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MODERNA SAYS ITS COVID-19 VACCINE PERFORMS AS WELL IN CHILDREN AS IT DOES IN
ADULTS

By John Bonifield, CNN



Updated 1203 GMT (2003 HKT) March 23, 2022


JUST WATCHED


MODERNA CHIEF MEDICAL OFFICER: THE END OF OMICRON WAVE IS IN SIGHT


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Moderna Chief Medical Officer: The end of Omicron wave is in sight 04:40

(CNN)Moderna announced interim results of its Covid-19 vaccine for children
younger than 6 on Wednesday.

The company said two 25-microgram doses of its Covid-19 vaccine for children
ages 6 months through 5 years old provided a similar immune response to two
100-microgram doses for adults ages 18 to 25, indicating that the benefit
conferred to young adults is also conferred to young children.
The two doses of vaccine are given to children 28 days apart.



The data showed "a robust neutralizing antibody response" and "a favorable
safety profile," according to a company news release issued Wednesday.

Moderna seeks FDA authorization for second Covid-19 booster shot for all adults
Based on the data, Moderna said it will ask the US Food and Drug Administration
to authorize the use of the vaccine in this younger age group in the coming
weeks.
Read More
"Given the need for a vaccine against COVID-19 in infants and young children we
are working with the U.S. FDA and regulators globally to submit these data as
soon as possible," Moderna CEO Stéphane Bancel said. "We believe these latest
results ... are good news for parents of children under 6 years of age."
The vaccine was not all that effective at preventing Covid-19 infections caused
by the Omicron variant, which predominated in the US during the study. For
children ages 6 months through 1 year old, the efficacy was 43.7%. For children
ages 2 through 5, the efficacy was 37.5%. Moderna said the lower efficacy was
still statistically significant and consistent with how vaccinated adults have
fared with the Omicron variant.



Moderna said it is preparing to evaluate the potential of a booster shot for all
children 6 months and older, which would target the original strain of the virus
as well as the Omicron variant.
The data is based on a group of 6,900 children ages 6 months through 5 years
old. The majority of adverse reactions were mild or moderate, and were more
frequent after the second shot. Moderna said no deaths and no cases of
myocarditis or pericarditis were reported. Myocarditis is inflammation of the
heart muscle and pericarditis is inflammation of the heart lining.
Get CNN Health's weekly newsletter

Sign up here to get The Results Are In with Dr. Sanjay Gupta every Tuesday from
the CNN Health team.


Moderna also announced that it has initiated a submission to the FDA for
emergency use authorization of the company's Covid-19 vaccine for children ages
6 through 11 years old. Children that age would get two shots of a larger
50-microgram version of the vaccine. Moderna also said it provided the FDA with
additional follow-up data on its vaccine for children ages 12 to 17. Children
that age would get two shots of a larger 100-microgram version of the vaccine.
Last month, the FDA postponed a meeting of its vaccine advisers to consider
Pfizer/BioNTech's Covid-19 vaccine for children younger than 5, and requested
additional data on third doses. The companies have said they expect that data to
be ready by early April.



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Questions swirl over whereabouts of Russia's defense minister


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