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News » Urology » Kidney Stones
Publish Date October 18, 2023
MARIJUANA USE TIED TO LOWER KIDNEY STONE RISK IN MEN
Jody A. Charnow
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Men who used marijuana 1 to 7 times per week had significant 38% lower odds of
kidney stones compared with nonusers. Source: Getty Images
Men who use marijuana regularly are less likely to report having kidney stones,
according to a recent study.
An analysis of 2009 to 2018 data from the National Health and Nutrition
Examination Survey (NHANES) revealed that male marijuana users had significant
28% lower odds of reporting kidney stones compared with nonusers after adjusting
for multiple variables, Xin Wei, MD, of West China Hospital, Sichuan University
in Chengdu, Sichuan, China, and colleagues reported in Frontiers in
Pharmacology. Men who used marijuana 1 to 7 times per week had significant 38%
lower odds. Those who used marijuana more than 7 times per week did not have
reduced odds of kidney stones. The investigators found no association between
marijuana use and kidney stones in women.
“To our knowledge, this study is the first cross-sectional study to explore the
association between marijuana use and the risk of kidney stones from the
population-based NHANES dataset,” the author wrote.
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The study included 14,324 participants aged 20 to 59 years with a complete
history of marijuana use and kidney stones. Of these, 26% reported having used
marijuana during their lifetime. The incidence rate of kidney stones was 7.8%.
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With respect to study limitations, the investigators pointed out that due to the
cross-sectional design of the NHANES dataset, they could not explore a causal
link between marijuana use and kidney stones. They also noted that information
about marijuana use was self-reported, with no indication of the exact type and
dose of cannabis.
“The study appears to have been well done, and the data appear credible,” said
David S. Goldfarb, MD, Clinical Chief of Nephrology and Director of the Kidney
Stone Prevention Program at NYU Langone Health in New York, who was not involved
in the current study. “I don’t think the study can really provide a plausible
mechanism for the effect in men, and the lack of an effect in women.”
The finding that marijuana use beyond 7 times per week did not further reduce
risk of stones was surprising, Dr Goldfarb said.
He added, “Most of the marijuana use reported here is almost certainly smoking;
it would be interesting to see if people using edibles, which has increased in
the US, would have the same risk.”
Reference
Di X, Xiang L, Wang M, Wei X. Association between marijuana use and kidney
stone: a cross-sectional study of NHANES 2009 to 2018. Front Pharmacol.
Published online September 7, 2023. doi:10.3389/fphar.2023.1214647
TOPICS:
Cannabinoids Epidemiology Kidney Stones Men's Health Smoking
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