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Buy now! EN English * DE Deutsch * * Solutions * Solutions * Nanofibrillar cellulose * OEM Flow Cytometry * OEM Flow Cytometry * OEM 3D Bioprinting * OEM 3D Bioprinting * Customer testimonials * Products & Services * Products & Services * Life Science Products * GrowDex® Hydrogels * GrowDex® Hydrogels * GrowDex® * GrowDex® * GrowDex®-T * GrowDex®-T * GrowDex®-A * GrowDex®-A * GrowDase™ * GrowDase™ * GrowInk™ * GrowInk™ * Clinical Products * FibDex® * FibDex® * GrowDex® Laboratory Services Test which product best suits your project. Read more * Applications * Applications * For Life Science * Liver Cells * Liver Cells * High Throughput Screening * High Throughput Screening * 3D Bioprinting * 3D Bioprinting * Stem Cells * Stem Cells * Neural Applications * Neural Applications * How to transfer animal-free * How to transfer animal-free * Animal Free Hydrogels * Animal Free Hydrogels * For Clinical * About us * About us * Resource Center * Resource Center * Application notes * Publications * Brochures & Instructions * Videos * MSDS * Learning Center * Guides * Support * Support * Product Support * GrowDex Support * GrowDex Support * GrowDex-T Support * GrowDex-T Support * GrowDex-A Support * GrowDex-A Support * GrowDase Support * GrowDase Support * GrowInk Support * GrowInk Support * FibDex® Support * FibDex® Support * Protocols * Technical Protocols * Technical Protocols * News & Events * News & Events * Contacts * Contacts * Contact form * Collaborate with us * Distributors * Careers UPM Biomedicals * Products & Services › * Life Science Products › GROWDEX® HYDROGEL RANGE Next generation solution for reproducible and scalable animal-free 3D cell culture applications providing convenience and consistent results. WHAT IS GROWDEX? GrowDex is an animal free, ready to use hydrogel that mimics the extracellular matrix (ECM) and supports cell growth and differentiation with consistent results. GrowDex is a proven solution for automation and high throughput screening. GrowDex can be used for 3D cell culture for spheroids and organoids, in personalised medicine, regenerative medicine, organ-on-a-chip models, drug release studies and more. GUIDE: TRANSFER YOUR 3D CELL CULTURE MATRICES TO ANIMAL-FREE GROWDEX Read more & download OUR PRODUCTS GROWDEX® With over 150 different assay protocols available GrowDex is our original hydrogel. Highly biocompatible GrowDex has been used widely for the culture of primary cells through to iPS and ES cells. Product page GROWDEX®-T GrowDex-T brings superior imaging quality for phase contrast and brightfield imaging. This hydrogel is completely transparent making imaging and automated analysis easy. Product page GROWDEX®-A If you are looking to customise your hydrogel then GrowDex-A is for you. GrowDex-A has been modified by the addition of an avidin group so you can attach any biotinylated molecule you like. Product page GROWDASE™ GrowDase enzyme breaks down GrowDex hydrogel to form a solution in an easy one step efficient cell recovery process. Product page GROWINK™ GrowInk Bioinks for 3D printing, can be mixed directly with cells for bioprinting applications. The matrix can be customised by the addition of molecules, such as growth factors or adhesion proteins, as needed by your specific cells. Product page WHY GO ANIMAL FREE IN CELL CULTURE? Despite their wide usage, animal derived matrices have been notoriously difficult to use. With animal free hydrogels like GrowDex, you'll get new benefits, such as: • Reproducible assays with no lot-to-lot variation • Handling in room temperatures • Defined composition without unknown protein composition • Ability to translate the cell culture assays towards clinical application • Sustainable and ethical material Read more FEATURES AND BENEFITS OF GROWDEX HYDROGELS ANIMAL FREE* Clean and well-defined hydrogels consisting of only nanofibrillar cellulose and purified water. No animal DNA interfering with readouts. *Excludes GrowDex-A after addition of biotinylated ligands Read more REPRODUCIBLE LOTS Do not add variation to your results. Our GrowDex hydrogels are manufactured to the highest standards with strict quality control criteria, so you can be sure the performance will be the same regardless of the production batch ordered. READY TO USE No gel preparation steps required. GrowDex hydrogels are provided ready to use, and they can be used and stored at room temperature. Just mix the hydrogel with your media and cells, dispense and incubate. ONE-STEP CELL RECOVERY Cells and organoids can be recovered from GrowDex with a gentle one-step enzymatic process with our GrowDase without affecting the cells. TEMPERATURE STABLE Easy and fast handling. Store and work at room temperature, no need to work on ice or at elevated temperatures. TUNABILITY Tune the microenvironment to suit your cells. The optimal stiffness is achieved by dilution with cell culture medium, and the culturing matrix can be customized easily by simply adding components such as growth factors or proteins directly to the gel. MICROSCOPE AND HIGH THROUGHPUT COMPATIBLE GrowDex hydrogels do not have auto-fluorescence so imaging with any microscope or high content imaging system is simple.The ambient handling of the hydrogels makes them ideal for high throughput assays. WHICH GROWDEX® HYDROGEL TO CHOOSE? FEATURE GrowDex® GrowDex®-T GrowDex®-A Cellulose type Native Anionic Anionic Cellulose fiber charge Neutral Negative Negative Stock concentration 1.5% 1.0% 1.0% Working concentration range 0.2% - 1.5% 0.1% - 1.0% 0.1% -1.0% Visual appearance Opaque Transparent Transparent Brightfield ** *** *** Phase contrast ** *** *** Fluorecence *** *** *** Ready-to-use Yes Yes Yes, mix with biotinylated molecule Shelf life 12 months 12 months 6 months WHY TRANSFER FROM 2D TO 3D IN HIGH THROUGHPUT SCREENING? Major part of the cell-based high throughput screening (HTS) assays are done still with traditional two-dimensional (2D) cultures that poorly represent the complex three-dimensional (3D) physiological environment, where living cells naturally grow. The highly artificial HTS monolayer (2D) cultures are thought to significantly impact on the predictive value of compound screens and lead to high failure rate in drug discovery. Advanced 3D cell-based assays for high throughput screening provide a more physiologically relevant solution. Some of the current 3D models possess major obstacles in scaling up for HTS assays, as they are not reproducible, the costs are high, and there are several technical problems that cause challenges, including: automation of liquid handling, temperature control, optimizing imaging and detection methods, chemical and physical properties of the matrix and downstream processing. SEE HOW OUR HYDROGELS HAVE BEEN USED IN LIFE SCIENCE APPLICATIONS Life Science Applications CONTACT US FOR MORE INFORMATION - OUR EXPERTS ARE READY TO HELP Contact us This content requires you to approve cookies. We use cookies on this website to ensure the best user experience and to target personalised content and relevant advertising. Please agree to approve cookies to see this content. See our Privacy Policy. Allow all We use cookies on this website to ensure the best user experience and to target personalised content and relevant advertising. For more information see our Privacy Policy. Allow all Use only necessary cookies New guide: 5 Ways to improve your cell assays * Solutions * Products & Services * Applications * About us * Resource Center * Support * News & Events * Contacts Back to top UPM Biomedicals Alvar Aallon katu 1 P.O. Box 380 00101 Helsinki, Finland Tel. +358 (0)204 15 111 Fax +358 (0)204 15 110 Subscribe to newsletter * Copyright © 2023 UPM * UPM Global * Legal Notice * Privacy Policy * Feedback Cookie settings * * * *