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In Vivo, Optimized
Unmatched sensitivity for bioluminescence and fluorescence - in just 3 clicks
New: Aura Kinetics
Automatically Acquire Bioluminescent Kinetic Curve Data in Real Time
Learn More
Aura 4.5
Features Include: Easy Mode, Smart Auto Exposure, Smooth Blend and more!
Get Your Free Download Today!
Better Data, Faster
Capture and analyze your data quickly, easily, and accurately
Robust Design
Built to support demanding requirements and withstand punishing environments
Ultimate in High Throughput
When discovery depends on precise timepoints, it’s important to capture data
both accurately – and efficiently – to meet today’s scientific demands
Robust & Reliable
Advanced optical imaging systems built to satisfy the most demanding, fast paced
core labs
Built for your life's work
Designed for scientists whose studies rely on obtaining high quality data in
small animal imaging
In Vivo, Optimized
Unmatched sensitivity for bioluminescence and fluorescence - in just 3 clicks
New: Aura Kinetics
Automatically Acquire Bioluminescent Kinetic Curve Data in Real Time
Learn More
Aura 4.5
Features Include: Easy Mode, Smart Auto Exposure, Smooth Blend and more!
Get Your Free Download Today!
Better Data, Faster
Capture and analyze your data quickly, easily, and accurately
Robust Design
Built to support demanding requirements and withstand punishing environments
Ultimate in High Throughput
When discovery depends on precise timepoints, it’s important to capture data
both accurately – and efficiently – to meet today’s scientific demands
Robust & Reliable
Advanced optical imaging systems built to satisfy the most demanding, fast paced
core labs
Built for your life's work
Designed for scientists whose studies rely on obtaining high quality data in
small animal imaging
In Vivo, Optimized
Unmatched sensitivity for bioluminescence and fluorescence - in just 3 clicks
New: Aura Kinetics
Automatically Acquire Bioluminescent Kinetic Curve Data in Real Time
Learn More
Aura 4.5
Features Include: Easy Mode, Smart Auto Exposure, Smooth Blend and more!
Get Your Free Download Today!
Better Data, Faster
Capture and analyze your data quickly, easily, and accurately
Robust Design
Built to support demanding requirements and withstand punishing environments
Ultimate in High Throughput
When discovery depends on precise timepoints, it’s important to capture data
both accurately – and efficiently – to meet today’s scientific demands
Robust & Reliable
Advanced optical imaging systems built to satisfy the most demanding, fast paced
core labs
Built for your life's work
Designed for scientists whose studies rely on obtaining high quality data in
small animal imaging

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10 MOUSE CAPACITY

Industry leading field of view maximizes your productivity




BLI FLI X-RAY

Advanced preclinical optical imaging: bioluminescence, fluorescence and X-ray 




PATENTED ILLUMINATION

100x more light on target gives you a stronger fluorescence signal with minimal
background for superior quantitation




36% MORE SENSITIVE

When comparing minimum detectable radiance for bio-luminescence to the leading
competitor




REVEALS COMPLEX BIOLOGICAL PROCESSES


WITHOUT BEING OVERLY COMPLICATED




 * ROBUST BUILD
   
   


 * LESS PIECES AND PARTS TO BREAK
   
   


 * ULTIMATE IN HIGH THROUGHPUT
   
   


 * FASTER ACQUISITION TIMES
   
   


 * HIGH SENSITIVITY
   
   


 * LOW BACKGROUND
   
   



View Systems
Learn More about Spectral’ s Technology
Download Brochure




REVEALS COMPLEX BIOLOGICAL PROCESSES


WITHOUT BEING OVERLY COMPLICATED




 * ROBUST BUILD
   
   


 * LESS PIECES AND PARTS TO BREAK
   
   


 * ULTIMATE IN HIGH THROUGHPUT
   
   


 * FASTER ACQUISITION TIMES
   
   


 * HIGH SENSITIVITY
   
   


 * LOW BACKGROUND
   
   



View Systems
Learn More about Spectral’ s Technology
Download Brochure




ADVANCED CAPABILITIES

See the Data


BIOLUMINESCENCE




FLUORESCENCE




X-RAY




MULTI MODALITY COREGISTRATION




QUANTITATIVE 3D OPTICAL IMAGING






AURA IN VIVO IMAGING SOFTWARE


 * AUTOMATICALLY ACQUIRE BIOLUMINESCENT KINETIC CURVE DATA IN REAL TIME
   
   Kinetics Mode ensures you're capturing peak data for optimal sensitivity &
   reproducibility


 * 3 CLICKS TO ACQUISITION
   
   New Easy Mode makes capturing data faster than ever before Simply select your
   probe & subject, then acquire your data.


 * EFFORTLESSLY ACQUIRE STUNNING IMAGES
   
   Smart AutoExp with proprietary SmoothBlend technology enables rapid data
   acquisition at maximum sensitivity without compromising image quality.


 * IMPORT LEGACY IMAGE FILES
   
   Display and analyze files from Living Image® (IVIS®)


 * 100% LICENSE FREE
   
   Available for PC & Mac users

Learn More
Download Brochure



DESIGN YOUR IN VIVO EXPERIMENTS WITH CONFIDENCE

Join Spectral Instrument Imaging’s applications expert Andrew Van Praagh, and
his guest speakers, for an educational webinar series highlighting best
practices for experimental design and more!

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EXPERTS TRUST EXPERTS

Spectral Instruments Imaging is the fusion of principal developers in in vivo
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advance pre-clinical imaging to reveal complex biological processes.




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WHAT RESEARCHERS ARE SAYING...

I would definitely say I prefer the Ami HT to the Xenogen IVIS. The software is
intuitive, the nose cone setup is more flexible, and the resolution is better,
but by far the best feature is how quickly the camera sensor cools down. No more
waiting around for ages if you forget to pre-cool the instrument!

Dr. David PeelerImperial College of London
We have used our Ami-X intensively for the past four years and have been
extremely pleased with the sensitivity and reliability of this instrument, both
for NIR fluorescence and bioluminescence capture. Operation is very simple and
the system needs almost no maintenance at all. On top of this, technical support
is easy to reach and quick to reply with solutions for general use and technical
questions. The Aura software is very simple to learn and having unlimited free
copies of this program available for all our computers is an enormous advantage
for image analysis. In fact, the system is so robust and easy to operate that we
use it not only for research but also for teaching in vivo imaging methods in
our graduate courses.

Mariano S. Viapiano, PhDSUNY Upstate Medical University
Our Ami has been an essential instrument in our lab for a few years now and has
always worked reliably, especially during many periods of intensive usage. The
Aura software is very user-friendly and intuitive to operate. Communicating with
technical support is always a quick and pleasant affair and they have been
incredibly forthcoming in replacing some minor lost parts, so that we could
continue using our Ami without delay.

Annika TamenangUniversity of California, San Francisco
We were so pleased with the instrument’s performance and SII’s support within
the very first year of use that we committed to a replacement of our entire
suite of older instruments with SII products. The LED based illumination meant
that there was nearly a 90X more light incident on the surface of the specimen
versus traditional white lights used by other manufacturers which translates to
earlier detection – sometimes weeks ahead – saving researchers time and money.
It also dramatically improved the utilization of the imaging core. SII has a
single-minded focus on building the best optical imaging instruments for
bioluminescence and fluorescence. The entire company – management, engineers,
sales team and support is aligned around that central focus. This has meant many
good things for us as a customer – where the innovation continues non-stop. We
are already seeing many new features in software and hardware that leave us very
optimistic about the future.

David M Colcher, PhDCity of Hope
"We really like the SII Lago imaging instrument because it has several
improvements as compared to our previous IVIS instrument. The second adapter
with 10 nosepieces allows us to image up to 10 mice at once, which saves us a
lot of time when imaging mice. Additionally, the software is very user-friendly
and easy to run. Nice features that we appreciate are the white light inside the
instrument that is very helpful for positioning the mice. Also, the button that
automatically opens the door of the instrument is helpful. Finally, we noticed
that the instrument reaches the temperature in a very short time allowing us to
begin imaging pretty much right away and this again saves us a lot of time"

Mariafausta Fischietti, PhDNorthwestern University
“The support from Spectral Instruments has been excellent. The only issue that
we have had with our two LagoX machines was self-inflicted. Aggressive firewall
and anti-virus software that we installed on the computer resulted in a camera
initialization issue. Spectral Instruments responded immediately and was on site
within 48 hours. They worked with us to identify and correct the issue. It is
refreshing to work with a company that is personally engaged and takes pride in
the quality and support of their product.”

MarkBig Pharma
I have been extremely pleased with SII. Bo Nelson and the team has been
outstanding with helping me with filter selections and filter exchanges based
upon fluorophore requirements, ensuring the instrument is operating to
specifications, with new software updates and any problems, albeit rare, we are
having with our Ami. The system is super robust and easy to train users. Another
huge benefit is the software is free, allowing me to refer to our users to SII
website and thereby allowing them to analyze the data on their own PCs saving
time and money.

Andy Schaber, PhDPurdue University
We are very happy with the Lago and LagoX systems. Great customer service too.

Alvin GogineniGenentech
[I am] impressed with its robustness and its abilities to detect a wide range of
labels and sensitivity of detection.

Dr. Robin ShattockImperial College of London
Due to the frustrating customer support experiences related to our Perkin
Elmer's IVIS instrument, we decided to give the Lago X a shot. As a core
laboratory, we offer it to multiple research groups. Our users transition from
IVIS to Lago was seamless. They are pleased by the faster cooling of the Lago
camera, the higher animal capacity of the imaging chamber, user friendliness of
the [free] Aura software (additional IVIS desktop analysis software copies must
be paid for) We have a great relationship with Bo, Andrew and the SI team.
Getting hardware or software support from them is just so easy!

Melissa Kazantis, PhDScripps
Having the ability to easily image up to 10 animals at a time has been such a
time saving bonus! I can get my data collected twice as fast which allows me
more time for data analysis and coffee! The Lago is very intuitive and so easy
to use. I have been using the system for over a year now and have not yet ran
across any type of malfunction issue, my previous equipment would require
constant troubleshooting.

Aneta BaranNorthwestern University
In our laboratory, we have found the AMI imaging system to provide reproducible
BLI imaging data in the context of orthotopic pancreatic and ovarian tumors in
mice. As these tumor types are located deeply within the mouse, it was essential
to have a system that had high sensitivity. One aspect of the AMI that we find
to be highly important is the reproducibility of the images including that the
signal detected from each mouse is independent of the relative order of the
mouse within the system, i.e. mouse 1 has the same signal regardless of if it is
in the 1, 2, 3, 4, or 5 position within the mouse holder. Additionally, we have
found the NIR fluorescence to be of high sensitivity with the ability to
differentiate signals at 680nm, 715nm, 750nm, and 800nm. Perhaps, the most
important aspect of our experience with Spectral Instruments Imaging has been
that they are very receptive to aiding the users and provide exceptional support
even well after our instrument purchase

Lacey McNally, PhDUniversity of Oklahoma
I have had over 20 years experience utilizing bioluminescence imaging in mouse
models of cancer in both industry and academic settings. This technology is
essential for the work performed by my lab and with our collaborators. Much of
our work is done with orthotopic and metastatic tumor models, but we also use it
for luciferase-enabled genetically engineered mouse models. We use
bioluminescence imaging to evaluate biologic aspects of tumor progression and
metastasis as well as response to experimental therapeutics. For the past 5
years, we have exclusively used the Spectral Instruments AMI HTX system having
switched from our IVIS 100. We have been impressed with the relative performance
of the AMI HTX system, from its rapid startup, stability, sensitivity and the
ease of using Aura software, which is freely available to my collaborators
facilitating our studies. Spectral Instruments has been a pleasure to work with
over the years responding rapidly to any questions that emerge. I am highly
recommending this system to anyone who uses this technology.

Michael Henry, PhDUniversity of Iowa
We have never experienced such an excellent customer relationship with any other
vendor and are truly appreciative.

Maricela CastellonUniversity of Illinois Chicago
Our core runs the Ami users all enjoy the machine. The software update with easy
mode has been great for new users to have a guided trial for different tests. As
the trainer for the past few months and managing this machine, I have collected
a lot of feedback. We are able to produce clear images with greater ease than
the IVIS system. Having a centralized mechanism for x-ray, fluorescence, and
bioluminescence has been a great tool for all users. Using the Ami-HTX, we have
been able to use a hypoxia-targeting dye to confirm the hypoxia status of two
cancer cell lines

Elle PoetaUT Southwestern
I would definitely say I prefer the Ami HT to the Xenogen IVIS. The software is
intuitive, the nose cone setup is more flexible, and the resolution is better,
but by far the best feature is how quickly the camera sensor cools down. No more
waiting around for ages if you forget to pre-cool the instrument!

Dr. David PeelerImperial College of London
We have used our Ami-X intensively for the past four years and have been
extremely pleased with the sensitivity and reliability of this instrument, both
for NIR fluorescence and bioluminescence capture. Operation is very simple and
the system needs almost no maintenance at all. On top of this, technical support
is easy to reach and quick to reply with solutions for general use and technical
questions. The Aura software is very simple to learn and having unlimited free
copies of this program available for all our computers is an enormous advantage
for image analysis. In fact, the system is so robust and easy to operate that we
use it not only for research but also for teaching in vivo imaging methods in
our graduate courses.

Mariano S. Viapiano, PhDSUNY Upstate Medical University

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WANT A 5 STAR IN VIVO IMAGING EXPERIENCE?



Ami HTX
Read More
Very satisfied long-term with AmiHTX - sensitive and stable.

Ami HTX
Read More
Fast, easy to use, attentive operations staff.

Ami HT
Read More
Great results! Would highly recommend this company and products.

Lago X
Read More
The Lago X is by far the best out there!

Ami HTX
Read More
Very satisfied long-term with AmiHTX - sensitive and stable.

Ami HTX
Read More
Fast, easy to use, attentive operations staff.

Ami HT
Read More
Great results! Would highly recommend this company and products.

Lago X
Read More
The Lago X is by far the best out there!

Ami HTX
Read More
Very satisfied long-term with AmiHTX - sensitive and stable.

Ami HTX
Read More
Fast, easy to use, attentive operations staff.

Ami HT
Read More
Great results! Would highly recommend this company and products.

Lago X
Read More
The Lago X is by far the best out there!

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