
<option value="magnetochemistry"> Magnetochemistry </option>
<option value="marinedrugs"> Marine Drugs </option>
<option value="materials"> Materials </option>
<option value="materproc"> Materials Proceedings </option>
<option value="mca"> Mathematical and Computational Applications (MCA) </option>
<option value="mathematics"> Mathematics </option>
<option value="medsci"> Medical Sciences </option>
<option value="msf"> Medical Sciences Forum </option>
<option value="medicina"> Medicina </option>
<option value="medicines"> Medicines </option>
<option value="membranes"> Membranes </option>
<option value="merits"> Merits </option>
<option value="metabolites"> Metabolites </option>
<option value="metals"> Metals </option>
<option value="meteorology"> Meteorology </option>
<option value="methane"> Methane </option>
<option value="mps"> Methods and Protocols (MPs) </option>
<option value="metrology"> Metrology </option>
<option value="micro"> Micro </option>
<option value="microbiolres"> Microbiology Research </option>
<option value="micromachines"> Micromachines </option>
<option value="microorganisms"> Microorganisms </option>
<option value="microplastics"> Microplastics </option>
<option value="minerals"> Minerals </option>
<option value="mining"> Mining </option>
<option value="modelling"> Modelling </option>
<option value="molbank"> Molbank </option>
<option value="molecules"> Molecules </option>
<option value="mti"> Multimodal Technologies and Interaction (MTI) </option>
<option value="muscles"> Muscles </option>
<option value="nanoenergyadv"> Nanoenergy Advances </option>
<option value="nanomanufacturing"> Nanomanufacturing </option>
<option value="nanomaterials"> Nanomaterials </option>
<option value="ndt"> NDT </option>
<option value="network"> Network </option>
<option value="neuroglia"> Neuroglia </option>
<option value="neurolint"> Neurology International </option>
<option value="neurosci"> NeuroSci </option>
<option value="nitrogen"> Nitrogen </option>
<option value="ncrna"> Non-Coding RNA (ncRNA) </option>
<option value="nursrep"> Nursing Reports </option>
<option value="nutraceuticals"> Nutraceuticals </option>
<option value="nutrients"> Nutrients </option>
<option value="obesities"> Obesities </option>
<option value="oceans"> Oceans </option>
<option value="onco"> Onco </option>
<option value="optics"> Optics </option>
<option value="oral"> Oral </option>
<option value="organics"> Organics </option>
<option value="organoids"> Organoids </option>
<option value="osteology"> Osteology </option>
<option value="oxygen"> Oxygen </option>
<option value="parasitologia"> Parasitologia </option>
<option value="particles"> Particles </option>
<option value="pathogens"> Pathogens </option>
<option value="pathophysiology"> Pathophysiology </option>
<option value="pediatrrep"> Pediatric Reports </option>
<option value="pets"> Pets </option>
<option value="pharmaceuticals"> Pharmaceuticals </option>
<option value="pharmaceutics"> Pharmaceutics </option>
<option value="pharmacoepidemiology"> Pharmacoepidemiology </option>
<option value="pharmacy"> Pharmacy </option>
<option value="philosophies"> Philosophies </option>
<option value="photochem"> Photochem </option>
<option value="photonics"> Photonics </option>
<option value="phycology"> Phycology </option>
<option value="physchem"> Physchem </option>
<option value="psf"> Physical Sciences Forum </option>
<option value="physics"> Physics </option>
<option value="physiologia"> Physiologia </option>
<option value="plants"> Plants </option>
<option value="plasma"> Plasma </option>
<option value="platforms"> Platforms </option>
<option value="pollutants"> Pollutants </option>
<option value="polymers"> Polymers </option>
<option value="polysaccharides"> Polysaccharides </option>
<option value="poultry"> Poultry </option>
<option value="powders"> Powders </option>
<option value="proceedings"> Proceedings </option>
<option value="processes"> Processes </option>
<option value="prosthesis"> Prosthesis </option>
<option value="proteomes"> Proteomes </option>
<option value="psychiatryint"> Psychiatry International </option>
<option value="psychoactives"> Psychoactives </option>
<option value="psycholint"> Psychology International </option>
<option value="publications"> Publications </option>
<option value="qubs"> Quantum Beam Science (QuBS) </option>
<option value="quantumrep"> Quantum Reports </option>
<option value="quaternary"> Quaternary </option>
<option value="radiation"> Radiation </option>
<option value="reactions"> Reactions </option>
<option value="realestate"> Real Estate </option>
<option value="receptors"> Receptors </option>
<option value="recycling"> Recycling </option>
<option value="religions"> Religions </option>
<option value="remotesensing"> Remote Sensing </option>
<option value="reports"> Reports </option>
<option value="reprodmed"> Reproductive Medicine (Reprod. Med.) </option>
<option value="resources"> Resources </option>
<option value="rheumato"> Rheumato </option>
<option value="risks"> Risks </option>
<option value="robotics"> Robotics </option>
<option value="ruminants"> Ruminants </option>
<option value="safety"> Safety </option>
<option value="sci"> Sci </option>
<option value="scipharm"> Scientia Pharmaceutica (Sci. Pharm.) </option>
<option value="sclerosis"> Sclerosis </option>
<option value="seeds"> Seeds </option>
<option value="sensors"> Sensors </option>
<option value="separations"> Separations </option>
<option value="sexes"> Sexes </option>
<option value="signals"> Signals </option>
<option value="sinusitis"> Sinusitis </option>
<option value="smartcities"> Smart Cities </option>
<option value="socsci"> Social Sciences </option>
<option value="siuj"> Société Internationale d’Urologie Journal (SIUJ) </option>
<option value="societies"> Societies </option>
<option value="software"> Software </option>
<option value="soilsystems"> Soil Systems </option>
<option value="solar"> Solar </option>
<option value="solids"> Solids </option>
<option value="spectroscj"> Spectroscopy Journal </option>
<option value="sports"> Sports </option>
<option value="standards"> Standards </option>
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<li class=""><label for="ms-opt-101" style="padding-left: 23px;"><input type="checkbox" value="cmd" title="Corrosion and Materials Degradation" id="ms-opt-101">Corrosion and Materials Degradation</label></li>
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<li class=""><label for="ms-opt-103" style="padding-left: 23px;"><input type="checkbox" value="covid" title="COVID" id="ms-opt-103">COVID</label></li>
<li class=""><label for="ms-opt-104" style="padding-left: 23px;"><input type="checkbox" value="crops" title="Crops" id="ms-opt-104">Crops</label></li>
<li class=""><label for="ms-opt-105" style="padding-left: 23px;"><input type="checkbox" value="cryptography" title="Cryptography" id="ms-opt-105">Cryptography</label></li>
<li class=""><label for="ms-opt-106" style="padding-left: 23px;"><input type="checkbox" value="crystals" title="Crystals" id="ms-opt-106">Crystals</label></li>
<li class=""><label for="ms-opt-107" style="padding-left: 23px;"><input type="checkbox" value="cimb" title="Current Issues in Molecular Biology" id="ms-opt-107">Current Issues in Molecular Biology</label></li>
<li class=""><label for="ms-opt-108" style="padding-left: 23px;"><input type="checkbox" value="curroncol" title="Current Oncology" id="ms-opt-108">Current Oncology</label></li>
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<li class=""><label for="ms-opt-111" style="padding-left: 23px;"><input type="checkbox" value="dentistry" title="Dentistry Journal" id="ms-opt-111">Dentistry Journal</label></li>
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Psychology and Education</label></li>
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<li class=""><label for="ms-opt-168" style="padding-left: 23px;"><input type="checkbox" value="gases" title="Gases" id="ms-opt-168">Gases</label></li>
<li class=""><label for="ms-opt-169" style="padding-left: 23px;"><input type="checkbox" value="gastroent" title="Gastroenterology Insights" id="ms-opt-169">Gastroenterology Insights</label></li>
<li class=""><label for="ms-opt-170" style="padding-left: 23px;"><input type="checkbox" value="gastrointestdisord" title="Gastrointestinal Disorders" id="ms-opt-170">Gastrointestinal Disorders</label></li>
<li class=""><label for="ms-opt-171" style="padding-left: 23px;"><input type="checkbox" value="gastronomy" title="Gastronomy" id="ms-opt-171">Gastronomy</label></li>
<li class=""><label for="ms-opt-172" style="padding-left: 23px;"><input type="checkbox" value="gels" title="Gels" id="ms-opt-172">Gels</label></li>
<li class=""><label for="ms-opt-173" style="padding-left: 23px;"><input type="checkbox" value="genealogy" title="Genealogy" id="ms-opt-173">Genealogy</label></li>
<li class=""><label for="ms-opt-174" style="padding-left: 23px;"><input type="checkbox" value="genes" title="Genes" id="ms-opt-174">Genes</label></li>
<li class=""><label for="ms-opt-175" style="padding-left: 23px;"><input type="checkbox" value="geographies" title="Geographies" id="ms-opt-175">Geographies</label></li>
<li class=""><label for="ms-opt-176" style="padding-left: 23px;"><input type="checkbox" value="geohazards" title="GeoHazards" id="ms-opt-176">GeoHazards</label></li>
<li class=""><label for="ms-opt-177" style="padding-left: 23px;"><input type="checkbox" value="geomatics" title="Geomatics" id="ms-opt-177">Geomatics</label></li>
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<li class=""><label for="ms-opt-181" style="padding-left: 23px;"><input type="checkbox" value="geriatrics" title="Geriatrics" id="ms-opt-181">Geriatrics</label></li>
<li class=""><label for="ms-opt-182" style="padding-left: 23px;"><input type="checkbox" value="glacies" title="Glacies" id="ms-opt-182">Glacies</label></li>
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<li class=""><label for="ms-opt-185" style="padding-left: 23px;"><input type="checkbox" value="hardware" title="Hardware" id="ms-opt-185">Hardware</label></li>
<li class=""><label for="ms-opt-186" style="padding-left: 23px;"><input type="checkbox" value="healthcare" title="Healthcare" id="ms-opt-186">Healthcare</label></li>
<li class=""><label for="ms-opt-187" style="padding-left: 23px;"><input type="checkbox" value="hearts" title="Hearts" id="ms-opt-187">Hearts</label></li>
<li class=""><label for="ms-opt-188" style="padding-left: 23px;"><input type="checkbox" value="hemato" title="Hemato" id="ms-opt-188">Hemato</label></li>
<li class=""><label for="ms-opt-189" style="padding-left: 23px;"><input type="checkbox" value="hematolrep" title="Hematology Reports" id="ms-opt-189">Hematology Reports</label></li>
<li class=""><label for="ms-opt-190" style="padding-left: 23px;"><input type="checkbox" value="heritage" title="Heritage" id="ms-opt-190">Heritage</label></li>
<li class=""><label for="ms-opt-191" style="padding-left: 23px;"><input type="checkbox" value="histories" title="Histories" id="ms-opt-191">Histories</label></li>
<li class=""><label for="ms-opt-192" style="padding-left: 23px;"><input type="checkbox" value="horticulturae" title="Horticulturae" id="ms-opt-192">Horticulturae</label></li>
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<li class=""><label for="ms-opt-194" style="padding-left: 23px;"><input type="checkbox" value="humanities" title="Humanities" id="ms-opt-194">Humanities</label></li>
<li class=""><label for="ms-opt-195" style="padding-left: 23px;"><input type="checkbox" value="humans" title="Humans" id="ms-opt-195">Humans</label></li>
<li class=""><label for="ms-opt-196" style="padding-left: 23px;"><input type="checkbox" value="hydrobiology" title="Hydrobiology" id="ms-opt-196">Hydrobiology</label></li>
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<li class=""><label for="ms-opt-198" style="padding-left: 23px;"><input type="checkbox" value="hydrology" title="Hydrology" id="ms-opt-198">Hydrology</label></li>
<li class=""><label for="ms-opt-199" style="padding-left: 23px;"><input type="checkbox" value="hygiene" title="Hygiene" id="ms-opt-199">Hygiene</label></li>
<li class=""><label for="ms-opt-200" style="padding-left: 23px;"><input type="checkbox" value="immuno" title="Immuno" id="ms-opt-200">Immuno</label></li>
<li class=""><label for="ms-opt-201" style="padding-left: 23px;"><input type="checkbox" value="idr" title="Infectious Disease Reports" id="ms-opt-201">Infectious Disease Reports</label></li>
<li class=""><label for="ms-opt-202" style="padding-left: 23px;"><input type="checkbox" value="informatics" title="Informatics" id="ms-opt-202">Informatics</label></li>
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<li class=""><label for="ms-opt-204" style="padding-left: 23px;"><input type="checkbox" value="infrastructures" title="Infrastructures" id="ms-opt-204">Infrastructures</label></li>
<li class=""><label for="ms-opt-205" style="padding-left: 23px;"><input type="checkbox" value="inorganics" title="Inorganics" id="ms-opt-205">Inorganics</label></li>
<li class=""><label for="ms-opt-206" style="padding-left: 23px;"><input type="checkbox" value="insects" title="Insects" id="ms-opt-206">Insects</label></li>
<li class=""><label for="ms-opt-207" style="padding-left: 23px;"><input type="checkbox" value="instruments" title="Instruments" id="ms-opt-207">Instruments</label></li>
<li class=""><label for="ms-opt-208" style="padding-left: 23px;"><input type="checkbox" value="ijerph" title="International Journal of Environmental Research and Public Health" id="ms-opt-208">International Journal of Environmental Research
and Public Health</label></li>
<li class=""><label for="ms-opt-209" style="padding-left: 23px;"><input type="checkbox" value="ijfs" title="International Journal of Financial Studies" id="ms-opt-209">International Journal of Financial Studies</label></li>
<li class=""><label for="ms-opt-210" style="padding-left: 23px;"><input type="checkbox" value="ijms" title="International Journal of Molecular Sciences" id="ms-opt-210">International Journal of Molecular Sciences</label></li>
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<li class=""><label for="ms-opt-214" style="padding-left: 23px;"><input type="checkbox" value="ijtm" title="International Journal of Translational Medicine" id="ms-opt-214">International Journal of Translational Medicine</label></li>
<li class=""><label for="ms-opt-215" style="padding-left: 23px;"><input type="checkbox" value="ijtpp" title="International Journal of Turbomachinery, Propulsion and Power" id="ms-opt-215">International Journal of Turbomachinery, Propulsion
and Power</label></li>
<li class=""><label for="ms-opt-216" style="padding-left: 23px;"><input type="checkbox" value="ime" title="International Medical Education" id="ms-opt-216">International Medical Education</label></li>
<li class=""><label for="ms-opt-217" style="padding-left: 23px;"><input type="checkbox" value="inventions" title="Inventions" id="ms-opt-217">Inventions</label></li>
<li class=""><label for="ms-opt-218" style="padding-left: 23px;"><input type="checkbox" value="IoT" title="IoT" id="ms-opt-218">IoT</label></li>
<li class=""><label for="ms-opt-219" style="padding-left: 23px;"><input type="checkbox" value="ijgi" title="ISPRS International Journal of Geo-Information" id="ms-opt-219">ISPRS International Journal of Geo-Information</label></li>
<li class=""><label for="ms-opt-220" style="padding-left: 23px;"><input type="checkbox" value="J" title="J" id="ms-opt-220">J</label></li>
<li class=""><label for="ms-opt-221" style="padding-left: 23px;"><input type="checkbox" value="jal" title="Journal of Ageing and Longevity" id="ms-opt-221">Journal of Ageing and Longevity</label></li>
<li class=""><label for="ms-opt-222" style="padding-left: 23px;"><input type="checkbox" value="jcdd" title="Journal of Cardiovascular Development and Disease" id="ms-opt-222">Journal of Cardiovascular Development and Disease</label></li>
<li class=""><label for="ms-opt-223" style="padding-left: 23px;"><input type="checkbox" value="jcto" title="Journal of Clinical & Translational Ophthalmology" id="ms-opt-223">Journal of Clinical & Translational Ophthalmology</label>
</li>
<li class=""><label for="ms-opt-224" style="padding-left: 23px;"><input type="checkbox" value="jcm" title="Journal of Clinical Medicine" id="ms-opt-224">Journal of Clinical Medicine</label></li>
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<li class=""><label for="ms-opt-226" style="padding-left: 23px;"><input type="checkbox" value="jcp" title="Journal of Cybersecurity and Privacy" id="ms-opt-226">Journal of Cybersecurity and Privacy</label></li>
<li class=""><label for="ms-opt-227" style="padding-left: 23px;"><input type="checkbox" value="jdb" title="Journal of Developmental Biology" id="ms-opt-227">Journal of Developmental Biology</label></li>
<li class=""><label for="ms-opt-228" style="padding-left: 23px;"><input type="checkbox" value="jeta" title="Journal of Experimental and Theoretical Analyses" id="ms-opt-228">Journal of Experimental and Theoretical Analyses</label></li>
<li class=""><label for="ms-opt-229" style="padding-left: 23px;"><input type="checkbox" value="jfb" title="Journal of Functional Biomaterials" id="ms-opt-229">Journal of Functional Biomaterials</label></li>
<li class=""><label for="ms-opt-230" style="padding-left: 23px;"><input type="checkbox" value="jfmk" title="Journal of Functional Morphology and Kinesiology" id="ms-opt-230">Journal of Functional Morphology and Kinesiology</label></li>
<li class=""><label for="ms-opt-231" style="padding-left: 23px;"><input type="checkbox" value="jof" title="Journal of Fungi" id="ms-opt-231">Journal of Fungi</label></li>
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<li class=""><label for="ms-opt-236" style="padding-left: 23px;"><input type="checkbox" value="jmse" title="Journal of Marine Science and Engineering" id="ms-opt-236">Journal of Marine Science and Engineering</label></li>
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Medicine</label></li>
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<li class=""><label for="ms-opt-354" style="padding-left: 23px;"><input type="checkbox" value="proteomes" title="Proteomes" id="ms-opt-354">Proteomes</label></li>
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RECENT ARTICLES 28 pages, 46615 KiB Open AccessArticle Influence of Coherent Vortex Rolls on Particle Dynamics in Unstably Stratified Turbulent Channel Flows by Domenico Zaza and Michele Iovieno Energies 2024, 17(11), 2725; https://doi.org/10.3390/en17112725 (registering DOI) - 3 Jun 2024 Abstract This work investigates the dynamics of heavy particles dispersed in turbulent channel flows under unstable thermal stratification conditions using point-particle direct numerical simulations (PP-DNS), to quantify the influence of large-scale coherent vortex rolls, arising from the combined effects of shear and buoyancy, on [...] Read more. This work investigates the dynamics of heavy particles dispersed in turbulent channel flows under unstable thermal stratification conditions using point-particle direct numerical simulations (PP-DNS), to quantify the influence of large-scale coherent vortex rolls, arising from the combined effects of shear and buoyancy, on the spatial distribution and preferential sampling behavior of inertial particles. We examined three particle Stokes numbers (St+=0.6,60,120) and two friction Richardson numbers, Riτ=0.272 and Riτ=27.2, which exemplify the regimes below and above the critical condition for vortex roll formation, respectively. The results indicate that the flow reorganization into large-scale longitudinal vortices significantly alters the topological features of small scales in the near-wall region impinged by the thermal plumes, resulting in a prevalence of vorticity-dominated topologies. The interplay between this phenomenon and the tendency of particles to preferentially sample strain-dominated topologies leads to a distinctive asymmetric particle distribution in the near-wall planes. Inertial particles markedly accumulate in the strain-dominated regions where the coherent thermal plumes emerge from the walls, while avoiding the vorticity-dominated impingement zones. This peculiar particle response to the vortex rolls is most pronounced when the particle response time matches the characteristic timescale of the large-scale coherent motions in the cross-stream planes. Full article (This article belongs to the Section J1: Heat and Mass Transfer) attachment Supplementary material: Supplementary File 1 (ZIP, 215 KiB) 28 pages, 39930 KiB Open AccessArticle Analysis and Optimization of Residential Elements from the Perspective of Multi-Child Families in the Yangtze River Delta Region by Xi Zhou, Fan Ye, Fang Zhang and Dengyu Wang Buildings 2024, 14(6), 1649; https://doi.org/10.3390/buildings14061649 (registering DOI) - 3 Jun 2024 Abstract Over the last few decades, policy changes have resulted in changes in family structure and cyclical changes within families. The structure of multi-child families will have a significant influence on housing demand and supply, necessitating a thorough demand study. This study examines the [...] Read more. Over the last few decades, policy changes have resulted in changes in family structure and cyclical changes within families. The structure of multi-child families will have a significant influence on housing demand and supply, necessitating a thorough demand study. This study examines the requirements of 739 multi-child families in the Yangtze River Delta (YRD) region at different stages and graphically displays the variables influencing their level of housing satisfaction, offering a scientific reference for the design and optimization of housing. Firstly, the residential elements that impact families with multiple children were categorized into 3 categories, 14 subcategories, and 65 influencing elements based on expert consultation and word frequency data. Secondly, 739 families in the YRD region were chosen for investigation, and importance–performance analysis (IPA) was employed to study and assess the residential elements of multi-child families. The IPA study findings were compared to those obtained from on-site surveys and network data crawling. Finally, the residential elements to be optimized were quantitatively determined, and the relevant optimization techniques were provided in conjunction with door-to-door interviewing. This study examines the needs of multi-child families at various phases, as well as the factors that impact their residential satisfaction, and provides optimization solutions for the long-term use and renewal of residential structures. Full article (This article belongs to the Section Architectural Design, Urban Science, and Real Estate) ►▼ Show Figures Figure 1 Figure 1 attachment Supplementary material: Supplementary File 1 (ZIP, 920 KiB) 18 pages, 19107 KiB Open AccessArticle Screening and Optimization of Soil Remediation Strategies Assisted by Machine Learning by Bowei Zhang, Xin Wang and Chongxuan Liu Processes 2024, 12(6), 1157; https://doi.org/10.3390/pr12061157 (registering DOI) - 3 Jun 2024 Abstract A numerical approach assisted by machine learning was developed for screening and optimizing soil remediation strategies. The approach includes a reactive transport model for simulating the remediation cost and effect of applicable remediation technologies and their combinations for a target site. The simulated [...] Read more. A numerical approach assisted by machine learning was developed for screening and optimizing soil remediation strategies. The approach includes a reactive transport model for simulating the remediation cost and effect of applicable remediation technologies and their combinations for a target site. The simulated results were used to establish a relationship between the cost and effect using a machine learning method. The relationship was then used by an optimization method to provide optimal remediation strategies under various constraints and requirements for the target site. The approach was evaluated for a site contaminated with both arsenic and polycyclic aromatic hydrocarbons at a former shipbuilding factory in Guangzhou City, China. An optimal strategy was obtained and successfully implemented at the site, which included the partial excavation of the contaminated soils and natural attenuation of the residual contaminated soils. The advantage of the approach is that it can fully consider the natural attenuation capacity in designing remediation strategies to reduce remediation costs and can provide cost-effective remediation strategies under variable constraints for policymakers. The approach is general and can be applied for screening and optimizing remediation strategies at other remediation sites. Full article (This article belongs to the Special Issue Advances in Remediation of Contaminated Sites: Volume II) ►▼ Show Figures Figure 1 Figure 1 18 pages, 1839 KiB Open AccessArticle Analysing Spatiotemporal Variability of Chlorophyll-a Concentration and Water Surface Temperature in Coastal Lagoons of the Ebro Delta (NW Mediterranean Sea, Spain) by Lara Talavera, José Antonio Domínguez-Gómez, Nuria Navarro and Inmaculada Rodríguez-Santalla J. Mar. Sci. Eng. 2024, 12(6), 941; https://doi.org/10.3390/jmse12060941 (registering DOI) - 3 Jun 2024 Abstract Coastal lagoons are highly productive transitional water bodies threatened by human factors and vulnerable to global climate change effects. Monitoring biophysical parameters in these ecosystems is crucial for their preservation. In this work, we used Sentinel-2 and Landsat imagery combined with in situ [...] Read more. Coastal lagoons are highly productive transitional water bodies threatened by human factors and vulnerable to global climate change effects. Monitoring biophysical parameters in these ecosystems is crucial for their preservation. In this work, we used Sentinel-2 and Landsat imagery combined with in situ data to (1) develop preliminary algorithms for retrieving the Chl-a concentration and water surface temperature of six lagoons located in the Ebro Delta (NE Mediterranean Sea, Spain), and to (2) compute maps and trend lines for analysing their spatiotemporal evolution from 2015 to 2022. Our findings showed that the algorithms’ accuracy ranged from 72% to 78% and had limited potential under high Chl-a concentration regimes. Even so, they revealed the lagoons’ trophic status, usual fluctuations, and deviations of both parameters attributed to seasonal (i.e., light and temperature) and short-term physical (i.e., winds) forcing, as well as valuable spatial patterns potentially useful for conservation efforts and land use planning. Future work will focus on the acquisition of a larger in situ data sample under a range of environmental conditions to improve the algorithms’ robustness, which in turn will allow the investigation of natural and human factors controlling the dynamics of the two investigated parameters. Full article (This article belongs to the Special Issue Wetland Evolution Based on Remote Sensing Data) 12 pages, 1732 KiB Open AccessArticle Fast-Growing Bio-Based Construction Materials as an Approach to Accelerate United Nations Sustainable Development Goals by Livia Cosentino, Jorge Fernandes and Ricardo Mateus Appl. Sci. 2024, 14(11), 4850; https://doi.org/10.3390/app14114850 (registering DOI) - 3 Jun 2024 Abstract The United Nations Sustainable Development Goals (UN SDGs) ensure future human well-being. However, they face challenges due to the pressing need to reduce carbon emissions, with nearly 40% originating from the construction sector. With the current global environmental and energy crisis, there is [...] Read more. The United Nations Sustainable Development Goals (UN SDGs) ensure future human well-being. However, they face challenges due to the pressing need to reduce carbon emissions, with nearly 40% originating from the construction sector. With the current global environmental and energy crisis, there is a pressing need to address building carbon emissions and prioritise investments in passive strategies for improving indoor thermal comfort. Exploring fast-growing bio-based materials like bamboo, straw, hemp, and flax directly addresses these concerns, fostering environmental sustainability. Material selection in construction is crucial for advancing the SDGs, for example, promoting sustainable cities and communities (SDG11) and responsible consumption and production (SDG12). This paper proposes a comparative analysis of conventional and bio-based construction materials, focusing on their production stages through life cycle analysis. Tools such as Building Emissions Accounting for Materials (BEAM) and the Methodology for Relative Assessment of Sustainability (MARS) enable a detailed comparison. The results highlight the benefits of bio-based materials in storing carbon more rapidly and their lower environmental impact compared to conventional alternatives. Moreover, bio-based materials contribute to indoor moisture regulation and a healthier indoor environment, underscoring their potential to accelerate progress towards the UN SDGs through informed material choices in design practices. Full article (This article belongs to the Special Issue Challenges for Sustainable Building: Innovation, Development and Characterisation of New Material Products and Systems) ►▼ Show Figures Figure 1 Figure 1 attachment Supplementary material: Supplementary File 1 (ZIP, 381 KiB) 16 pages, 3625 KiB Open AccessArticle Interleukin-8/CXCR1 Signaling Contributes to the Progression of Pulmonary Adenocarcinoma Resulting in Malignant Pleural Effusion by Yi-Ming Chang, Wen-Yen Huang, Shih-Hsien Yang, Chia-Ing Jan, Shin Nieh, Yaoh-Shiang Lin, Su-Feng Chen and Yu-Chun Lin Cells 2024, 13(11), 968; https://doi.org/10.3390/cells13110968 (registering DOI) - 3 Jun 2024 Abstract Pulmonary adenocarcinoma (PADC) treatment limited efficacy in preventing tumor progression, often resulting in malignant pleural effusion (MPE). MPE is filled with various mediators, especially interleukin-8 (IL-8). However, the role of IL-8 and its signaling mechanism within the fluid microenvironment (FME) implicated in tumor [...] Read more. Pulmonary adenocarcinoma (PADC) treatment limited efficacy in preventing tumor progression, often resulting in malignant pleural effusion (MPE). MPE is filled with various mediators, especially interleukin-8 (IL-8). However, the role of IL-8 and its signaling mechanism within the fluid microenvironment (FME) implicated in tumor progression warrants further investigation. Primary cultured cells from samples of patients with MPE from PADC, along with a commonly utilized lung cancer cell line, were employed to examine the role of IL-8 and its receptor, CXCR1, through comparative analysis. Our study primarily assessed migration and invasion capabilities, epithelial-mesenchymal transition (EMT), and cancer stem cell (CSC) properties. Additionally, IL-8 levels in MPE fluid versus serum, along with immunohistochemical expression of IL-8/CXCR1 signaling in tumor tissue and cell blocks were analyzed. IL-8/CXCR1 overexpression enhanced EMT and CSC properties. Furthermore, the immunocytochemical examination of 17 cell blocks from patients with PADC and MPE corroborated the significant correlation between upregulated IL-8 and CXCR1 expression and the co-expression of IL-8 and CXCR1 in MPE with distant metastasis. In summary, the IL-8/ CXCR1 axis in FME is pivotal to tumor promotion via paracrine and autocrine signaling. Our study provides a therapeutic avenue for improving the prognosis of PADC patients with MPE. Full article (This article belongs to the Special Issue Tumor Immune Microenvironment for Effective Therapy II) ►▼ Show Figures Figure 1 Figure 1 attachment Supplementary material: Supplementary File 1 (ZIP, 55842 KiB) 12 pages, 2509 KiB Open AccessBrief Report Comparative Mitogenomics and Phylogenetic Implications for Nine Species of the Subfamily Meconematinae (Orthoptera: Tettigoniidae) by Siyu Pang, Qianwen Zhang, Lili Liang, Yanting Qin, Shan Li and Xun Bian Insects 2024, 15(6), 413; https://doi.org/10.3390/insects15060413 (registering DOI) - 3 Jun 2024 Abstract Currently, the subfamily Meconematinae encompasses 1029 species, but whole-mitochondrial-genome assemblies have only been made available for 13. In this study, the whole mitochondrial genomes (mitogenomes) of nine additional species in the subfamily Meconematinae were sequenced. The size ranged from 15,627 bp to 17,461 [...] Read more. Currently, the subfamily Meconematinae encompasses 1029 species, but whole-mitochondrial-genome assemblies have only been made available for 13. In this study, the whole mitochondrial genomes (mitogenomes) of nine additional species in the subfamily Meconematinae were sequenced. The size ranged from 15,627 bp to 17,461 bp, indicating double-stranded circular structures. The length of the control region was the main cause of the difference in mitochondrial genome length among the nine species. All the mitogenomes including 13 protein-coding genes (PCGs), 22 transfer RNA genes (tRNAs), 2 ribosomal RNA genes (rRNAs) and a control region (CR). The majority strand encoded 23 genes, and the minority strand encoded 14 genes. A phylogenetic analysis reaffirmed the monophyletic status of each subfamily, but the monophysitism of Xizicus, Xiphidiopsis and Phlugiolopsis was not supported. Full article (This article belongs to the Special Issue Genetic Diversity of Insects) ►▼ Show Figures Figure 1 Figure 1 15 pages, 2039 KiB Open AccessArticle Tribological Behavior of Hydrocarbons in Rolling Contact by Daniel Merk, Thomas Koenig, Janine Fritz and Joerg W. H. Franke Lubricants 2024, 12(6), 201; https://doi.org/10.3390/lubricants12060201 (registering DOI) - 3 Jun 2024 Abstract In the analysis of tribological contacts, the focus is often on a singular question or result. However, this entails the potential risk that the overall picture and the relationships could be oversimplified or even that wrong conclusions could be drawn. In this article, [...] Read more. In the analysis of tribological contacts, the focus is often on a singular question or result. However, this entails the potential risk that the overall picture and the relationships could be oversimplified or even that wrong conclusions could be drawn. In this article, a comprehensive consideration of test results including component and lubricant analyses is demonstrated by using the example of rolling contact. For this purpose, thrust cylindrical roller bearings of type 81212 with unadditized base oils were tested in the mixed-friction area. Our study shows that by using an adapted and innovative surface analysis, a deeper dive into the tribo-film is feasible even without highly sophisticated analytical equipment. The characterization of the layers was performed by the three less time-consuming spatially resolved analysis methods of µXRF, ATR FTIR microscopy and Raman spectroscopy adapted by Schaeffler. This represents a bridge between industry and research. The investigations show that especially undocumented and uncontrolled contamination of the test equipment could lead to surprising findings, which would result in the wrong conclusions. Simple substances, like hydrocarbons, are demanding test specimens. Full article (This article belongs to the Special Issue Tribology in Germany: Latest Research and Development) 13 pages, 454 KiB Open AccessArticle Effects of Upper Limb Control on the Less-Affected Side on Upper Limb Function, Respiration, Balance, and Activities of Daily Living in Stroke by Ju-O Kim, Mi-Young Lee and Byoung-Hee Lee Medicina 2024, 60(6), 937; https://doi.org/10.3390/medicina60060937 (registering DOI) - 3 Jun 2024 Abstract Background and Objectives: This study aimed to investigate the effects of upper limb control exercises on upper limb function, respiration, balance, and activities of daily living in patients with stroke. Materials and Methods: The 28 patients who met the selection criteria were randomly [...] Read more. Background and Objectives: This study aimed to investigate the effects of upper limb control exercises on upper limb function, respiration, balance, and activities of daily living in patients with stroke. Materials and Methods: The 28 patients who met the selection criteria were randomly assigned to two groups of 14 patients each. Subsequently, upper limb control exercises using real-time feedback were applied. The same interventional exercise was applied to both the less-affected and affected limbs of the study participants, who were classified into a less-affected side upper limb control group and an affected side upper limb control exercise group. Interventional exercises, 30 min each, were performed five times weekly for 4 weeks, and follow-up examinations were performed 2 weeks after the end of exercise. Electronic muscle strength measurements and an electronic goniometer were used to evaluate upper limb function. A spirometer was used to measure respiration. Balance ability was evaluated using a force plate pressure distribution measuring system with a sensor that detects the movement of the body center on the ground. Daily life movements were evaluated using the Korean version of the modified Barthel index. Results: When examining the results, the upper limb function on the paralyzed side showed an increase in the electromyographic strength of shoulder joint depression and flexion angle. Improvements were also observed in respiration (forced vital capacity [L] and forced expiratory volume in 1 s [L]), balance (95% confidence ellipse area [mm2] and center of pressure displacement [mm]), and daily life activities, all of which showed statistically significant differences in the time × group interaction effect (p < 0.05). Conclusions: Thus, it was found that the upper limb control exercise on the less-affected side had a significant effect when the exercise was performed together with treatment on the affected side in patients with stroke. It is anticipated that this study will provide basic data for evaluating both the trunk and upper limbs of the less-affected and affected sides. Full article (This article belongs to the Special Issue New Advances in Acute Stroke Rehabilitation) 9 pages, 265 KiB Open AccessArticle The Role of Serum Dickkopf1 and CKAP4 Levels in Diagnosing Colorectal Cancer and Measuring the Disease Severity: A Prospective Study by Esra Dişçi, Rıfat Peksöz, Esra Laloğlu, Mehmet İlhan Yıldırgan, Yavuz Albayrak, Mehmet Akif Şirin, Enes Ağırman and Sabri Selçuk Atamanalp Medicina 2024, 60(6), 933; https://doi.org/10.3390/medicina60060933 (registering DOI) - 3 Jun 2024 Abstract Background and Objective: Colorectal cancer (CRC) is among the most common types of cancer. Although the disease is treatable in its early stages, five-year survival falls below 20% in the later stages. CEA and CA19-9 are tumor markers used in the diagnosis and [...] Read more. Background and Objective: Colorectal cancer (CRC) is among the most common types of cancer. Although the disease is treatable in its early stages, five-year survival falls below 20% in the later stages. CEA and CA19-9 are tumor markers used in the diagnosis and follow-up of the disease in clinical practice; however, their diagnostic effectiveness is insufficient. Therefore, the identification of biomarkers that can be easily studied from serum and can diagnose CRC and determine its severity is highly important. In this context, dickkopf1 (DKK1) and cytoskeleton-associated protein 4 (CKAP4) are both promising biomarkers. Materials and Methods: Serum DKK1 and CKAP4 levels were measured in 55 patients with CRC and 40 healthy controls. The patients with CRC were divided into groups based on pathological stages and histological differentiation. The serum levels of both proteins in patients with CRC were measured preoperatively and 10 and 30 days postoperatively. Results: Serum DKK1 and CKAP4 were significantly higher in the CRC group than in the healthy controls (p < 0.05). Serum levels of both proteins rose in line with the disease stage and grade but decreased following surgical resection. A positive correlation was observed between tumor diameter and protein blood levels. The diagnostic efficacy of DKK1 and CKAP4 in CRC (approximately 95%) was higher than that of markers such as CEA and CA19-9. Conclusions: The DKK1 and CKAP4 serum values of patients with CRC are promising biomarkers. They can potentially be used in CRC management, namely, in the diagnosis and treatment of tumor response access and in tumor aggressiveness prediction. Full article (This article belongs to the Special Issue Gastrointestinal Disorders - Incidence, Mortality, Survival, and Risk Factors) 10 pages, 476 KiB Open AccessArticle Comparison of Perinatal Outcome of Delta and Omicron Variant of COVID-19 Infection—A Retrospective Observational Study by Natasa Karadzov Orlic, Vesna Mandic-Markovic, Svetlana Jankovic, Relja Lukic, Zagorka Milovanovic, Dragana Maglic, Dunja Popov, Marko Stankovic, Suzana Drobnjak, Dasa Preradovic and Zeljko Mikovic Medicina 2024, 60(6), 935; https://doi.org/10.3390/medicina60060935 (registering DOI) - 3 Jun 2024 Abstract Background and Objectives: The aim of the present work was to compare the characteristics of delta and omicron variants of COVID-19 infection in pregnant women, the association of infection with comorbidity, clinical manifestation of the disease, type of delivery, and pregnancy outcome. [...] Read more. Background and Objectives: The aim of the present work was to compare the characteristics of delta and omicron variants of COVID-19 infection in pregnant women, the association of infection with comorbidity, clinical manifestation of the disease, type of delivery, and pregnancy outcome. Material and Methods: The study was designed as an observational, retrospective study of a single center. The analysis included the cohort of women who had SARS-CoV-2 infection during pregnancy and/or childbirth in the period from 1 March 2020 to 30 June 2023. Results: Out of a total of 675 pregnant women with SARS-CoV-2 infection, 130 gave birth with the delta and 253 with the omicron variant. In our retrospective analysis, pregnant women with both SARS-CoV-2 variants had a mild clinical history in most cases. In the omicron period, a significantly lower incidence of pregnancy loss (p < 0.01) and premature birth (p = 0.62) admission of mothers and newborns to the intensive care unit (p < 0.05) was recorded. Conclusions: In our retrospective analysis, pregnant women with COVID-19 infection generally exhibited a milder clinical manifestation with both variants (delta and omicron) of the viral infection. During the delta-dominant period, ten percent of affected pregnant women experienced a severe clinical history. However, during the omicron-dominant period infection, a significantly lower incidence of complications, pregnancy loss, preterm delivery, and admission of mothers and neonates to the intensive care unit was recorded. This can be partly explained by the greater presence of pregnant women with natural or induced vaccine immunity. Full article (This article belongs to the Section Obstetrics and Gynecology) ►▼ Show Figures Figure 1 21 pages, 960 KiB Open AccessCase Report Role of Electroconvulsive Therapy, Ketamine Infusion, and Deep Repetitive Transcranial Magnetic Stimulation in Treatment-Resistant Bipolar Depression: A Case Report by Keming Gao Medicina 2024, 60(6), 936; https://doi.org/10.3390/medicina60060936 (registering DOI) - 3 Jun 2024 Abstract Background and Objectives: Options for treatment-resistant bipolar depression (TRBPD) are limited. Electroconvulsive therapy (ECT) has shown efficacy in TRBPD. However, the cognitive deficits and memory concerns associated with ECT are problematic for a significant number of patients. It remains unclear what the [...] Read more. Background and Objectives: Options for treatment-resistant bipolar depression (TRBPD) are limited. Electroconvulsive therapy (ECT) has shown efficacy in TRBPD. However, the cognitive deficits and memory concerns associated with ECT are problematic for a significant number of patients. It remains unclear what the next step is for patients with TRBPD who fail ECT. Materials and Methods: In this case report, we present a patient with TRBPD who sequentially received 12 sessions of brief-pulse right unilateral ECT, 22 sessions of ketamine infusion at 0.5–0.75 mg/kg for 40 min, and 39 sessions of deep repetitive transcranial magnetic stimulation (dTMS). Results: The patient had some benefit from ECT, but declined continuation of ECT due to memory concerns. The patient tolerated ketamine infusion well but had limited benefit. However, the patient responded well to acute treatment with dTMS and maintained relative stability for more than 2 years. Conclusions: This case suggests that patients with TRBPD who fail ECT and/or ketamine infusion might benefit from dTMS. Full article (This article belongs to the Section Psychiatry) ►▼ Show Figures Figure 1 Figure 1 15 pages, 1908 KiB Open AccessReview The Dysregulation of Essential Fatty Acid (EFA) Metabolism May Be a Factor in the Pathogenesis of Sepsis by Undurti N. Das Medicina 2024, 60(6), 934; https://doi.org/10.3390/medicina60060934 (registering DOI) - 3 Jun 2024 Abstract I propose that a deficiency of essential fatty acids (EFAs) and an alteration in their (EFAs) metabolism could be a major factor in the pathogenesis of sepsis and sepsis-related mortality. The failure of corticosteroids, anti-TNF-α, and anti-interleukin-6 monoclonal antibodies can be attributed to [...] Read more. I propose that a deficiency of essential fatty acids (EFAs) and an alteration in their (EFAs) metabolism could be a major factor in the pathogenesis of sepsis and sepsis-related mortality. The failure of corticosteroids, anti-TNF-α, and anti-interleukin-6 monoclonal antibodies can be attributed to this altered EFA metabolism in sepsis. Vitamin C; folic acid; and vitamin B1, B6, and B12 serve as co-factors necessary for the activity of desaturase enzymes that are the rate-limiting steps in the metabolism of EFAs. The altered metabolism of EFAs results in an imbalance in the production and activities of pro- and anti-inflammatory eicosanoids and cytokines resulting in both hyperimmune and hypoimmune responses seen in sepsis. This implies that restoring the metabolism of EFAs to normal may form a newer therapeutic approach both in the prevention and management of sepsis and other critical illnesses. Full article ►▼ Show Figures Figure 1 Figure 1 30 pages, 1860 KiB Open AccessArticle An Enhanced Multiple Unmanned Aerial Vehicle Swarm Formation Control Using a Novel Fractional Swarming Strategy Approach by Abdul Wadood, Al-Fahad Yousaf and Aadel Mohammed Alatwi Fractal Fract. 2024, 8(6), 334; https://doi.org/10.3390/fractalfract8060334 (registering DOI) - 3 Jun 2024 Abstract This paper addresses the enhancement of multiple Unmanned Aerial Vehicle (UAV) swarm formation control in challenging terrains through the novel fractional memetic computing approach known as fractional-order velocity-pausing particle swarm optimization (FO-VPPSO). Existing particle swarm optimization (PSO) algorithms often suffer from premature convergence [...] Read more. This paper addresses the enhancement of multiple Unmanned Aerial Vehicle (UAV) swarm formation control in challenging terrains through the novel fractional memetic computing approach known as fractional-order velocity-pausing particle swarm optimization (FO-VPPSO). Existing particle swarm optimization (PSO) algorithms often suffer from premature convergence and an imbalanced exploration–exploitation trade-off, which limits their effectiveness in complex optimization problems such as UAV swarm control in rugged terrains. To overcome these limitations, FO-VPPSO introduces an adaptive fractional order β and a velocity pausing mechanism, which collectively enhance the algorithm’s adaptability and robustness. This study leverages the advantages of a meta-heuristic computing approach; specifically, fractional-order velocity-pausing particle swarm optimization is utilized to optimize the flying path length, mitigate the mountain terrain costs, and prevent collisions within the UAV swarm. Leveraging fractional-order dynamics, the proposed hybrid algorithm exhibits accelerated convergence rates and improved solution optimality compared to traditional PSO methods. The methodology involves integrating terrain considerations and diverse UAV control parameters. Simulations under varying conditions, including complex terrains and dynamic threats, substantiate the effectiveness of the approach, resulting in superior fitness functions for multi-UAV swarms. To validate the performance and efficiency of the proposed optimizer, it was also applied to 13 benchmark functions, including uni- and multimodal functions in terms of the mean average fitness value over 100 independent trials, and furthermore, an improvement at percentages of 29.05% and 2.26% is also obtained against PSO and VPPSO in the case of the minimum flight length, as well as 16.46% and 1.60% in mountain terrain costs and 55.88% and 31.63% in collision avoidance. This study contributes valuable insights to the optimization challenges in UAV swarm-formation control, particularly in demanding terrains. The FO-VPPSO algorithm showcases potential advancements in swarm intelligence for real-world applications. Full article (This article belongs to the Special Issue Modeling, Optimization, and Control of Fractional-Order Neural Networks and Nonlinear Systems) 22 pages, 659 KiB Open AccessArticle New Lie Symmetries and Exact Solutions of a Mathematical Model Describing Solute Transport in Poroelastic Materials by Roman Cherniha, Vasyl’ Davydovych and Alla Vorobyova Math. Comput. Appl. 2024, 29(3), 43; https://doi.org/10.3390/mca29030043 (registering DOI) - 3 Jun 2024 Abstract A one-dimensional model for fluid and solute transport in poroelastic materials (PEMs) is studied. Although the model was recently derived and some exact solutions, in particular steady-state solutions and their applications, were studied, special cases occurring when some parameters vanish were not analysed [...] Read more. A one-dimensional model for fluid and solute transport in poroelastic materials (PEMs) is studied. Although the model was recently derived and some exact solutions, in particular steady-state solutions and their applications, were studied, special cases occurring when some parameters vanish were not analysed earlier. Since the governing equations are nonintegrable in nonstationary cases, the Lie symmetry method and modern tools for solving ODE systems are applied in order to construct time-dependent exact solutions. Depending on parameters arising in the governing equations, several special cases with new Lie symmetries are identified. Some of them have a highly nontrivial structure that cannot be predicted from a physical point of view or using Lie symmetries of other real-world models. Applying the symmetries obtained, multiparameter families of exact solutions are constructed, including those in terms of elementary and special functions (hypergeometric, Whittaker, Bessel and modified Bessel functions). A possible application of the solutions obtained is demonstrated, and it is shown that some exact solutions can describe (at least qualitatively) the solute transport in PEM. The obtained exact solutions can also be used as test problems for estimating the accuracy of approximate analytical and numerical methods for solving relevant boundary value problems. Full article (This article belongs to the Collection Feature Papers in Mathematical and Computational Applications 2024) attachment Supplementary material: Supplementary File 1 (ZIP, 1062 KiB) 16 pages, 6762 KiB Open AccessArticle Transition Metal-Based Polyoxometalates for Oxygen Electrode Bifunctional Electrocatalysis by Jadranka Milikić, Filipe Gusmão, Sara Knežević, Nemanja Gavrilov, Anup Paul, Diogo M. F. Santos and Biljana Šljukić Batteries 2024, 10(6), 197; https://doi.org/10.3390/batteries10060197 (registering DOI) - 3 Jun 2024 Abstract Polyoxometalates (POMs) with transition metals (Co, Cu, Fe, Mn, Ni) of Keggin structure and lamellar-stacked multi-layer morphology were synthesized. They were subsequently explored as bifunctional electrocatalysts for oxygen electrodes, i.e., oxygen reduction (ORR) and evolution (OER) reaction, for aqueous rechargeable metal-air batteries in [...] Read more. Polyoxometalates (POMs) with transition metals (Co, Cu, Fe, Mn, Ni) of Keggin structure and lamellar-stacked multi-layer morphology were synthesized. They were subsequently explored as bifunctional electrocatalysts for oxygen electrodes, i.e., oxygen reduction (ORR) and evolution (OER) reaction, for aqueous rechargeable metal-air batteries in alkaline media. The lowest Tafel slope (85 mV dec−1) value and the highest OER current density of 93.8 mA cm−2 were obtained for the Fe-POM electrocatalyst. Similar OER electrochemical catalytic activity was noticed for the Co-POM electrocatalyst. This behavior was confirmed by electrochemical impedance spectroscopy, where Fe-POM gave the lowest charge transfer resistance of 3.35 Ω, followed by Co-POM with Rct of 15.04 Ω, during the OER. Additionally, Tafel slope values of 85 and 109 mV dec−1 were calculated for Fe-POM and Co-POM, respectively, during the ORR. The ORR at Fe-POM proceeded by mixed two- and four-electron pathways, while ORR at Co-POM proceeded exclusively by the four-electron pathway. Finally, capacitance studies were conducted on the synthesized POMs. Full article (This article belongs to the Section Battery Materials and Interfaces: Anode, Cathode, Separators and Electrolytes or Others) ►▼ Show Figures Figure 1 Figure 1 19 pages, 3768 KiB Open AccessReview Increase in Modulation Speed of Silicon Photonics Modulator with Quantum-Well Slab Wings: New Insights from a Numerical Study by Kensuke Ogawa Photonics 2024, 11(6), 535; https://doi.org/10.3390/photonics11060535 (registering DOI) - 3 Jun 2024 Abstract A Silicon Photonics modulator is a high-speed photonic integrated circuit for optical data transmission in high-capacity optical networks. Silicon Photonics modulators in the configuration of a Mach–Zehnder interferometer, in which a PN-junction rib-waveguide phase shifter is inserted in each arm of the interferometer, [...] Read more. A Silicon Photonics modulator is a high-speed photonic integrated circuit for optical data transmission in high-capacity optical networks. Silicon Photonics modulators in the configuration of a Mach–Zehnder interferometer, in which a PN-junction rib-waveguide phase shifter is inserted in each arm of the interferometer, are studied in this paper because of their superior performance of high-quality optical data generation in a wide range of spectral bands and their simplicity in fabrication processes suitable to production in foundries. Design, fabrication, and fundamental characteristics of Silicon Photonics Mach–Zehnder modulators are reviewed as an introduction to these high-speed PICs on the Silicon Photonics platform. Modulation speed, or modulation bandwidth, is a key performance item, as well as optical loss, in the application to high-speed optical transmitters. Limiting factors on modulation speed are addressed in equations. Electrical resistance–capacitance coupling, which causes optical modulation bandwidth–optical loss trade-off, is the most challenging limiting factor that limits high-speed modulation. Expansion of modulation bandwidth is not possible without increasing optical loss in the conventional approaches. A new idea including quantum-mechanical effect in the design of Silicon Photonics modulators is proposed and proved in computational analysis to resolve the bandwidth loss trade-off. By adding high-mobility quantum-well overlayers to the side slab wings of the rib-waveguide phase shifter, the modulation bandwidth is doubled without increasing optical loss to achieve a 200 Gbaud modulation rate. Full article (This article belongs to the Special Issue Novel Advances in Integrated Optics) 17 pages, 2031 KiB Open AccessReview Phytosterols: Physiological Functions and Potential Application by Mingyue Shen, Lanlan Yuan, Jian Zhang, Xufeng Wang, Mingyi Zhang, Haizhen Li, Ying Jing, Fengjiao Zeng and Jianhua Xie Foods 2024, 13(11), 1754; https://doi.org/10.3390/foods13111754 (registering DOI) - 3 Jun 2024 Abstract Dietary intake of natural substances to regulate physiological functions is currently regarded as a potential way of promoting health. As one of the recommended dietary ingredients, phytosterols that are natural bioactive compounds distributed in plants have received increasing attention for their health effects. [...] Read more. Dietary intake of natural substances to regulate physiological functions is currently regarded as a potential way of promoting health. As one of the recommended dietary ingredients, phytosterols that are natural bioactive compounds distributed in plants have received increasing attention for their health effects. Phytosterols have attracted great attention from scientists because of many physiological functions, for example, cholesterol-lowering, anticancer, anti-inflammatory, and immunomodulatory effects. In addition, the physiological functions of phytosterols, the purification, structure analysis, synthesis, and food application of phytosterols have been widely studied. Nowadays, many bioactivities of phytosterols have been assessed in vivo and in vitro. However, the mechanisms of their pharmacological activities are not yet fully understood, and in-depth investigation of the relationship between structure and function is crucial. Therefore, a contemporaneous overview of the extraction, beneficial properties, and the mechanisms, as well as the current states of phytosterol application, in the food field of phytosterols is provided in this review. Full article (This article belongs to the Section Food Physics and (Bio)Chemistry) ►▼ Show Figures Figure 1 Figure 1 16 pages, 1948 KiB Open AccessSystematic Review Changes of the Alveolar Bone Ridge Using Bone Mineral Grafts and Collagen Membranes after Tooth Extraction: A Systematic Review and Meta-Analysis by Nansi López-Valverde, Bruno Macedo de Sousa and José Antonio Blanco Rueda Bioengineering 2024, 11(6), 565; https://doi.org/10.3390/bioengineering11060565 (registering DOI) - 3 Jun 2024 Abstract Background: Alveolar preservation techniques for esthetic or functional purposes, or both, are a frequently used alternative for the treatment of post-extraction sockets, the aim of which is the regeneration of the lesion and the preservation of the alveolar bone crest. Methods: Studies published [...] Read more. Background: Alveolar preservation techniques for esthetic or functional purposes, or both, are a frequently used alternative for the treatment of post-extraction sockets, the aim of which is the regeneration of the lesion and the preservation of the alveolar bone crest. Methods: Studies published in PubMed (Medline), Web of Science, Embase, and Cochrane Library databases up to January 2024 were consulted. Inclusion criteria were established as intervention studies, according to the PICOs strategy: adult subjects undergoing dental extractions (participants), with alveoli treated with bone mineral grafts and collagen membranes (intervention), compared to spontaneous healing (comparison), and observing the response to treatment in clinical and radiological measures of the alveolar bone crest (outcomes). Results: We obtained 561 results and selected 12 studies. Risk of bias was assessed using the Cochrane Risk of Bias Tool, and methodological quality was assessed using the Joanna Briggs Institute. Due to the high heterogeneity of the studies (I2 > 75%), a random-effects meta-analysis was used. Despite the trend, no statistical significance (p > 0.05) was found in the experimental groups. Conclusions: The use of bone mineral grafts in combination with resorbable collagen barriers provides greater preservation of the alveolar ridge, although more clinical studies are needed. Full article (This article belongs to the Special Issue Tissue Engineering for Regenerative Dentistry) attachment Supplementary material: Supplementary File 1 (ZIP, 110 KiB) 12 pages, 1829 KiB Open AccessArticle Leukocyte Telomere Length Mediates the Associations between Blood Lead and Cadmium with Hypertension among Adults in the United States: A Cross-Sectional Study by Changping Ouyang, Yinan Yang, Jinhua Pan, Heming Liu, Xuemei Wang, Shengze Zhou, Xiaoru Shi, Yanxia Zhang, Dan Wang and Xiaobin Hu Toxics 2024, 12(6), 409; https://doi.org/10.3390/toxics12060409 (registering DOI) - 3 Jun 2024 Abstract There is evidence to support the links between lead and cadmium exposure with hypertension and also with leukocyte telomere length (LTL). The objective of this study is to investigate the role that LTL may play in the relationship between lead and cadmium exposure [...] Read more. There is evidence to support the links between lead and cadmium exposure with hypertension and also with leukocyte telomere length (LTL). The objective of this study is to investigate the role that LTL may play in the relationship between lead and cadmium exposure and hypertension. This study consisted of 3718 participants from the National Health and Nutrition Examination Survey (NHANES) 1999–2002. Logistic regression was used to analyze the relationship between blood metals with hypertension, and the mediating model was used to evaluate the mediating effect of LTL. In the fully adjusted model, both blood lead and cadmium ln-transformed concentrations were significantly positively associated with hypertension risk, as were all quartiles of blood lead. Additionally, we observed positive linear dose–response relationships with hypertension by restricted cubic spline analysis (both p overall < 0.001, p non-linear = 0.3008 for lead and p non-linear = 0.7611 for cadmium). The ln-transformed blood lead and cadmium concentrations were associated with shorter LTL. LTL was inversely related to hypertension and the OR was 0.65 (95% CI: 0.47 to 0.89). Furthermore, LTL had mediating effects on the associations of blood lead and cadmium with hypertension risk, and the mediation proportions were 2.25% and 4.20%, respectively. Our findings suggested that exposure to lead and cadmium raised the risk of hypertension, while LTL played as a mediating factor. Full article (This article belongs to the Special Issue Traditional and Emerging Pollutants: Human Exposure Profiles and Health Effects) ►▼ Show Figures Figure 1 Figure 1 10 pages, 1612 KiB Open AccessArticle Generation of Bright–Dark Pulse Pairs in the Er-Doped Mode-Locked Fiber Laser Based on Doped Fiber Saturable Absorber by Yaoyao Qi, Qixing Yu, Wei Sun, Yaqing Gao, Yu Zhang, Zhenxu Bai, Jie Ding, Bingzheng Yan, Yulei Wang, Zhiwei Lu and Dapeng Yan Photonics 2024, 11(6), 534; https://doi.org/10.3390/photonics11060534 (registering DOI) - 3 Jun 2024 Abstract : This study reports new types of passive mode-locked Er-doped fiber laser (EDFL) based on a segment of doped fiber saturable absorber (DFSA) with Tm/Ho-doped fiber (THDF), Yb-doped fiber (YDF), and Er-doped fiber (EDF). By employing THDF-SA, a bright pulse sequence with a [...] Read more. : This study reports new types of passive mode-locked Er-doped fiber laser (EDFL) based on a segment of doped fiber saturable absorber (DFSA) with Tm/Ho-doped fiber (THDF), Yb-doped fiber (YDF), and Er-doped fiber (EDF). By employing THDF-SA, a bright pulse sequence with a fundamental repetition rate of 17.86 MHz was obtained. In addition, various mode-locked output states, including dark pulses, dark–bright pulse pairs, bright–dark pulse pairs, and second-harmonic pulses, were obtained through polarization modulation and gain modulation, and the orthogonality of dark–bright pulses in both polarization directions was verified. Furthermore, using EDF-SA and YDF-SA, dark pulses and dark–bright pulses were obtained. A comparison of the three experiments revealed that THDF-SA effectively reduces the mode-locked threshold and improves the average output power. Compared with bright pulses, dark pulses offer several advantages such as resisting noise, increasing propagation speed, and suppressing nonlinear scattering (such as pulse-intrinsic Raman scattering); thus, the EDFL can find broad application in long-distance transmission, precision measurement, and other fields. Full article (This article belongs to the Special Issue Advanced Lasers and Their Applications II) attachment Supplementary material: Supplementary File 1 (ZIP, 100 KiB) 16 pages, 3115 KiB Open AccessArticle (-)-Gallocatechin Gallate Mitigates Metabolic Syndrome-Associated Diabetic Nephropathy in db/db Mice by Xin Xiao, Huifang Ge, Yijun Wang, Xiaochun Wan, Daxiang Li and Zhongwen Xie Foods 2024, 13(11), 1755; https://doi.org/10.3390/foods13111755 (registering DOI) - 3 Jun 2024 Abstract Metabolic syndrome (MetS) significantly predisposes individuals to diabetes and is a prognostic factor for the progression of diabetic nephropathy (DN). This study aimed to evaluate the efficacy of (-)–gallocatechin gallate (GCG) in alleviating signs of MetS-associated DN in db/db mice. We administered GCG [...] Read more. Metabolic syndrome (MetS) significantly predisposes individuals to diabetes and is a prognostic factor for the progression of diabetic nephropathy (DN). This study aimed to evaluate the efficacy of (-)–gallocatechin gallate (GCG) in alleviating signs of MetS-associated DN in db/db mice. We administered GCG and monitored its effects on several metabolic parameters, including food and water intake, urinary output, blood glucose levels, glucose and insulin homeostasis, lipid profiles, blood pressure, and renal function biomarkers. The main findings indicated that GCG intervention led to marked improvements in these metabolic indicators and renal function, signifying its potential in managing MetS and DN. Furthermore, transcriptome analysis revealed substantial modifications in gene expression, notably the downregulation of pro-inflammatory genes such as S100a8, S100a9, Cd44, Socs3, Mmp3, Mmp9, Nlrp3, IL–1β, Osm, Ptgs2, and Lcn2 and the upregulation of the anti-oxidative gene Gstm3. These genetic alterations suggest significant effects on pathways related to inflammation and oxidative stress. In conclusion, GCG demonstrates therapeutic efficacy for MetS–associated DN, mitigating metabolic disturbances and enhancing renal health by modulating inflammatory and oxidative responses. Full article (This article belongs to the Special Issue State-of-the-Art Review of Tea: Processing Technology, Quality Control and Health Benefits) ►▼ Show Figures Figure 1 Figure 1 17 pages, 2162 KiB Open AccessArticle Development of an Apple Snack Enriched with Probiotic Lacticaseibacillus rhamnosus: Evaluation of the Refractance Window Drying Process on Cell Viability by Helena Nuñez, Aldonza Jaques, Karyn Belmonte, Jamil Elitin, Mónika Valdenegro, Cristian Ramírez and Andrés Córdova Foods 2024, 13(11), 1756; https://doi.org/10.3390/foods13111756 (registering DOI) - 3 Jun 2024 Abstract The objective of this study was to develop a dried apple snack enriched with probiotics, evaluate its viability using Refractance Window (RWTM) drying, and compare it with conventional hot air drying (CD) and freeze-drying (FD). Apple slices were impregnated with Lacticaseibacillus [...] Read more. The objective of this study was to develop a dried apple snack enriched with probiotics, evaluate its viability using Refractance Window (RWTM) drying, and compare it with conventional hot air drying (CD) and freeze-drying (FD). Apple slices were impregnated with Lacticaseibacillus rhamnosus and dried at 45 °C using RWTM and CD and FD. Total polyphenol content (TPC), color (∆E*), texture, and viable cell count were measured, and samples were stored for 28 days at 4 °C. Vacuum impregnation allowed for a probiotic inoculation of 8.53 log CFU/gdb. Retention values of 6.30, 6.67, and 7.20 log CFU/gdb were observed for CD, RWTM, and FD, respectively; the population in CD, RWTM remained while FD showed a decrease of one order of magnitude during storage. Comparing RWTM with FD, ∆E* was not significantly different (p < 0.05) and RWTM presented lower hardness values and higher crispness than FD, but the RWTM-dried apple slices had the highest TPC retention (41.3%). Microstructural analysis showed that RWTM produced a smoother surface, facilitating uniform moisture diffusion and lower mass transfer resistance. The effective moisture diffusion coefficient was higher in RWTM than in CD, resulting in shorter drying times. As a consequence, RWTM produced dried apple snacks enriched with probiotics, with color and TPC retention comparable to FD. Full article (This article belongs to the Section Food Engineering and Technology) ►▼ Show Figures Graphical abstract Graphical abstract More Articles... 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HIGHLY ACCESSED ARTICLES Commentary Methodological Considerations Regarding the Quantification of DNA Impurities in the COVID-19 mRNA Vaccine Comirnaty® by Brigitte König and Jürgen O. Kirchner Methods Protoc. 2024, 7(3), 41; https://doi.org/10.3390/mps7030041 Published: 8 May 2024 Systematic Review The Risk of Aircraft-Acquired SARS-CoV-2 Transmission during Commercial Flights: A Systematic Review by Diana Zhao et al. Int. J. Environ. Res. Public Health 2024, 21(6), 654; https://doi.org/10.3390/ ijerph21060654 Published: 21 May 2024 Article Ketogenic Diet Induced Shifts in the Gut Microbiome Associate with Changes to Inflammatory Cytokines and Brain-Related miRNAs in Children with Autism Spectrum Disorder by Nina P. Allan et al. Nutrients 2024, 16(10), 1401; https://doi.org/10.3390/nu16101401 Published: 7 May 2024 Article Net Isotopic Signature of Atmospheric CO2 Sources and Sinks: No Change since the Little Ice Age by Demetris Koutsoyiannis Sci 2024, 6(1), 17; https://doi.org/10.3390/sci6010017 Published: 14 March 2024 Article The Impact of the Industrial Internet on the Innovation and Development Level of China’s Manufacturing Industry: Under the Perspective of Government Incentives by Liang Ma et al. Sustainability 2024, 16(10), 3935; https://doi.org/10.3390/su16103935 Published: 8 May 2024 Article CB1 Receptor Negative Allosteric Modulators as a Potential Tool to Reverse Cannabinoid Toxicity by Audrey Flavin et al. Molecules 2024, 29(8), 1881; https://doi.org/10.3390/molecules29081881 Published: 20 April 2024 Article The Russian Orthodox Mission in Beijing (XVIII–XX Centuries): Historiography, Missionary Role, and Contemporary Assessment by Jingcheng Li Religions 2024, 15(5), 557; https://doi.org/10.3390/rel15050557 Published: 29 April 2024 Communication Advancing Evidence Generation for Circulating Tumor DNA: Lessons Learned from A Multi-Assay Study of Baseline Circulating Tumor DNA Levels across Cancer Types and Stages by Brittany A. McKelvey et al. Diagnostics 2024, 14(9), 912; https://doi.org/10.3390/diagnostics14090912 Published: 27 April 2024 Review Autoimmunity in Syndromes of Orthostatic Intolerance: An Updated Review by Clarissa Pena et al. J. Pers. Med. 2024, 14(4), 435; https://doi.org/10.3390/jpm14040435 Published: 20 April 2024 LATEST BOOKS Open Access Book Optimization Problems in Transportation and Logistics: A Practical Guide Author: Raj Bridgelall Reprint Concrete Structures: Latest Advances and Prospects for a Sustainable Future Editors: Mariella Diaferio, Francisco B. Varona More Books and Reprints... NEWS 29 May 2024 Meet Us at the 26th IUFRO World Congress, 23–29 June 2024, Stockholm, Sweden 29 May 2024 MDPI Celebrates a Year of Continued Success in Open Access Publishing 23 May 2024 Transfer Service in MDPI More News & Announcements... BLOG POSTS 3 Jun 2024 Spotlight on Polymers 31 May 2024 Assessing Hurricanes with Remote Sensing Techniques More From Our Blog... 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