pubmed.ncbi.nlm.nih.gov Open in urlscan Pro
2600:1901:0:c831:: Public Scan

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Submitted URL:
https://r20.rs6.net/tn.jsp?f=001vRSj4sAlO7OPhsSmlZ9b5Dy0Xs3kNLSLSxeXyrtvnQNLmyrQ5YcMTekB9RovG3zBXDCN-806EPIYs_XGufav...
Effective URL:
https://pubmed.ncbi.nlm.nih.gov/35498050/
Submission: On May 05 via api (May 5th 2022, 7:55:08 pm UTC) from US — Scanned from DE

Form analysis
9 forms found in the DOM

GET /

<form action="/" method="get" autocomplete="off" class="usa-search usa-search-big search-form content-page-layout" id="search-form" role="search">
  <div class="inner-wrap">
    <a class="pubmed-logo" aria-label="Pubmed Logo" href="/" data-ga-category="featured_link" data-ga-action="pubmed_logo">


        <img src="https://cdn.ncbi.nlm.nih.gov/pubmed/ca993e9d-6117-4cbd-8ec4-f6eb2385bc9f/core/images/pubmed-logo-blue.svg" alt="pubmed logo">
      
    </a>
    <a href="#" class="search-input-trigger" data-alt-title="Hide search bar" title="Show search bar" aria-label="Show search bar" aria-hidden="true" tabindex="-1">
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    <div role="search" class="search-input">
      <div class="form-field ">
        <label class="usa-sr-only" for="id_term"> Search: </label>
        <span class="twitter-typeahead ncbi-autocomplete"><input type="search" name="term" data-skip-ie-scroll-to-top="" data-replace-term-with-exact="" data-exact-query="" placeholder="" class="term-input tt-input" required="required" id="id_term"
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          <div role="listbox" class="tt-menu" id="id_term_listbox" style="position: absolute; top: 100%; left: 0px; z-index: 100; display: none;">
            <div role="presentation" class="tt-dataset tt-dataset-0"></div>
          </div>
        </span><a href="#" class="clear-btn" title="Clear search input" role="button" data-pinger-ignore=""></a><button type="submit" class="search-btn" aria-label="Search" data-pinger-ignore=""><span
            class="usa-search-submit-text">Search</span></button>
      </div>
    </div>
    <!-- Create alert and Create RSS are buttons that look like links -->
    <!-- Better for them to look like buttons but no space -->
    <div class="search-links-wrapper content-page-layout">
      <div class="search-links">
        <a href="/advanced/" class="search-input-link adv-search-link" data-ga-category="featured_link" data-ga-action="adv_search">Advanced</a>
        <a href="/clipboard/" class="search-input-link clipboard-link hidden" data-ga-category="featured_link" data-ga-action="clipboard">
          Clipboard <span class="amount-in-clipboard"></span>
        </a>
      </div>
      <span class="search-input-link user-guide-link" role="navigation" aria-label="User guide">
        <a href="/help/" data-ga-category="featured_link" data-ga-action="user_guide">
            User Guide
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</form>

POST /results-export-ids/

<form id="save-action-panel-form" class="action-panel-content action-form" action="/results-export-ids/" data-by-search-action="/results-export-search-data/" data-by-ids-action="/results-export-ids/" method="post" data-by-search-method="post"
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    <label for="save-action-format" class="action-panel-label"> Format: </label>
    <select id="save-action-format" name="results-format" class="action-panel-selector">
      <option value="summary-text">Summary (text)</option>
      <option value="pubmed-text">PubMed</option>
      <option value="pmid">PMID</option>
      <option value="abstract">Abstract (text)</option>
      <option value="csv">CSV</option>
    </select>
  </div>
  <div class="action-panel-actions">
    <button class="action-panel-submit" type="submit" data-loading-label="Saving..." data-ga-category="save_share" data-ga-action="save" data-ga-label="save"> Create file </button>
    <button class="action-panel-cancel" aria-label="Close 'Save citations to file' panel" ref="linksrc=close_save_panel" aria-controls="save-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="save"
      data-ga-label="cancel"> Cancel </button>
  </div>
</form>

POST /send-email/

<form id="email-action-panel-form" class="action-panel-content action-form" action="/send-email/" data-by-search-action="/results-export-email-by-search-data/" data-by-ids-action="/send-email/" data-by-search-method="post" data-by-ids-method="post"
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  <input type="hidden" name="csrfmiddlewaretoken" value="yCOHXuA1q2iisnF22H6IJgp7kDowowjF1TGKPNmIeDjLmS84aFDwj1aoyDxEahH4">
  <div class="action-panel-control-wrap">
    <span class="action-panel-label"> Subject: </span>
    <span class="email-subject" id="email-subject" aria-label="Email subject">1 selected item: 35498050 - PubMed</span>
    <input type="hidden" name="email-subject" value="1 selected item: 35498050">
    <input type="hidden" name="email-subject-hash" value="f893105225b488fadf83b7b38e966e2155d75432692dea2762156a10f04f53fc">
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  <div class="action-panel-control-wrap">
    <label for="email-to" class="action-panel-label required-field-asterisk"> To: </label>
    <input type="email" aria-label="Recipient Email Address" placeholder="email@example.com" id="email-to" class="email-to" pattern="^[a-zA-Z0-9_.+-]+@[a-zA-Z0-9-]+\.[a-zA-Z0-9-.]+$" maxlength="100" required="">
  </div>
  <div class="action-panel-control-wrap">
    <label for="email-citation-format" class="action-panel-label"> Format: </label>
    <select id="email-citation-format" name="citation-format" class="action-panel-selector email-citation-format">
      <option selected="selected" value="summary">Summary</option>
      <option value="summary-text">Summary (text)</option>
      <option value="abstract">Abstract</option>
      <option value="abstract-text">Abstract (text)</option>
    </select>
  </div>
  <div class="include-supplemental-container" style="display: none;">
    <input type="checkbox" aria-label="Include MeSH and other data" name="include-supplemental" id="email-include-supplemental" class="email-include-supplemental">
    <label for="email-include-supplemental" class="email-include-supplemental-label">MeSH and other data</label>
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  <div class="form-field recaptcha ">
    <div class="g-recaptcha" id="id-recaptcha" data-sitekey="6LfsWHMdAAAAAClKbtOpjQ2pMjgsGxvv7NdZW9uI"></div>
  </div>
  <div id="captcha-error-message" class="usa-input-error-message captcha-validation-message" role="alert"></div>
  <div class="action-panel-actions">
    <button class="action-panel-submit" type="submit" data-loading-label="Sending..." data-ga-category="save_share" data-ga-action="email" data-ga-label="send"> Send email </button>
    <button class="action-panel-cancel" aria-label="Close 'Email citations' panel" ref="linksrc=close_email_panel" aria-controls="email-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="email" data-ga-label="cancel">
      Cancel </button>
  </div>
  <input type="hidden" name="email-search-details" value="">
  <input type="hidden" name="email-search-details-hash" value="0e42663a6c3bd85498fcb88798998fed7bfdc45d457db35281e41afe13cc0524">
</form>

<form id="collections-action-panel-form" class="collections-action-panel-form action-panel-content action-form action-panel-smaller-selectors" data-existing-collections-url="/list-existing-collections/"
  data-add-to-existing-collection-url="/add-to-existing-collection/" data-create-and-add-to-new-collection-url="/create-and-add-to-new-collection/" data-get-article-ids-by-search-url="/get-article-ids-by-search/"
  data-myncbi-max-collection-name-length="100" data-add-to-collection-max-amount="1000" data-collections-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/">
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  <div class="choice-group">
    <ul class="radio-group-items">
      <li>
        <input type="radio" id="collections-new" class="collections-new" name="collections" value="new">
        <label for="collections-new">Create a new collection</label>
      </li>
      <li>
        <input type="radio" id="collections-existing" class="collections-existing" name="collections" value="existing" checked="">
        <label for="collections-existing">Add to an existing collection</label>
      </li>
    </ul>
  </div>
  <div class="controls-wrapper">
    <div class="action-panel-control-wrap new-collections-controls">
      <label for="collections-action-add-to-new" class="action-panel-label required-field-asterisk"> Name your collection: </label>
      <input type="text" name="add-to-new-collection" id="collections-action-add-to-new" class="collections-action-add-to-new" pattern="[^&quot;&amp;=<>/]*" title="The following characters are not allowed in the Name field: &quot;&amp;=<>/"
        maxlength="100">
      <div class="collections-new-name-too-long usa-input-error-message selection-validation-message"> Name must be less than 100 characters </div>
    </div>
    <div class="action-panel-control-wrap existing-collections-controls">
      <label for="collections-action-add-to-existing" class="action-panel-label"> Choose a collection: </label>
      <select id="collections-action-add-to-existing" class="action-panel-selector collections-action-add-to-existing"></select>
      <div class="collections-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your collection due to an error<br>
        <a href="#">Please try again</a>
      </div>
    </div>
  </div>
  <div class="action-panel-actions">
    <button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore="" disabled=""> Add </button>
    <button class="action-panel-cancel" aria-label="Close 'Add to Collections' panel" ref="linksrc=close_collections_panel" aria-controls="collections-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="collection"
      data-ga-label="cancel"> Cancel </button>
  </div>
</form>

<form id="bibliography-action-panel-form" class="bibliography-action-panel-form action-panel-content action-form action-panel-smaller-selectors" data-add-to-bibliography-max-amount="100" data-add-to-bibliography-batch-size="10"
  data-bibliography-delegates-url="/list-bibliography-delegates/" data-add-to-bibliography-url="/add-to-bibliography/" data-get-article-ids-by-search-url="/get-article-ids-by-search/"
  data-mybib-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/mybibliography/">
  <input type="hidden" name="csrfmiddlewaretoken" value="yCOHXuA1q2iisnF22H6IJgp7kDowowjF1TGKPNmIeDjLmS84aFDwj1aoyDxEahH4">
  <div class="action-panel-control-wrap bibliographies-controls">
    <div class="choice-group">
      <ul class="bibliographies-action-add radio-group-items">
        <li>
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          <label for="my-bibliography">My Bibliography</label>
        </li>
      </ul>
    </div>
  </div>
  <div class="bibliographies-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your delegates due to an error<br>
    <a href="#">Please try again</a>
  </div>
  <div class="action-panel-actions">
    <button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore=""> Add </button>
    <button class="action-panel-cancel" aria-label="Close 'Add to bibliography' panel" ref="linksrc=close_bibliography_panel" aria-controls="bibliography-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="mybib"
      data-ga-label="cancel"> Cancel </button>
  </div>
</form>

<form id="saved-search-action-panel-form" class="saved-search-action-panel-form action-panel-content action-form" data-create-saved-search-url="/create-saved-search/" data-try-search-terms-url="/try-search-term/"
  data-saved-search-root-url="https://www.ncbi.nlm.nih.gov/myncbi/searches/">
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    <label for="saved-search-name" class="action-panel-label saved-search-name-label required-field-asterisk"> Name of saved search: </label>
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  </div>
  <div class="action-panel-control-wrap">
    <label for="saved-search-term" class="action-panel-label required-field-asterisk"> Search terms: </label>
    <textarea name="saved-search-term" id="saved-search-term" class="saved-search-term" required=""></textarea>
  </div>
  <div class="test-search-term-wrap">
    <a href="#" class="try-search-term">Test search terms</a>
  </div>
  <div class="choice-group action-panel-extra-margin-top">
    <span class="action-panel-label" id="fieldset-label"> Would you like email updates of new search results? </span>
    <fieldset id="saved-search-alert" aria-describedby="fieldset-label">
      <legend class="usa-sr-only">Saved Search Alert Radio Buttons</legend>
      <ul class="radio-group-items">
        <li>
          <input type="radio" id="saved-search-alert-yes" class="saved-search-alert-yes" name="saved-search-alert" value="yes" checked="">
          <label for="saved-search-alert-yes" class="action-panel-label">Yes</label>
        </li>
        <li>
          <input aria-label="No radio input" type="radio" id="saved-search-alert-no" class="saved-search-alert-no" name="saved-search-alert" value="no">
          <label for="saved-search-alert-no" class="action-panel-label">No</label>
        </li>
      </ul>
    </fieldset>
  </div>
  <div class="alert-schedule-wrap">
    <div class="action-panel-control-wrap">
      <label class="action-panel-label"> Email: </label>
      <span aria-label="Email address" id="saved-search-email" class="action-panel-label"><span class="action-panel-label-bold"></span> (<a class="myncbi-account-settings" href="https://www.ncbi.nlm.nih.gov/account/settings/">change</a>)</span>
    </div>
    <div class="action-panel-control-wrap action-panel-extra-margin-top">
      <label for="saved-search-frequency" class="action-panel-label"> Frequency: </label>
      <select id="saved-search-frequency" class="no-border-panel-selector saved-search-frequency">
        <option value="monthly">Monthly</option>
        <option value="weekly">Weekly</option>
        <option value="daily">Daily</option>
      </select>
    </div>
    <div class="action-panel-control-wrap saved-search-monthly-additional">
      <label for="saved-search-monthly-on-day" class="action-panel-label"> Which day? </label>
      <select id="saved-search-monthly-on-day" class="no-border-panel-selector">
        <option value="Sunday">The first Sunday</option>
        <option value="Monday">The first Monday</option>
        <option value="Tuesday">The first Tuesday</option>
        <option value="Wednesday">The first Wednesday</option>
        <option value="Thursday">The first Thursday</option>
        <option value="Friday">The first Friday</option>
        <option value="Saturday">The first Saturday</option>
        <option value="day">The first day</option>
        <option value="weekday">The first weekday</option>
      </select>
    </div>
    <div class="action-panel-control-wrap saved-search-weekly-additional" style="display: none;">
      <label for="saved-search-weekly-on-day" class="action-panel-label"> Which day? </label>
      <select id="saved-search-weekly-on-day" class="no-border-panel-selector saved-search-weekly-on-day">
        <option value="Sunday">Sunday</option>
        <option value="Monday">Monday</option>
        <option value="Tuesday">Tuesday</option>
        <option value="Wednesday">Wednesday</option>
        <option value="Thursday">Thursday</option>
        <option value="Friday">Friday</option>
        <option value="Saturday">Saturday</option>
      </select>
    </div>
    <div class="action-panel-control-wrap">
      <label for="saved-search-report" class="action-panel-label"> Report format: </label>
      <select id="saved-search-report" class="no-border-panel-selector saved-search-report">
        <option value="DocSum">Summary</option>
        <option value="DocSumText">Summary (text)</option>
        <option value="Abstract">Abstract</option>
        <option value="AbstractText">Abstract (text)</option>
        <option value="MEDLINE">PubMed</option>
      </select>
    </div>
    <div class="action-panel-control-wrap">
      <label for="saved-search-amount" class="action-panel-label"> Send at most: </label>
      <select id="saved-search-amount" class="no-border-panel-selector saved-search-amount">
        <option value="1">1 item</option>
        <option value="5" selected="">5 items</option>
        <option value="10">10 items</option>
        <option value="20">20 items</option>
        <option value="50">50 items</option>
        <option value="100">100 items</option>
        <option value="200">200 items</option>
      </select>
    </div>
    <div>
      <input type="checkbox" id="saved-search-send-if-no-result" class="saved-search-send-if-no-result" name="saved-search-send-if-no-result">
      <label for="saved-search-send-if-no-result" class="action-panel-label smaller-checkbox"> Send even when there aren't any new results </label>
    </div>
    <div class="action-panel-control-wrap option-text-in-email-wrap">
      <label for="saved-search-email-text" class="action-panel-label"> Optional text in email: </label>
      <textarea name="saved-search-email-text" id="saved-search-email-text" class="saved-search-email-text"></textarea>
    </div>
  </div>
  <div class="action-panel-actions">
    <button class="action-panel-submit" type="submit" data-loading-label="Saving..." data-ga-category="save_share" data-ga-action="alert" data-ga-label="save"> Save </button>
    <button class="action-panel-cancel" aria-label="Close 'Your saved search' panel" ref="linksrc=close_saved_search_panel" aria-controls="saved-search-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="alert"
      data-ga-label="cancel"> Cancel </button>
  </div>
</form>

POST /results-export-ids/

<form id="citation-manager-action-panel-form" class="action-panel-content action-form" action="/results-export-ids/" data-by-search-action="/results-export-search-data/" data-by-ids-action="/results-export-ids/" method="post"
  data-by-search-method="post" data-by-ids-method="post">
  <input type="hidden" name="csrfmiddlewaretoken" value="yCOHXuA1q2iisnF22H6IJgp7kDowowjF1TGKPNmIeDjLmS84aFDwj1aoyDxEahH4">
  <input name="results-format" type="hidden" value="pubmed">
  <div class="action-panel-actions">
    <button class="action-panel-submit" type="submit" data-loading-label="Sending..." data-ga-category="save_share" data-ga-action="citation_manager" data-ga-label="save"> Create file </button>
    <button class="action-panel-cancel" aria-label="Close 'Send citations to citation manager' panel" ref="linksrc=close_citation_manager_panel" aria-controls="citation-manager-action-panel" aria-expanded="false" data-ga-category="save_share"
      data-ga-action="citation_manager" data-ga-label="cancel"> Cancel </button>
  </div>
</form>

<form id="rss-action-panel-form" class="rss-action-panel-form action-panel-content action-form" data-create-rss-feed-url="/create-rss-feed-url/" data-search-form-term-value="">
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  <div class="action-panel-control-wrap">
    <label for="rss-name" class="action-panel-label required-field-asterisk"> Name of RSS Feed: </label>
    <input maxlength="200" placeholder="Name" type="text" name="rss-name" id="rss-name" class="rss-name" value="" required="" pattern="[^&quot;&amp;=<>/]*" title="The following characters are not allowed in the Name field: &quot;&amp;=<>/">
  </div>
  <div class="rss-limit-wrap">
    <div class="action-panel-control-wrap action-panel-extra-margin-top">
      <label for="rss-limit" class="action-panel-label"> Number of items displayed: </label>
      <select id="rss-limit" class="no-border-panel-selector rss-limit">
        <option value="5">5</option>
        <option value="10">10</option>
        <option value="15" selected="selected">15</option>
        <option value="20">20</option>
        <option value="50">50</option>
        <option value="100">100</option>
      </select>
    </div>
  </div>
  <div class="action-panel-actions">
    <button class="action-panel-submit" type="submit" data-loading-label="Creating..." data-ga-category="save_share" data-ga-action="alert" data-ga-label="save"> Create RSS </button>
    <button class="action-panel-cancel" aria-label="Close 'Your RSS' panel" ref="linksrc=close_rss_panel" aria-controls="rss-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="alert" data-ga-label="cancel"> Cancel
    </button>
  </div>
  <div class="action-panel-control-wrap rss-link-copy-wrap">
    <label for="rss-link" class="usa-sr-only">RSS Link</label>
    <input placeholder="Your RSS Feed Link" type="text" name="rss-link" id="rss-link" class="rss-link" title="RSS Link">
    <button type="button" disabled="" class="rss-link-copy-button disabled" data-ga-category="save_share" data-ga-action="rss" data-ga-label="copy"> Copy </button>
  </div>
</form>

POST

<form method="post">
  <input type="hidden" name="csrfmiddlewaretoken" value="yCOHXuA1q2iisnF22H6IJgp7kDowowjF1TGKPNmIeDjLmS84aFDwj1aoyDxEahH4">
  <button type="submit" class="export-button" data-ga-category="save_share" data-ga-action="cite" data-ga-label="download" title="Download a file for external citation management software" tabindex="3"> Download .nbib </button>
</form>

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. 2022 Apr 12;9:868521.
doi: 10.3389/fcvm.2022.868521. eCollection 2022.


L-ARGININE IMPROVES COGNITIVE IMPAIRMENT IN HYPERTENSIVE FRAIL OLDER ADULTS

Pasquale Mone  1   2   3 , Antonella Pansini  2 , Stanislovas S Jankauskas  1
, Fahimeh Varzideh  1 , Urna Kansakar  1 , Angela Lombardi  1 , Valentina
Trimarco  4 , Salvatore Frullone  2 , Gaetano Santulli  1   4
Affiliations Collapse



AFFILIATIONS

 * 1 Department of Medicine, Albert Einstein College of Medicine, New York, NY,
   United States.
 * 2 Azienda Sanitaria Locale (ASL) Avellino, Avellino, Italy.
 * 3 Campania University, Naples, Italy.
 * 4 University of Naples "Federico II", Naples, Italy.

 * PMID: 35498050
 * PMCID: PMC9039514
 * DOI: 10.3389/fcvm.2022.868521

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Case Reports


L-ARGININE IMPROVES COGNITIVE IMPAIRMENT IN HYPERTENSIVE FRAIL OLDER ADULTS

Pasquale Mone et al. Front Cardiovasc Med. 2022.
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. 2022 Apr 12;9:868521.
doi: 10.3389/fcvm.2022.868521. eCollection 2022.


AUTHORS

Pasquale Mone  1   2   3 , Antonella Pansini  2 , Stanislovas S Jankauskas  1
, Fahimeh Varzideh  1 , Urna Kansakar  1 , Angela Lombardi  1 , Valentina
Trimarco  4 , Salvatore Frullone  2 , Gaetano Santulli  1   4


AFFILIATIONS

 * 1 Department of Medicine, Albert Einstein College of Medicine, New York, NY,
   United States.
 * 2 Azienda Sanitaria Locale (ASL) Avellino, Avellino, Italy.
 * 3 Campania University, Naples, Italy.
 * 4 University of Naples "Federico II", Naples, Italy.

 * PMID: 35498050
 * PMCID: PMC9039514
 * DOI: 10.3389/fcvm.2022.868521

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ABSTRACT

Cognitive impairment is a prevailing event in hypertensive patients and in frail
older adults. Endothelial dysfunction has been shown to underlie both
hypertension and cognitive dysfunction. Our hypothesis is that L-Arginine, which
is known to ameliorate endothelial dysfunction, could counteract cognitive
impairment in a high-risk population of hypertensive frail older adults. We
designed a clinical trial to verify the effects of 4-weeks oral supplementation
of L-Arginine on global cognitive function of hypertensive frail older patients.
The study was successfully completed by 35 frail hypertensive elderly patients
assigned to L-Arginine and 37 assigned to placebo. At follow-up, we found a
significant difference in the Montreal Cognitive Assessment (MoCA) test score
between the L-Arginine treated group and placebo (p: 0.0178). Moreover, we
demonstrated that L-Arginine significantly attenuates Angiotensin II-induced
mitochondrial oxidative stress in human endothelial cells. In conclusion, our
findings indicate for the first time that oral L-Arginine supplementation
significantly improves cognitive impairment in frail hypertensive older adults.

Clinical trial registration: www.ClinicalTrials.gov, identifier: NCT04962841.

Keywords: L-Arg; L-Arginine; cardiac rehabilitation; cognitive impairment;
endothelial (dys)function; frail adults; frailty.

Copyright © 2022 Mone, Pansini, Jankauskas, Varzideh, Kansakar, Lombardi,
Trimarco, Frullone and Santulli.


CONFLICT OF INTEREST STATEMENT

The authors declare that the research was conducted in the absence of any
commercial or financial relationships that could be construed as a potential
conflict of interest.


FIGURES

Figure 1

Flow chart of the study.

Figure 1

Flow chart of the study.

Figure 1
Flow chart of the study.

Figure 2

MoCA (Montreal Cognitive Assessment) score…

Figure 2

MoCA (Montreal Cognitive Assessment) score evaluated at baseline and at
follow-up in the…

Figure 2
MoCA (Montreal Cognitive Assessment) score evaluated at baseline and at
follow-up in the placebo and in the L-Arginine arms. Data are means ± SE; *: p <
0.05.

Figure 3

Mitochondrial production of reactive oxygen…

Figure 3

Mitochondrial production of reactive oxygen species (ROS) evaluated in human
endothelial cells treated…

Figure 3
Mitochondrial production of reactive oxygen species (ROS) evaluated in human
endothelial cells treated with Angiotensin II (Ang II) (1 μM) + vehicle or Ang
II + L-Arginine (500 μM) for 24 hours; A.U., arbitrary units. Data are means ±
SE; *: p < 0.01.

See this image and copyright information in PMC



REFERENCES

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       et al. . Endothelium-macrophage crosstalk mediates blood-brain barrier
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       10.1161/HYPERTENSIONAHA.120.15581 - DOI - PMC - PubMed
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       al. . High systolic blood pressure induces cerebral microvascular
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       10.1161/HYPERTENSIONAHA.118.12048 - DOI - PubMed
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       10.1161/HYPERTENSIONAHA.109.143123 - DOI - PMC - PubMed
 5. 1. Moreno PR, Purushothaman KR, Fuster V, O'Connor WN. Intimomedial
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