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For US Healthcare Professionals
MENU
Chronic Lymphocytic Leukemia (CLL)
Prescribing Information/Medication Guide Prescribing Information/Medication
Guide Safety Safety
Non-Hodgkin's Lymphoma (NHL) Chronic Lymphocytic Leukemia (CLL) Rheumatoid
Arthritis (RA) Granulomatosis With Polyangiitis (GPA) & Microscopic Polyangiitis
(MPA) Pemphigus Vulgaris (PV)
Chronic Lymphocytic Leukemia (CLL)
* Non-Hodgkin's Lymphoma (NHL)
* Chronic Lymphocytic Leukemia (CLL)
* Rheumatoid Arthritis (RA)
* Granulomatosis With Polyangiitis (GPA) & Microscopic Polyangiitis (MPA)
* Pemphigus Vulgaris (PV)
* Home
* About CLL
* What is Chronic Lymphocytic Leukemia?
* Signs & Symptoms of CLL
* Understanding Tests for CLL
* Stages of CLL
* About RITUXAN
* How RITUXAN is Thought to Work
* Side Effects
* RITUXAN Side Effects
* Important Safety Information
* RITUXAN Data
* Goals of Treatment
* Dosing & Administration
* The Infusion Process
* Preparing for Your Infusion
* Your First Infusion
* Your Initial Treatment
* If You Relapse
* FAQs & Resources
* Questions to Consider Asking Your Doctor
* Financial Support
* Financial Assistance Options
* Apply for Financial Support
Prescribing Information/Medication Guide Safety
For US Healthcare Professionals
APPLY FOR THE GENENTECH PATIENT FOUNDATION.
To get started:
* Complete the Patient Consent Form, which is available in English and Spanish,
below:
* Patient Consent Form
* Formulario de Consentimiento del Paciente
* Once you have completed the Patient Consent Form, please let your doctor's
office know that you are applying for assistance with the Genentech Patient
Foundation. Your doctor will have to complete another form called the
Prescriber Foundation Form. Both forms are required. We must have both the
Patient Consent Form and the Prescriber Foundation Form before we can help
you.
What to expect next:
* The request will be processed within five business days upon receipt of both
required forms.
* You and your provider will be contacted to discuss the application outcome
and any next steps.
Genentech reserves the right to modify or discontinue the program at any time
and to verify the accuracy of information submitted.
QUESTIONS? CONTACT A FOUNDATION SPECIALIST
Call 888-941-3331 (Mon.-Fri., 6AM-5PM PST)
--------------------------------------------------------------------------------
Back to RITUXAN Financial Support Tool
IMPORTANT SAFETY INFORMATION & INDICATIONS
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INDICATIONS
WHAT IS RITUXAN?
RITUXAN is a prescription medicine used to treat adults with:
* Non-Hodgkin’s Lymphoma (NHL): alone or with other chemotherapy medicines.
* Chronic Lymphocytic Leukemia (CLL): with the chemotherapy medicines
fludarabine and cyclophosphamide.
It is not known if RITUXAN is safe and effective in children with CLL.
WHAT IS THE MOST IMPORTANT INFORMATION I SHOULD KNOW ABOUT RITUXAN?
RITUXAN can cause serious side effects that can lead to death, including:
* Infusion-Related Reactions: Infusion-related reactions are very common side
effects of RITUXAN treatment. Serious infusion-related reactions can happen
during your infusion or within 24 hours after your infusion of RITUXAN. Your
healthcare provider should give you medicines before your infusion of RITUXAN
to decrease your chance of having a severe infusion-related reactions. Tell
your healthcare provider or get medical help right away if you get any of
these symptoms during or after an infusion of RITUXAN:
* Hives (red itchy welts) or rash
* Itching
* Swelling of your lips, tongue, throat, or face
* Sudden cough
* Shortness of breath, difficulty breathing, or wheezing
* Weakness
* Dizziness or feel faint
* Palpitations (feel like your heart is racing or fluttering)
* Chest pain
* Severe Skin and Mouth Reactions: Tell your healthcare provider or get medical
help right away if you get any of these symptoms at any time during your
treatment with RITUXAN:
* Painful sores or ulcers on your skin, lips, or in your mouth
* Blisters
* Peeling skin
* Rash
* Pustules
* Hepatitis B Virus (HBV) Reactivation: Before you receive your RITUXAN
treatment, your healthcare provider will do blood tests to check for HBV
infection. If you have had hepatitis B or are a carrier of hepatitis B virus,
receiving RITUXAN could cause the virus to become an active infection again.
Hepatitis B reactivation may cause serious liver problems, including liver
failure, and death. Your healthcare provider will monitor you for hepatitis B
infection during and for several months after you stop receiving RITUXAN.
Tell your healthcare provider right away if you get worsening tiredness, or
yellowing of your skin or white part of your eyes during treatment with
RITUXAN
* Progressive Multifocal Leukoencephalopathy (PML): PML is a rare, serious
brain infection caused by a virus that can happen in people who receive
RITUXAN. People with weakened immune systems can get PML. PML can result in
death or severe disability. There is no known treatment, prevention, or cure
for PML.
Tell your healthcare provider right away if you have new or worsening
symptoms or if anyone close to you notices these symptoms:
* Confusion
* Dizziness or loss of balance
* Difficulty walking or talking
* Decreased strength or weakness on one side of your body
* Vision problems, such as blurred vision or loss of vision
WHAT SHOULD I TELL MY HEALTHCARE PROVIDER BEFORE RECEIVING RITUXAN?
Before receiving RITUXAN, tell your healthcare provider if you:
* Have had a severe reaction to RITUXAN or a rituximab product
* Have a history of heart problems, irregular heartbeat, or chest pain
* Have lung or kidney problems
* Have had an infection, currently have an infection, or have a weakened immune
system
* Have or have had any severe infections including:
* Hepatitis B virus (HBV)
* Hepatitis C virus (HCV)
* Cytomegalovirus (CMV)
* Herpes simplex virus (HSV)
* Parvovirus B19
* Varicella zoster virus (chickenpox or shingles)
* West Nile Virus
* Have had a recent vaccination or are scheduled to receive vaccinations. You
should not receive certain vaccines before or during treatment with RITUXAN
* Have any other medical conditions
* Are pregnant or plan to become pregnant. Talk to your healthcare provider
about the risks to your unborn baby if you receive RITUXAN during pregnancy.
Females who are able to become pregnant should use effective birth control
(contraception) during treatment with RITUXAN and for 12 months after the
last dose of RITUXAN. Talk to your healthcare provider about effective birth
control. Tell your healthcare provider right away if you become pregnant or
think that you are pregnant during treatment with RITUXAN
* Are breastfeeding or plan to breastfeed. RITUXAN may pass into your breast
milk. Do not breastfeed during treatment and for 6 months after your last
dose of RITUXAN
* Are taking any medications, including prescription and over-the-counter
medicines, vitamins, and herbal supplements
WHAT ARE THE POSSIBLE SIDE EFFECTS OF RITUXAN?
RITUXAN can cause serious side effects, including:
* Tumor Lysis Syndrome (TLS): TLS is caused by the fast breakdown of cancer
cells. TLS can cause you to have:
* Kidney failure and the need for dialysis treatment
* Abnormal heart rhythm
TLS can happen within 12 to 24 hours after an infusion of RITUXAN. Your
healthcare provider may do blood tests to check you for TLS. Your healthcare
provider may give you medicine to help prevent TLS. Tell your healthcare
provider right away if you have any of the following signs or symptoms of
TLS:
* Nausea
* Vomiting
* Diarrhea
* Lack of energy
* Serious Infections: Serious infections can happen during and after treatment
with RITUXAN, and can lead to death. RITUXAN can increase your risk of
getting infections and can lower the ability of your immune system to fight
infections. Types of serious infections that can happen with RITUXAN include
bacterial, fungal, and viral infections. After receiving RITUXAN, some people
have developed low levels of certain antibodies in their blood for a long
period of time (longer than 11 months). Some of these patients with low
antibody levels developed infections. People with serious infections should
not receive RITUXAN. Tell your healthcare provider right away if you have any
symptoms of infection:
* Fever
* Cold symptoms, such as runny nose or sore throat that do not go away
* Flu symptoms, such as cough, tiredness, and body aches
* Earache or headache
* Pain during urination
* Cold sores in the mouth or throat
* Cuts, scrapes, or incisions that are red, warm, swollen, or painful
* Heart Problems: RITUXAN may cause chest pain, irregular heartbeats, and heart
attack. Your healthcare provider may monitor your heart during and after
treatment with RITUXAN if you have symptoms of heart problems or have a
history of heart problems. Tell your healthcare provider right away if you
have chest pain or irregular heart-beats during treatment with RITUXAN
* Kidney Problems: especially if you are receiving RITUXAN for NHL. RITUXAN can
cause severe kidney problems that lead to death. Your healthcare provider
should do blood tests to check how well your kidneys are working
* Stomach and Serious Bowel Problems That Can Sometimes Lead to Death: Bowel
problems, including blockage or tears in the bowel can happen if you receive
RITUXAN with chemotherapy medicines. Tell your healthcare provider right away
if you have any stomach-area (abdomen) pain or repeated vomiting during
treatment with RITUXAN
Your healthcare provider will stop treatment with RITUXAN if you have severe,
serious, or life-threatening side effects.
WHAT ARE THE MOST COMMON SIDE EFFECTS DURING TREATMENT WITH RITUXAN?
* Infusion-related reactions
* Infections (may include fever, chills)
* Body aches
* Tiredness
* Nausea
Other side effects include:
* Aching joints during or within hours of receiving an infusion
* More frequent upper respiratory tract infections
These are not all of the possible side effects with RITUXAN.
Please see the RITUXAN full Prescribing Information, including the Medication
Guide, for additional Important Safety Information.
You may report side effects to the FDA at (800) FDA-1088 or
www.fda.gov/medwatch. You may also report side effects to Genentech at (888)
835-2555.
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