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Home All News Health New Cancer Therapy Completely Destroys Advanced Ovarian and
Colorectal Tumors in 6...
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NEW CANCER THERAPY COMPLETELY DESTROYS ADVANCED OVARIAN AND COLORECTAL TUMORS IN
6 DAYS
By
Good News Network
-
Mar 5, 2022
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Rice University bioengineer Omid Veiseh by Jeff Fitlow/Rice University
A new cancer therapy has completely destroyed advanced ovarian and bowel tumors
in just six days.
Clinical trials are expected to begin in the next few months, after results on
mice were described as “very exciting”.
Pinhead-sized drug ‘factories’ were delivered to give continuous, high bursts of
a protein that boosts the immune system.
“We just administer once, but they keep making the dose every day, where it’s
needed until the cancer is eliminated,” said co-author Dr. Omid Veiseh, of Rice
University in Houston, Texas, whose family friend died of the deadly disease.
“Once we determined the correct dose—how many factories we needed—we were able
to eradicate tumors in 100% of animals with ovarian cancer and in seven of eight
animals with colorectal cancer.”
The tiny beads have a protective shell containing cells engineered to produce
interleukin-2. They could be used to fight the most lethal cancers, including
those of the pancreas, liver and lungs.
They can be implanted with minimally invasive surgery, and could be tested on
human patients by autumn, so they can get them into hospitals as quickly as
possible.
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For the mixture, the team chose only components that had previously proven safe
for humans.
The drug-producing beads were placed next to tumors in lab rodents and within
the lining of the abdominal cavity, a sack-like lining that supports the
intestines, ovaries, and other abdominal organs, and limits exposure elsewhere.
“A major challenge in the field of immunotherapy is to increase tumor
inflammation and anti-tumor immunity while avoiding systemic side effects of
cytokines and other pro-inflammatory drugs,” said co-author Professor Amir
Jazaeri, of Texas University.
“In this study, we demonstrated that the ‘drug factories’ allow regulatable
local administration of interleukin-2 and the eradication of tumor in several
mouse models, which is very exciting.”
RELATED: Magnesium May Prime the Immune System to Fight Cancer and Infections
Interleukin-2 is a cytokine, a protein the immune system uses to recognize and
fight disease, which has been approved as a cancer treatment by the US Food and
Drug Administration.
Lead author Amanda Nash, a graduate student in Dr Veiseh’s lab, said the beads
provoke the strongest immune response to date.
“If you gave the same concentration of the protein through an IV pump, it would
be extremely toxic.
With the drug factories, the concentration we see elsewhere in the body, away
from the tumor site, is actually lower than what patients need to tolerate with
IV treatments. The high concentration is only at the tumor site.
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Remission
Ms. Nash said it opens the door to the same general approach to treat cancers of
the pancreas, liver, lungs and other organs.
If a different cytokine is needed to target a specific form of cancer, the beads
can be loaded with any immuno-therapeutic compound.
The bead’s outer shell shields its cytokine-producing cells from immune attacks,
as they are made of materials the immune system recognizes as foreign objects,
but not as immediate threats.
Dr. Veiseh said, “We found foreign body reactions safely and robustly turned off
the flow of cytokine from the capsules within 30 days.
In the research, published this week in the peer-reviewed journal Science
Advances, they also showed they could safely administer a second course of
treatment should it become necessary in the clinic.
Colorectal cancer is one of the most common cancers, while ovarian is
particularly lethal because it is usually only diagnosed in the late stages.
Avenge Bio, a Massachusetts-based startup co-founded by Dr Veiseh, has licensed
the cytokine-factory technology from Rice.
Watch a Rice U. video below:
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1 COMMENT
1. joestuffsda Mar 6, 2022 at 9:34 am
Check out oralee.org for a cancer treatment also progressing towards human
trials that treats any cancer without any discernable side effects.
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