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UPM Biomedicals
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GROWDEX® HYDROGEL RANGE

Next generation solution for reproducible and scalable animal-free 3D cell
culture applications providing convenience and consistent results.


 


WHAT IS GROWDEX?

GrowDex is an animal free, ready to use hydrogel that mimics the extracellular
matrix (ECM) and supports cell growth and differentiation with consistent
results. 

GrowDex is a proven solution for automation and high throughput screening.
GrowDex can be used for 3D cell culture for spheroids and organoids, in
personalised medicine, regenerative medicine, organ-on-a-chip models, drug
release studies and more. 


 


GUIDE: TRANSFER YOUR 3D CELL CULTURE MATRICES TO ANIMAL-FREE GROWDEX

Read more & download
 


OUR PRODUCTS

GROWDEX®

With over 150 different assay protocols available GrowDex is our original
hydrogel. Highly biocompatible GrowDex has been used widely for the culture of
primary cells through to iPS and ES cells.

Product page

GROWDEX®-T

GrowDex-T brings superior imaging quality for phase contrast and brightfield
imaging. This hydrogel is completely transparent making imaging and automated
analysis easy.

Product page

GROWDEX®-A

If you are looking to customise your hydrogel then GrowDex-A is for you.
GrowDex-A has been modified by the addition of an avidin group so you can attach
any biotinylated molecule you like.

Product page

GROWDASE™

GrowDase enzyme breaks down GrowDex hydrogel to form a solution in an easy one
step efficient cell recovery process.

Product page

GROWINK™

GrowInk Bioinks for 3D printing, can be mixed directly with cells for
bioprinting applications. The matrix can be customised by the addition of
molecules, such as growth factors or adhesion proteins, as needed by your
specific cells.

Product page
 


WHY GO ANIMAL FREE IN CELL CULTURE?

Despite their wide usage, animal derived matrices have been notoriously
difficult to use. With animal free hydrogels like GrowDex, you'll get new
benefits, such as: • Reproducible assays with no lot-to-lot variation • Handling
in room temperatures • Defined composition without unknown protein composition •
Ability to translate the cell culture assays towards clinical application •
Sustainable and ethical material

Read more

 


FEATURES AND BENEFITS OF GROWDEX HYDROGELS

 

ANIMAL FREE*

Clean and well-defined hydrogels consisting of only nanofibrillar cellulose and
purified water. No animal DNA interfering with readouts. *Excludes GrowDex-A
after addition of biotinylated ligands

Read more

REPRODUCIBLE LOTS

Do not add variation to your results. Our GrowDex hydrogels are manufactured to
the highest standards with strict quality control criteria, so you can be sure
the performance will be the same regardless of the production batch ordered.

READY TO USE

No gel preparation steps required. GrowDex hydrogels are provided ready to use,
and they can be used and stored at room temperature. Just mix the hydrogel with
your media and cells, dispense and incubate.

ONE-STEP CELL RECOVERY

Cells and organoids can be recovered from GrowDex with a gentle one-step
enzymatic process with our GrowDase without affecting the cells.

TEMPERATURE STABLE

Easy and fast handling. Store and work at room temperature, no need to work on
ice or at elevated temperatures.

TUNABILITY

Tune the microenvironment to suit your cells. The optimal stiffness is achieved
by dilution with cell culture medium, and the culturing matrix can be customized
easily by simply adding components such as growth factors or proteins directly
to the gel.

MICROSCOPE AND HIGH THROUGHPUT COMPATIBLE

GrowDex hydrogels do not have auto-fluorescence so imaging with any microscope
or high content imaging system is simple.The ambient handling of the hydrogels
makes them ideal for high throughput assays.

 

 


WHICH GROWDEX® HYDROGEL TO CHOOSE?

 

 

FEATURE

GrowDex®

GrowDex®-T

GrowDex®-A

Cellulose type

Native

Anionic

Anionic

Cellulose fiber charge

Neutral

Negative

Negative

Stock concentration

1.5%

1.0%

1.0%

Working concentration range

0.2% - 1.5%

0.1% - 1.0%

0.1% -1.0%

Visual appearance

Opaque

Transparent

Transparent

Brightfield

**

***

***

Phase contrast

**

***

***

Fluorecence

***

***

***

Ready-to-use

Yes

Yes

Yes, mix with

biotinylated molecule

Shelf life

12 months

12 months

6 months

 
 


WHY TRANSFER FROM 2D TO 3D IN HIGH THROUGHPUT SCREENING?

Major part of the cell-based high throughput screening (HTS) assays are done
still with traditional two-dimensional (2D) cultures that poorly represent the
complex three-dimensional (3D) physiological environment, where living cells
naturally grow. The highly artificial HTS monolayer (2D) cultures are thought to
significantly impact on the predictive value of compound screens and lead to
high failure rate in drug discovery.

Advanced 3D cell-based assays for high throughput screening provide a more
physiologically relevant solution. Some of the current 3D models possess major
obstacles in scaling up for HTS assays, as they are not reproducible, the costs
are high, and there are several technical problems that cause challenges,
including: automation of liquid handling, temperature control, optimizing
imaging and detection methods, chemical and physical properties of the matrix
and downstream processing.


 
 


SEE HOW OUR HYDROGELS HAVE BEEN USED IN LIFE SCIENCE APPLICATIONS

Life Science Applications


CONTACT US FOR MORE INFORMATION - OUR EXPERTS ARE READY TO HELP

Contact us
 




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New guide: 5 Ways to improve your cell assays
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UPM Biomedicals
Alvar Aallon katu 1
P.O. Box 380
00101 Helsinki, Finland

Tel. +358 (0)204 15 111
Fax +358 (0)204 15 110



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