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Submitted URL: https://doi.org/10.1044/2020_AJSLP-20-00007
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Submission: On May 20 via api from US — Scanned from DE
Effective URL: https://pubs.asha.org/doi/10.1044/2020_AJSLP-20-00007
Submission: On May 20 via api from US — Scanned from DE
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10.1044/2020_AJSLP-20-00007
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No AccessAmerican Journal of Speech-Language PathologyClinical Focus12 Nov 2020
DIAGNOSTIC ASSESSMENT IN PRIMARY PROGRESSIVE APHASIA: AN ILLUSTRATIVE CASE
EXAMPLE
* Eduardo Europa
,
* Leonardo Iaccarino
,
* David C. Perry
,
* Elizabeth Weis
,
* Ariane E. Welch
,
* Gil D. Rabinovici
,
* Bruce L. Miller
,
* Maria Luisa Gorno-Tempini
and
* Maya L. Henry
Eduardo Europa
https://orcid.org/0000-0003-1226-3193
Memory and Aging Center, University of California, San Francisco
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,
Leonardo Iaccarino
Memory and Aging Center, University of California, San Francisco
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,
David C. Perry
Memory and Aging Center, University of California, San Francisco
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,
Elizabeth Weis
Memory and Aging Center, University of California, San Francisco
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,
Ariane E. Welch
Memory and Aging Center, University of California, San Francisco
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,
Gil D. Rabinovici
Memory and Aging Center, University of California, San Francisco
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,
Bruce L. Miller
Memory and Aging Center, University of California, San Francisco
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,
Maria Luisa Gorno-Tempini
Memory and Aging Center, University of California, San Francisco
Dyslexia Center, University of California, San Francisco
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and
Maya L. Henry
Department of Communication Sciences and Disorders, The University of Texas at
Austin
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https://doi.org/10.1044/2020_AJSLP-20-00007
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ABSTRACT
PURPOSE
Diagnosis and classification of primary progressive aphasia (PPA) requires
confirmation of specific speech and language symptoms, highlighting the
important role of speech-language pathologists in the evaluation process. The
purpose of this case report is to inform speech-language pathologists regarding
current practices for diagnostic assessment in PPA, describing standard
approaches as well as complementary, state-of-the-art procedures that may
improve diagnostic precision.
METHOD
We describe the diagnostic evaluation of a 49-year-old woman with complaints of
progressive word-finding difficulty. She completed standard neurological,
neuropsychological, and speech-language evaluations, as well as magnetic
resonance and positron emission tomography imaging of her brain. In addition, a
history of developmental speech, language, and learning abilities was obtained,
as well as genetic testing and assessment of cerebrospinal fluid biomarkers. We
discuss the evaluation results in the context of the most current research
related to PPA diagnosis.
CONCLUSION
Detailed behavioral assessment, thorough intake of symptom history and
neurodevelopmental differences, multimodal neuroimaging, and comprehensive
examination of genes and biomarkers are of paramount importance for detecting
and characterizing PPA, with ramifications for early behavioral and/or
pharmacological intervention.
SUPPLEMENTAL MATERIAL
https://doi.org/10.23641/asha.12771113
ADDITIONAL RESOURCES
WE RECOMMEND
1. Considerations in Subtyping and Monitoring of Symptom Progression in Primary
Progressive Aphasia
Daisy Sapolsky et al., American Journal of Audiology, 2014
2. The Logopenic Variant of Primary Progressive Aphasia: Effects on Linguistic
Communication
Nidhi Mahendra, American Journal of Audiology, 2012
3. SIG 2 Perspectives Vol. 24, No. 4, October 2014
American Journal of Audiology
4. Neuropsychological Assessment of Primary Progressive Aphasia (PPA)
Brianne M. Bettcher et al., American Journal of Audiology, 2014
5. Primary Progressive Aphasia and Its Three Variants
Jennifer M. Ogar, American Journal of Audiology, 2010
1. Case of early-onset Alzheimer’s disease with atypical manifestation
Lin Zhu et al., General Psychiatry, 2021
2. When Communication Becomes Difficult: Is It Dementia?
Mary Ann E. Zagaria et al., US Pharmacist, 2013
3. Be Vivid: Bimekizumab versus ustekinumab for the treatment of moderate to
severe plaque psoriasis (BE VIVID): efficacy and safety from a 52-week,
multicentre, double-blind, active comparator and placebo controlled phase 3
trial
Kristian Reich et al., The Lancet, 2021
4. Research advances in neuroimaging and genetic characteristics of the
non-fluent/agrammatic variant of primary progressive aphasia
Yi-Jing Bai et al., Chinese Medical Journal, 2021
5. ‘I felt pain. Deep pain…’ : experiences of primary caregivers of stroke
survivors with aphasia in a South African township
Khetsiwe P. Masuku et al., South African Health Review, 2018
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* Cited By
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VOLUME 29
ISSUE 4
NOVEMBER 2020
Pages: 1833-1849
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History
* Received: Jan 16, 2020
* Revised: May 15, 2020
* Accepted: May 27, 2020
* Published online: Sep 10, 2020
* Published in issue: Nov 12, 2020
*
PubMed ID: 32910678
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