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 1. Home
 2. Archives
 3. Vol. 2 No. 2 (2018)
 4. Featured Article


UTILITY OF FOOD PATCH TESTING IN THE EVALUATION AND MANAGEMENT OF IRRITABLE
BOWEL SYNDROME


MAIN ARTICLE CONTENT

Grace Shin
Lewis Katz School of Medicine at Temple University

Michael Smith
Icahn School of Medicine at Mount Sinai

Butros Toro
Lewis Katz School of Medicine at Temple University

Adam Ehrlich
Lewis Katz School of Medicine at Temple University

Sanjana Luther
Lewis Katz School of Medicine at Temple University

Deena Midani
Lewis Katz School of Medicine at Temple University

Inki Hong
Lewis Katz School of Medicine at Temple University

Michael Stierstorfer
University of Pennsylvania School of Medicine
http://orcid.org/0000-0002-0505-7431



KEYWORDS

Irritable bowel syndrome, IBS, delayed-type hypersensitivity, type 4
hypersensitivity, patch testing, food allergy, skin tests


ABSTRACT

Background

Irritable Bowel Syndrome (IBS) is a functional gastrointestinal (GI) disorder of
unknown etiology.

Objective

We sought to investigate whether specific type 4 food allergens identified by
skin patch testing, when eliminated from the diet, alleviate symptoms of IBS.

Methods

In this case series, skin patch testing was performed on 60 IBS patients using
an extensive panel of type 4 food allergens after which food avoidance diets
directed by the patch test results were implemented. Questionnaires assessing
abdominal pain/discomfort and global improvement in IBS symptoms were used to
assess one month and three or more month outcomes.

Results

There were statistically significant improvements in abdominal pain/discomfort
and in global IBS symptoms after one month and again at an average of 7.6 months
of patch test-guided food avoidance.

Conclusions

Sustained improvement with avoidance of type 4 food allergens identified by skin
patch testing suggests a role for delayed-type food hypersensitivities in the
pathogenesis of some cases of IBS. A subset of patients whose IBS symptoms
resolve completely may be better characterized as having a newly proposed
disease, allergic contact enteritis (ACE). 

 


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ARTICLE SIDEBAR

Full Article PDF
Published
Mar 9, 2018
DOI https://doi.org/10.25251/skin.2.2.2


ARTICLE DETAILS

How to Cite
Shin, G., Smith, M., Toro, B., Ehrlich, A., Luther, S., Midani, D., Hong, I., &
Stierstorfer, M. (2018). Utility of Food Patch Testing in the Evaluation and
Management of Irritable Bowel Syndrome. SKIN The Journal of Cutaneous Medicine,
2(2), 96–110. https://doi.org/10.25251/skin.2.2.2
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Issue
Vol. 2 No. 2 (2018)
Section
Featured Article

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Author Biographies


GRACE SHIN, LEWIS KATZ SCHOOL OF MEDICINE AT TEMPLE UNIVERSITY

Department of Medicine, Section of Gastroenterology


MICHAEL SMITH, ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

Professor and Chairman

Department of Medicine, Section of Gastroenterology


BUTROS TORO, LEWIS KATZ SCHOOL OF MEDICINE AT TEMPLE UNIVERSITY

Department of Medicine


ADAM EHRLICH, LEWIS KATZ SCHOOL OF MEDICINE AT TEMPLE UNIVERSITY

Assistant Professor of Medicine

Department of Medicine, Section of Gastroenterology


DEENA MIDANI, LEWIS KATZ SCHOOL OF MEDICINE AT TEMPLE UNIVERSITY

Department of Medicine, Section of Gastroenterology


MICHAEL STIERSTORFER, UNIVERSITY OF PENNSYLVANIA SCHOOL OF MEDICINE

Clinical Associate Professor

Department of Dermatology

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SKIN is a bi-monthly, peer-reviewed, online medical journal dedicated to
providing an enhanced route to disseminate new dermatologic knowledge on all
aspects of cutaneous disease. The Journal is Open Access. ISSN: 2574-1624

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