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https://www.birminghammail.co.uk/black-country/deadly-disease-overtaking-covid-new-27058806
Submission: On June 07 via manual from US — Scanned from DE
Submission: On June 07 via manual from US — Scanned from DE
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Black Country
By
Martin BagotHealth and Science Correspondent
Isabelle Bates
* 14:56, 5 JUN 2023
Bookmark
Prof Robert Wilkinson at his lab in Cape Town
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An ancient disease is overtaking covid as the world's most deadly, experts have
warned. Tuberculosis, known as TB, poses a threat to the UK.
A clinical trial is currently underway in Africa which hopes to tackle the
hidden pandemic. British Professor Robert Wilkinson is leading a global call to
find a one-shot vaccine with research institutions in the US, India, Vietnam,
Indonesia, Madagascar and the Ivory Coast.
Currently medication takes at least six months, and if drugs are stopped early
it can come back in a much more deadly drug-resistant form. The NHS stopped
offering the BCG vaccine against TB to all children in 2005, instead targeting
only children who may travel to badly-affected countries, the Mirror reports.
READ MORE: Brothers made paedophile pensioner drive to remote road before
beating him to death
However, immunity does not last past the teenage years. This is the focus of a
clinic run by Prof Wilkinson, of London's Francis Crick Institute.
"It's inevitable TB will be the most deadly infectious disease in the world
again," he said. "The proportion of resistant TB is gradually increasing
everywhere and that is a problem in Europe too.
"We should ensure all legal and illegal arrivals to the UK have access to health
care and, if necessary, screening and early treatment. Even if they are detained
for illegal arrival, they have a right to care and it is advantageous for the UK
to provide that."
TB cases imported into England have started to increase after a decade-long
decline. Almost a third of patients who catch this growing mutant form die.
PROMOTED STORIES
The World Health Organisation put annual TB deaths at 1.6 million during 2021,
with 2022 figures expected to be higher. Our World in Data, based at Oxford
University, puts Covid-19 deaths in 2022 at around 1.2m.
Prof Wilkinson added: "Most people, if you told them TB deaths were of a similar
order of magnitude as Covid, they would not believe you. There aren’t enough
resources compared to covid. It’s a drop in the ocean."
Latest data shows a TB rate of 7.8 cases per 100,000 in England in 2021. This
compared to 4.7 in Germany and 2.4 in the US. Dr Meera Chand, of the UK Health
Security Agency, said: "We are working with the NHS to strengthen prevention,
detection and treatment."
HISTORY AND SYMPTOMS:
TB has been around for 9,000 years and from 1600 to 1800 in Europe caused 25 per
cent of all deaths. It is still killing one person every 20 seconds globally.
This means it comes back stronger and treating these super strains can take two
years. Sadly, almost a third of such patients do not survive.
Therefore it is vital to develop quicker treatments that kill off the disease
before more mutant strains develop and spread.
TB most often affects the lungs and is caused by a type of bacteria. It spreads
through the air when infected people cough, sneeze or spit.
The problem with quickly finding and treating patients who catch TB is that the
symptoms can be more wide ranging.
They can include a prolonged cough sometimes with blood, chest pain, weakness,
fatigue, weight loss, fever and night sweats.
In rare but severe cases where the infection goes to the brain it can cause
severe headaches, irritability, and whole body pain.
Children are at higher risk from TB as are smokers and people with weakened
immune systems and diabetes.
Prof Wilkinson is leading talks with research institutions in the US, India,
Vietnam, Indonesia, Madagascar and the Ivory Coast with the ultimate aim to find
a 'one shot' treatment that cures TB. The aim is to enrol 10 to 15 of them to
set up trials at multiple sites and repurpose existing drugs for TB including
powerful anti-inflammatory pills.
One being considered, Infliximab, is currently used to treat autoimmune diseases
such as rheumatoid arthritis. Prof Wilkinson said: "There’s evidence to suggest
the target of that drug contributes to the tissue damage in TB meningitis.
"It is a very powerful, long acting anti-inflammatory with the advantage that
you only need an injection every two to four weeks. That would be a one shot jab
but it’s only a hypothesis at this stage."
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The as-yet unnamed pilot study will be modelled on Oxford University’s Recovery
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Prof Wilkinson added: "It would be the biggest-ever clinical trial into TB if we
can get the funding."
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TikTok murder trial live as Mahek Bukhari's co-accused take stand
Mahek Bukhari
Raees Jamal, who is accused of ramming the victims' car off the road, is in the
witness box
Recap as 'professional hitmen' and accomplice jailed over botched £100k contract
killing bid
Sheldon
Connor Palmer, 40, Craig Miller, 37, and Elijah Stokes, 38, were previously
convicted of conspiracy to murder a man who was shot in Sheldon
Appalled Sainsbury's staff find cockerel 'cruelly' dumped in bin bag and bound
with tape at store
Worcestershire
Cruel fly tippers abandoned the bird in a supermarket recycling area in Redditch
with its beak taped up
Factory fire shuts Aldi as 50 firefighters tackle blaze
Black Country
A big blaze at a factory unit in Peartree Lane in Dudley led to a number of
businesses being shut for hours including supermarket giant Aldi
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